Publications by authors named "Carolyn S Calfee"

100Publications

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes.

Lancet Respir Med 2020 Oct 16. Epub 2020 Oct 16.

Feinstein Institute for Medical Research, Manhasset, NY, USA; Department of Pediatrics, Cohen Children's Medical Center, New Hyde Park, NY, USA; Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY, USA.

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http://dx.doi.org/10.1016/S2213-2600(20)30404-5DOI Listing
October 2020

Severe COVID-19 Infections-Knowledge Gained and Remaining Questions.

JAMA Intern Med 2020 Sep 18. Epub 2020 Sep 18.

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco.

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http://dx.doi.org/10.1001/jamainternmed.2020.6047DOI Listing
September 2020

Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study.

Lancet Respir Med 2020 Aug 27. Epub 2020 Aug 27.

Critical Care Directorate, Royal Gwent Hospital, Newport, UK; Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1016/S2213-2600(20)30366-0DOI Listing
August 2020

Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate.

Am J Respir Cell Mol Biol 2020 Aug 21. Epub 2020 Aug 21.

UCSF, San Francisco, California, United States;

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http://dx.doi.org/10.1165/rcmb.2020-0209OCDOI Listing
August 2020

COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?

Lancet Respir Med 2020 08 6;8(8):816-821. Epub 2020 Jul 6.

Center for Acute Respiratory Failure, New York-Presbyterian Medical Center, New York, NY, USA; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.

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http://dx.doi.org/10.1016/S2213-2600(20)30304-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338016PMC
August 2020

Is a "Cytokine Storm" Relevant to COVID-19?

JAMA Intern Med 2020 Jun 30. Epub 2020 Jun 30.

Division of Pulmonary, Department of Medicine, Critical Care, Allergy and Sleep Medicine; University of California, San Francisco.

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http://dx.doi.org/10.1001/jamainternmed.2020.3313DOI Listing
June 2020

Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention.

JAMA Intern Med 2020 Jun 17. Epub 2020 Jun 17.

Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California, San Francisco.

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http://dx.doi.org/10.1001/jamainternmed.2020.3027DOI Listing
June 2020

Cigarette Smoking and ARDS After Blunt Trauma: The Influence of Changing Smoking Patterns and Resuscitation Practices.

Chest 2020 Oct 20;158(4):1490-1498. Epub 2020 Jun 20.

Department of Medicine, University of California San Francisco, San Francisco, CA; Center for Tobacco Control Research and Education, University of California San Francisco, San Francisco, CA; Department of Anesthesia and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1016/j.chest.2020.05.603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545485PMC
October 2020

Machine Learning Classifier Models Can Identify Acute Respiratory Distress Syndrome Phenotypes Using Readily Available Clinical Data.

Am J Respir Crit Care Med 2020 Oct;202(7):996-1004

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, and.

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http://dx.doi.org/10.1164/rccm.202002-0347OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528785PMC
October 2020

Subphenotypes in critical care: translation into clinical practice.

Lancet Respir Med 2020 06;8(6):631-643

Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK; Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.

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http://dx.doi.org/10.1016/S2213-2600(20)30124-7DOI Listing
June 2020

The attributable mortality of acute respiratory distress syndrome.

Intensive Care Med 2020 Jul 25;46(7):1510-1511. Epub 2020 May 25.

Department of Anesthesia, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s00134-020-06099-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246296PMC
July 2020

Long-term ozone exposure is positively associated with telomere length in critically ill patients.

Environ Int 2020 Aug 8;141:105780. Epub 2020 May 8.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2020.105780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535086PMC
August 2020

ARDS Subphenotypes: Understanding a Heterogeneous Syndrome.

Crit Care 2020 Mar 24;24(1):102. Epub 2020 Mar 24.

Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1186/s13054-020-2778-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092435PMC
March 2020

Lack of Clinical Benefit of Interferon β-1a Among Patients With Severe Acute Respiratory Distress Syndrome: Time to Overhaul Drug Trials in ARDS?

JAMA 2020 Feb 17. Epub 2020 Feb 17.

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Departments of Medicine and Anesthesia and Cardiovascular Research Institute, University of California, San Francisco.

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http://dx.doi.org/10.1001/jama.2019.22524DOI Listing
February 2020

Gender Differences in Authorship of Critical Care Literature.

