Carole Ober

Carole Ober

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T cell phenotypes are associated with serum IgE levels in Amish and Hutterite children.

J Allergy Clin Immunol 2019 Aug 8. Epub 2019 Aug 8.

Department of Medicine, Section of Pulmonary and Critical Care Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.07.034DOI Listing
August 2019

Effects of an FcγRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies.

Genes Immun 2019 07 6;20(6):462-472. Epub 2018 Jul 6.

Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1038/s41435-018-0038-8DOI Listing
July 2019

Associations between fungal and bacterial microbiota of airways and asthma endotypes.

J Allergy Clin Immunol 2019 Jul 3. Epub 2019 Jul 3.

Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Ill. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.06.025DOI Listing
July 2019

Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search.

Hum Hered 2018 22;83(3):130-152. Epub 2019 Jan 22.

Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1159/000489765DOI Listing
June 2019

Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.

Lancet Respir Med 2019 Jun 27;7(6):509-522. Epub 2019 Apr 27.

Department of Medicine, The University of Chicago, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(19)30055-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534440PMC
June 2019

Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2.

JACC Basic Transl Sci 2019 Apr 29;4(2):204-221. Epub 2019 Apr 29.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.jacbts.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488817PMC
April 2019

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos.

J Allergy Clin Immunol 2019 Mar 7;143(3):957-969. Epub 2018 Sep 7.

Program in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, San Francisco, Calif; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, Calif; Department of Medicine, University of California, San Francisco, San Francisco, Calif.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183127
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http://dx.doi.org/10.1016/j.jaci.2016.08.057DOI Listing
March 2019

Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions.

PLoS One 2018 11;13(9):e0203906. Epub 2018 Sep 11.

Committee on Genetics, Genomics & Systems Biology, University of Chicago, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203906PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133383PMC
March 2019

Lessons Learned From GWAS of Asthma.

Allergy Asthma Immunol Res 2019 Mar;11(2):170-187

Department of Human Genetics, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.4168/aair.2019.11.2.170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340805PMC
March 2019

CDHR3 Asthma-Risk Genotype Affects Susceptibility of Airway Epithelium to Rhinovirus C Infections.

Am J Respir Cell Mol Biol 2019 Mar 27. Epub 2019 Mar 27.

University of Wisconsin-Madison, Pediatrics, Madison, Wisconsin, United States ;

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http://dx.doi.org/10.1165/rcmb.2018-0220OCDOI Listing
March 2019

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.

Nat Commun 2019 02 20;10(1):880. Epub 2019 Feb 20.

Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1038/s41467-019-08469-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382865PMC
February 2019

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 09;50(9):1343

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41588-018-0197-6DOI Listing
September 2018

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 08 16;50(8):1072-1080. Epub 2018 Jul 16.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41588-018-0157-1DOI Listing
August 2018

Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus.

J Allergy Clin Immunol 2018 06 31;141(6):2282-2286.e6. Epub 2018 Jan 31.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Pulmonary Genetics Center and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2017.11.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994185PMC
June 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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http://www.nature.com/articles/s41588-017-0014-7
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http://dx.doi.org/10.1038/s41588-017-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974PMC
January 2018

Positive selection on human gamete-recognition genes.

PeerJ 2018 11;6:e4259. Epub 2018 Jan 11.

Department of Mathematics, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.7717/peerj.4259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767332PMC
January 2018

Rare non-coding variants are associated with plasma lipid traits in a founder population.

Sci Rep 2017 11 27;7(1):16415. Epub 2017 Nov 27.

Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1038/s41598-017-16550-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704019PMC
November 2017

Immune development and environment: lessons from Amish and Hutterite children.

Curr Opin Immunol 2017 Oct 29;48:51-60. Epub 2017 Aug 29.

Department of Cellular and Molecular Medicine, Asthma and Airway Disease Research Center, and Bio5 Institute, The University of Arizona, Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1016/j.coi.2017.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682224PMC
October 2017

Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers.

