Publications by authors named "Caroline Dive"

100Publications

Brief report on the clinical characteristics of patients whose samples generate small cell lung cancer circulating tumour cell derived explants.

Lung Cancer 2020 Nov 5;150:216-220. Epub 2020 Nov 5.

The Christie NHS Foundation Trust, Withington, Greater Manchester, M20 4BX, UK; The University of Manchester, Oxford Road, Manchester, Greater Manchester, M13 9PL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2020.11.002DOI Listing
November 2020

Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers.

Mol Cell 2020 11;80(4):562-577

Pathology and Laboratory Medicine and Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.molcel.2020.10.033DOI Listing
November 2020

A model of -mer surprisal to quantify local sequence information content surrounding splice regions.

PeerJ 2020 4;8:e10063. Epub 2020 Nov 4.

Computational Biology Group, CRUK Beatson Institute, Glasgow, United Kingdom.

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http://dx.doi.org/10.7717/peerj.10063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648452PMC
November 2020

The biomolecule corona of lipid nanoparticles contains circulating cell-free DNA.

Nanoscale Horiz 2020 11 27;5(11):1476-1486. Epub 2020 Aug 27.

Nanomedicine Lab, Faculty of Biology, Medicine and Health, The University of Manchester, AV Hill Building, Manchester, UK.

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http://dx.doi.org/10.1039/d0nh00333fDOI Listing
November 2020

The Rare YAP1 Subtype of SCLC Revisited in a Biobank of 39 Circulating Tumor Cell Patient Derived Explant Models: A Brief Report.

J Thorac Oncol 2020 Dec 25;15(12):1836-1843. Epub 2020 Jul 25.

Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester, Manchester, United Kingdom; Cancer Research UK Lung Cancer Centre of Excellence, Manchester, United Kingdom; Division of Cancer Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2020.07.008DOI Listing
December 2020

Liquid Biopsy-Based Biomarkers of Treatment Response and Resistance.

Cancer Cell 2020 04;37(4):485-495

Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester, Alderley Park, Macclesfield SK10 4TG, UK; Cancer Research UK Lung Cancer Centre of Excellence, University of Manchester, Oxford Road, Manchester M13 9PL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.03.012DOI Listing
April 2020

Pazopanib and Fosbretabulin in recurrent ovarian cancer (PAZOFOS): A multi-centre, phase 1b and open-label, randomised phase 2 trial.

Gynecol Oncol 2020 03 10;156(3):545-551. Epub 2020 Jan 10.

Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2020.01.005DOI Listing
March 2020

Identification of a Biomarker Panel for Early Detection of Lung Cancer Patients.

J Proteome Res 2019 09 21;18(9):3369-3382. Epub 2019 Aug 21.

Stoller Biomarker Discovery Centre, Institute of Cancer Sciences, Faculty of Medical and Human Sciences , University of Manchester , Manchester M13 9PL , United Kingdom.

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https://pubs.acs.org/doi/10.1021/acs.jproteome.9b00287
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http://dx.doi.org/10.1021/acs.jproteome.9b00287DOI Listing
September 2019

Dynamics of circulating vascular endothelial growth factor-A predict benefit from antiangiogenic cediranib in metastatic or recurrent cervical cancer patients.

Br J Clin Pharmacol 2019 08 13;85(8):1781-1789. Epub 2019 Apr 13.

Division of Cancer Sciences, University of Manchester, Christie Hospital NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1111/bcp.13965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624436PMC
August 2019

Genomic Evaluation of Multiparametric Magnetic Resonance Imaging-visible and -nonvisible Lesions in Clinically Localised Prostate Cancer.

Eur Urol Oncol 2019 02 5;2(1):1-11. Epub 2018 Sep 5.

Belfast-Manchester Movember Centre of Excellence, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, UK; Prostate Oncobiology, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, UK. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472613PMC
February 2019

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death.

EJNMMI Res 2019 Feb 19;9(1):18. Epub 2019 Feb 19.

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1186/s13550-019-0487-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381199PMC
February 2019

Molecular characterisation and liquid biomarkers in Carcinoma of Unknown Primary (CUP): taking the 'U' out of 'CUP'.

Br J Cancer 2019 01 23;120(2):141-153. Epub 2018 Dec 23.

The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1038/s41416-018-0332-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342985PMC
January 2019

Will liquid biopsies improve outcomes for patients with small-cell lung cancer?

