Publications by authors named "Caron P Misita"

5 Publications

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A proactive medical necessity review program reduces revenue loss associated with outpatient medical benefit drugs.

Am J Health Syst Pharm 2021 Feb 18. Epub 2021 Feb 18.

UNC Health, Durham, NC, USA.

Disclaimer: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.

Purpose: A common denial trend that occurs with "outpatient medical benefit drugs" is payers not requiring or permitting prior authorization (PA) proactively, yet denying the drug after administration for medical necessity. In this situation, a preemptive strategy of complying with payer-mandated requirements is critical for revenue protection. To address this need, our institution incorporated a medical necessity review into its existing closed-loop, pharmacy-managed precertification and denials management program.

Summary: Referrals for targeted payers and high-dollar medical benefit drugs not eligible for PA and deemed high risk for denial were incorporated into the review. Payer medical policies were evaluated and clinical documentation assessed to confirm alignment. This descriptive report outlines the medical necessity workflow as a component of the larger precertification process, details the decision-making process when performing the review, and delineates the roles and responsibilities for involved team members. A total of 526 drug orders were evaluated from September 2018 to August 2019, with 146 interventions completed. Of the 761 individual claims affected by proactive medical necessity review, 99.2% resulted in payment and less than 1% resulted in revenue loss, safeguarding more than $5.3 million in annual institutional drug reimbursement. At the time of analysis, there were only 3 cases of revenue loss.

Conclusion: Our institution's pharmacy-managed medical necessity review program for high-dollar outpatient drugs safeguards reimbursement for therapies not eligible for payer PA. It is a revenue cycle best practice that can be replicated at other institutions.
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http://dx.doi.org/10.1093/ajhp/zxab046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929436PMC
February 2021

Prospective study of supplemental vitamin K therapy in patients on oral anticoagulants with unstable international normalized ratios.

J Thromb Thrombolysis 2007 Aug 24;24(1):23-7. Epub 2007 Feb 24.

Department of Pharmacy, University of North Carolina Hospitals, Chapel Hill, NC 27599, USA.

Background: It is not known whether patients on oral vitamin K antagonists who have unstable INRs achieve more stable INRs with daily vitamin K supplementation. We sought to determine whether vitamin K supplementation may decrease INR variability in patients with a history of unstable INRs, how soon the INR decreases after vitamin K therapy is initiated, the time to reach a therapeutic INR after vitamin K initiation, and how much of an increase in oral anticoagulant dose is needed to maintain the INR in the desired range.

Methods: This is a prospective open label crossover study of patients on warfarin with a history of fluctuating INRs. A 9 week observation phase was followed by an 8 week period with patients receiving 500 microg of oral vitamin K daily. INRs were determined once weekly with a home point of care monitoring instrument.

Results: Vitamin K supplementation led to a decrease in INR variability in five of the nine patients studied (56%). INR decrease occurred 2-7 days after initiation of vitamin K. Therapeutic INRs were achieved 2-35 days after vitamin K therapy was initiated and an increase in warfarin dose of 6-95% was required to bring the INR back into the therapeutic range.

Conclusions: INR fluctuations may decrease in selected patients with unstable INRs who receive vitamin K supplementation. A study with a larger sample size and longer follow-up period is needed. The results of the present study can help design such a study.
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http://dx.doi.org/10.1007/s11239-007-0014-zDOI Listing
August 2007

Antiphospholipid antibodies.

Circulation 2005 Jul;112(3):e39-44

The Carolina Cardiovascular Biology Center, Division of Hematology-Oncology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.548495DOI Listing
July 2005

Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease.

Circulation 2005 May;111(19):e289-93

Department of Internal Medicine, of Human Genetics, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1161/01.CIR.0000165142.37711.E7DOI Listing
May 2005

Bioterrorism web sites for pharmacists.

Ann Pharmacother 2003 Jan;37(1):132-5

McWhorter School of Pharmacy, Samford University, Birmingham, A 35229-7027, USAL.

Objective: To identify Internet Web sites for ease of accessibility to bioterrorism-related information, comprehensive provision of bioterrorism-related information, and provision of bioterrorism information that specifically pertains to the pharmacy profession.

Data Sources: Web sites of national pharmacy organizations, US government agencies, and medical organizations, as well as Web sites related to bioterrorism.

Data Synthesis: Pharmacists need access to relevant bioterrorism information in a timely manner. An evaluation of Web sites was performed to identify those that include a discussion of the potential infectious microorganisms and prevention and treatment methods, as well as unique features for pharmacy practice.

Results: The American Society of Health-System Pharmacists and American Pharmaceutical Association Web sites provide pharmacy-specific recommendations. The Centers for Disease Control and Prevention provides biological agent information and health department contact numbers. Additional agent-specific data are provided by the American Medical Association, The Johns Hopkins University, and the Food and Drug Administration (FDA) Web sites. Information addressing food safety is provided by the FDA.

Conclusions: Pharmacy-specific bioterrorism information is available only at selected national pharmacy organization Internet Web sites. However, other Web sites provide comprehensive bioterrorism information useful for pharmacists.
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http://dx.doi.org/10.1345/aph.1C275DOI Listing
January 2003