J Allergy Clin Immunol 2017 Aug 21;140(2):534-542. Epub 2016 Dec 21.

Asthma and Airway Disease Research Center, University of Arizona, Tucson, Ariz; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Ariz; Arizona Center for the Biology of Complex Diseases, University of Arizona, Tucson, Ariz; Bio5 Institute, University of Arizona, Tucson, Ariz. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479765PMC
August 2017

Response to correspondence of NDUFS4-related Leigh syndrome in Hutterites.

Am J Med Genet A 2017 May 28;173(5):1452. Epub 2017 Mar 28.

Division of Medical Genetics, Department of Pediatrics, University of Saskatchewan, Saskatoon, Saskatchewan.

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http://dx.doi.org/10.1002/ajmg.a.38227DOI Listing
May 2017

Reducing mitochondrial reads in ATAC-seq using CRISPR/Cas9.

Sci Rep 2017 05 26;7(1):2451. Epub 2017 May 26.

Department of Human Genetics, University of Chicago, 920 E 58th St Room 515, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1038/s41598-017-02547-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446398PMC
May 2017

A novel NDUFS4 frameshift mutation causes Leigh disease in the Hutterite population.

Am J Med Genet A 2017 Mar 27;173(3):596-600. Epub 2016 Sep 27.

Division of Medical Genetics, Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada.

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http://dx.doi.org/10.1002/ajmg.a.37983DOI Listing
March 2017

Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.

Microbiome 2017 02 1;5(1):16. Epub 2017 Feb 1.

Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1186/s40168-016-0227-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286564PMC
February 2017

Innate Immunity and Asthma Risk.

N Engl J Med 2016 11;375(19):1898-1899

University of Arizona, Tucson, AZ

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http://dx.doi.org/10.1056/NEJMc1611699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495101PMC
November 2016

A LASSO penalized regression approach for genome-wide association analyses using related individuals: application to the Genetic Analysis Workshop 19 simulated data.

BMC Proc 2016 18;10(Suppl 7):221-226. Epub 2016 Oct 18.

Department of Human Genetics, University of Chicago, 920 E. 58th Street, CLSC 4th floor, Chicago, IL 60637 USA.

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http://dx.doi.org/10.1186/s12919-016-0034-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133525PMC
October 2016

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.

N Engl J Med 2016 Aug;375(5):411-421

Department of Human Genetics (M.M. Stein, C.I., R.L.A., C.O.), the Department of Medicine, Section of Pulmonary and Critical Care Medicine, and the Committee on Immunology (C.L.H., A.I.S.), the Department of Ecology and Evolution (J.A.G.), and the Department of Surgery (J.A.G.), University of Chicago, Chicago, and the Institute for Genomic and Systems Biology, Argonne National Laboratory, Argonne (J.A.G.) - all in Illinois; the NIEHS Training Program in Environmental Toxicology and Graduate Program in Cellular and Molecular Medicine (J.G.), and the Departments of Cellular and Molecular Medicine (V.P., D.V.), Medicine (J.G.L.), Chemical and Environmental Engineering (M. Marques dos Santos), and Soil, Water, and Environmental Science (J.W.N., R.M.M.), University of Arizona, and the Arizona Respiratory Center and Bio5 Institute (J.G., V.P., S.E.M., J.G.L., F.D.M., D.V.) - all in Tucson; the Department of Occupational and Environmental Health, University of Iowa, Iowa City (N.M., P.S.T.); Allergy and Asthma Consultants, Indianapolis (M.H.); and Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany (E.M.).

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http://dx.doi.org/10.1056/NEJMoa1508749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137793PMC
August 2016

Genome-Wide Association Studies of the Human Gut Microbiota.

PLoS One 2015 3;10(11):e0140301. Epub 2015 Nov 3.

