Carolyn Y Ho

Carolyn Y Ho

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Carolyn Y Ho

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Screening children at risk for hypertrophic cardiomyopathy: balancing benefits and harms.

Eur Heart J 2019 Jul 9. Epub 2019 Jul 9.

Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1093/eurheartj/ehz487DOI Listing
July 2019

Left Ventricular Strain Is Abnormal in Preclinical and Overt Hypertrophic Cardiomyopathy: Cardiac MR Feature Tracking.

Radiology 2019 Mar 18;290(3):640-648. Epub 2018 Dec 18.

From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Md (D.M.V., M.W.T.); Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, England (D.M.V., M.W.T., J.A.N.); Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Mass (D.M.V.); Division of Cardiology (E.Y.) and Russell H. Morgan Department of Radiology and Radiological Science (L.C.), Johns Hopkins Hospital, Baltimore, Md; University of Chicago, The College, Chicago, Ill (P.J.J.); Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio (M.W.T.); Cardiovascular Division, Brigham and Women's Hospital, Boston, Mass (H.F., C.Y.H.); Departments of Internal Medicine and Pediatrics, University of Michigan, Ann Arbor, Mich (S.M.D., M.W.R.); Department of Cardiology, Boston Children's Hospital, Boston, Mass (S.D.C.); The Heart Institute and Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (J.T.);New York University Langone Medical Center, New York, NY (M.V.S.); Department of Pediatrics, Washington University School of Medicine, St Louis, Mo (C.E.C.); Department of Nursing, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, Mass (L.S.); and School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792 (D.A.B.).

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http://dx.doi.org/10.1148/radiol.2018180339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394738PMC
March 2019

Genetic Testing and Counseling for Hypertrophic Cardiomyopathy.

Cardiol Clin 2019 Feb 29;37(1):35-43. Epub 2018 Oct 29.

Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07338651183086
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http://dx.doi.org/10.1016/j.ccl.2018.08.003DOI Listing
February 2019

Multilayer Myocardial Mechanics in Genotype-Positive Left Ventricular Hypertrophy-Negative Patients With Hypertrophic Cardiomyopathy.

Am J Cardiol 2018 11 21;122(10):1754-1760. Epub 2018 Aug 21.

Department of Cardiology, B Padeh Medical Center, Poriya and Bar-Ilan University, Israel.

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http://dx.doi.org/10.1016/j.amjcard.2018.08.008DOI Listing
November 2018

Intrinsic mitral valve alterations in hypertrophic cardiomyopathy sarcomere mutation carriers.

Eur Heart J Cardiovasc Imaging 2018 10;19(10):1109-1116

Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA.

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http://dx.doi.org/10.1093/ehjci/jey095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148328PMC
October 2018

Genetic evaluation of cardiomyopathy: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).

Genet Med 2018 09 14;20(9):899-909. Epub 2018 Jun 14.

Departments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1038/s41436-018-0039-zDOI Listing
September 2018

Ω-Net (Omega-Net): Fully automatic, multi-view cardiac MR detection, orientation, and segmentation with deep neural networks.

Med Image Anal 2018 08 22;48:95-106. Epub 2018 May 22.

Institute of Biomedical Engineering, Department of Engineering, University of Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.media.2018.05.008DOI Listing
August 2018

Genetic Evaluation of Cardiomyopathy-A Heart Failure Society of America Practice Guideline.

J Card Fail 2018 May 19;24(5):281-302. Epub 2018 Mar 19.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.

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https://linkinghub.elsevier.com/retrieve/pii/S10719164183010
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http://dx.doi.org/10.1016/j.cardfail.2018.03.004DOI Listing
May 2018

When the VEST Does Not Fit: Representations of Trial Results Deviating From Rigorous Data Interpretation.