Lancet Oncol 2018 09;19(9):e470-e481

Clinical and Experimental Pharmacology Group and Manchester Centre for Cancer Biomarker Sciences, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK; Cancer Research UK Lung Cancer Centre of Excellence at University College London, London, UK; University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(18)30455-8DOI Listing
September 2018

Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Authors:
Christopher Abbosh Nicolai J Birkbak Gareth A Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari John Le Quesne David A Moore Selvaraju Veeriah Rachel Rosenthal Teresa Marafioti Eser Kirkizlar Thomas B K Watkins Nicholas McGranahan Sophia Ward Luke Martinson Joan Riley Francesco Fraioli Maise Al Bakir Eva Grönroos Francisco Zambrana Raymondo Endozo Wenya Linda Bi Fiona M Fennessy Nicole Sponer Diana Johnson Joanne Laycock Seema Shafi Justyna Czyzewska-Khan Andrew Rowan Tim Chambers Nik Matthews Samra Turajlic Crispin Hiley Siow Ming Lee Martin D Forster Tanya Ahmad Mary Falzon Elaine Borg David Lawrence Martin Hayward Shyam Kolvekar Nikolaos Panagiotopoulos Sam M Janes Ricky Thakrar Asia Ahmed Fiona Blackhall Yvonne Summers Dina Hafez Ashwini Naik Apratim Ganguly Stephanie Kareht Rajesh Shah Leena Joseph Anne Marie Quinn Phil A Crosbie Babu Naidu Gary Middleton Gerald Langman Simon Trotter Marianne Nicolson Hardy Remmen Keith Kerr Mahendran Chetty Lesley Gomersall Dean A Fennell Apostolos Nakas Sridhar Rathinam Girija Anand Sajid Khan Peter Russell Veni Ezhil Babikir Ismail Melanie Irvin-Sellers Vineet Prakash Jason F Lester Malgorzata Kornaszewska Richard Attanoos Haydn Adams Helen Davies Dahmane Oukrif Ayse U Akarca John A Hartley Helen L Lowe Sara Lock Natasha Iles Harriet Bell Yenting Ngai Greg Elgar Zoltan Szallasi Roland F Schwarz Javier Herrero Aengus Stewart Sergio A Quezada Karl S Peggs Peter Van Loo Caroline Dive C Jimmy Lin Matthew Rabinowitz Hugo J W L Aerts Allan Hackshaw Jacqui A Shaw Bernhard G Zimmermann Charles Swanton

Nature 2018 02 20;554(7691):264. Epub 2017 Dec 20.

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http://dx.doi.org/10.1038/nature25161DOI Listing
February 2018

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer.

Clin Colorectal Cancer 2018 03 1;17(1):80-83. Epub 2017 Nov 1.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2017.10.017DOI Listing
March 2018

Targeting DNA damage in SCLC.

Lung Cancer 2017 12 16;114:12-22. Epub 2017 Oct 16.

Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK; Institute of Cancer Sciences, University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.10.006DOI Listing
December 2017

The clinical utility of circulating tumour cells in patients with small cell lung cancer.

Transl Lung Cancer Res 2017 Aug;6(4):409-417

Institute of Cancer Sciences, CRUK Manchester Institute, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.21037/tlcr.2017.07.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583068PMC
August 2017

Circulating tumor cells and CDX models as a tool for preclinical drug development.

Transl Lung Cancer Res 2017 Aug;6(4):397-408

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.

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http://tlcr.amegroups.com/article/view/14974/12187
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http://dx.doi.org/10.21037/tlcr.2017.08.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583071PMC
August 2017

Spotlight on circulating tumour cells.

Transl Lung Cancer Res 2017 Aug;6(4):396

Cancer Research UK Lung Cancer Centre of Excellence, CRUK Manchester Institute, University of Manchester, Manchester, UK. (Email:

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http://dx.doi.org/10.21037/tlcr.2017.08.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583069PMC
August 2017

Progress and prospects of early detection in lung cancer.

Open Biol 2017 09;7(9)

Cancer Research UK Lung Cancer Centre of Excellence at Manchester and University College London, UK

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http://dx.doi.org/10.1098/rsob.170070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627048PMC
September 2017

twoddpcr: an R/Bioconductor package and Shiny app for Droplet Digital PCR analysis.

