Caroline Norez

Caroline Norez

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Caroline Norez

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Complexity of phenotypes induced by p.Asn1303Lys-CFTR correlates with difficulty to rescue and activate this protein.

Cell Mol Biol (Noisy-le-grand) 2017 Nov 30;63(11):106-110. Epub 2017 Nov 30.

EA3808, Université de Poitiers, Pôle Biologie Santé, France.

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http://dx.doi.org/10.14715/cmb/2017.63.11.18DOI Listing
November 2017

In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity.

C R Biol 2017 Aug 4;340(8):367-371. Epub 2017 Aug 4.

EA3808, Université de Poitiers, UFR SFA, Pôle Biologie Santé, bâtiment B36/B37, 1, rue Georges-Bonnet, TSA51106, 86073 Poitiers cedex 9, France. Electronic address:

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http://dx.doi.org/10.1016/j.crvi.2017.06.001DOI Listing
August 2017

Calumenin contributes to ER-Ca homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.

Cell Calcium 2017 03 4;62:47-59. Epub 2017 Feb 4.

INSERM U1078 « Génétique, Génomique fonctionnelle et biotechnologies », Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, 29200 Brest, France. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2017.01.011DOI Listing
March 2017

Pushing the limits of catalytic C-H amination in polyoxygenated cyclobutanes.

Org Biomol Chem 2016 Mar;14(9):2780-96

Laboratoire de Synthèse Organique et Molécules Bioactives (SYBIO), Université de Strasbourg/CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux (ECPM), 25 rue Becquerel, 67087 Strasbourg, France.

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http://dx.doi.org/10.1039/c5ob02602dDOI Listing
March 2016

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.

Eur J Pharmacol 2015 Oct 8;765:337-45. Epub 2015 Aug 8.

Laboratoire Signalisation et Transports Ioniques Membranaires, Université de Poitiers-CNRS, Pôle Biologie Santé, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.08.005DOI Listing
October 2015

SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells.

Biochim Biophys Acta 2015 May 4;1853(5):892-903. Epub 2015 Feb 4.

NSERM U1078, Université Bretagne Occidentale, 22 Avenue Camille Desmoulins, 29200 Brest, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.01.010DOI Listing
May 2015

Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells.

PLoS One 2014 19;9(2):e88964. Epub 2014 Feb 19.

Institut National de la Santé et de la Recherche Médicale, UMR1078, Brest, France ; C.H.U. Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, Brest, France ; Université de Bretagne Occidentale, Faculté de Médecine et des sciences de la santé, Brest, France ; Etablissement Français du Sang - Bretagne, Brest, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088964PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929654PMC
January 2015

The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity.

Cell Calcium 2015 Jan 18;57(1):38-48. Epub 2014 Nov 18.

Laboratoire Signalisation et Transports Ioniques Membranaires ERL 7368 CNRS, Université de Poitiers, 86073 Poitiers, France. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2014.11.005DOI Listing
January 2015

A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

Eur J Med Chem 2014 Aug 14;83:455-65. Epub 2014 Jun 14.

Université Grenoble Alpes, Joseph Fourier/CNRS, UMR 5063, Département de Pharmacochimie Moléculaire, 470 rue de la Chimie, F-38041 Grenoble, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.06.028DOI Listing
August 2014

ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts.

J Mol Cell Cardiol 2014 Mar 9;68:12-9. Epub 2014 Jan 9.

ERL CNRS 7368, Université de Poitiers, 1 rue Georges Bonnet, 86022 Poitiers Cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2013.12.027DOI Listing
March 2014

Bronchorelaxation of the human bronchi by CFTR activators.

Pulm Pharmacol Ther 2014 Feb 1;27(1):38-43. Epub 2013 Jul 1.

Institut de Physiologie et Biologie Cellulaires CNRS FRE3511, Université de Poitiers, Poitiers, France. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2013.06.008DOI Listing
February 2014

Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

J Cyst Fibros 2013 Dec 10;12(6):584-91. Epub 2013 Jun 10.

Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, CNRS FRE 3511, 86022 Poitiers, France.

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http://dx.doi.org/10.1016/j.jcf.2013.05.008DOI Listing
December 2013

Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors.

Chembiochem 2013 Oct 13;14(15):2050-8. Epub 2013 Sep 13.

Laboratoire de Synthèse Organique et Molécules Bioactives, Université de Strasbourg et CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux, 25 rue Becquerel, 67087 Strasbourg (France); Institut Universitaire de France, 103 Bd Saint-Michel, 75005 Paris (France).

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http://dx.doi.org/10.1002/cbic.201300312DOI Listing
October 2013

CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes.

Hum Mutat 2012 Nov 2;33(11):1557-65. Epub 2012 Jul 2.

Institut de Physiologie et Biologie Cellulaires, Centre National de la Recherche Scientifique Formation de Recherche en Evolution FRE 3511, Université de Poitiers, Poitiers, France.

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http://dx.doi.org/10.1002/humu.22129DOI Listing
November 2012

CFTR and Ca Signaling in Cystic Fibrosis.

Front Pharmacol 2011 25;2:67. Epub 2011 Oct 25.

Institut de Physiologie et de Biologie Cellulaires, Université de Poitiers, CNRS Poitiers, France.

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http://dx.doi.org/10.3389/fphar.2011.00067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200540PMC
November 2011

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.

Org Biomol Chem 2011 Aug 21;9(15):5373-88. Epub 2011 Apr 21.

CNRS and Univ. Paris Sud, Glycochimie Moléculaire et Macromoléculaire, ICMMO, UMR 8182, Orsay, F-91405, France.

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http://dx.doi.org/10.1039/c1ob05119aDOI Listing
August 2011

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

Eur J Med Chem 2011 May 23;46(5):1935-41. Epub 2011 Feb 23.

University Joseph Fourier-Grenoble 1/CNRS, UMR 5063, Département de Pharmacochimie Moléculaire, ICMG FR 2607, Bât. E 470 rue de la Chimie, BP 53 F-38041, Grenoble Cedex 9, France.

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http://dx.doi.org/10.1016/j.ejmech.2011.02.037DOI Listing
May 2011

Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis.

Am J Respir Cell Mol Biol 2011 Jan 4;44(1):83-90. Epub 2010 Mar 4.

Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, Centre National de la Recherche Scientifique, 40 Avenue du Recteur Pineau, Poitiers, France.

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http://dx.doi.org/10.1165/rcmb.2009-0347OCDOI Listing
January 2011

Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15.

J Pharmacol Exp Ther 2009 Oct 7;331(1):2-13. Epub 2009 Jul 7.

Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1124/jpet.109.155341DOI Listing
October 2009

A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype.

Am J Respir Cell Mol Biol 2009 Aug 8;41(2):217-25. Epub 2009 Jan 8.

IPBC, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers, France.

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http://dx.doi.org/10.1165/rcmb.2008-0285OCDOI Listing
August 2009

Anti-inflammatory effect of miglustat in bronchial epithelial cells.

J Cyst Fibros 2008 Nov 23;7(6):555-65. Epub 2008 Sep 23.

Laboratory of Molecular Pathology, Laboratory of Clinical Chemistry and Haematology, University Hospital of Verona, Verona, Italy.

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http://dx.doi.org/10.1016/j.jcf.2008.06.002DOI Listing
November 2008

Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.

Respir Res 2008 Oct 30;9:70. Epub 2008 Oct 30.

Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, CNRS, 86022 Poitiers, France.

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http://dx.doi.org/10.1186/1465-9921-9-70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584091PMC
October 2008

Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells.

Eur J Pharmacol 2008 Sep 4;592(1-3):33-40. Epub 2008 Jul 4.

Institut de Physiologie et Biologie Cellulaires; Université de Poitiers; CNRS, 40 avenue du recteur Pineau, 86022 Poitiers, France.