Circ Heart Fail 2018 04;11(4):e005116

Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora (L.A.A.). Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego (E.D.A.). l'Institut del Cor, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (A.B.-G.). Temple Heart and Vascular Institute, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (M.A.B.-B.). Division of Cardiology, Department of Medicine, University of Pennsylvania, Philadelphia (J.A.C.). Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (B.L.C., C.Y.H.). Division of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City (J.C.F.). Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark (F.G.). The Cardiovascular Center, Tufts Medical Center, Boston, MA (N.K.K.). Sarver Heart Center, University of Arizona, Tucson (J.L.C., S.E.K., N.K.S.). Section of Advanced Heart Failure and Mechanical Circulatory Support, UMass Memorial Medical Center, Worcester, MA (R.D.K.). Section of Advanced Heart Failure and Transplant Cardiology, Henry Ford Hospital, Detroit, MI (D.E.L.). Department of Medicine, Minneapolis VA Health Care System and University of Minnesota, Minneapolis (O.V.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005116DOI Listing
April 2018

Lamin and the heart.

Heart 2018 03 25;104(6):468-479. Epub 2017 Nov 25.

Biomedical Research Center, NIHR University College London Hospitals, London, UK.

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http://dx.doi.org/10.1136/heartjnl-2017-312338DOI Listing
March 2018

Predicting the Future in Hypertrophic Cardiomyopathy.

Circulation 2018 03;137(10):1024-1026

Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas (M.S.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.032627DOI Listing
March 2018

Care in Specialized Centers and Data Sharing Increase Agreement in Hypertrophic Cardiomyopathy Genetic Test Interpretation.

Circ Cardiovasc Genet 2017 Oct;10(5)

From the California Department of Biological Sciences, State University, Stanislaus, Turlock, CA (A.F.); Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI (P.A., S.M.D.); Genetics Unit, Careggi University Hospital, Florence, Italy (F.G.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (A.L.C., C.Y.H.); Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands (M.M.); Referral Center for Myocardial Diseases, Azienda Ospedaliera Universitaria Careggi, Florence, Italy (I.O.); Stanford Center for Inherited Cardiovascular Disease, Stanford Medical Center, CA (E.A., C.C.); Division of Cardiovascular Medicine (E.A.) and Division of Medical Genetics (C.C.), Stanford University Medical Center, Stanford, CA; and Translational Research, MyoKardia Inc., South San Francisco, CA (E.M.G.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001700DOI Listing
October 2017

A Comparison of Whole Genome Sequencing to Multigene Panel Testing in Hypertrophic Cardiomyopathy Patients.

Circ Cardiovasc Genet 2017 Oct;10(5)

From the Cardiovascular Division (A.L.C., N.K.L., B.M., D.A., M.W., P.O., C.A.M., C.E.S., C.Y.H.), Department of Pathology (H.L.R.), and Division of Genetics (C.B., R.C.G., C.A.M.), Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA (N.K.L., B.M., D.A., M.W., P.O., H.L.R., R.C.G., C.A.M., C.E.S., C.Y.H.); Albany Medical College, NY (L.C.); Broad Institute of Harvard and MIT, Cambridge, MA (H.L.R., R.C.G., C.A.M.); Laboratory for Molecular Medicine (H.L.R., K.M., M.L.), Leadership Team (R.C.G.), Partners HealthCare Personalized Medicine, Cambridge, MA; and Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683423PMC
October 2017

Evolution of hypertrophic cardiomyopathy in sarcomere mutation carriers.

Heart 2016 Nov 2;102(22):1805-1812. Epub 2016 Sep 2.

Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/heartjnl-2016-310015DOI Listing
November 2016

Ultrasonic Assessment of Myocardial Microstructure in Hypertrophic Cardiomyopathy Sarcomere Mutation Carriers With and Without Left Ventricular Hypertrophy.

Circ Heart Fail 2016 09;9(9)

From the Cardiovascular Division, Department of Medicine (P.H., P.R.L., R.Y.K., C.Y.H., S.C.) and Department of Radiology (M.J.-H.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (J.E.H.); SessionM, Boston, MA (A.W.C.); and Division of Cardiology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI (S.A.A.).

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.116
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.116.003026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024718PMC
September 2016

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation.