Bioinformatics 2017 Sep;33(17):2743-2745

RNA Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20?4BX, UK.

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http://dx.doi.org/10.1093/bioinformatics/btx308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860069PMC
September 2017

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Authors:
Christopher Abbosh Nicolai J Birkbak Gareth A Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari John Le Quesne David A Moore Selvaraju Veeriah Rachel Rosenthal Teresa Marafioti Eser Kirkizlar Thomas B K Watkins Nicholas McGranahan Sophia Ward Luke Martinson Joan Riley Francesco Fraioli Maise Al Bakir Eva Grönroos Francisco Zambrana Raymondo Endozo Wenya Linda Bi Fiona M Fennessy Nicole Sponer Diana Johnson Joanne Laycock Seema Shafi Justyna Czyzewska-Khan Andrew Rowan Tim Chambers Nik Matthews Samra Turajlic Crispin Hiley Siow Ming Lee Martin D Forster Tanya Ahmad Mary Falzon Elaine Borg David Lawrence Martin Hayward Shyam Kolvekar Nikolaos Panagiotopoulos Sam M Janes Ricky Thakrar Asia Ahmed Fiona Blackhall Yvonne Summers Dina Hafez Ashwini Naik Apratim Ganguly Stephanie Kareht Rajesh Shah Leena Joseph Anne Marie Quinn Phil A Crosbie Babu Naidu Gary Middleton Gerald Langman Simon Trotter Marianne Nicolson Hardy Remmen Keith Kerr Mahendran Chetty Lesley Gomersall Dean A Fennell Apostolos Nakas Sridhar Rathinam Girija Anand Sajid Khan Peter Russell Veni Ezhil Babikir Ismail Melanie Irvin-Sellers Vineet Prakash Jason F Lester Malgorzata Kornaszewska Richard Attanoos Haydn Adams Helen Davies Dahmane Oukrif Ayse U Akarca John A Hartley Helen L Lowe Sara Lock Natasha Iles Harriet Bell Yenting Ngai Greg Elgar Zoltan Szallasi Roland F Schwarz Javier Herrero Aengus Stewart Sergio A Quezada Karl S Peggs Peter Van Loo Caroline Dive C Jimmy Lin Matthew Rabinowitz Hugo J W L Aerts Allan Hackshaw Jacqui A Shaw Bernhard G Zimmermann Charles Swanton

Nature 2017 04;545(7655):446-451

Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.

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http://dx.doi.org/10.1038/nature22364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812436PMC
April 2017

Tracking the Evolution of Non-Small-Cell Lung Cancer.

N Engl J Med 2017 06 26;376(22):2109-2121. Epub 2017 Apr 26.

