Dr Caroline Bonner, PhD - Institue Pasteur, Lille, France, Affiliated with Inserm UMR 1190 Translational Research for Diabetes - Senior Research Scientist: Novel therapies for type 2 diabetes

Dr Caroline Bonner

PhD

Institue Pasteur, Lille, France, Affiliated with Inserm UMR 1190 Translational Research for Diabetes

Senior Research Scientist: Novel therapies for type 2 diabetes

Lille, Lille | France

Main Specialties: Biology

Additional Specialties: Human Islet Biology / Physiology and Disease

ORCID logohttps://orcid.org/0000-0002-4430-8280


Top Author

Dr Caroline Bonner, PhD - Institue Pasteur, Lille, France, Affiliated with Inserm UMR 1190 Translational Research for Diabetes - Senior Research Scientist: Novel therapies for type 2 diabetes

Dr Caroline Bonner

PhD

Introduction

Dr Bonner has completed her PhD in Molecular Endocrinology in 2009 from the Royal
College of Surgeons in Dublin, Ireland. Her thesis work focused on the differentation and
regeneration of beta cells using genetic models of Maturity onset-diabetes of the young
(MODY): HNF1A-MODY and HNF4A-MODY. She pursued a post-doctoral fellow in
translational studies in the same laboratory (2009-2011), focusing on the discovery and
validation of serum biomarkers (microRNAs and secreted proteins) in MODY patients as well
as in T1D and T2D subjects. Dr Bonner joined Inserm UMR 1190 in 2012 at the University of
Lille, France to pursue an independent project on the transcriptional regulation of non-beta
cells (alpha cells) on pancreatic hormone secretion and gene expression. Recently, Dr. Bonner
joined Institut Pasteur de Lille (affiliated with Inserm UMR1190) as a Senior Research
Scientist. Dr Bonner’s professional interests are in the area of translational research to
develop novel therapies to improve glycemic control, with a specific emphasis on glucose
transport and changes that may be involved in the mechanism(s) underlying type 2 diabetes.

Primary Affiliation: Institue Pasteur, Lille, France, Affiliated with Inserm UMR 1190 Translational Research for Diabetes - Lille, Lille , France

Specialties:

Additional Specialties:

Research Interests:


View Dr Caroline Bonner’s Resume / CV

Education

Apr 2006 - Jul 2009
Royal College of Surgeons in Ireland
PhD
Dept of Physiology and Medical Physics

Experience

Feb 2017
Pasteur Institute of Lille
Senior Research Scientist
Inserm UMR 1190 Translational Research for Diabetes

Publications

36Publications

1104Reads

74Profile Views

305PubMed Central Citations

27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8-9th May 2019.

Cardiovasc Endocrinol Metab 2019 Sep 10;8(3):88-89. Epub 2019 Sep 10.

Institute of Clinical Physiology, CNR, Pisa, Italy.

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http://dx.doi.org/10.1097/XCE.0000000000000179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779843PMC
September 2019

The GLP1R Agonist Liraglutide Reduces Hyperglucagonemia Induced by the SGLT2 Inhibitor Dapagliflozin via Somatostatin Release.

Cell Rep 2019 Aug;28(6):1447-1454.e4

University of Lille, U1190-EGID, 59000 Lille, France; INSERM, U1190, 59000 Lille, France; Institut Pasteur de Lille, 59000 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.009DOI Listing
August 2019
124 Reads
7.207 Impact Factor

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks.

Cell Metab 2017 02 29;25(2):400-411. Epub 2016 Dec 29.

Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom; Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona 08036, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid 28029, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300904PMC
February 2017
61 Reads
19 Citations
17.570 Impact Factor

Human Recombinant Antithrombin (ATrynsup/sup) Administration Improves Survival and Prevents Intravascular Coagulation After Intraportal Islet Transplantation in a Piglet Model.

Cell Transplant.

Human islet transplantation is a viable treatment option for type 1 diabetes mellitus (T1D). However, pancreatic isletinflammation after transplantation induced by innate immune responses is likely to hinder graft function. This is mediated by incompatibility between islets and the blood interface, known as instant blood-mediated inflammatory reaction (IBMIR). Herein, we hypothesized that portal venous administration of islet cells with human recombinant antithrombin (ATryn®), a serine protease inhibitor (serpin), which plays a central role in the physiological regulation of coagulation and exerts indirect anti-inflammatory activities may offset coagulation abnormalities such as Disseminated Intravascular Coagulation (DIC) and IBMIR. The current prospective, randomized experiment was conducted using an established pre-clinical pig model. Three groups were constituted for digested pancreatic tissue transplantation (0.15ml/kg): Control: NaCl 0.9% (n=7); gold standard: heparin (25 UI/Kg) (n=7) and human recombinant ATryn® (500 UI/kg) (n=7). Blood samples were collected over time (T0 to T 24h) and biochemical, coagulation and inflammatory parameters were evaluated. In both control and heparin groups, one animal died after a portal thrombosis, while no deaths occurred in the ATryn® treated group. As expected, islet transplantation was associated with an increase in plasma IL-6 or TNF-α levels in all three groups. However, DIC was only observed in the control group, an effect that was suppressed after ATryn® administration. ATryn® administration increased antithrombin activity 800%, which remained at 200% for the remaining period of the study, without any hemorrhagic complications. These studies suggest that co-administration of ATryn® and pancreatic islets via intraportal transplantation may be a valuable therapeutic approach for DIC without risk for islets and subjects.

