Carol Ann Remme

Carol Ann Remme

UNVERIFIED PROFILE

Are you Carol Ann Remme?   Register this Author

Register author
Carol Ann Remme

Carol Ann Remme

Publications by authors named "Carol Ann Remme"

Are you Carol Ann Remme?   Register this Author

55Publications

1740Reads

25Profile Views

'Mature' resting membrane potentials in human-induced pluripotent stem cell-derived cardiomyocytes: fact or artefact?

Europace 2019 Oct 3. Epub 2019 Oct 3.

Department of Medical Biology, Amsterdam UMC, Location Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/europace/euz243DOI Listing
October 2019

Functional Consequences of the -p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice.

Int J Mol Sci 2019 Oct 11;20(20). Epub 2019 Oct 11.

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20205033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829230PMC
October 2019

Down the rabbit hole: deciphering the short QT syndrome.

Eur Heart J 2019 Mar;40(10):854-856

Department of Clinical and Experimental Cardiology, Heart Center, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/eurheartj/ehy906DOI Listing
March 2019

Scientists on the Spot: Carol Ann Remme on her research and career.

Cardiovasc Res 2018 11;114(13):e102

Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, Meibergdreef 9, AZ Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
https://academic.oup.com/cardiovascres/article/114/13/e102/5
Publisher Site
http://dx.doi.org/10.1093/cvr/cvy238DOI Listing
November 2018

Disease Modifiers of Inherited Channelopathy.

Front Cardiovasc Med 2018 1;5:137. Epub 2018 Oct 1.

Department of Clinical and Experimental Cardiology, Heart Centre, Academic Medical Center, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fcvm.2018.00137/
Publisher Site
http://dx.doi.org/10.3389/fcvm.2018.00137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174200PMC
October 2018

RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling.

Circulation 2018 09;138(13):1330-1342

Department of Experimental Cardiology (M.M.G.v.d.H., A.B., A.S.A., I.v.d.M., S.A., M.A.F.K., C.A.S., J.A.J., C.A.R., A.o.V., A.B., Y.M.P., E.E.C.), Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.117.031947DOI Listing
September 2018

Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy.

Int J Cardiol 2018 07;263:54-62

Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2018.03.044DOI Listing
July 2018

Intramural clefts and structural discontinuities in Brugada syndrome: the missing gap?

Cardiovasc Res 2018 04;114(5):638-640

Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvy028DOI Listing
April 2018

K4.3 Expression Modulates Na1.5 Sodium Current.

Front Physiol 2018 12;9:178. Epub 2018 Mar 12.

Department of Experimental Cardiology, Academic Medical Center, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2018.00178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857579PMC
March 2018

Therapeutic approaches for Long QT syndrome type 3: an update.

Europace 2018 02;20(2):222-224

Heart Centre, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
https://academic.oup.com/europace/article/20/2/222/3583233
Publisher Site
http://dx.doi.org/10.1093/europace/eux039DOI Listing
February 2018

Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes.

J Am Heart Assoc 2017 Dec 8;6(12). Epub 2017 Dec 8.

Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.117.007622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779058PMC
December 2017

The Brugada Syndrome Susceptibility Gene Modulates Cardiac Transmural Ion Channel Patterning and Electrical Heterogeneity.

Circ Res 2017 Aug 21;121(5):537-548. Epub 2017 Jun 21.

From the Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, Amsterdam, The Netherlands (C.C.V., S.P., R.T., E.M.L., I.M., L.B., A.A.M.W., R.C., A.O.V., C.A.R., C.R.B.); Department of Medicine, Cardiovascular Genetics Center, Montreal Heart Institute, Canada (R.T.); Université de Montréal, Canada (R.T.); Department of Medical Biology, Academic Medical Center, Amsterdam, The Netherlands (B.d.J., R.W., B.J.B., A.O.V.); INSERM, CNRS, Université de Nantes, L'institut du Thorax, Nantes, France (J.B.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia (A.A.M.W.); and Electrophysiology and Heart Modeling Institute LIRYC, Université de Bordeaux, France (R.C.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.31095
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.117.310959DOI Listing
August 2017

Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.

Cardiovasc Res 2017 Jun;113(7):829-838

Department of Clinical and Experimental Cardiology/Heart Centre, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22660, 1100 DD Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvx077DOI Listing
June 2017

Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations.

Cardiovasc Drugs Ther 2017 Jun;31(3):325-344

Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Room K2-104-2, Meibergdreef 15, PO Box 22700, 1100 DE, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10557-017-6735-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550530PMC
June 2017

Chemokine ligand 9 modulates cardiac repolarization via Cxcr3 receptor binding.

Int J Cardiol 2015 Dec 31;201:49-52. Epub 2015 Jul 31.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2015.07.096DOI Listing
December 2015

Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction.

Heart Rhythm 2015 May 23;12(5):1036-45. Epub 2015 Jan 23.

Department of Biology, Gilead Sciences, Fremont, California. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2015.01.029DOI Listing
May 2015

PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.

Circulation 2014 Jul 3;130(2):147-60. Epub 2014 Jun 3.