Department of Human Genetics, University of Chicago, Chicago, IL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140301PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631601PMC
June 2016

Genetic Determinants of the Gut Microbiome in UK Twins.

Cell Host Microbe 2016 May;19(5):731-43

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA; Department of Microbiome Science, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915943PMC
May 2016

Development of a diagnostic DNA chip to screen for 30 autosomal recessive disorders in the Hutterite population.

Mol Genet Genomic Med 2016 May 19;4(3):312-21. Epub 2016 Jan 19.

Departments of Biochemistry & Medical GeneticsUniversity of ManitobaWinnipegCanada; Pediatrics & Child HealthUniversity of Manitoba745 Bannatyne Ave.WinnipegMB R3E 0J9Canada; Clinical Biochemistry and GeneticsDiagnostic Services Manitoba at Health Sciences CentreWinnipegMB R3A 1R9Canada.

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http://dx.doi.org/10.1002/mgg3.206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867565PMC
May 2016

Leveraging gene-environment interactions and endotypes for asthma gene discovery.

J Allergy Clin Immunol 2016 Mar;137(3):667-79

Department of Human Genetics, University of Chicago, Chicago, Ill. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749160012
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http://dx.doi.org/10.1016/j.jaci.2016.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004762PMC
March 2016

Nasal Microbiome Composition Is Associated with Chitotriosidase (Chit1) Activity in Adult Hutterites.

Ann Am Thorac Soc 2016 Mar;13 Suppl 1:S100-1

4 Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1513/AnnalsATS.201508-521MGDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015738PMC
March 2016

Asthma Genetics in the Post-GWAS Era.

Authors:
Carole Ober

Ann Am Thorac Soc 2016 Mar;13 Suppl 1:S85-90

Department of Human Genetics, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1513/AnnalsATS.201507-459MGDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015734PMC
March 2016

The effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines.

PLoS One 2014 5;9(9):e107166. Epub 2014 Sep 5.

Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107166PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156430PMC
February 2016

Ultra-fast local-haplotype variant calling using paired-end DNA-sequencing data reveals somatic mosaicism in tumor and normal blood samples.

Nucleic Acids Res 2016 Feb 29;44(3):e25. Epub 2015 Sep 29.

Program of Computational Genomics & Medicine, NorthShore University HealthSystem, Evanston, IL 60201, USA Department of Health Studies, University of Chicago, Chicago, IL 60637, USA

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http://dx.doi.org/10.1093/nar/gkv953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756850PMC
February 2016

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.