From the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., G.A.W., N. McGranahan, N.J.B., S.V., S.S., D.H.J., R.R., S.-M.L., M.D.F., C.A., S.M.J., C.D., C.S.), London and Manchester, Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., J.A.H.), Bill Lyons Informatics Centre (J.H.), and Cancer Immunology Unit (S.A.Q.), UCL Cancer Institute, the Translational Cancer Therapeutics Laboratory (G.A.W., N. McGranahan, N.J.B., T.B.K.W., A.R., T.C., S. Turajlic, H.X., C.T.H., C.S.), Department of Bioinformatics and Biostatistics (R.M., M.S., S.H., M.E., A.S.), Advanced Sequencing Facility (N. Matthews), and Cancer Genomics Laboratory (S.D., P.V.L.), Francis Crick Institute, the Renal and Skin Units, Royal Marsden Hospital (S. Turajlic), the Departments of Medical Oncology (M.J.-H., S.-M.L., M.D.F., T.A., C.A., C.S.), Pathology (M.F., E.B., T.M.), Cardiothoracic Surgery (D.L., M.H., S. Kolvekar, N.P.), Respiratory Medicine (S.M.J., R.T.), and Radiology (A.A.), UCL Hospitals, Lungs for Living, UCL Respiratory, UCL (S.M.J.), the Department of Radiotherapy, North Middlesex University Hospital (G.A.), the Department of Respiratory Medicine, Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., H.B., Y.N., A.H.), London, Cancer Studies, University of Leicester (D.A.M., D.A.F., J.A.S., J.L.Q.), the Department of Thoracic Surgery, Glenfield Hospital (A.N., S.R.), and the Medical Research Center Toxicology Unit (J.L.Q.), Leicester, the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., Y.S.), the Departments of Cardiothoracic Surgery (R.S.) and Pathology (L.J., A.M.Q.) and the North West Lung Centre (P.A.C.), University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Manchester, the Departments of Thoracic Surgery (B.N.) and Cellular Pathology (G.L., S. Trotter), Birmingham Heartlands Hospital, Molecular Pathology Diagnostic Services, Queen Elizabeth Hospital (P.T., B.O.), and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Birmingham, the Departments of Medical Oncology (M.N.), Cardiothoracic Surgery (H.R.), Pathology (K.K.), Respiratory Medicine (M.C.), and Radiology (L.G.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen, the Department of Respiratory Medicine, Barnet and Chase Farm Hospitals, Barnet (S. Khan), the Department of Respiratory Medicine, Princess Alexandra Hospital, Harlow (P.R.), the Department of Clinical Oncology, St. Luke's Cancer Centre, Guildford (V.E.), the Departments of Pathology (B.I.), Respiratory Medicine (M.I.-S.), and Radiology (V.P.), Ashford and St. Peters' Hospitals, Surrey, the Department of Clinical Oncology, Velindre Hospital (J.F.L.), the Departments of Radiology (H.A.) and Respiratory Medicine (H.D.), University Hospital Llandough, the Departments of Pathology (R.A.) and Cardiothoracic Surgery (M.K.), University Hospital of Wales, and Cardiff University (R.A.), Cardiff, and Wellcome Trust Sanger Institute, Hinxton, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom; the Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby (Z.S.); the Computational Health Informatics Program, Boston Children's Hospital and Harvard Medical School, Boston (Z.S.); MTA-SE-NAP, Brain Metastasis Research Group, 2nd Department of Pathology, Semmelweis University, Budapest, Hungary (Z.S.); Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin (R.F.S.); and the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.).

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http://dx.doi.org/10.1056/NEJMoa1616288DOI Listing
June 2017

Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models.

Mol Cancer Res 2017 08 25;15(8):1012-1016. Epub 2017 Apr 25.

RNA Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0431DOI Listing
August 2017

SnapShot: Circulating Tumor Cells.

Cell 2017 03;169(1):176

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http://dx.doi.org/10.1016/j.cell.2017.03.017DOI Listing
March 2017

SnapShot: Circulating Tumor Cells.

Cell 2017 02;168(4):742-742.e1

Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.cell.2017.01.026DOI Listing
February 2017

Novel risk models for early detection and screening of ovarian cancer.

Oncotarget 2017 Jan;8(1):785-797

Stoller Biomarker Discovery Centre and Pathology Node, Division of Molecular and Clinical Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.18632/oncotarget.13648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352196PMC
January 2017

Imaging biomarker roadmap for cancer studies.

Nat Rev Clin Oncol 2017 03 11;14(3):169-186. Epub 2016 Oct 11.

CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/nrclinonc.2016.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378302PMC
March 2017

Circulating Tumor Cells Detected in the Tumor-Draining Pulmonary Vein Are Associated with Disease Recurrence after Surgical Resection of NSCLC.

J Thorac Oncol 2016 10 25;11(10):1793-7. Epub 2016 Jul 25.

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, Manchester, United Kingdom; Cancer Research UK Lung Cancer Centre of Excellence, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.jtho.2016.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063509PMC
October 2016

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer.

Cell Rep 2016 07 30;16(3):644-56. Epub 2016 Jun 30.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956576PMC
July 2016

Inhibition of PI3K/BMX Cell Survival Pathway Sensitizes to BH3 Mimetics in SCLC.

Mol Cancer Ther 2016 06 29;15(6):1248-60. Epub 2016 Mar 29.

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom. CRUK Lung Cancer Centre of Excellence, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0885DOI Listing
June 2016

Protein Z: A putative novel biomarker for early detection of ovarian cancer.

Int J Cancer 2016 Jun 19;138(12):2984-92. Epub 2016 Feb 19.

Stoller Biomarker Discovery Centre and Pathology Node, Institute of Cancer Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1002/ijc.30020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840324PMC
June 2016

Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response.

NPJ Genom Med 2016 20;1:16020. Epub 2016 Jul 20.