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October 2016
12 Reads

Sodium glucose transport modulation in type 2 diabetes and gastric bypass surgery.

Surg Obes Relat Dis 2016 Jul 26;12(6):1206-12. Epub 2016 Apr 26.

Univ. Lille, Inserm, U1190, Translational Research for Diabetes, F-59000, Lille, France; European Genomic Institute for Diabetes, F-59000, Lille, France; CHU Lille, Department of General and Endocrine Surgery, F-59000, Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.soard.2016.04.022DOI Listing
July 2016
35 Reads
1 Citation
4.070 Impact Factor

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response.

Cell Rep 2016 05 21;15(5):1051-1061. Epub 2016 Apr 21.

University Lille, UMR 8199 - EGID, 59000 Lille, France; CNRS, UMR 8199, 59000 Lille, France; Institut Pasteur de Lille, 59000 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.079DOI Listing
May 2016
112 Reads
5 Citations
7.210 Impact Factor

Bile Diversion in Roux-en-Y Gastric Bypass Modulates Sodium-Dependent Glucose Intestinal Uptake.

Cell Metab 2016 Mar 25;23(3):547-53. Epub 2016 Feb 25.

University Lille, Inserm, CHU Lille, U1190 Translational research for diabetes, 59000 Lille, France; European Genomic Institute for Diabetes, EGID, 59000 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.01.018DOI Listing
March 2016
46 Reads
11 Citations
17.570 Impact Factor

Fischer 344 Rat: A Preclinical Model for Epithelial Ovarian Cancer Folate-Targeted Therapy.

Int J Gynecol Cancer 2015 Sep;25(7):1194-200

*University of Lille, Inserm, CHU Lille, U1189-ONCO THAI- Image Assisted Laser Therapy for Oncology, F-59000 Lille, France; †Department of Gynecology, University Hospital of Lille, F-59000 Lille, France; ‡European Genomic Institute for Diabetes, FR 3508, University of Lille, F-59000 Lille, France; §Centre de biologie-pathologie, University of Lille, F-59000 Lille, France; ∥Plate-forme d'imagerie cellulaire BICEL-IFR 114, University of Lille, F-59000 Lille, France; and ¶Laboratoire Réactions et Génie des Procédés, UMR 7274 CNRS-University of Lorraine, Nancy, France.

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http://dx.doi.org/10.1097/IGC.0000000000000497DOI Listing
September 2015
30 Reads
1 Citation
1.950 Impact Factor

Hypothalamic Neuropeptide 26RFa Acts as an Incretin to Regulate Glucose Homeostasis.

Diabetes 2015 Aug 9;64(8):2805-16. Epub 2015 Apr 9.

INSERM U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Rouen, France Normandy University, Caen, France University of Rouen, Rouen, France

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http://dx.doi.org/10.2337/db14-1864DOI Listing
August 2015
97 Reads
3 Citations
8.100 Impact Factor

Impact of Procedure-Related Complications on Long-term Islet Transplantation Outcome.

Transplantation 2015 May;99(5):979-84

1 French National Institute of Health and Medical Research-INSERM UMR 859, Diabetes Cell Therapy Lille, France. 2 General and Endocrine Surgery Department, Université Lille Nord de France, Lille University Hospital, Lille, France. 3 Endocrinology and Metabolism Department, Université Lille Nord de France, Lille University Hospital, Lille, France. 4 Université de Lille, Lille, France. 5 Radiology Department, Université Lille Nord de France, Lille University Hospital, Lille, France. 6 Nephrology Department, Université Lille Nord de France, Lille University Hospital, Lille, France.

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http://pdfs.journals.lww.com/transplantjournal/2015/05000/Im
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http://dx.doi.org/10.1097/TP.0000000000000458DOI Listing
May 2015
33 Reads
3.830 Impact Factor

Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion.

Nat Med 2015 May 20;21(5):512-7. Epub 2015 Apr 20.

