Carol J Thiele

Carol J Thiele

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Carol J Thiele

Carol J Thiele

Publications by authors named "Carol J Thiele"

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62Publications

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Targeting Histone Deacetylase Activity to Arrest Cell Growth and Promote Neural Differentiation in Ewing Sarcoma.

Mol Neurobiol 2018 Sep 3;55(9):7242-7258. Epub 2018 Feb 3.

Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, 90035-003, Brazil.

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September 2018

P53/PUMA are potential targets that mediate the protection of brain-derived neurotrophic factor (BDNF)/TrkB from etoposide-induced cell death in neuroblastoma (NB).

Apoptosis 2018 Aug;23(7-8):408-419

Medical Research Center, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping District, Shenyang, 110004, China.

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August 2018

When LMO1 Meets MYCN, Neuroblastoma Is Metastatic.

Cancer Cell 2017 09;32(3):273-275

Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address:

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September 2017

Inhibition of with the Generation 2.5 Antisense Oligonucleotide, AZD9150, Decreases Neuroblastoma Tumorigenicity and Increases Chemosensitivity.

Clin Cancer Res 2017 Apr 19;23(7):1771-1784. Epub 2016 Oct 19.

Cell & Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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April 2017

High-SETD8 inactivates p53 in neuroblastoma.

Oncoscience 2017 Mar 14;4(3-4):21-22. Epub 2017 Apr 14.

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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March 2017

Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma.

Sci Rep 2017 02 6;7:42062. Epub 2017 Feb 6.

Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, 110004, China.

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February 2017

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.

Cancer Cell 2017 01;31(1):50-63

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, CRC, 1-3940, 10 Center Drive MSC-1105, Bethesda, MD 20892, USA. Electronic address:

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January 2017

PI3K and MAPK pathways mediate the BDNF/TrkB-increased metastasis in neuroblastoma.

Tumour Biol 2016 Oct 17. Epub 2016 Oct 17.

Medical Research Center, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping District, Shenyang, 110004, China.

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October 2016

Trk inhibitor attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo.

Cancer Biol Ther 2015 ;16(3):477-83

a Cell & Molecular Biology Section, Pediatric Oncology Branch , National Institutes of Health , Bethesda , MD , USA.

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January 2016

Zinc finger transcription factor CASZ1 interacts with histones, DNA repair proteins and recruits NuRD complex to regulate gene transcription.

Oncotarget 2015 Sep;6(29):27628-40

Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.

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September 2015

Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma.

Dis Model Mech 2015 May 18;8(5):429-41. Epub 2015 Mar 18.

Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK

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May 2015

Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review).

Oncol Lett 2014 May 24;7(5):1333-1340. Epub 2014 Feb 24.

Research Center for Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.

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May 2014

Dihydropyrimidinase-like protein 3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma.

Cancer Sci 2013 Dec 21;104(12):1586-92. Epub 2013 Oct 21.

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China; Cell & Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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December 2013

CASZ1 inhibits cell cycle progression in neuroblastoma by restoring pRb activity.

Cell Cycle 2013 Jul;12(14):2210-8

Pediatric Oncology Branch; National Cancer Institute; Bethesda, MD, USA.

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July 2013

Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo.

Oncotarget 2013 Mar;4(3):433-45

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, USA.

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March 2013

MYCN and the epigenome.

Front Oncol 2013 25;3. Epub 2013 Jan 25.

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute Bethesda, MD, USA.

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February 2013

Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or rapamycin enhances the antitumor growth effect in neuroblastoma.

Clin Cancer Res 2012 Jul 1;18(13):3603-15. Epub 2012 May 1.

Cell & Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

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July 2012

Genetically InFormed therapies--a "GIFT" for children with cancer.

Clin Cancer Res 2012 May;18(10):2735-9

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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May 2012

Epigenetic changes in pediatric solid tumors: promising new targets.

Clin Cancer Res 2012 May;18(10):2768-79

Department of Pediatrics and Pathology, University of Michigan, Ann Arbor, Michigan, USA.

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May 2012

Characterization of critical domains within the tumor suppressor CASZ1 required for transcriptional regulation and growth suppression.

Mol Cell Biol 2012 Apr 13;32(8):1518-28. Epub 2012 Feb 13.

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.

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April 2012

ALK and MYCN: when two oncogenes are better than one.

Cancer Cell 2012 Mar;21(3):325-6

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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March 2012

EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR.

Cancer Res 2012 Jan 8;72(1):315-24. Epub 2011 Nov 8.

Cell & Molecular Biology Section, National Cancer Institute, NIH, Bethesda, Bethesda, MD 20892, USA.

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January 2012

Perifosine-induced inhibition of Akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo.

Cancer 2011 Dec 16;117(23):5412-22. Epub 2011 May 16.

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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December 2011

CASZ1b, the short isoform of CASZ1 gene, coexpresses with CASZ1a during neurogenesis and suppresses neuroblastoma cell growth.

PLoS One 2011 Apr 7;6(4):e18557. Epub 2011 Apr 7.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.

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April 2011

NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α.

Mol Cell Neurosci 2011 Feb 9;46(2):498-506. Epub 2010 Dec 9.