Am J Respir Crit Care Med 2020 04;201(7):840-847

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.1164/rccm.201910-1957OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124723PMC
April 2020

Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.

Lancet Respir Med 2020 03 13;8(3):247-257. Epub 2020 Jan 13.

Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Anesthesia, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/S2213-2600(19)30369-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543720PMC
March 2020

Biomarkers and Precision Medicine: State of the Art.

Crit Care Clin 2020 Jan 22;36(1):155-165. Epub 2019 Oct 22.

Department of Medicine, Vanderbilt University School of Medicine, T1218 MCN, 1161 21st Avenue South, Nashville, TN 37232-2650, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA; Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T1218 MCN, 1161 21st Avenue South, Nashville, TN 37232-2650, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccc.2019.08.012DOI Listing
January 2020

Peripheral blood leukocyte telomere length is associated with survival of sepsis patients.

Eur Respir J 2020 01 16;55(1). Epub 2020 Jan 16.

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Dept of Medicine, University of California, San Francisco, San Francisco, CA, USA

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http://dx.doi.org/10.1183/13993003.01044-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359873PMC
January 2020

Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice.

Am J Physiol Lung Cell Mol Physiol 2019 11 11;317(5):L717-L736. Epub 2019 Sep 11.

Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California.

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http://dx.doi.org/10.1152/ajplung.00132.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879898PMC
November 2019

A new frontier in ARDS trials: phenotyping before randomisation.

Lancet Respir Med 2019 10 6;7(10):830-831. Epub 2019 Aug 6.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(19)30175-4DOI Listing
October 2019

Inflammasomes Assemble: Cytoplasmic Guardians or Fallen Heroes?

Crit Care Med 2019 08;47(8):1161-1163

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine; and Department of Anesthesia, University of California, San Francisco, San Francisco, CA Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine; Department of Anesthesia; and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1097/CCM.0000000000003872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043370PMC
August 2019

Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction.

Respir Care 2019 Sep 28;64(9):1101-1108. Epub 2019 May 28.

University of California San Francisco Medical Center at Parnassus, Department of Medicine.

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http://dx.doi.org/10.4187/respcare.06544DOI Listing
September 2019

Acute Respiratory Distress Syndrome Phenotypes.

Semin Respir Crit Care Med 2019 02 6;40(1):19-30. Epub 2019 May 6.

Division of Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1055/s-0039-1684049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657496PMC
February 2019

Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation.

J Trauma Acute Care Surg 2019 08;87(2):371-378

From the Department of Surgery (L.Z.K., A.J.R., A.S.C., B.J.R., B.M.H., M.F.N.), Zuckerberg San Francisco General Hospital and the University of California, San Francisco, San Francisco, California; Department of Medicine (C.M.H., C.S.C.), University of California, San Francisco, San Francisco, California; Department of Biostatistics (S.M.), University of California, Berkeley, Berkeley, California; and Department of Surgery (M.J.C.), Denver Health Medical Center and the University of Colorado, Denver, Colorado.

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http://dx.doi.org/10.1097/TA.0000000000002331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660388PMC
August 2019

Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.

Lancet Respir Med 2019 04;7(4):e14

Department of Medicine and Anesthesia, University of California, San Francisco, CA 94143, USA; Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/S2213-2600(19)30083-9DOI Listing
April 2019

The authors reply.

Crit Care Med 2019 04;47(4):e380-e381

Department of Anesthesiology and Perioperative Medicine, University of California Los Angeles, Los Angeles, CA; Departments of Medicine and Anesthesia, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1097/CCM.0000000000003666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494106PMC
April 2019

The authors reply.

Crit Care Med 2019 04;47(4):e375-e376

Department of Anesthesiology and Perioperative Medicine, University of California Los Angeles, Los Angeles, CA; Departments of Medicine and Anesthesia, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA.

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http://Insights.ovid.com/crossref?an=00003246-201904000-0003
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http://dx.doi.org/10.1097/CCM.0000000000003648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467538PMC
April 2019

Acute respiratory distress syndrome.

Nat Rev Dis Primers 2019 03 14;5(1):18. Epub 2019 Mar 14.

Cardiovacular Research Institute, University of California-San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41572-019-0069-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709677PMC
March 2019

Phenotypes in acute respiratory distress syndrome: moving towards precision medicine.

Curr Opin Crit Care 2019 02;25(1):12-20

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine.