1] European Genomic Institute for Diabetes, Lille, France. [2] INSERM UMR 1190, Lille, France. [3] Centre Hospitalier Régional Universitaire, Lille, France. [4] Université de Lille, Lille, France.

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http://dx.doi.org/10.1038/nm.3828DOI Listing
May 2015
69 Reads
70 Citations
27.363 Impact Factor

PSP/reg: a potent and enigmatic trophic factor, which is upregulated during the pathogenesis of diabetes.

Authors:
Caroline Bonner

Endocrine 2015 Apr 11;48(3):725-7. Epub 2014 Dec 11.

European Genomic Institute for Diabetes (EGID), FR 3508, 59000, Lille Cedex, France,

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http://dx.doi.org/10.1007/s12020-014-0500-yDOI Listing
April 2015
9 Reads
3.530 Impact Factor

Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: implications for maturity-onset diabetes of the young.

J Transl Med 2013 Jun 26;11:156. Epub 2013 Jun 26.

Department of Endocrinology, Mater Misericordiae University Hospital, 30 Eccles Street, Dublin 7, Ireland.

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http://dx.doi.org/10.1186/1479-5876-11-156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707779PMC
June 2013
26 Reads
1 Citation
3.930 Impact Factor

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis.

Neurobiol Aging 2012 Sep 30;33(9):2200-9. Epub 2011 Jul 30.

Experimental Neurosurgery, Center for Neurology and Neurosurgery, Goethe University Hospital, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.06.012DOI Listing
September 2012
7 Reads
9 Citations
5.013 Impact Factor

Rapamycin protects against dominant negative-HNF1A-induced apoptosis in INS-1 cells.

Apoptosis 2011 Nov;16(11):1128-37

Department of Endocrinology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.

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http://dx.doi.org/10.1007/s10495-011-0641-xDOI Listing
November 2011
11 Reads
1 Citation
3.685 Impact Factor

AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.

J Biol Chem 2010 Nov 14;285(46):36199-206. Epub 2010 Sep 14.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1074/jbc.M110.138107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975242PMC
November 2010
13 Reads
13 Citations
4.573 Impact Factor

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.

Diabetes 2010 Nov 3;59(11):2799-808. Epub 2010 Aug 3.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.2337/db09-1478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963538PMC
November 2010
23 Reads
16 Citations
8.100 Impact Factor

Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability.

J Neurochem 2010 Jul 30;114(2):606-16. Epub 2010 Apr 30.

Department of Physiology, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://doi.wiley.com/10.1111/j.1471-4159.2010.06790.x
Publisher Site
http://dx.doi.org/10.1111/j.1471-4159.2010.06790.xDOI Listing
July 2010
13 Reads
8 Citations
4.281 Impact Factor

AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis.

J Cell Biol 2010 Apr 29;189(1):83-94. Epub 2010 Mar 29.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland Research Institute, Dublin 2, Ireland.

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http://dx.doi.org/10.1083/jcb.200909166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854380PMC
April 2010
14 Reads
44 Citations
9.834 Impact Factor

Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways.

Neurobiol Dis 2008 Dec 4;32(3):442-53. Epub 2008 Sep 4.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/j.nbd.2008.08.008DOI Listing
December 2008
22 Reads
33 Citations
5.080 Impact Factor

NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner.

J Neurochem 2008 May 13;105(3):891-903. Epub 2007 Dec 13.

Department of Physiology and Medical Physics and RCSI Neuroscience Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1111/j.1471-4159.2007.05187.xDOI Listing
May 2008
17 Reads
16 Citations
4.281 Impact Factor

Induction of transcription factor CEBP homology protein mediates hypoglycaemia-induced necrotic cell death in human neuroblastoma cells.

J Neurochem 2006 Nov 29;99(3):952-64. Epub 2006 Aug 29.

Experimental Neurosurgery, Center for Neurology and Neurosurgery, Johann Wolfgang Goethe University Clinics, Frankfurt, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04135.xDOI Listing
November 2006
11 Reads
4 Citations
4.281 Impact Factor

Top co-authors

Julie Kerr-Conte
Julie Kerr-Conte

University Lille Nord de France

13
Francois Pattou
Francois Pattou

Université de Lille 2

12
Valery Gmyr
Valery Gmyr

Université Lille Nord de France

7
Thomas Hubert
Thomas Hubert

Ghent University

6
Maria M Byrne
Maria M Byrne

Mater Misericordiae University Hospital

6
Manus W Ward
Manus W Ward

Royal College of Surgeons in Ireland

5
Nathalie Delalleau
Nathalie Delalleau

France. [3] Université de Lille

5
Angela M Farrelly
Angela M Farrelly

Royal College of Surgeons in Ireland

4