Prof. Carsten Carlberg, PhD - University of Eastern Finland - Professor of Biochemistry

Prof. Carsten Carlberg

PhD

University of Eastern Finland

Professor of Biochemistry

Kuopio | Finland

Additional Specialties: Gene regulation

ORCID logohttps://orcid.org/0000-0003-2633-0684

Prof. Carsten Carlberg, PhD - University of Eastern Finland - Professor of Biochemistry

Prof. Carsten Carlberg

PhD

Introduction

Primary Affiliation: University of Eastern Finland - Kuopio , Finland

Additional Specialties:

Publications

120Publications

1610Reads

582Profile Views

1723PubMed Central Citations

In vivo transcriptome changes of human white blood cells in response to vitamin D.

J Steroid Biochem Mol Biol 2019 Apr 8;188:71-76. Epub 2018 Dec 8.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09600760183062
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http://dx.doi.org/10.1016/j.jsbmb.2018.11.019DOI Listing
April 2019
18 Reads
3.628 Impact Factor

Machine learning approaches infer vitamin D signaling: Critical impact of vitamin D receptor binding within topologically associated domains.

J Steroid Biochem Mol Biol 2019 Jan 22;185:103-109. Epub 2018 Jul 22.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FIN-70211 Kuopio, Finland.

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http://dx.doi.org/10.1016/j.jsbmb.2018.07.015DOI Listing
January 2019
15 Reads
3.630 Impact Factor

Modulation of vitamin D signaling by the pioneer factor CEBPA.

Biochim Biophys Acta Gene Regul Mech 2019 Jan 11;1862(1):96-106. Epub 2018 Dec 11.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18749399183041
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http://dx.doi.org/10.1016/j.bbagrm.2018.12.004DOI Listing
January 2019
14 Reads
6.332 Impact Factor

The impact of the vitamin D-modulated epigenome on VDR target gene regulation.

Biochim Biophys Acta Gene Regul Mech 2018 08 3;1861(8):697-705. Epub 2018 Jul 3.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2018.05.006DOI Listing
August 2018
1 Read
6.332 Impact Factor

In vivo response of the human epigenome to vitamin D: A Proof-of-principle study.

J Steroid Biochem Mol Biol 2018 06 6;180:142-148. Epub 2018 Jan 6.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1016/j.jsbmb.2018.01.002DOI Listing
June 2018
25 Reads
3 Citations
3.630 Impact Factor

Highlights from the 6 International Conference on Vitamin D Deficiency, "Nutrition and Human Health", Abu Dhabi, United Arab Emirates, March 9-10, 2017.

J Steroid Biochem Mol Biol 2018 06;180:1-3

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2018.04.019DOI Listing
June 2018
8 Reads
3.630 Impact Factor

Vitamin D Genomics: From to .

Authors:
Carsten Carlberg

Front Endocrinol (Lausanne) 2018 23;9:250. Epub 2018 May 23.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.3389/fendo.2018.00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974042PMC
May 2018

ETS transcription factor family member GABPA contributes to vitamin D receptor target gene regulation.

J Steroid Biochem Mol Biol 2018 03 11;177:46-52. Epub 2017 Sep 11.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2017.08.006DOI Listing
March 2018
2 Citations
3.630 Impact Factor

The concept of the personal vitamin D response index.

J Steroid Biochem Mol Biol 2018 01 26;175:12-17. Epub 2016 Dec 26.

Research & Development, Gulf Diagnostic Center Hospital, Abu Dhabi, United Arab Emirates.

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http://dx.doi.org/10.1016/j.jsbmb.2016.12.011DOI Listing
January 2018
35 Reads
7 Citations
3.630 Impact Factor

Molecular evaluation of vitamin D responsiveness of healthy young adults.

J Steroid Biochem Mol Biol 2017 11 6;174:314-321. Epub 2016 Jun 6.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.06.003DOI Listing
November 2017
21 Reads
2 Citations
3.630 Impact Factor

Molecular Approaches for Optimizing Vitamin D Supplementation.

Authors:
Carsten Carlberg

Vitam Horm 2016 30;100:255-71. Epub 2015 Nov 30.

Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/bs.vh.2015.10.001DOI Listing
January 2017
34 Reads
2 Citations
2.040 Impact Factor

The vitamin D-dependent transcriptome of human monocytes.