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http://dx.doi.org/10.1097/MCC.0000000000000571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814152PMC
February 2019

Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study.

Intensive Care Med 2018 Nov 5;44(11):1859-1869. Epub 2018 Oct 5.

Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, 505 Parnassus Ave, Box 0111, San Francisco, CA, 94143-0111, USA.

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http://link.springer.com/10.1007/s00134-018-5378-3
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http://dx.doi.org/10.1007/s00134-018-5378-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317524PMC
November 2018

Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome.

Crit Care Med 2018 11;46(11):1820-1831

Departments of Medicine and Anesthesia, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1097/CCM.0000000000003406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277052PMC
November 2018

Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome.

Am J Respir Crit Care Med 2019 02;199(3):333-341

6 Respiratory Care Services, Department of Anesthesia and Perioperative Care, University of California, San Francisco at Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.

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http://dx.doi.org/10.1164/rccm.201804-0692OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363976PMC
February 2019

Assessment of industry data on pulmonary and immunosuppressive effects of IQOS.

Tob Control 2018 11 29;27(Suppl 1):s20-s25. Epub 2018 Aug 29.

Department of Medicine, University of California San Francisco, San Francisco, California, USA.

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http://tobaccocontrol.bmj.com/lookup/doi/10.1136/tobaccocont
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http://dx.doi.org/10.1136/tobaccocontrol-2018-054296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252496PMC
November 2018

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.

Lancet Respir Med 2018 09 2;6(9):691-698. Epub 2018 Aug 2.

Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK; Regional Intensive Care Unit, The Royal Hospitals Belfast, Belfast, UK.

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http://dx.doi.org/10.1016/S2213-2600(18)30177-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201750PMC
September 2018

Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis.

Am J Physiol Lung Cell Mol Physiol 2018 11 19;315(5):L638-L644. Epub 2018 Jul 19.

Cardiovascular Research Institute, University of California , San Francisco, California.

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http://dx.doi.org/10.1152/ajplung.00286.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295506PMC
November 2018

Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury.

Trauma Surg Acute Care Open 2018 27;3(1):e000171. Epub 2018 Jun 27.

Department of Surgery, University of California San Francisco, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.

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http://dx.doi.org/10.1136/tsaco-2018-000171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045722PMC
June 2018

Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury.

J Trauma Acute Care Surg 2018 11;85(5):873-880

From the Department of Surgery (L.Z.K, A.J.R., A.S.C., A.T.F., R.A.C.,), Zuckerberg San Francisco General Hospital and the University of California, San Francisco, San Francisco, California; Department of Medicine (C.M.H., C.S.C.), San Francisco General Hospital and the University of California, San Francisco, San Francisco, California; and Department of Surgery (M.J.C.), Denver Health Medical Center and the University of Colorado; Denver, Colorado.

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http://dx.doi.org/10.1097/TA.0000000000002025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202182PMC
November 2018

Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care.

J Trauma Acute Care Surg 2018 07;85(1):148-154

From the Department of Surgery (A.J.R., L.Z.K., B.M.H., A.S.C., R.A.C.), Department of Medicine (C.M.H., F.M., C.S.C.), San Francisco General Hospital and the University of California, San Francisco, San Francisco, California; and Department of Surgery (M.J.C.), Denver Health Medical Center and the University of Colorado, Denver, Colorado.

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http://dx.doi.org/10.1097/TA.0000000000001926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029709PMC
July 2018

Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis.

Eur J Anaesthesiol 2018 09;35(9):702-709

From the Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil (ASN, PPZAC), Department of Intensive Care, Academic Medical Center (ASN, LDB, PPZAC, SNTH, MJS), Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center (LDB, MJS), Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (SNTH, MWH, AMT-dB), Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany (TB, AG, TK, MGdA), Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, California, USA (CSC), Interdisciplinary Center for Clinical Trials (IZKS), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany (MF), Department of Anaesthesiology, Hospital de Sant Pau, Barcelona, Spain (II), Department of Anaesthesiology, University Hospital Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany (RL-F), Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota (JS, TNW), Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA (DS, MFVM), Department of Surgical Sciences and Integrated Diagnostics, IRCCS San Martino IST, University of Genoa, Genoa, Italy (PP) and Mahidol Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand (MJS). PROVHILO = PROtective Ventilation with HIgh or LOw PEEP-trial. PROVE = PROtective VEntilation (http://www.provenet.eu).

