Publications by authors named "Caroline Delaunay"

6 Publications

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Comparing the self-perceived effects of a facial anti-aging product to those automatically detected from selfie images of Chinese women of different ages and cities.

Skin Res Technol 2021 Apr 6. Epub 2021 Apr 6.

ModiFace, A L'Oréal Group Company, Toronto, ON, Canada.

Objective: To assess the agreement, after 1-month application of a popular and efficient anti-aging product, between self-perceived facial signs of aging and those detected and graded by an automatic A.I-based system, using smartphones' selfie images.

Material And Methods: Of 1065 Chinese women, aged 18-60 years, from eight different Chinese cities were recruited. They were asked to apply daily, for 1 month, a referential anti-aging product onto their whole face. Selfie images were taken by all subjects at D and D and sent to our facilities for being analyzed through 10 different facial signs. At D , all subjects were asked to fill a questionnaire on the status of their faces, through six general statements.

Results: A global agreement between both approaches is reached, particularly among women older than 40 years where the severity of facial signs is already more pronounced or among younger women who present at least facial signs scored above one grading units. This limit becomes, therefore, a prerequisite in the recruitment of Chinese subjects in the case of anti-aging applied studies and possible automatically based on automatic grading system. When respecting such conditions, the positive effects of the product on most facial signs can be demonstrated after 28 days of successive applications.

Conclusion: Such methodological approach paves the road in fulfilling the need of consumers of a better transparency in the claims of an anti-aging product.
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http://dx.doi.org/10.1111/srt.13037DOI Listing
April 2021

The respective weights of facial signs on the perception of age and a tired-look among differently aged Korean men.

Skin Res Technol 2021 Apr 5. Epub 2021 Apr 5.

L'Oréal Research and Innovation, Clichy, France.

Objectives: To determine the respective weights of certain facial signs on the assessment of the perceived age and a tired-look on Korean men of different ages.

Material And Methods: Photographs were taken of the faces of 101 Korean men (20-80 years) under standardized conditions. These photographs allowed to define 16 signs, which were then graded by 15 experts/dermatologists, using standardized scales provided by a referential Skin Aging Atlas. These signs were dispatched into 5 clusters, namely Wrinkles/Texture, Ptosis/Sagging, Cheek pores, Pigmentation, and Vascular signs. A naïve panel of 200 Korean individuals (100 women, 100 men), of similar age range, were asked, when viewing full-face photographs, to (a) attribute on a 0-10 scale their perception of a tired-look and (b) estimate the age of the subject.

Results: The severity of all clusters increased with age, although at different rates. The Wrinkles/Texture or Ptosis/Sagging showed a rather regular progression, whereas Vascular presented the weakest changes. Although perceived and real ages were found highly correlated, almost 85% of the subjects were judged older by 1-15 years. The signs/clusters were found significantly correlated with perceived age, highly for Wrinkles/Texture and Ptosis/Sagging, moderate for Pigmentation, and low for Vascular and Cheek pores. The weights in perceived ages of Wrinkles/Texture and Ptosis/Sagging represent 81% and Pigmentation at 19%. Facial tired-look of Korean men was found significantly correlated with perceived age. Although Vascular and Cheek pores were found not impacting, Wrinkles/Texture, Ptosis/Sagging, and Pigmentation presented a clear influence.

Conclusion: Within facial clusters, Wrinkles/Texture, Ptosis/Sagging, and Pigmentation are major factors in the assessment of perceived age in Korean men. The perception of an increased tired-look is significantly associated with increased perceived age.
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http://dx.doi.org/10.1111/srt.13041DOI Listing
April 2021

Japanese experiment of a complete and objective automatic grading system of facial signs from selfie pictures: Validation with dermatologists and characterization of changes due to age and sun exposures.

Skin Res Technol 2020 Dec 27. Epub 2020 Dec 27.

L'Oréal Research and Innovation, Clichy, France.

Objective: To evaluate the capacity of the automatic detection system to accurately grade, from smartphones' selfie pictures, the severity of ten facial signs in Japanese women and their changes due to age and sun exposures.

Methods: A three-step approach was conducted, based on self-taken selfie images. At first, to check on 310 Japanese women (18-69 years) enrolled in the northerner Hokkaido area (latitude 43.2°N), how, on ten facial signs, the A.I-based automatic grading system may correlate with dermatological assessments, taken as reference. Second, to assess and compare age changes in 310 Japanese and 112 Korean women. Third, as these Japanese panelists were recruited according to their usual behavior toward sun exposure, that is, non-sun-phobic (NSP, N = 114) and sun-phobic (SP, N = 196), and through their regular and early use of a photo-protective product, to characterize the facial photo-damages.

