Carole A Long

Carole A Long

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Carole A Long

Carole A Long

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Plasmodium yoelii Erythrocyte-Binding-like Protein Modulates Host Cell Membrane Structure, Immunity, and Disease Severity.

mBio 2020 01 7;11(1). Epub 2020 Jan 7.

Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/mBio.02995-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946805PMC
January 2020

A Universal Plug-and-Display Vaccine Carrier Based on HBsAg VLP to Maximize Effective Antibody Response.

Front Immunol 2019 12;10:2931. Epub 2019 Dec 12.

Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.02931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921968PMC
December 2019

Strong concordance between percent inhibition in oocyst and sporozoite intensities in a Plasmodium falciparum standard membrane-feeding assay.

Parasit Vectors 2019 May 6;12(1):206. Epub 2019 May 6.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD, 20852, USA.

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http://dx.doi.org/10.1186/s13071-019-3470-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501457PMC
May 2019

Identification of domains within Pfs230 that elicit transmission blocking antibody responses.

Vaccine 2019 Mar 26;37(13):1799-1806. Epub 2019 Feb 26.

Division of Molecular Parasitology, Proteo-Science Center, Ehime University, Toon, Ehime 791-0295, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2019.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708081PMC
March 2019

Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention.

Sci Rep 2018 10 16;8(1):15280. Epub 2018 Oct 16.

Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, 20892-8132, USA.

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http://www.nature.com/articles/s41598-018-33599-1
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http://dx.doi.org/10.1038/s41598-018-33599-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191451PMC
October 2018

Malaria Derived Glycosylphosphatidylinositol Anchor Enhances Anti-Pfs25 Functional Antibodies That Block Malaria Transmission.

Biochemistry 2018 02 16;57(5):516-519. Epub 2018 Jan 16.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, Maryland 20852, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b01099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803671PMC
February 2018

Evaluation of a Plasmodium-Specific Carrier Protein To Enhance Production of Recombinant s25, a Leading Transmission-Blocking Vaccine Candidate.

Infect Immun 2018 01 19;86(1). Epub 2017 Dec 19.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

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http://iai.asm.org/lookup/doi/10.1128/IAI.00486-17
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http://dx.doi.org/10.1128/IAI.00486-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736822PMC
January 2018

Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model.

Sci Rep 2017 09 5;7(1):10438. Epub 2017 Sep 5.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-8132, USA.

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http://www.nature.com/articles/s41598-017-10776-2
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http://dx.doi.org/10.1038/s41598-017-10776-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585408PMC
September 2017

Immune Responses in Malaria.

Cold Spring Harb Perspect Med 2017 Aug 1;7(8). Epub 2017 Aug 1.

Departmentof Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205.

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http://dx.doi.org/10.1101/cshperspect.a025577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538407PMC
August 2017

A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence.

Nat Commun 2017 08 9;8(1):223. Epub 2017 Aug 9.

Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-017-00267-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548792PMC
August 2017

Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model.

PLoS Pathog 2016 Oct 7;12(10):e1005930. Epub 2016 Oct 7.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055354PMC
October 2016

Malaria vaccines and human immune responses.

Curr Opin Microbiol 2016 08 2;32:96-102. Epub 2016 Jun 2.

Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, United States.

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http://dx.doi.org/10.1016/j.mib.2016.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983510PMC
August 2016

Transmission-blocking activity is determined by transmission-reducing activity and number of control oocysts in Plasmodium falciparum standard membrane-feeding assay.

Vaccine 2016 07 29;34(35):4145-4151. Epub 2016 Jun 29.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1016/j.vaccine.2016.06.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958521PMC
July 2016

Immunogenicity of a chimeric Plasmodium falciparum merozoite surface protein vaccine in Aotus monkeys.

Malar J 2016 Mar 15;15:159. Epub 2016 Mar 15.

Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA.

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http://dx.doi.org/10.1186/s12936-016-1226-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791798PMC
March 2016

Genome-wide Analysis of Host-Plasmodium yoelii Interactions Reveals Regulators of the Type I Interferon Response.

Cell Rep 2015 Jul 16;12(4):661-72. Epub 2015 Jul 16.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132, USA; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, PRC. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520759PMC
July 2015

The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages.

J Biol Chem 2014 Dec 28;289(50):34827-37. Epub 2014 Oct 28.

