Publications by authors named "Caroline Springer"

62Publications

Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography.

Authors:
Jin Li Konstantinos Zormpas-Petridis Jessica K R Boult Emma L Reeves Andreas Heindl Maria Vinci Filipa Lopes Craig Cummings Caroline J Springer Louis Chesler Chris Jones Jeffrey C Bamber Yinyin Yuan Ralph Sinkus Yann Jamin Simon P Robinson

Cancer Res 2019 11 11;79(22):5874-5883. Epub 2019 Oct 11.

Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.

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November 2019

2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.

Authors:
Deborah A Smithen Leo M H Leung Mairi Challinor Rae Lawrence HaoRan Tang Dan Niculescu-Duvaz Simon P Pearce Robert Mcleary Filipa Lopes Mohammed Aljarah Michael Brown Louise Johnson Graeme Thomson Richard Marais Caroline Springer

J Med Chem 2020 03 4;63(5):2308-2324. Epub 2019 Sep 4.

Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.

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March 2020

Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.

Authors:
HaoRan Tang Leo Leung Grazia Saturno Amaya Viros Duncan Smith Gianpiero Di Leva Eamonn Morrison Dan Niculescu-Duvaz Filipa Lopes Louise Johnson Nathalie Dhomen Caroline Springer Richard Marais

Nat Commun 2019 Jul 18;10(1):3151. Epub 2019 Jul 18.

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, M20 4BX, UK.

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July 2019

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships.

Authors:
Leo Leung Dan Niculescu-Duvaz Deborah Smithen Filipa Lopes Cedric Callens Robert McLeary Grazia Saturno Lawrence Davies Mohammed Aljarah Michael Brown Louise Johnson Alfonso Zambon Tim Chambers Delphine Ménard Natasha Bayliss Ruth Knight Laura Fish Rae Lawrence Mairi Challinor HaoRan Tang Richard Marais Caroline Springer

J Med Chem 2019 06 23;62(12):5863-5884. Epub 2019 May 23.

Cancer Research UK Centre for Cancer Therapeutics , The Institute of Cancer Research , 15 Cotswold Road , London SM2 5NG , United Kingdom.

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June 2019

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.

Authors:
HaoRan Tang Leo Leung Grazia Saturno Amaya Viros Duncan Smith Gianpiero Di Leva Eamonn Morrison Dan Niculescu-Duvaz Filipa Lopes Louise Johnson Nathalie Dhomen Caroline Springer Richard Marais

Nat Commun 2017 04 18;8:14909. Epub 2017 Apr 18.

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4BX, UK.

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April 2017

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma.

Authors:
Maria Romina Girotti Filipa Lopes Natasha Preece Dan Niculescu-Duvaz Alfonso Zambon Lawrence Davies Steven Whittaker Grazia Saturno Amaya Viros Malin Pedersen Bart M J M Suijkerbuijk Delphine Menard Robert McLeary Louise Johnson Laura Fish Sarah Ejiama Berta Sanchez-Laorden Juliane Hohloch Neil Carragher Kenneth Macleod Garry Ashton Anna A Marusiak Alberto Fusi John Brognard Margaret Frame Paul Lorigan Richard Marais Caroline Springer

Cancer Cell 2017 03;31(3):466

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March 2017

Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma.

Authors:
Victoria L Bridgeman Elaine Wan Shane Foo Mark R Nathan Jonathan C Welti Sophia Frentzas Peter B Vermeulen Natasha Preece Caroline J Springer Thomas Powles Paul D Nathan James Larkin Martin Gore Naveen S Vasudev Andrew R Reynolds

Mol Cancer Ther 2016 Jan 20;15(1):172-83. Epub 2015 Oct 20.

Tumour Biology Team, The Breast Cancer Now Toby Robins Research Centre, Mary-Jean Mitchell Green Building, The Institute of Cancer Research (ICR), London, United Kingdom.

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January 2016

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

Authors:
Bryan W Miller Jennifer P Morton Mark Pinese Grazia Saturno Nigel B Jamieson Ewan McGhee Paul Timpson Joshua Leach Lynn McGarry Emma Shanks Peter Bailey David Chang Karin Oien Saadia Karim Amy Au Colin Steele Christopher Ross Carter Colin McKay Kurt Anderson Thomas R Jeffry Evans Richard Marais Caroline Springer Andrew Biankin Janine T Erler Owen J Sansom

EMBO Mol Med 2015 Aug;7(8):1063-76

Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK

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August 2015

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.

Authors:
Maria Romina Girotti Filipa Lopes Natasha Preece Dan Niculescu-Duvaz Alfonso Zambon Lawrence Davies Steven Whittaker Grazia Saturno Amaya Viros Malin Pedersen Bart M J M Suijkerbuijk Delphine Menard Robert McLeary Louise Johnson Laura Fish Sarah Ejiama Berta Sanchez-Laorden Juliane Hohloch Neil Carragher Kenneth Macleod Garry Ashton Anna A Marusiak Alberto Fusi John Brognard Margaret Frame Paul Lorigan Richard Marais Caroline Springer

Cancer Cell 2015 Jan 11;27(1):85-96. Epub 2014 Dec 11.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK. Electronic address:

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January 2015

BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling.

Authors:
Berta Sanchez-Laorden Amaya Viros Maria Romina Girotti Malin Pedersen Grazia Saturno Alfonso Zambon Dan Niculescu-Duvaz Samra Turajlic Andrew Hayes Martin Gore James Larkin Paul Lorigan Martin Cook Caroline Springer Richard Marais

Sci Signal 2014 Mar 25;7(318):ra30. Epub 2014 Mar 25.

1Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

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March 2014

Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance.

Authors:
Yann Jamin Thomas R Eykyn Evon Poon Caroline J Springer Simon P Robinson

Mol Imaging Biol 2014 Apr;16(2):152-7

Cancer Research UK and EPRSC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK,

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April 2014

Bacterial-directed enzyme prodrug therapy.

Authors:
Panos Lehouritis Caroline Springer Mark Tangney

J Control Release 2013 Aug 17;170(1):120-31. Epub 2013 May 17.

Cork Cancer Research Centre, Biosciences Institute, University College Cork, Cork, Ireland.

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August 2013

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.

Authors:
Dan Niculescu-Duvaz Ion Niculescu-Duvaz Bart M J M Suijkerbuijk Delphine Ménard Alfonso Zambon Lawrence Davies Jean-Francois Pons Steven Whittaker Richard Marais Caroline J Springer

Bioorg Med Chem 2013 Mar 3;21(5):1284-304. Epub 2013 Jan 3.

The Institute of Cancer Research, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.

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March 2013

Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes.

Authors:
Malin Pedersen Heidi V N Küsters-Vandevelde Amaya Viros Patricia J T A Groenen Berta Sanchez-Laorden Jacobus H Gilhuis Ilse A van Engen-van Grunsven Willy Renier Jolanda Schieving Ion Niculescu-Duvaz Caroline J Springer Benno Küsters Pieter Wesseling Willeke A M Blokx Richard Marais

Cancer Discov 2013 Apr 9;3(4):458-469. Epub 2013 Jan 9.

Signal Transduction Team, The Institute of Cancer Research, London, SW3 6JB, UK.

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April 2013

BRAF as a therapeutic target: a patent review (2006 - 2012).

Authors:
Alfonso Zambon Dan Niculescu-Duvaz Ion Niculescu-Duvaz Richard Marais Caroline J Springer

Expert Opin Ther Pat 2013 Feb 7;23(2):155-64. Epub 2013 Jan 7.

The Institute of Cancer Research, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

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February 2013

Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma.

Authors:
Maria R Girotti Malin Pedersen Berta Sanchez-Laorden Amaya Viros Samra Turajlic Dan Niculescu-Duvaz Alfonso Zambon John Sinclair Andrew Hayes Martin Gore Paul Lorigan Caroline Springer James Larkin Claus Jorgensen Richard Marais

Cancer Discov 2013 Feb 14;3(2):158-67. Epub 2012 Dec 14.

Signal Transduction Team, The Institute of Cancer Research, Royal Marsden Hospital, London, UK.

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February 2013

Topical 5-fluorouracil elicits regressions of BRAF inhibitor-induced cutaneous squamous cell carcinoma.

Authors:
Amaya Viros Robert Hayward Matthew Martin Sharona Yashar Clarissa C Yu Berta Sanchez-Laorden Alfonso Zambon Dan Niculescu-Duvaz Caroline Springer Roger S Lo Richard Marais

J Invest Dermatol 2013 Jan 16;133(1):274-6. Epub 2012 Aug 16.

Seccio Dermatologia, Departament de Medicina, Hospital Universitari Vall d’Hebron, Universitat Autonomade Barcelona, Spain.

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January 2013

Contrasting effects of sunitinib within in vivo models of metastasis.

Authors:
Jonathan C Welti Thomas Powles Shane Foo Morgane Gourlaouen Natasha Preece Julie Foster Sophia Frentzas Demelza Bird Kevin Sharpe Antoinette van Weverwijk David Robertson Julie Soffe Janine T Erler Roberto Pili Caroline J Springer Stephen J Mather Andrew R Reynolds

Angiogenesis 2012 Dec 28;15(4):623-41. Epub 2012 Jul 28.

Tumour Biology Team, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK.

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December 2012

RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.

Authors:
Fei Su Amaya Viros Carla Milagre Kerstin Trunzer Gideon Bollag Olivia Spleiss Jorge S Reis-Filho Xiangju Kong Richard C Koya Keith T Flaherty Paul B Chapman Min Jung Kim Robert Hayward Matthew Martin Hong Yang Qiongqing Wang Holly Hilton Julie S Hang Johannes Noe Maryou Lambros Felipe Geyer Nathalie Dhomen Ion Niculescu-Duvaz Alfonso Zambon Dan Niculescu-Duvaz Natasha Preece Lídia Robert Nicholas J Otte Stephen Mok Damien Kee Yan Ma Chao Zhang Gaston Habets Elizabeth A Burton Bernice Wong Hoa Nguyen Mark Kockx Luc Andries Brian Lestini Keith B Nolop Richard J Lee Andrew K Joe James L Troy Rene Gonzalez Thomas E Hutson Igor Puzanov Bartosz Chmielowski Caroline J Springer Grant A McArthur Jeffrey A Sosman Roger S Lo Antoni Ribas Richard Marais

N Engl J Med 2012 Jan;366(3):207-15

Hoffmann-La Roche, Nutley, NJ, USA.

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January 2012

Small molecule inhibitors of BRAF in clinical trials.

Authors:
Alfonso Zambon Ion Niculescu-Duvaz Dan Niculescu-Duvaz Richard Marais Caroline J Springer

Bioorg Med Chem Lett 2012 Jan 3;22(2):789-92. Epub 2011 Dec 3.

The Institute of Cancer Research, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.

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January 2012