Authors:
Lavinia Paternoster Marie Standl Johannes Waage Hansjörg Baurecht Melanie Hotze David P Strachan John A Curtin Klaus Bønnelykke Chao Tian Atsushi Takahashi Jorge Esparza-Gordillo Alexessander Couto Alves Jacob P Thyssen Herman T den Dekker Manuel A Ferreira Elisabeth Altmaier Patrick Ma Sleiman Feng Li Xiao Juan R Gonzalez Ingo Marenholz Birgit Kalb Maria Pino Yanes Cheng-Jian Xu Lisbeth Carstensen Maria M Groen-Blokhuis Cristina Venturini Craig E Pennell Sheila J Barton Albert M Levin Ivan Curjuric Mariona Bustamante Eskil Kreiner-Møller Gabrielle A Lockett Jonas Bacelis Supinda Bunyavanich Rachel A Myers Anja Matanovic Ashish Kumar Joyce Y Tung Tomomitsu Hirota Michiaki Kubo Wendy L McArdle A J Henderson John P Kemp Jie Zheng George Davey Smith Franz Rüschendorf Anja Bauerfeind Min Ae Lee-Kirsch Andreas Arnold Georg Homuth Carsten O Schmidt Elisabeth Mangold Sven Cichon Thomas Keil Elke Rodríguez Annette Peters Andre Franke Wolfgang Lieb Natalija Novak Regina Fölster-Holst Momoko Horikoshi Juha Pekkanen Sylvain Sebert Lise L Husemoen Niels Grarup Johan C de Jongste Fernando Rivadeneira Albert Hofman Vincent Wv Jaddoe Suzanne Gma Pasmans Niels J Elbert André G Uitterlinden Guy B Marks Philip J Thompson Melanie C Matheson Colin F Robertson Janina S Ried Jin Li Xian Bo Zuo Xiao Dong Zheng Xian Yong Yin Liang Dan Sun Maeve A McAleer Grainne M O'Regan Caoimhe Mr Fahy Linda E Campbell Milan Macek Michael Kurek Donglei Hu Celeste Eng Dirkje S Postma Bjarke Feenstra Frank Geller Jouke Jan Hottenga Christel M Middeldorp Pirro Hysi Veronique Bataille Tim Spector Carla Mt Tiesler Elisabeth Thiering Badri Pahukasahasram James J Yang Medea Imboden Scott Huntsman Natàlia Vilor-Tejedor Caroline L Relton Ronny Myhre Wenche Nystad Adnan Custovic Scott T Weiss Deborah A Meyers Cilla Söderhäll Erik Melén Carole Ober Benjamin A Raby Angela Simpson Bo Jacobsson John W Holloway Hans Bisgaard Jordi Sunyer Nicole M Probst Hensch L Keoki Williams Keith M Godfrey Carol A Wang Dorret I Boomsma Mads Melbye Gerard H Koppelman Deborah Jarvis Wh Irwin McLean Alan D Irvine Xue Jun Zhang Hakon Hakonarson Christian Gieger Esteban G Burchard Nicholas G Martin Liesbeth Duijts Allan Linneberg Marjo-Riitta Jarvelin Markus M Noethen Susanne Lau Norbert Hübner Young-Ae Lee Mayumi Tamari David A Hinds Daniel Glass Sara J Brown Joachim Heinrich David M Evans Stephan Weidinger

Nat Genet 2015 Dec 19;47(12):1449-1456. Epub 2015 Oct 19.

Department of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.3424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753676PMC
December 2015

Genome-wide association study of recalcitrant atopic dermatitis in Korean children.

J Allergy Clin Immunol 2015 Sep 30;136(3):678-684.e4. Epub 2015 Apr 30.

Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562879PMC
September 2015

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.

Nat Cell Biol 2015 Aug 13;17(8):1074-1087. Epub 2015 Jul 13.

Section of Ophthalmology and Neuroscience, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, LS9 7TF, UK.

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http://www.nature.com/articles/ncb3201
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http://dx.doi.org/10.1038/ncb3201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536769PMC
August 2015

Directional dominance on stature and cognition in diverse human populations.