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http://linkinghub.elsevier.com/retrieve/pii/S001429990800715
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http://dx.doi.org/10.1016/j.ejphar.2008.06.103DOI Listing
September 2008

Chemical conjugation of DeltaF508-CFTR corrector deoxyspergualin to transporter human serum albumin enhances its ability to rescue Cl- channel functions.

Am J Physiol Lung Cell Mol Physiol 2008 Aug 30;295(2):L336-47. Epub 2008 May 30.

Laboratory of Molecular Pathology, Laboratory of Clinical Chemistry and Hematology, University Hospital of Verona, Verona, Italy.

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http://dx.doi.org/10.1152/ajplung.00059.2008DOI Listing
August 2008

Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells.

Exp Cell Res 2008 Jul 4;314(11-12):2199-211. Epub 2008 May 4.

Institut de Physiologie et de Biologie Cellulaires, CNRS UMR6187, Université de Poitiers, France; CHU de Poitiers, BP577, 86021 Poitiers cedex, France.

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http://linkinghub.elsevier.com/retrieve/pii/S001448270800174
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http://dx.doi.org/10.1016/j.yexcr.2008.04.012DOI Listing
July 2008

Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

J Pharmacol Exp Ther 2008 Apr 29;325(1):89-99. Epub 2008 Jan 29.

Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, Centre National de la Recherche Scientifique, 86022 Poitiers, France.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.107.13450
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http://dx.doi.org/10.1124/jpet.107.134502DOI Listing
April 2008

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

Cell Calcium 2008 Feb 27;43(2):175-83. Epub 2007 Jun 27.

Institut de Physiologie et de Biologie Cellulaires, Université de Poitiers, CNRS UMR 6187, Poitiers Cedex, France.

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http://dx.doi.org/10.1016/j.ceca.2007.05.002DOI Listing
February 2008

Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel.

Biochem Pharmacol 2008 Jan 8;75(2):476-83. Epub 2007 Sep 8.

Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, CNRS, 40 avenue du recteur Pineau, 86022 Poitiers, France.

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http://dx.doi.org/10.1016/j.bcp.2007.09.004DOI Listing
January 2008

Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

Am J Respir Cell Mol Biol 2007 Dec 19;37(6):631-9. Epub 2007 Jul 19.

Laboratoire de Virologie et Pathologie Humaine, Université de Lyon 1 and CNRS FRE 3011, Faculté de Médecine Laennec and IFR Lyon-Est, Lyon, France.

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http://dx.doi.org/10.1165/rcmb.2007-0026TEDOI Listing
December 2007

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.

J Pharmacol Exp Ther 2007 Sep 19;322(3):1023-35. Epub 2007 Jun 19.

Département de Pharmacochimie Moléculaire, Université de Grenoble, Centre National de la Recherche Scientifique, Bât. E, rue de la Chimie, BP 53, 38041 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1124/jpet.107.123307DOI Listing
September 2007

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels.

J Pharmacol Exp Ther 2006 Oct 7;319(1):349-59. Epub 2006 Jul 7.

IPBC CNRS UMR 6187, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers, France.

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http://dx.doi.org/10.1124/jpet.106.104521DOI Listing
October 2006

Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells.

Reprod Nutr Dev 2006 May-Jun;46(3):241-55. Epub 2006 May 30.

Institut de Physiologie et de Biologie Cellulaires CNRS UMR 6187, Université de Poitiers, 86022 Poitiers, France.

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http://dx.doi.org/10.1051/rnd:2006013DOI Listing
August 2006

Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

Respir Res 2006 Aug 28;7:113. Epub 2006 Aug 28.

Institut de Physiologie et Biologie Cellulaires CNRS UMR 6187, Université de Poitiers, 40 Avenue du Recteur Pineau 86022 Poitiers, Cedex, France.

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http://dx.doi.org/10.1186/1465-9921-7-113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560124PMC
August 2006

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network.

J Pharmacol Exp Ther 2006 May 19;317(2):500-5. Epub 2006 Jan 19.