Proc Natl Acad Sci U S A 2016 06 31;113(24):6701-6. Epub 2016 May 31.

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305; Stanford Center for Inherited Cardiovascular Disease, Stanford University, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1606950113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914177PMC
June 2016

Integrating Genetics and Medicine: Disease-Modifying Treatment Strategies for Hypertrophic Cardiomyopathy.

Authors:
Carolyn Y Ho

Prog Pediatr Cardiol 2016 Mar;40:21-23

Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, Tel: 617-732-5685.

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http://dx.doi.org/10.1016/j.ppedcard.2016.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862597PMC
March 2016

Functional effects of losartan in hypertrophic cardiomyopathy-a randomised clinical trial.

Heart 2016 02 9;102(4):285-91. Epub 2015 Dec 9.

Unit for Inherited Cardiac Diseases, Department of Cardiology, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1136/heartjnl-2015-308343DOI Listing
February 2016

Left ventricular volume predicts exercise capacity in hypertrophic cardiomyopathy.

Int J Cardiol 2016 Jan 6;203:676-8. Epub 2015 Nov 6.

Unit for Inherited Cardiac Diseases, Department of Cardiology, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.ijcard.2015.11.029DOI Listing
January 2016

Research priorities in sarcomeric cardiomyopathies.

Cardiovasc Res 2015 Apr 28;105(4):449-56. Epub 2015 Jan 28.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvv019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375392PMC
April 2015

Genetic advances in sarcomeric cardiomyopathies: state of the art.

Cardiovasc Res 2015 Apr 29;105(4):397-408. Epub 2015 Jan 29.

Department of Cardiology, Academic Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

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http://cardiovascres.oxfordjournals.org/content/cardiovascre
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http://cardiovascres.oxfordjournals.org/cgi/doi/10.1093/cvr/
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http://dx.doi.org/10.1093/cvr/cvv025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349164PMC
April 2015

Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy.

Circ Cardiovasc Imaging 2014 Nov 16;7(6):863-71. Epub 2014 Sep 16.

From the Department of Cardiovascular Science (G.C., L.R.L., V.P., V.M., W.J.M., P.M.E., J.C.M.) and Biostatistics Joint Research Office (P.B.), University College London, London, United Kingdom; Department of Inherited Cardiovascular Diseases (G.C., L.R.L., V.P., M.T.E., W.J.M., P.M.E., J.C.M.) and Cardiac Imaging Department (G.C., G.F., M.T.E., W.J.M., J.C.M.), Barts Heart Centre, London, United Kingdom; Department of Developmental Biology, MRC National Institutes for Medical Research, Mill Hill, United Kingdom (T.J.M.); Department of Radiology, University of Pennsylvania, Philadelphia (C.L.); Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Center for Clinical Magnetic Resonance Research (OCMR), Oxford, United Kingdom (V.M.F.); UCL Department for Cardiovascular Imaging, Great Ormond Street Hospital for Children, London, United Kingdom (V.M.); Department of Cardiology, Mount Sinai Roosevelt Hospital, Icahn School of Medicine at Mount Sinai, New York, NY (M.V.S.); Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor (S.M.D.); Pediatric Cardiology Department, Washington University School of Medicine, St Louis, MO (C.E.C.); Department of Genetics, Harvard Medical School, Boston, MA (C.E.S.); Radiology and Imaging Sciences Department, National Institutes of Health/Clinical Center, Bethesda, MD (D.A.B.); and Cardiovascular Department, Brigham and Women's Hospital, Boston, MA (C.Y.H.).

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http://dx.doi.org/10.1161/CIRCIMAGING.114.002411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237712PMC
November 2014

Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations.

Cardiovasc Res 2014 Jul 16;103(2):248-57. Epub 2014 May 16.

Department of Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, Amsterdam, The Netherlands ICIN Netherlands Heart Institute, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvu127DOI Listing
July 2014

Muscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation?

J Muscle Res Cell Motil 2014 Feb 4;35(1):37-45. Epub 2014 Feb 4.

Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 63, 50134, Florence, Italy,

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http://dx.doi.org/10.1007/s10974-014-9374-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982612PMC
February 2014

Genetic testing for inherited heart disease.

Circulation 2013 Jul;128(1):e4-8

Cardiovascular Division, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769178PMC
July 2013

A clinical approach to inherited hypertrophy: the use of family history in diagnosis, risk assessment, and management.

Circ Cardiovasc Genet 2013 Feb;6(1):118-31

Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305-5406, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.110.959387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898734PMC
February 2013

Genetic considerations in hypertrophic cardiomyopathy.

Authors:
Carolyn Y Ho

Prog Cardiovasc Dis 2012 May-Jun;54(6):456-60

Cardiovascular Division, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.pcad.2012.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604192PMC
September 2012

Hypertrophic cardiomyopathy in 2012.

Authors:
Carolyn Y Ho

Circulation 2012 Mar;125(11):1432-8

Cardiovascular Division, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.110.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.017277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328186PMC
March 2012

Genetics and clinical destiny: improving care in hypertrophic cardiomyopathy.

Authors:
Carolyn Y Ho

Circulation 2010 Dec;122(23):2430-40; discussion 2440

Cardiovascular Genetics Center, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.978924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100192PMC
December 2010

Profound left ventricular remodeling associated with LAMP2 cardiomyopathy.

Am J Cardiol 2010 Oct;106(8):1194-6

Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1016/j.amjcard.2010.06.035DOI Listing
October 2010

Hypertrophic cardiomyopathy.

Authors:
Carolyn Y Ho

Heart Fail Clin 2010 Apr;6(2):141-59

Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15517136090011
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http://dx.doi.org/10.1016/j.hfc.2009.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031113PMC
April 2010

Hypertrophic cardiomyopathy: preclinical and early phenotype.

Authors:
Carolyn Y Ho

J Cardiovasc Transl Res 2009 Dec 26;2(4):462-70. Epub 2009 Sep 26.

Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://link.springer.com/10.1007/s12265-009-9124-7
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http://dx.doi.org/10.1007/s12265-009-9124-7DOI Listing
December 2009

[Clinical spectrum of preclinical hypertrophic cardiomyopathy: characterizing carriers of sarcomere gene mutation].

Authors:
Carolyn Y Ho

Zhonghua Xin Xue Guan Bing Za Zhi 2009 Apr;37(4):289-93

Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.

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April 2009

Handheld echocardiography offers rapid assessment of clinical volume status.

Am Heart J 2008 Sep 17;156(3):537-42. Epub 2008 Jun 17.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000287030800294
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http://dx.doi.org/10.1016/j.ahj.2008.04.015DOI Listing
September 2008

Heart failure and genomics.

J Am Coll Cardiol 2007 Mar 23;49(10):1106; author reply 1106-7. Epub 2007 Feb 23.

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http://dx.doi.org/10.1016/j.jacc.2006.12.020DOI Listing
March 2007

Genetic testing in cardiac disease: from bench to bedside.

Nat Clin Pract Cardiovasc Med 2006 Sep;3(9):462-3

Cardiovascular Genetics Center of the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/ncpcardio0654DOI Listing
September 2006

A contemporary approach to hypertrophic cardiomyopathy.

Circulation 2006 Jun;113(24):e858-62

Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.105.5
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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.591982DOI Listing
June 2006

Novel locus for an inherited cardiomyopathy maps to chromosome 7.

Circulation 2006 May 1;113(18):2186-92. Epub 2006 May 1.

Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.615658DOI Listing
May 2006

A clinician's guide to tissue Doppler imaging.

Circulation 2006 Mar;113(10):e396-8

Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.579268DOI Listing
March 2006

Postinfarction ventricular septal defect with pseudoaneurysm repair after failed percutaneous closure.

Ann Thorac Surg 2005 Feb;79(2):701-3

Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.athoracsur.2003.08.075DOI Listing
February 2005