RNA Biology Group, CRUK Manchester Institute, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/npjgenmed.2016.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417364PMC
July 2016

Development of a circulating miRNA assay to monitor tumor burden: From mouse to man.

Mol Oncol 2016 Feb 28;10(2):282-91. Epub 2015 Oct 28.

Clinical & Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750526PMC
February 2016

Discovery and Validation of Predictive Biomarkers of Survival for Non-small Cell Lung Cancer Patients Undergoing Radical Radiotherapy: Two Proteins With Predictive Value.

EBioMedicine 2015 Aug 19;2(8):841-50. Epub 2015 Jun 19.

Stoller Biomarker Discovery Centre, Manchester Academic Health Science Centre, The University of Manchester, Wolfson Molecular Imaging Centre, Manchester M20 3LJ, UK.

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http://dx.doi.org/10.1016/j.ebiom.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563120PMC
August 2015

Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells.

BMC Cancer 2015 May 10;15:387. Epub 2015 May 10.

Clinical and Experimental Pharmacology Group, Manchester Cancer Research Centre, Cancer Research UK Manchester Institute, University of Manchester, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1186/s12885-015-1382-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436118PMC
May 2015

Circulating Tumor Cell Enumeration in a Phase II Trial of a Four-Drug Regimen in Advanced Colorectal Cancer.

Clin Colorectal Cancer 2015 Jun 31;14(2):115-22.e1-2. Epub 2014 Dec 31.

Clinical and Experimental Pharmacology, Cancer Research UK Manchester Institute, Manchester, UK.

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http://dx.doi.org/10.1016/j.clcc.2014.12.006DOI Listing
June 2015

Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.

PLoS Biol 2014 Jul 8;12(7):e1001906. Epub 2014 Jul 8.

Translational Cancer Therapeutics Laboratory, University College London Cancer Institute, London, United Kingdom; Department of Medical Oncology, University College London Hospitals, London, United Kingdom; Translational Cancer Therapeutics Laboratory, London Research Institute, London, United Kingdom.

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http://orbit.dtu.dk/files/101357162/Tracking_Genomic_Cancer.
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http://dx.plos.org/10.1371/journal.pbio.1001906
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http://dx.doi.org/10.1371/journal.pbio.1001906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086714PMC
July 2014

The combination of circulating Ang1 and Tie2 levels predicts progression-free survival advantage in bevacizumab-treated patients with ovarian cancer.

Clin Cancer Res 2014 Sep 19;20(17):4549-4558. Epub 2014 Jun 19.

Translational Angiogenesis Group, University of Manchester and Christie Hospital, Wilmslow Road, Withington, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154862PMC
September 2014

Circulating biomarkers in hepatocellular carcinoma.

Cancer Chemother Pharmacol 2014 Aug 13;74(2):323-32. Epub 2014 Jun 13.

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s00280-014-2508-7DOI Listing
August 2014

BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.

Neoplasia 2014 Feb;16(2):147-57

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1593/neo.131376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978395PMC
February 2014

Optimisation of an immunohistochemistry method for the determination of androgen receptor expression levels in circulating tumour cells.

BMC Cancer 2014 Mar 28;14:226. Epub 2014 Mar 28.

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester Cancer Research Centre, Manchester M20 4BX, UK.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-14-226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977890PMC
March 2014

Quantification of skeletal metastases in castrate-resistant prostate cancer predicts progression-free and overall survival.

BJU Int 2014 Dec 27;114(6b):E70-E73. Epub 2014 Jul 27.

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.

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http://doi.wiley.com/10.1111/bju.12717
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http://dx.doi.org/10.1111/bju.12717DOI Listing
December 2014

Molecular analysis of circulating tumour cells-biology and biomarkers.

Nat Rev Clin Oncol 2014 Mar 21;11(3):129-44. Epub 2014 Jan 21.

Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester and Manchester Cancer Research Centre, 550 Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1038/nrclinonc.2013.253DOI Listing
March 2014

A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data.

Bioinformatics 2014 Feb 15;30(4):549-58. Epub 2013 Dec 15.

Clinical and Experimental Pharmacology Group, CRUK Manchester Institute, University of Manchester, Manchester M20 4BX, UK, Stem Cell and Leukaemia Proteomics Laboratory, Institute of Cancer Sciences, Manchester Academic Health Science Centre, Wolfson Molecular Imaging Centre, University of Manchester, Manchester M20 3LJ, UK and Centre for Biostatistics, Institute of Population Health, University of Manchester, Oxford Road, Manchester M13 9PL, UK.

