Carsten Skarke

Carsten Skarke

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Carsten Skarke

Carsten Skarke

Publications by authors named "Carsten Skarke"

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35Publications

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A Pilot Characterization of the Human Chronobiome.

Sci Rep 2017 12 7;7(1):17141. Epub 2017 Dec 7.

Department of Systems Pharmacology and Translational Therapeutics, at the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41598-017-17362-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719427PMC
December 2017

Bioactive products formed in humans from fish oils.

J Lipid Res 2015 Sep 15;56(9):1808-20. Epub 2015 Jul 15.

Institute for Translational Medicine and Therapeutics (ITMAT), Smilow Center for Translational Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.

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http://dx.doi.org/10.1194/jlr.M060392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548785PMC
September 2015

Selective COX-2 inhibitors suppress prostacyclin.

Clin Ther 2014 Dec 23;36(12):2120-2121. Epub 2014 Oct 23.

Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.clinthera.2014.09.024DOI Listing
December 2014

Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia.

Naunyn Schmiedebergs Arch Pharmacol 2013 Oct 18;386(10):865-73. Epub 2013 Jun 18.

Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, Goethe-University, Theodor Stern Kai 7, 60590, Frankfurt, Germany,

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http://dx.doi.org/10.1007/s00210-013-0889-5DOI Listing
October 2013

GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary Dose-Exposure Relationships to Define Clinical Development Strategies.

Clin Pharmacol Drug Dev 2013 Oct 25;2(4):379-86. Epub 2013 Jul 25.

Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/cpdd.47DOI Listing
October 2013

Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.

Fitoterapia 2013 Jan 23;84:89-98. Epub 2012 Oct 23.

Central Laboratory of German Pharmacists, Carl-Mannich-Str. 20, 65760 Eschborn, Germany.

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http://dx.doi.org/10.1016/j.fitote.2012.10.002DOI Listing
January 2013

Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures.

J Clin Pharmacol 2012 Oct 13;52(10):1592-600. Epub 2011 Dec 13.

Institute for Translational Medicine and Therapeutics (ITMAT), Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1177/0091270011422811DOI Listing
October 2012

Training translators for smart drug discovery.

Sci Transl Med 2010 Apr;2(26):26cm12

Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scitranslmed.3000890DOI Listing
April 2010

On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance.

Eur J Pharmacol 2009 Mar 5;606(1-3):246-54. Epub 2009 Feb 5.

Department for Pharmaceutical Analytics, Pharmaceutical Institute, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.ejphar.2009.01.044DOI Listing
March 2009

Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

Pharmacogenomics 2007 Dec;8(12):1643-60

Johann Wolfgang Goethe-University, pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Theodor Stern Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.2217/14622416.8.12.1643DOI Listing
December 2007

The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production.

Clin Pharmacol Ther 2006 Dec;80(6):621-32

Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.clpt.2006.08.021DOI Listing
December 2006

Rapid identification of three functionally relevant polymorphisms in the OATP1B1 transporter gene using Pyrosequencing.

Pharmacogenomics 2006 Mar;7(2):167-76

pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.

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http://dx.doi.org/10.2217/14622416.7.2.167DOI Listing
March 2006

Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites.

Clin Pharmacol Ther 2006 Jan;79(1):35-48

Pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt, Germany.

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http://doi.wiley.com/10.1016/j.clpt.2005.09.005
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http://dx.doi.org/10.1016/j.clpt.2005.09.005DOI Listing
January 2006

Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.

Clin Pharmacol Ther 2006 Jan;79(1):72-89

Pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.clpt.2005.09.010DOI Listing
January 2006

Rapid genotyping for relevant CYP1A2 alleles by pyrosequencing.

Eur J Clin Pharmacol 2005 Dec 24;61(12):887-92. Epub 2005 Nov 24.

pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00228-005-0029-3DOI Listing
December 2005

The 5-hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine-induced respiratory depression.

Clin Pharmacol Ther 2005 Sep;78(3):278-87

pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.clpt.2005.05.010DOI Listing
September 2005

Is morphine-3-glucuronide of therapeutic relevance?

Pain 2005 Aug;116(3):177-80

Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, pharmazentrum frankfurt/ZAFES, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.pain.2005.06.006DOI Listing
August 2005

Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives.

Clin Pharmacokinet 2004 ;43(14):983-1013

Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany.

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http://link.springer.com/10.2165/00003088-200443140-00003
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http://dx.doi.org/10.2165/00003088-200443140-00003DOI Listing
February 2005

Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans.

Anesthesiology 2004 Dec;101(6):1394-9

Pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Germany.

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http://dx.doi.org/10.1097/00000542-200412000-00020DOI Listing
December 2004

Comprehensive mu-opioid-receptor genotyping by pyrosequencing.

Clin Chem 2004 Mar;50(3):640-4

Pharmazentrum frankfurt, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Theodor Stern Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1373/clinchem.2003.027607DOI Listing
March 2004

Simultaneous screening for three mutations in the ABCB1 gene.

Genomics 2003 Nov;82(5):503-10

Pharmazentrum Frankfurt, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.

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http://dx.doi.org/10.1016/s0888-7543(03)00117-4DOI Listing
November 2003

Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers.

Pharmacogenetics 2003 Nov;13(11):651-60

Pharmazentrum frankfurt, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Theodor Stern Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1097/00008571-200311000-00001DOI Listing
November 2003

Olfactory function in mild cognitive impairment and Alzheimer's disease: an investigation using psychophysical and electrophysiological techniques.

Am J Psychiatry 2003 Nov;160(11):1995-2002

Department of Psychiatry and Psychotherapy I, University Hospital, Johann Wolfgang Goethe-University of Frankfurt am Main, Heinrich-Hoffmann-Strasse 10, 60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1176/appi.ajp.160.11.1995DOI Listing
November 2003

Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine.

Clin Pharmacol Ther 2003 Oct;74(4):303-11

pharmazentrum frankfurt, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/S0009-9236(03)00220-0DOI Listing
October 2003

Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome.

Br J Clin Pharmacol 2003 Aug;56(2):228-31

pharmazentrum frankfurt, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884272PMC
http://dx.doi.org/10.1046/j.1365-2125.2003.01866.xDOI Listing
August 2003

Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers.

Clin Pharmacol Ther 2003 Jan;73(1):107-21

pharmazentrum frankfurt, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Germany.

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http://dx.doi.org/10.1067/mcp.2003.5DOI Listing
January 2003

Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?

Anesthesiology 2002 Oct;97(4):814-9

pharmazentrum-frankfurt, Department of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1097/00000542-200210000-00011DOI Listing
October 2002

The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats.

Neurosci Lett 2002 Aug;329(2):145-8

pharmazentrum frankfurt, Department of Clinical Pharmacology, Johann Wolfgang Goethe-University, Theodor Stern Kai 7, D-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/s0304-3940(02)00618-3DOI Listing
August 2002

Pharmacokinetic modeling to predict morphine and morphine-6-glucuronide plasma concentrations in healthy young volunteers.

Clin Pharmacol Ther 2002 Aug;72(2):151-62

Department of Clinical Pharmacology, pharmazentrum frankfurt, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, Frankfurt, Germany D-60590.

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http://dx.doi.org/10.1067/mcp.2002.126172DOI Listing
August 2002

Drug interactions with patient-controlled analgesia.

Clin Pharmacokinet 2002 ;41(1):31-57

Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt, Germany.

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http://dx.doi.org/10.2165/00003088-200241010-00004DOI Listing
April 2002