Publications by authors named "Carter Van Waes"

100Publications

Regulation of NFκB Signalling by Ubiquitination: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma?

Cancers (Basel) 2020 Oct 7;12(10). Epub 2020 Oct 7.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute of Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/cancers12102877DOI Listing
October 2020

Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells.

Elife 2020 07 7;9. Epub 2020 Jul 7.

Translational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.

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http://dx.doi.org/10.7554/eLife.54854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340502PMC
July 2020

ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer.

Oncoimmunology 2020 9;9(1):1710398. Epub 2020 Jan 9.

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1080/2162402X.2019.1710398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959437PMC
January 2020

Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition.

Oncoimmunology 2019 19;8(11):e1638207. Epub 2019 Jul 19.

Translational Tumor Immunology Program, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1080/2162402X.2019.1638207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791428PMC
July 2019

Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen-Specific T Cells.

Clin Cancer Res 2020 02 23;26(3):679-689. Epub 2019 Oct 23.

Translational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-2209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002203PMC
February 2020

Head and Neck Cancers Promote an Inflammatory Transcriptome through Coactivation of Classic and Alternative NF-κB Pathways.

Cancer Immunol Res 2019 11 17;7(11):1760-1774. Epub 2019 Oct 17.

Tumor Biology Section and Clinical Genomics Unit, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941750PMC
November 2019

A comprehensive, multidisciplinary, precision medicine approach to discover effective therapy for an undiagnosed, progressive, fibroinflammatory disease.

Transl Res 2020 01 28;215:31-40. Epub 2019 Aug 28.

Section of Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland; NIH Undiagnosed Diseases Program, Common Fund, Office of the Director, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.trsl.2019.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939610PMC
January 2020

Cisplatin and oxaliplatin induce similar immunogenic changes in preclinical models of head and neck cancer.

Oral Oncol 2019 08 20;95:127-135. Epub 2019 Jun 20.

Integrative Therapeutics Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662630PMC
August 2019

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV and HPV Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy.

Clin Cancer Res 2019 11 2;25(21):6463-6474. Epub 2019 Jul 2.

Tumor Biology Section, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825532PMC
November 2019

Lymphotoxin-β receptor-NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer.

Mol Carcinog 2019 03 28;58(3):411-425. Epub 2018 Nov 28.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

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http://doi.wiley.com/10.1002/mc.22938
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http://dx.doi.org/10.1002/mc.22938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066987PMC
March 2019

Genomic and Transcriptomic Characterization Links Cell Lines with Aggressive Head and Neck Cancers.

Cell Rep 2018 10;25(5):1332-1345.e5

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280671PMC
October 2018

WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy.

Oncoimmunology 2018 23;7(10):e1488359. Epub 2018 Jul 23.

Translational Tumor Immunology Program, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, USA.

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1488359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169577PMC
July 2018

Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133 Skin Cancer Stem Cells.

Mol Cancer Ther 2018 09 29;17(9):2034-2048. Epub 2018 Jun 29.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461743PMC
September 2018

Nanocomplex-based gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms.

Oncoimmunology 2018 7;7(7):e1404216. Epub 2018 May 7.

Translational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1080/2162402X.2017.1404216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993490PMC
May 2018

PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation.

Oncoimmunology 2018 27;7(3):e1395996. Epub 2017 Nov 27.

Translational Tumor Immunology Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1080/2162402X.2017.1395996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790397PMC
November 2017

Cisplatin Alters Antitumor Immunity and Synergizes with PD-1/PD-L1 Inhibition in Head and Neck Squamous Cell Carcinoma.

Cancer Immunol Res 2017 12 2;5(12):1141-1151. Epub 2017 Nov 2.

Office of the Clinical Director, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712281PMC
December 2017

Genomics and advances towards precision medicine for head and neck squamous cell carcinoma.

Laryngoscope Investig Otolaryngol 2017 10 22;2(5):310-319. Epub 2017 Aug 22.

Head and Neck Surgery Branch National Institute on Deafness and Other Communication Disorders Bethesda Maryland U.S.A.

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http://doi.wiley.com/10.1002/lio2.86
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http://dx.doi.org/10.1002/lio2.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655563PMC
October 2017

Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells.

Oncotarget 2017 Aug 11;8(34):55804-55820. Epub 2017 Jun 11.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.18437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593525PMC
August 2017

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

Cancer Cell 2017 06 18;31(6):820-832.e3. Epub 2017 May 18.

Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502825PMC
June 2017

Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ.

Cancer Res 2017 05 31;77(10):2607-2619. Epub 2017 Mar 31.