J Steroid Biochem Mol Biol 2016 11 30;164:180-187. Epub 2015 Oct 30.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2015.10.018DOI Listing
November 2016
5 Reads
6 Citations
3.630 Impact Factor

Vitamin D receptor 2016: novel ligands and structural insights.

Expert Opin Ther Pat 2016 Nov 12;26(11):1291-1306. Epub 2016 Aug 12.

d School of Medicine, Institute of Biomedicine , University of Eastern Finland , Kuopio , Finland.

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https://www.researchgate.net/profile/Carsten_Carlberg/public
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http://dx.doi.org/10.1080/13543776.2016.1216547DOI Listing
November 2016
82 Reads
2 Citations
4.300 Impact Factor

Vitamin D-dependent chromatin association of CTCF in human monocytes.

Biochim Biophys Acta 2016 11 25;1859(11):1380-1388. Epub 2016 Aug 25.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI 70211, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2016.08.008DOI Listing
November 2016
27 Reads
2 Citations

Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF.

Nucleic Acids Res 2016 05 28;44(9):4090-104. Epub 2015 Dec 28.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland

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http://dx.doi.org/10.1093/nar/gkv1519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872072PMC
May 2016
10 Reads
7 Citations
9.112 Impact Factor

Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes.

Oncotarget 2016 May;7(21):30018-31

Edward A. Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.18632/oncotarget.9065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058660PMC
May 2016
38 Reads
6 Citations
6.360 Impact Factor

Characterization of genomic vitamin D receptor binding sites through chromatin looping and opening.

PLoS One 2014 24;9(4):e96184. Epub 2014 Apr 24.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096184PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999108PMC
July 2015
6 Reads
7 Citations
3.234 Impact Factor

Vitamin D receptor signaling and its therapeutic implications: Genome-wide and structural view.

Can J Physiol Pharmacol 2015 May 21;93(5):311-8. Epub 2015 Jan 21.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, POB 1627, FI-70211 Kuopio, Finland.

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http://dx.doi.org/10.1139/cjpp-2014-0383DOI Listing
May 2015
1 Read
6 Citations
1.550 Impact Factor

Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism.

PLoS Comput Biol 2015 Apr 24;11(4):e1004236. Epub 2015 Apr 24.

Molecular Cell Physiology, VU University Amsterdam, Amsterdam, The Netherlands; Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, United Kingdom; Synthetic Systems Biology, Netherlands Institute for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pcbi.1004236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409292PMC
April 2015
14 Reads
3 Citations

Dissecting high from low responders in a vitamin D3 intervention study.

J Steroid Biochem Mol Biol 2015 Apr 13;148:275-82. Epub 2014 Nov 13.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2014.11.012DOI Listing
April 2015
28 Reads
9 Citations
3.630 Impact Factor

The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D.

Biochim Biophys Acta 2015 Mar 5;1849(3):300-8. Epub 2014 Dec 5.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.12.001DOI Listing
March 2015
11 Reads
4 Citations

What do we learn from the genome-wide perspective on vitamin D3?

Authors:
Carsten Carlberg

Anticancer Res 2015 Feb;35(2):1143-51

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

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February 2015
2 Reads
5 Citations
1.872 Impact Factor

Patterns of genome-wide VDR locations.

PLoS One 2014 30;9(4):e96105. Epub 2014 Apr 30.

Department of Biosciences, University of Eastern Finland, Kuopio, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096105PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005760PMC
January 2015
5 Reads
28 Citations
3.234 Impact Factor

Tracing the molecular basis of transcriptional dynamics in noisy data by using an experiment-based mathematical model.

Nucleic Acids Res 2015 Jan 3;43(1):153-61. Epub 2014 Dec 3.

Systems Bioinformatics, VU University Amsterdam, De Boelelaan 1087, NL-1081 HV Amsterdam, The Netherlands

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http://dx.doi.org/10.1093/nar/gku1272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288170PMC
January 2015
8 Reads
2 Citations
9.112 Impact Factor

The ASAP2 gene is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages.

J Steroid Biochem Mol Biol 2014 Oct 31;144 Pt A:12-8. Epub 2013 Aug 31.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2013.08.014DOI Listing
October 2014
6 Reads
5 Citations
3.630 Impact Factor

Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals.