Institut National de la Sante et de la Recherche Medicale U467, Université René Descartes Paris 5, Faculté de Médecine Paris 5, Paris, France.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.105.09766
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http://dx.doi.org/10.1124/jpet.105.097667DOI Listing
May 2006

Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.

Traffic 2006 May;7(5):562-73

Institut de Physiologie et Biologie Cellulaires CNRS UMR 6187, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers, France.

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http://dx.doi.org/10.1111/j.1600-0854.2006.00409.xDOI Listing
May 2006

Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat.

FEBS Lett 2006 Apr 10;580(8):2081-6. Epub 2006 Mar 10.

Institut de Physiologie et Biologie Cellulaires, CNRS UMR 6187, Université de Poitiers, 40 avenue du recteur Pineau, Poitiers 86022, France.

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http://dx.doi.org/10.1016/j.febslet.2006.03.010DOI Listing
April 2006

The glycine residues G551 and G1349 within the ATP-binding cassette signature motifs play critical roles in the activation and inhibition of cystic fibrosis transmembrane conductance regulator channels by phloxine B.

J Membr Biol 2005 Dec 7;208(3):203-12. Epub 2006 Apr 7.

Institut de Physiologie et Biologie Cellulaires, CNRS UMR6187, Université de Poitiers, 40 avenue du recteur Pineau, 86022, Poitiers, France.

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http://link.springer.com/10.1007/s00232-005-7001-0
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http://dx.doi.org/10.1007/s00232-005-7001-0DOI Listing
December 2005

Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells.

J Physiol 2005 Oct 4;568(Pt 2):483-95. Epub 2005 Aug 4.

Institut de Physiologie et Biologie Cellulaires, CNRS UMR 6187, Université de Poitiers, France.

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http://dx.doi.org/10.1113/jphysiol.2005.085019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474747PMC
October 2005

Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.

J Cyst Fibros 2004 Aug;3 Suppl 2:119-21

Institut de Physiologie et Biologie Cellulaires CNRS UMR 6187, Université de Poitiers, 40 Avenue du Recteur Pineau, Poitiers, 86022 France.

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http://dx.doi.org/10.1016/j.jcf.2004.05.025DOI Listing
August 2004

The cystic fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein.

Biochem Pharmacol 2004 Jun;67(12):2187-96

Institut de Physiologie et Biologie Cellulaires CNRS UMR 6187, Université de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers, France.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520400127
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http://dx.doi.org/10.1016/j.bcp.2004.02.022DOI Listing
June 2004

Regulation of the cystic fibrosis transmembrane conductance regulator channel by beta-adrenergic agonists and vasoactive intestinal peptide in rat smooth muscle cells and its role in vasorelaxation.

J Biol Chem 2004 May 11;279(20):21160-8. Epub 2004 Mar 11.

Laboratoire des Biomembranes et Signalisation Cellulaire CNRS Unité Mixte de Recherche 6558, Université de Poitiers, 86022 Poitiers, France.

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http://dx.doi.org/10.1074/jbc.M312199200DOI Listing
May 2004

Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity.

J Cell Sci 2004 Apr 23;117(Pt 10):1923-35. Epub 2004 Mar 23.

Laboratoire de Génétique Cellulaire et Moléculaire, UPRES EA 2622, CHU de Poitiers, BP 577, 86021 Poitiers CEDEX, France.

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http://dx.doi.org/10.1242/jcs.01070DOI Listing
April 2004

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels.

Br J Pharmacol 2004 Mar 16;141(6):905-14. Epub 2004 Feb 16.

Institut de Neurosciences Physiologiques et Cognitives, INPC-CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille, Cedex 20, France.

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http://dx.doi.org/10.1038/sj.bjp.0705684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574262PMC
March 2004

Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels.

J Med Chem 2004 Feb;47(4):962-72

Laboratoire de Chimie Organique, Faculté de Médecine et de Pharmacie, Université de Poitiers, 34 rue du Jardin des Plantes, BP 199, 86005 Poitiers Cedex, France.

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http://dx.doi.org/10.1021/jm0308848DOI Listing
February 2004