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466078PMC
May 2017

Genetic alterations in TRAF3 and CYLD that regulate nuclear factor κB and interferon signaling define head and neck cancer subsets harboring human papillomavirus.

Cancer 2017 05 13;123(10):1695-1698. Epub 2017 Mar 13.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland.

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http://dx.doi.org/10.1002/cncr.30659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419858PMC
May 2017

Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways.

Clin Cancer Res 2017 Mar 30;23(6):1379-1387. Epub 2016 Dec 30.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-16-2172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354945PMC
March 2017

Established T Cell-Inflamed Tumors Rejected after Adaptive Resistance Was Reversed by Combination STING Activation and PD-1 Pathway Blockade.

Cancer Immunol Res 2016 12 7;4(12):1061-1071. Epub 2016 Nov 7.

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

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http://cancerimmunolres.aacrjournals.org/cgi/doi/10.1158/232
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http://dx.doi.org/10.1158/2326-6066.CIR-16-0104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134907PMC
December 2016

Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer.

Oral Oncol 2016 07 20;58:59-70. Epub 2016 May 20.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912416PMC
July 2016

Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer.

Case Rep Otolaryngol 2016 25;2016:2313714. Epub 2016 Feb 25.

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1155/2016/2313714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818816PMC
April 2016

Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers.

Cancer Immunol Res 2016 07 13;4(7):611-20. Epub 2016 Apr 13.

Tumor Biology Section, Head and Neck Surgery Branch, National Institutes of Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland. Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930724PMC
July 2016

Pools of programmed death-ligand within the oral cavity tumor microenvironment: Variable alteration by targeted therapies.

Head Neck 2016 08 9;38(8):1176-86. Epub 2016 Apr 9.

Tumor Biology Section, Head and Neck Surgery Branch, National Institutes of Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/hed.24269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669909PMC
August 2016

Anti-Tumor Immunity in Head and Neck Cancer: Understanding the Evidence, How Tumors Escape and Immunotherapeutic Approaches.

Cancers (Basel) 2015 Dec 9;7(4):2397-414. Epub 2015 Dec 9.

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.mdpi.com/2072-6694/7/4/0900
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http://dx.doi.org/10.3390/cancers7040900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695900PMC
December 2015

mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer.

Oncotarget 2015 Nov;6(34):36400-17

Tumor Biology Section, Head and Neck Surgery Branch, National Institutes of Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.5063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742185PMC
November 2015

Genetic Landscape of Human Papillomavirus-Associated Head and Neck Cancer and Comparison to Tobacco-Related Tumors.

J Clin Oncol 2015 Oct 8;33(29):3227-34. Epub 2015 Sep 8.

D. Neil Hayes, The University of North Carolina, Chapel Hill, NC; Carter Van Waes, National Institute on Deafness and Other Communication Disorders, Bethesda, MD; and Tanguy Y. Seiwert, The University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1200/JCO.2015.62.1086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586167PMC
October 2015

Immunohistochemical analysis of NF-κB in human tumor tissue.

Methods Mol Biol 2015 ;1280:459-68

Tumor Biology Section, Head and Neck Surgery Branch, National Institutes of Deafness and Other Communication Disorders (NICDC)/NIH, 10 Center Drive, CRC 4-2740, Bethesda, MD, 20892, USA,

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http://link.springer.com/10.1007/978-1-4939-2422-6_28
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http://dx.doi.org/10.1007/978-1-4939-2422-6_28DOI Listing
November 2015

CCR 20th anniversary commentary: Preclinical study of proteasome inhibitor bortezomib in head and neck cancer.

Clin Cancer Res 2015 Mar;21(5):942-3

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351792PMC
March 2015

Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384.

Clin Cancer Res 2015 Jun 27;21(12):2792-801. Epub 2015 Feb 27.

Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470749PMC
June 2015

Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC.

Laryngoscope 2015 Mar 28;125(3):E118-24. Epub 2014 Nov 28.

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland, U.S.A.; NIH Medical Research Scholars Program, National Institutes of Health, Bethesda, Maryland, U.S.A.; Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, U.S.A.

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http://doi.wiley.com/10.1002/lary.25056
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http://dx.doi.org/10.1002/lary.25056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336212PMC
March 2015

CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer.

Neoplasia 2014 Oct 23;16(10):789-800. Epub 2014 Oct 23.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1016/j.neo.2014.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212254PMC
October 2014

Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: a case report.

Head Neck 2015 Jan 27;37(1):E1-3. Epub 2014 Jun 27.

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.