Mol Nutr Food Res 2014 Oct 28;58(10):2036-45. Epub 2014 Jul 28.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1002/mnfr.201400291DOI Listing
October 2014
44 Reads
4 Citations
4.603 Impact Factor

The physiology of vitamin D-far more than calcium and bone.

Authors:
Carsten Carlberg

Front Physiol 2014 2;5:335. Epub 2014 Sep 2.

School of Medicine, Institute of Biomedicine, University of Eastern Finland Kuopio, Finland.

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http://dx.doi.org/10.3389/fphys.2014.00335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151027PMC
September 2014
2 Reads
7 Citations

Primary vitamin D receptor target genes as biomarkers for the vitamin D3 status in the hematopoietic system.

J Nutr Biochem 2014 Aug 24;25(8):875-84. Epub 2014 Apr 24.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FIN-70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2014.04.002DOI Listing
August 2014
21 Reads
3 Citations
3.794 Impact Factor

Primary 1,25-dihydroxyvitamin D3 response of the interleukin 8 gene cluster in human monocyte- and macrophage-like cells.

PLoS One 2013 21;8(10):e78170. Epub 2013 Oct 21.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078170PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824026PMC
June 2014
1 Read
12 Citations
3.234 Impact Factor

Genome-wide (over)view on the actions of vitamin D.

Authors:
Carsten Carlberg

Front Physiol 2014 29;5:167. Epub 2014 Apr 29.

School of Medicine, Institute of Biomedicine, University of Eastern Finland Kuopio, Finland.

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http://dx.doi.org/10.3389/fphys.2014.00167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010781PMC
June 2014
30 Reads
24 Citations

Dynamics of 1α,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes.

Biochim Biophys Acta 2013 Dec 1;1829(12):1266-75. Epub 2013 Nov 1.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FIN-70211 Kuopio, Finland.

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http://dx.doi.org/10.1016/j.bbagrm.2013.10.003DOI Listing
December 2013
41 Reads
10 Citations

Gene regulatory scenarios of primary 1,25-dihydroxyvitamin d3 target genes in a human myeloid leukemia cell line.

Cancers (Basel) 2013 Oct 16;5(4):1221-41. Epub 2013 Oct 16.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, POB 1627, Kuopio FI-70211, Finland.

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http://dx.doi.org/10.3390/cancers5041221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875937PMC
October 2013
3 Reads
3 Citations

The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor.

J Steroid Biochem Mol Biol 2013 Jul 7;136:62-7. Epub 2012 Dec 7.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FIN-70210 Kuopio, Finland.

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http://dx.doi.org/10.1016/j.jsbmb.2012.11.011DOI Listing
July 2013
6 Reads
8 Citations
3.630 Impact Factor

Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor.

Steroids 2013 Feb 23;78(2):127-36. Epub 2012 Nov 23.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1016/j.steroids.2012.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668715PMC
February 2013
4 Reads
49 Citations
2.640 Impact Factor

Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1α,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression.

Nucleic Acids Res 2013 Jan 23;41(1):110-24. Epub 2012 Oct 23.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FIN-70210 Kuopio, Finland.

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http://dx.doi.org/10.1093/nar/gks959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592476PMC
January 2013
5 Reads
13 Citations
9.112 Impact Factor

Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D₃ via the NF-κB pathway.

FASEB J 2012 Nov 13;26(11):4400-7. Epub 2012 Jul 13.

Institute of Biomedicine, Department of Physiology, Oulu University Hospital, Oulu, Finland.

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http://dx.doi.org/10.1096/fj.12-210880DOI Listing
November 2012
41 Reads
21 Citations
5.043 Impact Factor

Current status of vitamin D signaling and its therapeutic applications.

Curr Top Med Chem 2012 ;12(6):528-47

Department of Biosciences, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland.

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September 2012
22 Citations
3.402 Impact Factor

Dataset integration identifies transcriptional regulation of microRNA genes by PPARγ in differentiating mouse 3T3-L1 adipocytes.

Nucleic Acids Res 2012 May 7;40(10):4446-60. Epub 2012 Feb 7.

Life Sciences Research Unit, University of Luxembourg, L-1511 Luxembourg, Luxembourg.

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http://dx.doi.org/10.1093/nar/gks025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378868PMC
May 2012
22 Reads
23 Citations
9.112 Impact Factor

Differential effects of 1α,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes.

Eur J Nutr 2012 Apr 24;51(3):335-42. Epub 2011 Jun 24.