From the Department of Clinical Research, University of Bern, Bern, Switzerland (D.S., L.G., J.O., M.A., J.-S.R., M.C.E., N.S., H.A.); Department of Anatomy, Embryology and Physiology (A.O.V.) and Department of Clinical and Experimental Cardiology (R.W., J.B., R.F.M., C.R.B., C.A.R.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.B.); Center for Human and Clinical Genetics, Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands (A.M.v.M.); Institute of Pathology, University of Lausanne, Lausanne, Switzerland (S.R.); Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche 1087, L'Institut du Thorax, Nantes, France (R.R.); Centre National de la Recherche Scientifique Unité Mixte de Recherche 6291, Nantes, France (R.R.); Université de Nantes, Nantes, France (R.R.); and Centre Hospitalier Universitaire Nantes, L'Institut du Thorax, Service de Cardiologie, Nantes, France (R.R.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.113.007852DOI Listing
July 2014

Targeting sodium channels in cardiac arrhythmia.

Curr Opin Pharmacol 2014 Apr 21;15:53-60. Epub 2013 Dec 21.

Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coph.2013.11.014DOI Listing
April 2014

Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects.

Authors:
Carol Ann Remme

J Physiol 2013 Sep 1;591(17):4099-116. Epub 2013 Jul 1.

C. A. Remme: Department of Experimental Cardiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/jphysiol.2013.256461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779105PMC
September 2013

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

Nat Genet 2013 Sep 21;45(9):1044-9. Epub 2013 Jul 21.

Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.2712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869788PMC
September 2013

Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract.

Circ Res 2013 Jul 9;113(2):137-41. Epub 2013 May 9.

Department of Anatomy, Embryology, and Physiology, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.113.301565DOI Listing
July 2013

Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.

PLoS Genet 2012 6;8(12):e1003113. Epub 2012 Dec 6.

Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516546PMC
May 2013

Transgenic models of cardiac arrhythmias and sudden death.

Authors:
Carol Ann Remme

Front Physiol 2013 28;4:60. Epub 2013 Mar 28.

Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2013.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610080PMC
April 2013

Late sodium current inhibition in acquired and inherited ventricular (dys)function and arrhythmias.

Cardiovasc Drugs Ther 2013 Feb;27(1):91-101

Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10557-012-6433-xDOI Listing
February 2013

Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration.

Cardiovasc Res 2013 Jan 20;97(1):182-91. Epub 2012 Sep 20.

Department of Anatomy, Embryology, and Physiology, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvs299DOI Listing
January 2013

Zebrafish: a novel research tool for cardiac (patho)electrophysiology and ion channel disorders.

Front Physiol 2012 10;3:255. Epub 2012 Jul 10.

Department of Anatomy, Embryology, and Physiology, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2012.00255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429032PMC
October 2012

Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology.

Circ Res 2012 Jul 20;111(3):333-43. Epub 2012 Jun 20.

Department of Anatomy, Embryology, and Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.112.274035DOI Listing
July 2012

Connexin43 and Na(V)1.5: partners in crime?

Authors:
Carol Ann Remme

Heart Rhythm 2012 Apr 17;9(4):608-9. Epub 2011 Dec 17.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2011.12.011DOI Listing
April 2012

Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse.

J Mol Cell Cardiol 2011 Mar 18;50(3):380-9. Epub 2010 Sep 18.

Heart Failure Research Center, Department of Experimental Cardiology, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2010.09.009DOI Listing
March 2011

Sodium channel (dys)function and cardiac arrhythmias.

Cardiovasc Ther 2010 Oct 14;28(5):287-94. Epub 2010 Jul 14.

Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1755-5922.2010.00210.xDOI Listing
October 2010

Cardiac desmosomal (dys)function and myocyte viability.

Cell Cycle 2010 Apr;9(7):1246-52

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.9.7.11065DOI Listing
April 2010

Tubulin polymerization modifies cardiac sodium channel expression and gating.

Cardiovasc Res 2010 Mar 26;85(4):691-700. Epub 2009 Oct 26.

Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvp352DOI Listing
March 2010

SCN5A overlap syndromes: no end to disease complexity?

Europace 2008 Nov 26;10(11):1253-5. Epub 2008 Sep 26.

View Article

Download full-text PDF

Source
https://academic.oup.com/europace/article-lookup/doi/10.1093
Publisher Site
http://dx.doi.org/10.1093/europace/eun267DOI Listing
November 2008

Dilated cardiomyopathy due to sodium channel dysfunction: what is the connection?

Circ Arrhythm Electrophysiol 2008 Jun;1(2):80-2

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.108.791434DOI Listing
June 2008

Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations.

Trends Cardiovasc Med 2008 Apr;18(3):78-87

Department of Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcm.2008.01.002DOI Listing
April 2008

Genetic modulation of cardiac repolarization reserve.

Heart Rhythm 2007 May 3;4(5):608-10. Epub 2007 Mar 3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2007.02.025DOI Listing
May 2007

Diagnosis and treatment of VIPoma in a female patient.

Eur J Gastroenterol Hepatol 2006 Jan;18(1):93-9

Department of Internal Medicine, Red Cross Hospital, Beverwijk, and Department of Experimental Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00042737-200601000-00017DOI Listing
January 2006