Cell & Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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February 2011

In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine.

J Natl Cancer Inst 2010 Jun 12;102(11):758-70. Epub 2010 May 12.

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, 10 Center Drive MSC-1928, Bldg 10/CRC 1-3940, Bethesda, MD 20892, USA.

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June 2010

Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.

Cell Cycle 2010 May 15;9(9):1830-8. Epub 2010 May 15.

Cell & Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.

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May 2010

Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo.

Clin Cancer Res 2009 Nov 13;15(21):6602-8. Epub 2009 Oct 13.

Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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November 2009

On Trk--the TrkB signal transduction pathway is an increasingly important target in cancer biology.

Clin Cancer Res 2009 Oct 15;15(19):5962-7. Epub 2009 Sep 15.

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, CRC, NCI, Bethesda, Maryland 20892, USA.

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October 2009

Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma.

Pediatr Blood Cancer 2008 Feb;50(2):208-12

Department of Pediatrics, College of Medicine, Korea University, Seoul 152-703, South Korea.

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February 2008

Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway.

Expert Opin Ther Targets 2007 Dec;11(12):1611-21

Cell & Molecular Biology Section, Paediatric Oncology Branch National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10/CRC, Room 1-5816, Bethesda, MD 20892, USA.

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December 2007

Inactivation of glycogen synthase kinase-3beta contributes to brain-derived neutrophic factor/TrkB-induced resistance to chemotherapy in neuroblastoma cells.

Mol Cancer Ther 2007 Dec;6(12 Pt 1):3113-21

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 10 Center Drive MSC-1928, Bldg. 10/CRC 1-3940, Bethesda, MD 20892, USA.

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December 2007

Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma.

J Clin Invest 2007 Sep;117(9):2702-12

Division of Hematology-Oncology, Department of Pediatrics, Childrens Hospital Los Angeles (CHLA), Los Angeles, California 90027, USA.

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September 2007

Targeting caspase 8 to reduce the formation of metastases in neuroblastoma.

Expert Opin Ther Targets 2006 Oct;10(5):703-8

National Cancer Institute, NIH, Cell & Molecular Biology Section, Paediatric Oncology Branch, 10 Center Drive, Building 10/CRC, Room 1-5816, Bethesda, MD 20892, USA.

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October 2006

Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation.

Biochem Biophys Res Commun 2006 Jun 19;344(3):834-44. Epub 2006 Apr 19.

Cell and Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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June 2006

TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism.

J Biol Chem 2005 Aug 16;280(32):29199-207. Epub 2005 Jun 16.

Cancer Research Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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August 2005

Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells.

Cancer Res 2005 Jun;65(11):4775-81

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

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June 2005

Pediatric pancreatoblastoma: histopathologic and cytogenetic characterization of tumor and derived cell line.

Cancer Genet Cytogenet 2005 Mar;157(2):109-17

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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March 2005

Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death.

Cancer Res 2005 Mar;65(6):2070-5

Cell and Molecular Biology Section, Pediatric Oncology Branch and Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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March 2005

Interferon gamma enhances the effectiveness of tumor necrosis factor-related apoptosis-inducing ligand receptor agonists in a xenograft model of Ewing's sarcoma.

Cancer Res 2004 Nov;64(22):8349-56

Pediatric Oncology Branch and Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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November 2004

Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death.

FASEB J 2004 Jul 7;18(10):1162-4. Epub 2004 May 7.

Department of Microbiology, Immunology & Cell Biology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, West Virginia 26506, USA.

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July 2004

NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number.

Oncogene 2004 Feb;23(8):1522-30

Cell & Molecular Biology Section, Pediatric Oncology Branch, NCI, NIH, Bethesda, MD 20892, USA.

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February 2004

Fibroblast growth factor 2 induces differentiation and apoptosis of Askin tumour cells.

J Pathol 2004 Jan;202(1):103-12

Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.

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January 2004

Effect of imatinib mesylate on neuroblastoma tumorigenesis and vascular endothelial growth factor expression.

J Natl Cancer Inst 2004 Jan;96(1):46-55

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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January 2004

Targeting the tumor necrosis factor-related apoptosis-inducing ligand path in neuroblastoma.

Cancer Lett 2003 Jul;197(1-2):137-43

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 10 Center Dr., Bethesda, MD 20892, USA.

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July 2003

Cisplatin-induced cytotoxicity is blocked by brain-derived neurotrophic factor activation of TrkB signal transduction path in neuroblastoma.

Cancer Lett 2003 Apr;193(1):109-14

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, NCI, 10 Center Dr. MSC-1928, Bethesda, MD, USA.

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April 2003

Biologically relevant orthotopic neuroblastoma xenograft models: primary adrenal tumor growth and spontaneous distant metastasis.

In Vivo 2002 Mar-Apr;16(2):77-85

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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January 2003

MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors.

Cancer Res 2002 Nov;62(21):6108-15

Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

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November 2002

Potential use of imatinib in Ewing's Sarcoma: evidence for in vitro and in vivo activity.

J Natl Cancer Inst 2002 Nov;94(22):1673-9

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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November 2002

The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors.

Cancer Res 2002 Jan;62(1):323-8

Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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January 2002