Department of Medicine Huddinge, Lipid Laboratory, Karolinska Institutet, NVS, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00394-011-0218-zDOI Listing
April 2012
25 Reads
17 Citations
3.470 Impact Factor

Vitamin D receptor ligands: the impact of crystal structures.

Expert Opin Ther Pat 2012 Apr 27;22(4):417-35. Epub 2012 Mar 27.

University of Eastern Finland, School of Medicine, Institute of Biomedicine, Kuopio, Finland.

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http://www.theproteinlab.eu/Publications_files/PDF/Articles/
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http://www.tandfonline.com/doi/full/10.1517/13543776.2012.67
Publisher Site
http://dx.doi.org/10.1517/13543776.2012.673590DOI Listing
April 2012
4 Reads
7 Citations
4.300 Impact Factor

The impact of transcriptional cycling on gene regulation.

Authors:
Carsten Carlberg

Transcription 2010 Jul-Aug;1(1):13-6

University of Luxembourg, Luxembourg.

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http://dx.doi.org/10.4161/trns.1.1.11984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035189PMC
March 2012
24 Reads
4 Citations

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages.

BMC Genomics 2012 Jan 31;13:50. Epub 2012 Jan 31.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FIN-70210 Kuopio, Finland.

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http://dx.doi.org/10.1186/1471-2164-13-50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295715PMC
January 2012
10 Reads
23 Citations
3.990 Impact Factor

The first genome-wide view of vitamin D receptor locations and their mechanistic implications.

Anticancer Res 2012 Jan;32(1):271-82

Department of Biosciences, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland.

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January 2012
3 Reads
23 Citations
1.872 Impact Factor

Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy.

Nucleic Acids Res 2011 Nov 16;39(21):9181-93. Epub 2011 Aug 16.

Department of Biosciences, University of Eastern Finland, FIN-70210 Kuopio, Finland.

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http://dx.doi.org/10.1093/nar/gkr654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241659PMC
November 2011
13 Reads
68 Citations
9.112 Impact Factor

Screening for PPAR Responsive Regulatory Modules in Cancer.

PPAR Res 2008 ;2008:749073

Life Sciences Research Unit, University of Luxembourg, 1511 Luxembourg, Luxembourg.

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http://dx.doi.org/10.1155/2008/749073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2422871PMC
July 2011
23 Reads
2 Citations
2.510 Impact Factor

Dynamic nature of transcriptional regulation of nuclear receptor target genes in the context of chromatin organization.

Dermatoendocrinol 2011 Jul 1;3(3):125-9. Epub 2011 Jul 1.

Department of Biosciences; University of Kuopio; Kuopio, Finland.

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http://dx.doi.org/10.4161/derm.3.3.15803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219162PMC
July 2011
2 Reads
1 Citation

A Role for the PPARgamma in Cancer Therapy.

PPAR Res 2008 ;2008:314974

Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1155/2008/314974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408680PMC
July 2011
15 Reads
16 Citations
2.510 Impact Factor

Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling.

PPAR Res 2007 ;2007:26839

Nutrigenomics Consortium, Wageningen Centre for Food Sciences, Wageningen, The Netherlands.

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http://dx.doi.org/10.1155/2007/26839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233741PMC
July 2011
4 Reads
67 Citations
2.510 Impact Factor

Mechanism of 1α,25-dihydroxyvitamin D(3)-dependent repression of interleukin-12B.

Biochim Biophys Acta 2011 May 18;1813(5):810-8. Epub 2011 Feb 18.

Department of Biosciences, University of Eastern Finland, FI-70211 Kuopio, Finland.

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http://dx.doi.org/10.1016/j.bbamcr.2011.01.037DOI Listing
May 2011
20 Reads
15 Citations

Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism.

J Biol Chem 2011 Apr 25;286(16):14019-27. Epub 2011 Feb 25.

Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FIN-70211 Kuopio, Finland.

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http://dx.doi.org/10.1074/jbc.M110.190710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077602PMC
April 2011
24 Reads
62 Citations
4.573 Impact Factor

Cyclical regulation of the insulin-like growth factor binding protein 3 gene in response to 1alpha,25-dihydroxyvitamin D3.

Nucleic Acids Res 2011 Jan 19;39(2):502-12. Epub 2010 Sep 19.