Authors:
Peter K Joshi Tonu Esko Hannele Mattsson Niina Eklund Ilaria Gandin Teresa Nutile Anne U Jackson Claudia Schurmann Albert V Smith Weihua Zhang Yukinori Okada Alena Stančáková Jessica D Faul Wei Zhao Traci M Bartz Maria Pina Concas Nora Franceschini Stefan Enroth Veronique Vitart Stella Trompet Xiuqing Guo Daniel I Chasman Jeffery R O'Connel Tanguy Corre Suraj S Nongmaithem Yuning Chen Massimo Mangino Daniela Ruggiero Michela Traglia Aliki-Eleni Farmaki Tim Kacprowski Andrew Bjonnes Ashley van der Spek Ying Wu Anil K Giri Lisa R Yanek Lihua Wang Edith Hofer Cornelius A Rietveld Olga McLeod Marilyn C Cornelis Cristian Pattaro Niek Verweij Clemens Baumbach Abdel Abdellaoui Helen R Warren Dragana Vuckovic Hao Mei Claude Bouchard John R B Perry Stefania Cappellani Saira S Mirza Miles C Benton Ulrich Broeckel Sarah E Medland Penelope A Lind Giovanni Malerba Alexander Drong Loic Yengo Lawrence F Bielak Degui Zhi Peter J van der Most Daniel Shriner Reedik Mägi Gibran Hemani Tugce Karaderi Zhaoming Wang Tian Liu Ilja Demuth Jing Hua Zhao Weihua Meng Lazaros Lataniotis Sander W van der Laan Jonathan P Bradfield Andrew R Wood Amelie Bonnefond Tarunveer S Ahluwalia Leanne M Hall Erika Salvi Seyhan Yazar Lisbeth Carstensen Hugoline G de Haan Mark Abney Uzma Afzal Matthew A Allison Najaf Amin Folkert W Asselbergs Stephan J L Bakker R Graham Barr Sebastian E Baumeister Daniel J Benjamin Sven Bergmann Eric Boerwinkle Erwin P Bottinger Archie Campbell Aravinda Chakravarti Yingleong Chan Stephen J Chanock Constance Chen Y-D Ida Chen Francis S Collins John Connell Adolfo Correa L Adrienne Cupples George Davey Smith Gail Davies Marcus Dörr Georg Ehret Stephen B Ellis Bjarke Feenstra Mary F Feitosa Ian Ford Caroline S Fox Timothy M Frayling Nele Friedrich Frank Geller Generation Scotland Irina Gillham-Nasenya Omri Gottesman Misa Graff Francine Grodstein Charles Gu Chris Haley Christopher J Hammond Sarah E Harris Tamara B Harris Nicholas D Hastie Nancy L Heard-Costa Kauko Heikkilä 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Patarcic Francesca Pavani Patricia A Peyser Kirsi Pietilainen Neil Poulter Inga Prokopenko Sarju Ralhan Paul Redmond Stephen S Rich Harri Rissanen Antonietta Robino Lynda M Rose Richard Rose Cinzia Sala Babatunde Salako Veikko Salomaa Antti-Pekka Sarin Richa Saxena Helena Schmidt Laura J Scott William R Scott Bengt Sennblad Sudha Seshadri Peter Sever Smeeta Shrestha Blair H Smith Jennifer A Smith Nicole Soranzo Nona Sotoodehnia Lorraine Southam Alice V Stanton Maria G Stathopoulou Konstantin Strauch Rona J Strawbridge Matthew J Suderman Nikhil Tandon Sian-Tsun Tang Kent D Taylor Bamidele O Tayo Anna Maria Töglhofer Maciej Tomaszewski Natalia Tšernikova Jaakko Tuomilehto Andre G Uitterlinden Dhananjay Vaidya Astrid van Hylckama Vlieg Jessica van Setten Tuula Vasankari Sailaja Vedantam Efthymia Vlachopoulou Diego Vozzi Eero Vuoksimaa Melanie Waldenberger Erin B Ware William Wentworth-Shields John B Whitfield Sarah Wild Gonneke Willemsen Chittaranjan S Yajnik Jie Yao Gianluigi Zaza Xiaofeng Zhu The BioBank Japan Project Rany M Salem Mads Melbye Hans Bisgaard Nilesh J Samani Daniele Cusi David A Mackey Richard S Cooper Philippe Froguel Gerard Pasterkamp Struan F A Grant Hakon Hakonarson Luigi Ferrucci Robert A Scott Andrew D Morris Colin N A Palmer George Dedoussis Panos Deloukas Lars Bertram Ulman Lindenberger Sonja I Berndt Cecilia M Lindgren Nicholas J Timpson Anke Tönjes Patricia B Munroe Thorkild I A Sørensen Charles N Rotimi Donna K Arnett Albertine J Oldehinkel Sharon L R Kardia Beverley Balkau Giovanni Gambaro Andrew P Morris Johan G Eriksson Margie J Wright Nicholas G Martin Steven C Hunt John M Starr Ian J Deary Lyn R Griffiths Henning Tiemeier Nicola Pirastu Jaakko Kaprio Nicholas J Wareham Louis Pérusse James G Wilson Giorgia Girotto Mark J Caulfield Olli Raitakari Dorret I Boomsma Christian Gieger Pim van der Harst Andrew A Hicks Peter Kraft Juha Sinisalo Paul Knekt Magnus Johannesson Patrik K E Magnusson Anders Hamsten Reinhold Schmidt Ingrid B Borecki Erkki Vartiainen Diane M Becker Dwaipayan Bharadwaj Karen L Mohlke Michael Boehnke Cornelia M van Duijn Dharambir K Sanghera Alexander Teumer Eleftheria Zeggini Andres Metspalu Paolo Gasparini Sheila Ulivi Carole Ober Daniela Toniolo Igor Rudan David J Porteous Marina Ciullo Tim D Spector Caroline Hayward Josée Dupuis Ruth J F Loos Alan F Wright Giriraj R Chandak Peter Vollenweider Alan Shuldiner Paul M Ridker Jerome I Rotter Naveed Sattar Ulf Gyllensten Kari E North Mario Pirastu Bruce M Psaty David R Weir Markku Laakso Vilmundur Gudnason Atsushi Takahashi John C Chambers Jaspal S Kooner David P Strachan Harry Campbell Joel N Hirschhorn Markus Perola Ozren Polašek James F Wilson