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http://doi.wiley.com/10.1002/hed.23703
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http://dx.doi.org/10.1002/hed.23703DOI Listing
January 2015

Epidermal overexpression of transgenic ΔNp63 promotes type 2 immune and myeloid inflammatory responses and hyperplasia via NF-κB activation.

J Pathol 2014 Feb;232(3):356-68

Clinical Genomics Unit and Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD, 20892, USA; Central Laboratory, Nanshan Hospital, Guangdong Medical College, Shenzhen, Guangdong, 518052, China.

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http://dx.doi.org/10.1002/path.4302DOI Listing
February 2014

Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling.

Oral Oncol 2014 Oct 28;50(10):930-41. Epub 2013 Oct 28.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13688375130071
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http://dx.doi.org/10.1016/j.oraloncology.2013.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002662PMC
October 2014

Signaling Networks of Activated Oncogenic and Altered Tumor Suppressor Genes in Head and Neck Cancer.

J Carcinog Mutagen 2013 Aug;Suppl 7

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD USA.

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https://www.omicsonline.org/signaling-networks-of-activated-
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http://dx.doi.org/10.4172/2157-2518.S7-004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289631PMC
August 2013

HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.

Transl Oncol 2013 Aug 1;6(4):429-41. Epub 2013 Aug 1.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730018PMC
http://dx.doi.org/10.1593/tlo.13292DOI Listing
August 2013

Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.

Proc Natl Acad Sci U S A 2012 Nov 5;109(47):19403-7. Epub 2012 Nov 5.

Molecular Physiology and Therapeutics Branch, and Neurobiology and Pain Therapeutics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1210662109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511089PMC
November 2012

Audiovestibular dysfunction associated with adoptive cell immunotherapy for melanoma.

Otolaryngol Head Neck Surg 2012 Oct 17;147(4):744-9. Epub 2012 May 17.

Department of Otolaryngology-Head and Neck Surgery, Georgetown University Medical Center, Washington, DC 20007, USA.

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http://dx.doi.org/10.1177/0194599812448356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318787PMC
October 2012

Targeting NF-κB in mouse models of lung adenocarcinoma.

Authors:
Carter Van Waes

Cancer Discov 2011 Aug;1(3):200-2

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-11-0159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526371PMC
August 2011

TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer.

Cancer Res 2011 Nov 20;71(21):6867-77. Epub 2011 Sep 20.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-2460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206154PMC
November 2011

ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.

Cancer Res 2011 May;71(10):3688-700

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443863PMC
May 2011

Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.

Cell Commun Signal 2011 May 15;9:13. Epub 2011 May 15.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1478-811X-9-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117821PMC
May 2011

EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy.

Expert Opin Ther Targets 2011 Jan 26;15(1):63-74. Epub 2010 Nov 26.

National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Head and Neck Surgery Branch, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1517/14728222.2011.541440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399735PMC
January 2011

Emergence of protein kinase CK2 as a key target in cancer therapy.

Biofactors 2010 May-Jun;36(3):187-95

Cellular and Molecular Biochemistry Research Laboratory, Research Service, Minneapolis V.A. Medical Center, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55417, USA.

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http://doi.wiley.com/10.1002/biof.96
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http://dx.doi.org/10.1002/biof.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916697PMC
September 2010

CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules.

Clin Cancer Res 2010 Apr 6;16(8):2295-307. Epub 2010 Apr 6.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892-1419, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861417PMC
April 2010

Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer.

Int J Radiat Oncol Biol Phys 2010 Jun 30;77(2):447-54. Epub 2009 Oct 30.

Head and Neck Surgery Branch, National Institute of Deafness and Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2009.05.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868084PMC
June 2010

Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer.

Clin Cancer Res 2009 Oct 29;15(19):5974-84. Epub 2009 Sep 29.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892-0001, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760015PMC
October 2009

Current and potential inflammation targeted therapies in head and neck cancer.

Curr Opin Pharmacol 2009 Aug 29;9(4):389-95. Epub 2009 Jun 29.

Howard Hughes Medical Institute, National Institutes of Health Research Scholars Program, 1 Cloister Ct, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.1016/j.coph.2009.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731001PMC
August 2009

Dyskeratosis congenita: the first NIH clinical research workshop.

Pediatr Blood Cancer 2009 Sep;53(3):520-3

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA.

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http://dx.doi.org/10.1002/pbc.22061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739803PMC
September 2009

Attenuated transforming growth factor beta signaling promotes nuclear factor-kappaB activation in head and neck cancer.

Cancer Res 2009 Apr 7;69(8):3415-24. Epub 2009 Apr 7.