Department of Biosciences, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1093/nar/gkq820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025564PMC
January 2011
2 Reads
11 Citations
9.112 Impact Factor

Primary effect of 1α,25(OH)₂D₃ on IL-10 expression in monocytes is short-term down-regulation.

Biochim Biophys Acta 2010 Nov 4;1803(11):1276-86. Epub 2010 Aug 4.

Department of Biosciences, University of Eastern Finland, FIN-70211 Kuopio, Finland.

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http://dx.doi.org/10.1016/j.bbamcr.2010.07.009DOI Listing
November 2010
25 Reads
22 Citations

Dynamics of nuclear receptor target gene regulation.

Chromosoma 2010 Oct 13;119(5):479-84. Epub 2010 Jul 13.

Life Sciences Research Unit, University of Luxembourg, Luxembourg.

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http://dx.doi.org/10.1007/s00412-010-0283-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938416PMC
October 2010
23 Reads
19 Citations
4.602 Impact Factor

Time-resolved expression profiling of the nuclear receptor superfamily in human adipogenesis.

PLoS One 2010 Sep 27;5(9):e12991. Epub 2010 Sep 27.

Department of Biosciences, University of Eastern Finland, Kuopio, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012991PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946337PMC
September 2010
4 Reads
12 Citations
3.234 Impact Factor

The down-regulation of the human MYC gene by the nuclear hormone 1alpha,25-dihydroxyvitamin D3 is associated with cycling of corepressors and histone deacetylases.

J Mol Biol 2010 Jul 21;400(3):284-94. Epub 2010 May 21.

Department of Biosciences, University of Eastern Finland, FIN-70211 Kuopio, Finland.

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http://dx.doi.org/10.1016/j.jmb.2010.05.031DOI Listing
July 2010
9 Reads
19 Citations
4.333 Impact Factor

The number of vitamin D receptor binding sites defines the different vitamin D responsiveness of the CYP24 gene in malignant and normal mammary cells.

J Biol Chem 2010 Jul 11;285(31):24174-83. Epub 2010 May 11.

Department of Biosciences, University of Eastern Finland, FIN-70211 Kuopio, Finland.

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Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis.

Nucleic Acids Res 2010 May 27;38(9):2839-50. Epub 2010 Jan 27.

Nutrition, Metabolism and Genomics group, Division of Human Nutrition, Wageningen University, Bomenweg 2, NL-6703 HD Wageningen, The Netherlands.

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May 2010
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Molecular mechanism of allosteric communication in the human PPARalpha-RXRalpha heterodimer.

Proteins 2010 Mar;78(4):873-87

Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio FIN-70211, Finland.

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25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand.

J Steroid Biochem Mol Biol 2010 Feb 26;118(3):162-70. Epub 2009 Nov 26.

Department of Anatomy, Medical School, University of Tampere, Tampere, FIN-33014, Finland.

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Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene.

J Mol Biol 2009 Oct 14;393(2):261-71. Epub 2009 Aug 14.

Department of Biosciences, University of Kuopio, Finland.

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A genomic perspective on vitamin D signaling.

Anticancer Res 2009 Sep;29(9):3485-93

Life Sciences Research Unit, University of Luxembourg, Luxembourg.

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Population-level transcription cycles derive from stochastic timing of single-cell transcription.

Cell 2009 Aug;138(3):489-501

Department of Biosciences, University of Kuopio, 70211 Kuopio, Finland.

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Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling.

J Biol Chem 2009 Jul 5;284(27):18270-81. Epub 2009 May 5.

Department of Bioscience, of Kuopio, FIN-70211 Kuopio, Finland.

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Peroxisome proliferator-activated receptor alpha controls hepatic heme biosynthesis through ALAS1.

J Mol Biol 2009 May 14;388(2):225-38. Epub 2009 Mar 14.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 (CDKN1A) gene in response to 1alpha,25-dihydroxyvitamin D3.

J Biol Chem 2009 Mar 3;284(12):8073-82. Epub 2009 Jan 3.

Department of Biosciences, University of Kuopio, FIN-70210 Kuopio, Finland.

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March 2009
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40 Citations
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Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice.

Biochim Biophys Acta 2008 Nov-Dec;1781(11-12):694-702. Epub 2008 Aug 12.

Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K.U. Leuven, Leuven, Belgium.

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Meta-analysis of primary target genes of peroxisome proliferator-activated receptors.