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http://dx.doi.org/10.1093/bioinformatics/btt722DOI Listing
February 2014

Prevalence and heterogeneity of circulating tumour cells in metastatic cutaneous melanoma.

Melanoma Res 2014 Feb;24(1):40-6

aClinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research bThe Christie NHS Foundation Trust cSchool of Cancer and Enabling Sciences, Manchester Cancer Research Centre and Manchester Academic Health Sciences Centre, University of Manchester, Manchester dAstraZeneca Pharmaceuticals, Alderley Park, UK.

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http://dx.doi.org/10.1097/CMR.0000000000000025DOI Listing
February 2014

Prognostic and predictive biomarkers in early stage NSCLC: CTCs and serum/plasma markers.

Transl Lung Cancer Res 2013 Oct;2(5):382-97

Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, M20 4BX, UK ; ; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.

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http://www.tlcr.org/article/view/1611
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http://dx.doi.org/10.3978/j.issn.2218-6751.2013.09.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367728PMC
October 2013

Method validation of circulating tumour cell enumeration at low cell counts.

BMC Cancer 2013 Sep 11;13:415. Epub 2013 Sep 11.

Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester Cancer Research Centre, University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1186/1471-2407-13-415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848977PMC
September 2013

Clinical utility of circulating tumour cell detection in non-small-cell lung cancer.

Curr Treat Options Oncol 2013 Dec;14(4):610-22

Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Withington, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1007/s11864-013-0253-5DOI Listing
December 2013

Synchronous apoptosis in established tumors leads to the induction of adaptive immunity.

Oncoimmunology 2013 Jun 16;2(6):e24501. Epub 2013 Apr 16.

Targeted Therapy Group; Institute of Cancer Science; Paterson Institute for Cancer Research; Manchester University; Manchester Cancer Research Centre; Manchester Academic Health Sciences Centres; Manchester UK.

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http://dx.doi.org/10.4161/onci.24501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716746PMC
June 2013

Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma.

Magn Reson Med 2014 May 24;71(5):1854-62. Epub 2013 Jun 24.

Centre for Imaging Sciences, The University of Manchester, Manchester, UK; University of Manchester Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/mrm.24826DOI Listing
May 2014

Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha.

PLoS One 2013 13;8(6):e65304. Epub 2013 Jun 13.

Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065304PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681794PMC
January 2014

Biomarker utility of circulating tumor cells in metastatic cutaneous melanoma.

J Invest Dermatol 2013 Jun 6;133(6):1582-90. Epub 2012 Dec 6.

Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester, UK.

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http://dx.doi.org/10.1038/jid.2012.468DOI Listing
June 2013

Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion.

Anal Chem 2012 Nov 29;84(22):9848-57. Epub 2012 Oct 29.

School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.

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http://pubs.acs.org/doi/10.1021/ac302227c
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November 2012

Biology and clinical relevance of circulating tumour cells.

J Thorac Dis 2012 Oct;4(5):453-5

Clinical and Experimental Pharmacology Group, Paterson institute for Cancer Research, Manchester, UK;

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http://dx.doi.org/10.3978/j.issn.2072-1439.2012.09.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461082PMC
October 2012

Biomarkers of cell death applicable to early clinical trials.

Exp Cell Res 2012 Jul 27;318(11):1252-9. Epub 2012 Mar 27.

Paterson Institute for Cancer Research, The University of Manchester, Withington, Manchester, UK.

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http://dx.doi.org/10.1016/j.yexcr.2012.03.020DOI Listing
July 2012

Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery.

J Proteome Res 2012 Apr 12;11(4):2103-13. Epub 2012 Mar 12.

Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Wilmslow Road, Manchester M20 4BX, United Kingdom.

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http://pubs.acs.org/doi/10.1021/pr200636x
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320746PMC
April 2012

A pilot study assessing the prognostic value of CK18 and nDNA biomarkers in severe sepsis patients.

Clin Drug Investig 2012 Mar;32(3):179-87

Clinical Experimental & Pharmacology Group, Paterson Institute for Cancer Research, Withington, Manchester, UK.

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http://link.springer.com/10.2165/11598610-000000000-00000
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March 2012