Carol E Schrader

Carol E Schrader

UNVERIFIED PROFILE

Are you Carol E Schrader?   Register this Author

Register author
Carol E Schrader

Carol E Schrader

Publications by authors named "Carol E Schrader"

Are you Carol E Schrader?   Register this Author

31Publications

356Reads

10Profile Views

The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.

J Immunol 2016 10 24;197(7):2918-29. Epub 2016 Aug 24.

Department of Pathology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; Lymphoma and Myeloma Center Amsterdam, 1105 AZ Amsterdam, the Netherlands;

View Article

Download full-text PDF

Source
http://www.jimmunol.org/content/197/7/2918.full.pdf
Web Search
http://dx.doi.org/10.4049/jimmunol.1501989DOI Listing
October 2016

Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.

PLoS One 2015 12;10(8):e0134397. Epub 2015 Aug 12.

Department of Microbiology and Physiological Systems, Univ. of Massachusetts Medical School, Worcester, MA, 01605, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534307PMC
May 2016

Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells.

PLoS Genet 2015 Aug 11;11(8):e1005438. Epub 2015 Aug 11.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1005438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532491PMC
August 2015

Response to comment on "IgH chain class switch recombination: mechanism and regulation".

J Immunol 2015 Mar;194(5):2040

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1500050DOI Listing
March 2015

IgH chain class switch recombination: mechanism and regulation.

J Immunol 2014 Dec;193(11):5370-8

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1401849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447316PMC
December 2014

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.

J Immunol 2014 Jul 16;193(2):931-9. Epub 2014 Jun 16.

Department of Molecular and Physiological Systems, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01655;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1400002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105697PMC
July 2014

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation.

Proc Natl Acad Sci U S A 2014 Jun 9;111(25):9217-22. Epub 2014 Jun 9.

Department of Microbiology and Physiological Systems, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01655; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1405590111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078814PMC
June 2014

ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination.

J Immunol 2014 May 11;192(10):4887-96. Epub 2014 Apr 11.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1303481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049217PMC
May 2014

DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.

DNA Repair (Amst) 2013 Dec 29;12(12):1087-93. Epub 2013 Sep 29.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2013.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000569PMC
December 2013

The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.

PLoS One 2012 20;7(4):e36061. Epub 2012 Apr 20.

Department of Microbiology and Physiological Systems, Medical School, University of Massachusetts, Worcester, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036061PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334981PMC
August 2012

AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].

J Immunol 2011 Sep 29;187(5):2464-75. Epub 2011 Jul 29.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1101406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159830PMC
September 2011

p53 represses class switch recombination to IgG2a through its antioxidant function.

J Immunol 2010 Jun 5;184(11):6177-87. Epub 2010 May 5.

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0904085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235438PMC
June 2010

The role of Apex2 in class-switch recombination of immunoglobulin genes.

Int Immunol 2010 Mar;22(3):213; author reply 213-4

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/intimm/dxq003DOI Listing
March 2010

Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.

J Immunol 2009 Jul 24;183(2):1222-8. Epub 2009 Jun 24.

Immunology Program and Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0900135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677205PMC
July 2009

The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch.

Philos Trans R Soc Lond B Biol Sci 2009 Mar;364(1517):645-52

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01545, USA.

View Article

Download full-text PDF

Source
http://rstb.royalsocietypublishing.org/cgi/doi/10.1098/rstb.
Publisher Site
http://dx.doi.org/10.1098/rstb.2008.0200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660920PMC
March 2009

Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.

J Immunol 2008 Dec;181(12):8450-9

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656362PMC
http://dx.doi.org/10.4049/jimmunol.181.12.8450DOI Listing
December 2008

Mechanism and regulation of class switch recombination.

Annu Rev Immunol 2008 ;26:261-92

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655-012, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev.immunol.26.021607.090248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707252PMC
June 2008

Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair.

J Immunol 2007 Nov;179(9):6064-71

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.179.9.6064DOI Listing
November 2007

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

J Exp Med 2007 Nov 19;204(12):3017-26. Epub 2007 Nov 19.

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://www.jem.org/lookup/doi/10.1084/jem.20071289
Publisher Site
http://dx.doi.org/10.1084/jem.20071289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118529PMC
November 2007

Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination.

Trends Genet 2006 Jan 23;22(1):23-8. Epub 2005 Nov 23.

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655-0122, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tig.2005.11.002DOI Listing
January 2006

Inducible DNA breaks in Ig S regions are dependent on AID and UNG.

J Exp Med 2005 Aug;202(4):561-8

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20050872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212854PMC
August 2005

Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2.

J Exp Med 2005 Jun 13;201(12):1885-90. Epub 2005 Jun 13.

Genetics Program, Tufts University School of Medicine, Boston, MA 02111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20042491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212040PMC
June 2005

Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions.

J Exp Med 2004 Aug 26;200(3):321-30. Epub 2004 Jul 26.

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave. North, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20040052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211985PMC
August 2004

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination.

EMBO J 2003 Nov;22(21):5893-903

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655-0122, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/emboj/cdg550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275407PMC
November 2003

The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2.

Immunity 2003 Oct;19(4):515-24

Genetics Program, Tufts University School of Medicine, Boston, MA 02111, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1074-7613(03)00262-0DOI Listing
October 2003

Mlh1 can function in antibody class switch recombination independently of Msh2.

J Exp Med 2003 May 12;197(10):1377-83. Epub 2003 May 12.

Department of Molecular Genetics and Microbiology, and Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Ave. North, Worcester, MA 01655-0122, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20022190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193780PMC
May 2003

The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA.

J Immunol 2002 Mar;168(6):2847-56

Division of Molecular Genetics, Dana--Farber Cancer Institute and Harvard Medical School, and Department of Biology, Boston University, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.168.6.2847DOI Listing
March 2002

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions.

J Exp Med 2002 Feb;195(3):367-73

Department of Molecular Genetics and Microbiology and Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193596PMC
http://dx.doi.org/10.1084/jem.20011877DOI Listing
February 2002