Genome Biol 2007 ;8(7):R147

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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February 2008
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Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to Trichostatin A and 1alpha,25-dihydroxyvitamin D3.

Nucleic Acids Res 2008 Jan 13;36(1):121-32. Epub 2007 Nov 13.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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January 2008
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The vitamin D receptor.

Dermatol Clin 2007 Oct;25(4):515-23, viii

Life Sciences Research Unit, Universitè of Luxembourg, 162A, Avenue de la Faïencerie, L-1511 Luxembourg, Luxembourg.

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Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis.

Exp Cell Res 2007 Sep 29;313(15):3222-38. Epub 2007 Jun 29.

Department of Oral and Dental Science, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK.

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Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.

J Mol Biol 2007 Sep 19;372(2):341-55. Epub 2007 Jul 19.

Department of Biochemistry, University of Kuopio, FIN-70211, Kuopio, Finland.

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Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene.

Biochim Biophys Acta 2007 Jul 19;1771(7):864-72. Epub 2007 Apr 19.

Institute of Pharmaceutical Chemistry, University of Frankfurt, D-60438 Frankfurt, Germany.

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Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene.

Nucleic Acids Res 2007 10;35(8):2734-47. Epub 2007 Apr 10.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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June 2007
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Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB.

J Biol Chem 2007 Apr 15;282(15):11530-9. Epub 2007 Feb 15.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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April 2007
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Controlling the chromatin organization of vitamin D target genes by multiple vitamin D receptor binding sites.

J Steroid Biochem Mol Biol 2007 Mar 16;103(3-5):338-43. Epub 2007 Jan 16.

Department of Biochemistry, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.

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March 2007
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Detailed molecular understanding of agonistic and antagonistic vitamin D receptor ligands.

Curr Top Med Chem 2006 ;6(12):1243-53

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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February 2007
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The insulin-like growth factor-binding protein 1 gene is a primary target of peroxisome proliferator-activated receptors.

J Biol Chem 2006 Dec 24;281(51):39607-19. Epub 2006 Oct 24.

Department of Biochemistry and A.I. Virtanen Institute, University of Kuopio, FIN-70211 Kuopio, Finland.

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The impact of chromatin organization of vitamin D target genes.

Anticancer Res 2006 Jul-Aug;26(4A):2637-45

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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Epigenetic corruption of VDR signalling in malignancy.

Anticancer Res 2006 Jul-Aug;26(4A):2557-66

Institute of Biomedical Research, Endocrinology and Metabolism, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, UK.

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August 2006
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Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site.

Biochim Biophys Acta 2006 Jul 26;1761(7):686-97. Epub 2006 Apr 26.

Institute of Pharmaceutical Chemistry/ZAFES, University of Frankfurt, Marie-Curie-Str. 9, D-60439 Frankfurt, Germany.

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An integrated biological approach to nuclear receptor signaling in physiological control and disease.

Crit Rev Eukaryot Gene Expr 2006 ;16(1):1-22

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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May 2006
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Vitamin D receptor agonists specifically modulate the volume of the ligand-binding pocket.

J Biol Chem 2006 Apr 13;281(15):10516-26. Epub 2006 Feb 13.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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April 2006
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Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor.

Nucleic Acids Res 2006 24;34(2):543-54. Epub 2006 Jan 24.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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February 2006
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81 Citations
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Regulation of multiple insulin-like growth factor binding protein genes by 1alpha,25-dihydroxyvitamin D3.

Nucleic Acids Res 2005 26;33(17):5521-32. Epub 2005 Sep 26.

Department of Biochemistry, University of Kuopio, P.O. box 1627, IN-70211 Kuopio, Finland.

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October 2005
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A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors.

FASEB J 2005 Oct 19;19(12):1710-2. Epub 2005 Jul 19.

Department of Dermatology, University Hospital Schleswig-Holstein, Campus Lübeck, University of Lübeck, Lübeck, Germany.

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October 2005
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Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein.

Mol Endocrinol 2005 Sep 19;19(9):2258-72. Epub 2005 May 19.

Department of Biochemistry, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.

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September 2005
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Gene regulatory potential of nonsteroidal vitamin D receptor ligands.

Mol Endocrinol 2005 Aug 28;19(8):2060-73. Epub 2005 Apr 28.

Department of Chemistry, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.

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August 2005
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Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3.