Results: (a) On the ten facial signs, detected automatically, nine were found significantly (P < .0001) highly correlated with the evaluations made by three Japanese dermatologists (Wrinkles: r = .75; Sagging: r = .80; Pigmentation: r = .75). (b) The automatic scores showed significant changes with age, by decade, of Wrinkles/Texture, Pigmentation, and Ptosis/Sagging (P < .05). (c) After 45 years, a significantly increased severity of Wrinkles/Texture and Pigmentation was observed in NSP vs. SP women (P < .05). A trend of an increased Ptosis/Sagging (P = .09) was observed.

Conclusion: This work illustrates, for the first time through investigations conducted at home, some impacts of aging and sun exposures on facial signs of Japanese women. Results significantly confirm the importance of sun avoidance coupled with photo-protective measures. In epidemiological studies, the AI-based system offers a fast, affordable, and confidential approach in detection and quantification of facial signs and their dependence with ages, environments and lifestyles.
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http://dx.doi.org/10.1111/srt.12982DOI Listing
December 2020

Changes in facial signs due to age and their respective weights on the perception of age and skin plumpness among differently aged Korean women.

Skin Res Technol 2020 Nov 9. Epub 2020 Nov 9.

L'Oréal Research and Innovation, Clichy, France.

Objective: To determine the respective weights of certain facial signs on the assessment of perceived age and plumpness on Korean women of different ages.

Material And Methods: Photographs were taken of the faces of 112 Korean women of different ages (18-80 years) under standardized conditions. These photographs allowed to focus and define 19 facial signs, which were then graded by 15 experts and dermatologists, using standardized scales provided by a reference Skin Aging Atlas. The facial signs were dispatched into 5 clusters, namely Wrinkles/Texture, Ptosis/Sagging, Pigmentation disorders, Vascular disorders, and Cheek skin pores. A naïve panel, composed of 92 Korean women, of similar age range were asked, when viewing full-face photographs, to: (a) attribute on a 0-10 scale their perception of the skin plumpness (ie supple/hydrated/nourished) and (b) estimate the age of the subject.

Results: With the exception of Vascular disorders, the severity of all 4 clusters increased with age, although at different rates. The Wrinkles/Texture or Ptosis/Sagging showed a rather regular progression. Although perceived ages and real ages were found highly correlated, half of the subjects were judged older by 2-12 years. The facial signs/clusters were significantly correlated with perceived age, with the exceptions of vascular disorders, size of pigmentary spots and cheek skin pores. The weights in perceived ages of Wrinkles/Texture and Ptosis/Sagging represent 37% each and Pigmentation disorders at 26%. Skin plumpness was logically found significantly anti-correlated with perceived age. If, surprisingly, Vascular disorders were found not impacting the plumpness aspect, Cheek skin pores presented a clear influence.

Conclusion: Within facial clinical clusters, Wrinkles/Texture, Ptosis/Sagging, and Pigmentation disorders are major factors in the assessment of perceived age in Korean women. The perception of a decreased skin plumpness is significantly associated with increased perceived age.
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http://dx.doi.org/10.1111/srt.12980DOI Listing
November 2020

Infliximab to etanercept switch in patients with spondyloarthropathies and psoriatic arthritis: preliminary data.

J Rheumatol 2005 Nov;32(11):2183-5

Department of Rheumatology, Henri Mondor Teaching Hospital, Créteil, France.

Objective: To report early experience of switching anti-tumor necrosis factor-a (TNF-alpha) therapy from infliximab to etanercept in patients with spondyloarthropathy (SpA) and psoriatic arthritis (PsA).

Methods: Thirteen patients with various SpA (7 with ankylosing spondylitis and 6 with undifferentiated SpA) and 2 patients with PsA were receiving infliximab. Because they were experiencing inadequate response or adverse events, therapy was changed to etanercept. Patients were evaluated for response to the change in anti-TNF-alpha therapy at baseline, after 3 months, and then every 6 months.

Results: During the mean 10-month followup after the change in therapy, 9 of 13 patients with SpA and both patients with PsA responded to etanercept and none experienced intolerance to this agent.

Conclusion: These data suggest that switching between anti-TNF-alpha drugs may be useful for patients with SpA who are unresponsive or intolerant to a first anti-TNF-alpha agent.
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November 2005