Nature 2015 Jul 1;523(7561):459-462. Epub 2015 Jul 1.

Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.

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July 2015

Seasonal variation in human gut microbiome composition.

PLoS One 2014 11;9(3):e90731. Epub 2014 Mar 11.

Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America.

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May 2015

An estimate of the average number of recessive lethal mutations carried by humans.

Genetics 2015 Apr 18;199(4):1243-54. Epub 2015 Feb 18.

Department of Biological Sciences, Columbia University, New York, New York 10027 Department of Systems Biology, Columbia University, New York, New York 10032

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April 2015

Host genetic variation influences gene expression response to rhinovirus infection.

PLoS Genet 2015 Apr 13;11(4):e1005111. Epub 2015 Apr 13.

Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America.

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April 2015

Evolutionary forward genomics reveals novel insights into the genes and pathways dysregulated in recurrent early pregnancy loss.

Hum Reprod 2015 Mar 12;30(3):519-29. Epub 2015 Jan 12.

Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA Department of Obstetrics and Gynecology, The University of Chicago, Chicago, IL 60637, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325674PMC
March 2015

PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population.

PLoS Comput Biol 2015 Mar 3;11(3):e1004139. Epub 2015 Mar 3.

Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America; Departments of Medicine, and Statistics, The University of Chicago, Chicago, Illinois, United States of America.

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March 2015

Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem Cells.

Cell Rep 2015 Mar 12;10(11):1828-35. Epub 2015 Mar 12.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Cecil H. & Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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March 2015

Disclosure of genetic research results to members of a founder population.

J Genet Couns 2014 Dec 29;23(6):984-91. Epub 2014 Apr 29.

Department of Human Genetics, University of Chicago, 5841 S. Maryland Ave. M/C 0077, Chicago, IL, 60637, USA.

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December 2014

Variants in DPF3 and DSCAML1 are associated with sperm morphology.

J Assist Reprod Genet 2014 Feb 26;31(2):131-7. Epub 2013 Nov 26.

Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.

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February 2014

Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile.

J Biol Chem 2013 Dec 12;288(51):36741-9. Epub 2013 Nov 12.

From the Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan.

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December 2013

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.

Circ Cardiovasc Genet 2013 Aug 17;6(4):327-36. Epub 2013 Jul 17.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Calgary, AB, Canada.

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August 2013

A population-based study of autosomal-recessive disease-causing mutations in a founder population.

Am J Hum Genet 2012 Oct 13;91(4):608-20. Epub 2012 Sep 13.

Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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October 2012