J Mol Biol 2005 Jul;350(1):65-77

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators.

J Biol Chem 2005 Jul 11;280(28):26543-56. Epub 2005 May 11.

Department of Biochemistry, University of Kuopio, Kuopio FIN-70211, Finland.

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The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor.

J Mol Biol 2005 Jun 7;349(2):248-60. Epub 2005 Apr 7.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter.

Nucleic Acids Res 2005 29;33(8):2440-51. Epub 2005 Apr 29.

Department of Biochemistry, University of Kuopio PO Box 1627, FIN-70211 Kuopio, Finland.

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May 2005
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The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene.

J Biol Chem 2005 Apr 18;280(15):14636-44. Epub 2005 Feb 18.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis.

J Mol Biol 2005 Feb 5;346(2):505-19. Epub 2005 Jan 5.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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A structural basis for the species-specific antagonism of 26,23-lactones on vitamin D signaling.

Chem Biol 2004 Aug;11(8):1147-56

Department of Chemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs.

J Biol Chem 2004 Aug 19;279(32):33558-66. Epub 2004 May 19.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien.

Nucleic Acids Res 2004 1;32(10):2995-3004. Epub 2004 Jun 1.

Genetic Institute, Justus-Liebig-University, Heinrich-Buff-Ring 58-62, D-35392 Giessen, Germany.

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June 2004
15 Reads
8 Citations
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Using chromatin immunoprecipitation to monitor 1alpha,25-dihydroxyvitamin D3-dependent chromatin activity on the human CYP24 promoter.

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):277-9

Department of Biochemistry, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.

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Ligand-mediated conformational changes of the VDR are required for gene transactivation.

Authors:
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J Steroid Biochem Mol Biol 2004 May;89-90(1-5):227-32

Department of Biochemistry, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.

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May 2004
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The genes of the coactivator TIF2 and the corepressor SMRT are primary 1alpha,25(OH)2D3 targets.

J Steroid Biochem Mol Biol 2004 May;89-90(1-5):257-60

Department of Biochemistry, University of Kuopio, P.O. box 1627, FIN-70211 Kuopio, Finland.

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May 2004
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Current understanding of the function of the nuclear vitamin D receptor in response to its natural and synthetic ligands.

Authors:
Carsten Carlberg

Recent Results Cancer Res 2003 ;164:29-42

Department of Biochemistry, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland.

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December 2003
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Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor.

J Biol Chem 2003 Oct 1;278(44):43299-310. Epub 2003 Aug 1.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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Corepressor excess shifts the two-side chain vitamin D analog Gemini from an agonist to an inverse agonist of the vitamin D receptor.

Mol Endocrinol 2003 Oct 3;17(10):2028-38. Epub 2003 Jul 3.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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October 2003
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Structural evaluation of the agonistic action of a vitamin D analog with two side chains binding to the nuclear vitamin D receptor.

Mol Pharmacol 2003 Jun;63(6):1230-7

Department of Biochemistry, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.

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Differential nuclear receptor signalling from DR4-type response elements.

J Cell Biochem 2002 ;86(3):601-12

Institute for Physiological Chemistry I, Heinrich-Heine-University, D-40001 Düsseldorf, Germany.

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March 2003
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Molecular basis of the selective activity of vitamin D analogues.

Authors:
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J Cell Biochem 2003 Feb;88(2):274-81

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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The critical role of carboxy-terminal amino acids in ligand-dependent and -independent transactivation of the constitutive androstane receptor.

Mol Endocrinol 2003 Feb;17(2):234-46

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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February 2003
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Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors.

Mol Pharmacol 2002 Aug;62(2):366-78

Department of Pharmaceutics, University of Kuopio, Kuopio, Finland.

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August 2002
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Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands.

J Cell Biochem 2002 ;85(1):72-82

Institute for Physiological Chemistry I, Heinrich-Heine-University, Düsseldorf, Germany.

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June 2002
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Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors.

J Biol Chem 2002 May 12;277(21):18501-9. Epub 2002 Mar 12.

Department of Biochemistry, University of Kuopio, FIN-70211 Kuopio, Finland.

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May 2002
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Critical role of helix 12 of the vitamin D(3) receptor for the partial agonism of carboxylic ester antagonists.

J Mol Biol 2002 Jan;315(2):229-38

Department of Biochemistry, University of Kuopio, Finland.

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January 2002
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