Howard Hughes Medical Institute-NIH Research Scholars Program, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696277PMC
April 2009

Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer.

Clin Cancer Res 2009 Apr 24;15(7):2361-72. Epub 2009 Mar 24.

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689817PMC
April 2009

Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancer.

Int J Radiat Oncol Biol Phys 2009 Jul 29;74(4):1040-6. Epub 2008 Dec 29.

Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2008.09.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720824PMC
July 2009

NF-kappaB in carcinoma therapy and prevention.

Expert Opin Ther Targets 2008 Sep;12(9):1109-22

National Institute on Deafness and Other Communication Disorders, Head and Neck Surgery Branch, Bethesda, MD 20892, USA.

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http://www.tandfonline.com/doi/full/10.1517/14728222.12.9.11
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605706PMC
September 2008

Dynamic effect of bortezomib on nuclear factor-kappaB activity and gene expression in tumor cells.

Mol Pharmacol 2008 Nov 6;74(5):1215-22. Epub 2008 Aug 6.

Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Room B602, Bldg. 41, 41 Library Dr., Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1124/mol.108.049114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715175PMC
November 2008

Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanisms.

Mol Cancer Ther 2008 Jul;7(7):1949-60

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, 10/5D55, MSC-1419, Bethesda, MD 20892-1419, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-07
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http://dx.doi.org/10.1158/1535-7163.MCT-07-2046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743084PMC
July 2008

Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer.

Clin Cancer Res 2008 Jul;14(13):4175-85

Tumor Biology Section, Head and Neck Surgery Branch, National Institute of Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4470DOI Listing
July 2008

Pulsed high-intensity focused ultrasound enhances apoptosis and growth inhibition of squamous cell carcinoma xenografts with proteasome inhibitor bortezomib.

Radiology 2008 Aug 23;248(2):485-91. Epub 2008 Jun 23.

Diagnostic Radiology Department, Clinical Center and Head and Neck Surgery Branch, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1148/radiol.2482071674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621259PMC
August 2008

Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy.

J Natl Cancer Inst 2008 Apr 25;100(7):502-12. Epub 2008 Mar 25.

Department of Otolaryngology, University of Pittsburgh Medical School, Pittsburgh, PA, USA.

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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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April 2008

Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.

Cancer Res 2008 Mar;68(5):1601-8

Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5186DOI Listing
March 2008

cDNA microarray and bioinformatic analysis of nuclear factor-kappaB related genes in squamous cell carcinoma.

Methods Mol Biol 2007 ;383:81-99

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/978-1-59745-335-6_6DOI Listing
April 2008

A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas.

Int J Cancer 2008 May;122(9):1987-98

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892-1419, USA.

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http://dx.doi.org/10.1002/ijc.23324DOI Listing
May 2008

The Role of the NF-kappaB Transcriptome and Proteome as Biomarkers in Human Head and Neck Squamous Cell Carcinomas.

Biomark Med 2008 ;2(4):409-426

Head and Neck Surgery Branch, national Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, 20892, USA Tel: +1 301-402-4216.

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https://www.futuremedicine.com/doi/10.2217/17520363.2.4.409
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681266PMC
January 2008

Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer.

Clin Cancer Res 2007 Nov;13(22 Pt 1):6568-78

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1591DOI Listing
November 2007

A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status.

Clin Cancer Res 2007 Oct;13(19):5680-91

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892-1419, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-07-0670DOI Listing
October 2007

Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma.

Clin Cancer Res 2007 Sep;13(17):4956-9

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1287DOI Listing
September 2007

Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinoma.

Clin Cancer Res 2007 Jun;13(11):3182-90

Tumor Biology Section, Head and Neck Surgery Branch, National Institute of Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-3047DOI Listing
June 2007

Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck.

Head Neck 2007 Oct;29(10):959-71

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 10 Center Drive, CRC 4-2732, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1002/hed.20615DOI Listing
October 2007

Nuclear factor-kappaB in development, prevention, and therapy of cancer.

Authors:
Carter Van Waes

Clin Cancer Res 2007 Feb;13(4):1076-82

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders and Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2221DOI Listing
February 2007

Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine.

Immunol Lett 2006 Nov 12;107(2):131-9. Epub 2006 Sep 12.

Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016524780600208
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http://dx.doi.org/10.1016/j.imlet.2006.08.005DOI Listing
November 2006

Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells.

Cancer Res 2006 Jul;66(13):6722-31

Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders/NIH, 10 Center Drive, Bethesda, MD 20892, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-3758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839920PMC
July 2006