Publications by authors named "Caroline Jane Lodge"

4 Publications

  • Page 1 of 1

Infant Body Mass Index Trajectories, and Asthma & Lung Function.

J Allergy Clin Immunol 2021 Mar 1. Epub 2021 Mar 1.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia. Electronic address:

Background: The impact of early rapid body mass index (BMI) increase on asthma risk and subsequent lung function remains contentious, with limited prospective studies during a critical window for lung growth.

Objective: We investigated the associations between BMI trajectories in the first 2 years of life, and adolescent asthma and lung function.

Methods: Anthropometric data was collected up to 18 times in the first 24 months on 620 infants from the Melbourne Atopy Cohort Study. BMI trajectories were developed using group-based trajectory modelling. Associations between these trajectories and spirometry, fractional exhaled nitric oxide, and current asthma status at 12 and/or 18 years of age were modelled using multiple linear and logistic regression.

Results: Five BMI trajectories were identified. Compared to the "average trajectory", children belonging to the "early low and catch up" and "persistently high" BMI trajectories were at higher risk of asthma at 18 years (OR=2·2; 95%CI 1·0, 4·8 and 2·4; 1·1, 5·3 respectively). These trajectories were also associated with lower FEV1 by FVC, and higher FeNO levels at 18 years. In addition, children belonging to the "persistently low" trajectory had lower FEV1 (β=-183·9 ml; 95%CI -340·9, -26·9) and FVC (β=-207·8 ml; -393·6, -22·0) at 18 years.

Conclusion: In this cohort, "early low & catch up" and "persistently high" trajectories were associated with asthma and obstructive lung function pattern in adolescence. Having a persistently low BMI at an early age was associated with a restrictive pattern. Thus, maintenance of normal growth patterns may lead to improved adolescent respiratory health.
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http://dx.doi.org/10.1016/j.jaci.2021.02.020DOI Listing
March 2021

Transient childhood wheeze is associated with less atopy in adolescence.

Pediatr Allergy Immunol 2020 11 14;31(8):913-919. Epub 2020 Jul 14.

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Australia.

Background: The relationships between childhood wheeze phenotypes and subsequent allergic conditions other than asthma, including hay fever, eczema and sensitization, have not been widely reported. We aimed to investigate this relationship up to late adolescence.

Methods: Using five childhood wheeze phenotypes defined from 620 children in a high-atopy risk birth cohort (Melbourne Atopy Cohort Study), we investigated their relationships with sensitization, eczema, hay fever and fractional exhaled nitric oxide (FeNO) at ages 12 and/or 18 years using logistic and linear regression models.

Results: 'Early Persistent wheeze' was associated with the increased risk of eczema (odds ratio: 3.69; 95% CI: 1.23, 11.12) and sensitization (4.52; 1.50, 13.64) at 12 years. 'Intermediate Onset wheeze' was associated with the increased risk of eczema at 12 years (2.57; 1.11, 5.97), hay fever at 12 (2.87; 1.44, 5.74) and 18 years (2.19; 1.20, 4.02), sensitization at 12 (2.25; 1.17, 4.34) and 18 years (2.46; 1.18, 5.12), and raised FeNO at 18 years. 'Late Onset wheeze' was associated with the increased risk of hay fever at 12 (5.18; 1.11, 24.20) and 18 years (4.20; 1.03, 17.11) and sensitization at 12 years (3.27; 0.81, 13.27). In contrast, 'Early Transient wheeze' was associated with the reduced risk of eczema (0.44; 0.20, 0.96), hay fever (0.57; 0.33, 0.99) and sensitization (0.59; 0.35, 0.99) at 18 years and a lower FeNO compared with 'Never/Infrequent wheezers'.

Conclusions: Persistent wheeze phenotypes were associated with allergic outcomes up to 18 years with 'Intermediate Onset wheeze' being the most atopic group. In contrast, 'Early Transient wheezers' had less risk of allergic outcomes at 18 years. This protective effect may reassure parents of wheezy infants and young children.
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http://dx.doi.org/10.1111/pai.13304DOI Listing
November 2020

Is self-reported history of eczema and hay fever a valid measure of atopy in those who report current asthma?

Allergy 2020 11 7;75(11):2981-2984. Epub 2020 Aug 7.

Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Vic., Australia.

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http://dx.doi.org/10.1111/all.14440DOI Listing
November 2020

Do hydrolysed infant formulas reduce the risk of allergic disease?

BMJ 2016 Mar 8;352:i1143. Epub 2016 Mar 8.

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Vic 3010, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783515PMC
http://dx.doi.org/10.1136/bmj.i1143DOI Listing
March 2016