From the Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129,

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http://dx.doi.org/10.1074/jbc.M114.615831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263882PMC
December 2014

Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria.

PLoS One 2014 28;9(2):e87140. Epub 2014 Feb 28.

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America ; University of Virginia, Department of Pathology, Charlottesville, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087140PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938406PMC
November 2014

Antigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malaria.

Infect Immun 2014 Nov 25;82(11):4842-53. Epub 2014 Aug 25.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA

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http://dx.doi.org/10.1128/IAI.02097-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249335PMC
November 2014

Effect of ingested human antibodies induced by RTS, S/AS01 malaria vaccination in children on Plasmodium falciparum oocyst formation and sporogony in mosquitoes.

Malar J 2014 Jul 9;13:263. Epub 2014 Jul 9.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1186/1475-2875-13-263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100490PMC
July 2014

Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut.

Proc Natl Acad Sci U S A 2014 Jan 13;111(4):E492-500. Epub 2014 Jan 13.

The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.

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http://dx.doi.org/10.1073/pnas.1315517111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910608PMC
January 2014

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality.

Proc Natl Acad Sci U S A 2014 Jan 13;111(4):E511-20. Epub 2014 Jan 13.

Laboratory of Malaria and Vector Research, and Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1316467111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910569PMC
January 2014

Functional comparison of Plasmodium falciparum transmission-blocking vaccine candidates by the standard membrane-feeding assay.

Infect Immun 2013 Dec 16;81(12):4377-82. Epub 2013 Sep 16.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.

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http://dx.doi.org/10.1128/IAI.01056-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838000PMC
December 2013

A chimeric Plasmodium falciparum merozoite surface protein vaccine induces high titers of parasite growth inhibitory antibodies.

Infect Immun 2013 Oct 29;81(10):3843-54. Epub 2013 Jul 29.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/IAI.00522-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811772PMC
October 2013

Qualification of standard membrane-feeding assay with Plasmodium falciparum malaria and potential improvements for future assays.

PLoS One 2013 6;8(3):e57909. Epub 2013 Mar 6.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057909PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590281PMC
September 2013

Overcoming allelic specificity by immunization with five allelic forms of Plasmodium falciparum apical membrane antigen 1.

Infect Immun 2013 May 19;81(5):1491-501. Epub 2013 Feb 19.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.

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http://dx.doi.org/10.1128/IAI.01414-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648006PMC
May 2013

Evaluation of the immunogenicity and vaccine potential of recombinant Plasmodium falciparum merozoite surface protein 8.

Infect Immun 2012 Jul 14;80(7):2473-84. Epub 2012 May 14.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

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http://iai.asm.org/lookup/doi/10.1128/IAI.00211-12
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http://dx.doi.org/10.1128/IAI.00211-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416454PMC
July 2012

Non-apical membrane antigen 1 (AMA1) IgGs from Malian children interfere with functional activity of AMA1 IgGs as judged by growth inhibition assay.

PLoS One 2011 13;6(6):e20947. Epub 2011 Jun 13.

Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020947PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113848PMC
October 2011

Evidence for erythrocyte-binding antigen 175 as a component of a ligand-blocking blood-stage malaria vaccine.

Proc Natl Acad Sci U S A 2011 May 18;108(18):7553-8. Epub 2011 Apr 18.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1104050108
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http://dx.doi.org/10.1073/pnas.1104050108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088598PMC
May 2011

Immunological responses against Plasmodium falciparum Apical Membrane Antigen 1 vaccines vary depending on the population immunized.

Vaccine 2011 Mar 31;29(12):2255-61. Epub 2011 Jan 31.

Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1016/j.vaccine.2011.01.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046304PMC
March 2011

Engineering the chloroplast targeted malarial vaccine antigens in Chlamydomonas starch granules.

PLoS One 2010 Dec 15;5(12):e15424. Epub 2010 Dec 15.

Centre National de la Recherche Scientifique, CNRS UMR 8576, UGSF, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015424PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002285PMC
December 2010

Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region.

J Biol Chem 2010 Aug 7;285(32):24855-62. Epub 2010 Jun 7.

Structural Biology Section, Research Technologies Branch, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.118612
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http://dx.doi.org/10.1074/jbc.M110.118612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915721PMC
August 2010