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http://dx.doi.org/10.1097/EJA.0000000000000846DOI Listing
September 2018

Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS.

Thorax 2018 09 14;73(9):840-846. Epub 2018 Jun 14.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1136/thoraxjnl-2017-211280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410734PMC
September 2018

Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries.

Trauma Surg Acute Care Open 2017 28;2(1):e000121. Epub 2017 Aug 28.

Departments of Medicine and Anesthesia and the Cardiovascular Research Institute, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1136/tsaco-2017-000121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887582PMC
August 2017

Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.

Am J Physiol Lung Cell Mol Physiol 2018 07 15;315(1):L25-L40. Epub 2018 Mar 15.

Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California , San Francisco, California.

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http://dx.doi.org/10.1152/ajplung.00405.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087899PMC
July 2018

Stability of ARDS subphenotypes over time in two randomised controlled trials.

Thorax 2018 05 24;73(5):439-445. Epub 2018 Feb 24.

Departments of Medicine and Anesthesia, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1136/thoraxjnl-2017-211090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497167PMC
May 2018

Exposing the bidirectional effects of alcohol on coagulation in trauma: Impaired clot formation and decreased fibrinolysis in rotational thromboelastometry.

J Trauma Acute Care Surg 2018 01;84(1):97-103

From the Department of Surgery (B.M.H., L.Z.K., B.J.R., A.S.C., M.F.N., R.A.C.), San Francisco General Hospital and Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Anesthesia (C.S.C.), University of California San Francisco; San Francisco, California; Denver Health Medical Center (M.J.C.), University of Colorado School of Medicine, Denver, Colorado.

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http://dx.doi.org/10.1097/TA.0000000000001716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063843PMC
January 2018

Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure.

J Trauma Acute Care Surg 2018 02;84(2):365-371

From the Department of Medicine (F.M., C.H., C.S.C.), University of California San Francisco; San Francisco General Hospital (M.N., A.C.), San Francisco, California; Department of Surgery (M.J.C.), University of Colorado, Denver, Colorado; Department of Anesthesia (C.S.C.), University of California San Francisco; Cardiovascular Research Institute (C.S.C.), and Center for Tobacco Control Research and Education (C.S.C.), University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1097/TA.0000000000001738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780202PMC
February 2018

Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".

Am J Physiol Lung Cell Mol Physiol 2017 11;313(5):L966-L967

Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco.

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http://dx.doi.org/10.1152/ajplung.00428.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792183PMC
November 2017

Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome.

Lancet Respir Med 2017 06 26;5(6):512-523. Epub 2017 May 26.

Department of Medicine and Department of Anesthesia, University of California, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(17)30187-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103930PMC
June 2017

External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome.

Intensive Care Med 2017 Aug 7;43(8):1123-1131. Epub 2017 Jun 7.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University, T1218 MCN, 1161 21st Avenue S., Nashville, TN, 37232-2650, USA.

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http://dx.doi.org/10.1007/s00134-017-4854-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978765PMC
August 2017

Pulmonary toxicity of e-cigarettes.

Am J Physiol Lung Cell Mol Physiol 2017 08 18;313(2):L193-L206. Epub 2017 May 18.

Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California.

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http://dx.doi.org/10.1152/ajplung.00071.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582932PMC
August 2017

Reply: Next Step to Understanding Subphenotypes of Acute Respiratory Distress Syndrome.

Am J Respir Crit Care Med 2017 09;196(6):796

2 Kaiser Permanente Oakland, California.

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http://dx.doi.org/10.1164/rccm.201704-0693LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620680PMC
September 2017

Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.

Nicotine Tob Res 2017 Sep;19(9):1033-1039

Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA.

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http://dx.doi.org/10.1093/ntr/ntx062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896544PMC
September 2017

Characterization of distinct coagulopathic phenotypes in injury: Pathway-specific drivers and implications for individualized treatment.

J Trauma Acute Care Surg 2017 06;82(6):1055-1062

From the Department of Surgery (S.A.C., L.Z.K., B.M.H., A.S.C., R.C.K., M.F.N., C.M.H., C.S.C., R.A.C.), San Francisco General Hospital and the University of California, San Francisco, California; and Denver Health Medical Center and the University of Colorado (M.J.C.), Denver, Colorado.

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http://dx.doi.org/10.1097/TA.0000000000001423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019554PMC
June 2017

Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.

Crit Care Med 2017 May;45(5):858-866

1Division of Critical Care, Department of Pediatrics, UCSF School of Medicine, Benioff Children's Hospital, San Francisco, CA. 2Departments of Medicine and Anesthesia, UCSF School of Medicine, Cardiovascular Research Institute, San Francisco, CA. 3Division of Critical Care, Department of Pediatrics, UCLA Geffen School of Medicine, Mattel Children's Hospital, Los Angeles, CA.

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http://dx.doi.org/10.1097/CCM.0000000000002370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392136PMC
May 2017

Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.

Am J Physiol Lung Cell Mol Physiol 2017 05 17;312(5):L579-L585. Epub 2017 Feb 17.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1152/ajplung.00381.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451593PMC
May 2017

Clinical Predictors of Hospital Mortality Differ Between Direct and Indirect ARDS.

Chest 2017 04 20;151(4):755-763. Epub 2016 Sep 20.

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1016/j.chest.2016.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472517PMC
April 2017

A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome.

Pediatr Crit Care Med 2016 10;17(10):907-916

1Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA.2Departments of Anesthesia and Medicine, University of California, San Francisco, CA.3Division of Critical Care, Department of Pediatrics, University of California, Benioff Children's Hospital-San Francisco, San Francisco, CA.4Departments of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA.5Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.6Department of Pediatrics, Children's Hospital of Central California, Fresno, CA.7Department of Pediatrics, University of Wisconsin-Madison, Madison, WI.8Division of Pediatric Critical Care, University of California, San Francisco Benioff Children's Hospital-Oakland, Oakland, CA.9Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1097/PCC.0000000000000865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268071PMC
October 2016

The authors reply.

Crit Care Med 2016 08;44(8):e771

Department of Medicine, Division of Hospital Medicine, University of California, San Francisco, CA; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN; Department of Medicine, Division of Pulmonary and Critical Care, University of California, San Francisco, CA, and Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA; Department of Medicine, Division of Pulmonary and Critical Care, University of California, San Francisco, CA, Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA.

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http://dx.doi.org/10.1097/CCM.0000000000001909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338942PMC
August 2016

The authors reply.

Crit Care Med 2016 08;44(8):e769-70

Department of Medicine, Division of Hospital Medicine, University of California, San Francisco, CA; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN; Department of Medicine, Division of Pulmonary and Critical Care, University of California, San Francisco, CA, and Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA; Department of Medicine, Division of Pulmonary and Critical Care, University of California, San Francisco, CA, Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA.

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http://dx.doi.org/10.1097/CCM.0000000000001910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031148PMC
August 2016

Personalized medicine for ARDS: the 2035 research agenda.

Intensive Care Med 2016 May 4;42(5):756-767. Epub 2016 Apr 4.

Research Institute, HCor, Hospital do Coração, São Paulo, Brazil.

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http://dx.doi.org/10.1007/s00134-016-4331-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850840PMC
May 2016

Diagnostic workup for ARDS patients.

Intensive Care Med 2016 May 23;42(5):674-685. Epub 2016 Mar 23.

Division of Pulmonary Critical Care, and Sleep Medicine, Departments of Medicine, Memphis Veterans Affairs Medical Center, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s00134-016-4324-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080099PMC
May 2016

Focusing on the alveolar epithelium: Alveolar fluid clearance in diffuse versus focal acute respiratory distress syndrome.

Anaesth Crit Care Pain Med 2016 Apr 26;35(2):75-7. Epub 2016 Feb 26.

Departments of medicine and anaesthesia, division of pulmonary and critical care medicine, university of California-San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1016/j.accpm.2016.02.003DOI Listing
April 2016

The acute respiratory distress syndrome following isolated severe traumatic brain injury.

J Trauma Acute Care Surg 2016 06;80(6):989-97

From the Division of Pulmonary and Critical Care Medicine (C.M.H., H.Z., C.S.C, M.A.M.) and Division of Nephrology and Critical Care Medicine (K.D.L.), Departments of Medicine and Anesthesia, University of California San Francisco; and Department of Surgery (B.M.H., L.Z.K., A.S.C., M.F.N., M.J.C.) and Department of Neurological Surgery (G.T.M.), University of California San Francisco and San Francisco General Hospital; San Francisco, California.

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http://dx.doi.org/10.1097/TA.0000000000000982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851280PMC
June 2016