Publications by authors named "Carmen Meseguer"

9 Publications

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Striated muscle hamartoma in a newborn.

Pediatr Dermatol 2014 Jul-Aug;31(4):e110-1. Epub 2014 Jun 4.

Department of Dermatology, Txagorritxu Hospital, Vitoria, Spain.

Striated muscle hamartoma (SMH) is an uncommon benign lesion, that is usually congenital, polypoid, and primarily located on the head and neck. The key histopathologic sign is the existence of individualized fascicles of striated muscle affecting the dermis and subcutaneous fat tissue. Here we report the case of a newborn girl with an SMH, who presented with a congenital infiltrated plaque on her chin without any other associations.
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http://dx.doi.org/10.1111/pde.12324DOI Listing
May 2015

Dermoscopy of acral fibromyxoma.

J Am Acad Dermatol 2014 Jan;70(1):e5-6

Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid, Spain.

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http://dx.doi.org/10.1016/j.jaad.2013.09.001DOI Listing
January 2014

Trends in leisure time and occupational physical activity in the Madrid region, 1995-2008.

Rev Esp Cardiol 2011 Jan 30;64(1):21-7. Epub 2010 Dec 30.

Área de Sistemas de Información Farmacéutica, Consejería de Sanidad de Madrid, Madrid, Spain.

Introduction And Objectives: Information on trends in physical activity is very scarce in Mediterranean countries, which have the highest sedentariness in Europe. This study describes recent trends in leisure time physical activity (LTPA) and at work in the Madrid region.

Methods: The data were taken from representative annual surveys of population aged 18-64 years, between 1995-2008, 28,084 people participated. We calculated total energy, quantified in metabolic equivalent (MET-1 h per week), spent on LTPA and on light LTPA (<3 MET), moderate LTPA (3-6 MET) and vigorous LTPA (>6 MET). The annual change in LTPA was estimated by linear regression, and occupational activity by logistic regression, adjusting for age, gender and educational level.

Results: The total amount of LTPA in MET-1 h per week declined by 19.8% (P<.001) between 1995-2008; for both genders, all age groups and educational levels, except for those with the lowest level of education. The adjusted annual change in MET-1 h per week was: -0.21 (P<.001) for total LTPA; -0.1 (P<.001) for light; -0.08 (P<.001) for moderate; and -0.03 (P=.192) for vigorous. This decline is reflected by a shift to the left of the LTPA distribution in the population. Occupational physical inactivity has increased in the general population (odds ratio for annual change=1.01; 95% confidence interval, 1-1.02); specially in women, young and middle aged, and intermediate educational level.

Conclusions: There has been a decline in LTPA, mainly in light and moderate activities, accompanied by greater occupational physical inactivity. This could have contributed to the increase in obesity in the Community of Madrid between 1995-2008.
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http://dx.doi.org/10.1016/j.recesp.2010.07.007DOI Listing
January 2011

Self-rated health according to amount, intensity and duration of leisure time physical activity.

Prev Med 2010 Nov 9;51(5):378-83. Epub 2010 Sep 9.

Department of Epidemiology, Madrid Health Authority, Madrid, Spain c/Julián Camarillo, 4 B, Madrid, Spain.

Objective: To examine the dose-response relationship between leisure time physical activity (LTPA) and self-rated health.

Methods: A survey (n=18,058) representative of the population aged 18-64years of Madrid (Spain) conducted between 2000 and 2008. A questionnaire on the frequency and duration of numerous activities was used to assess the total amount, the intensity, and the duration of LTPA. Self-rated health was classified as optimal or sub-optimal (fair/bad/very bad). Analyses were performed using logistic regression.

Results: Compared with no LTPA, active people in the lowest quintile for total amount of LTPA showed an odds ratio (OR) of sub-optimal health of 0.69; a linear dose-response relationship (p<0.001) was observed, with the OR gradually decreasing to 0.49 in the highest quintile of LTPA. There was an inverse gradient for LTPA intensity adjusted for energy expenditure, so that the OR of sub-optimal health was 0.69 for light LTPA, 0.60 for moderate, and 0.48 for vigorous (p linear trend <0.001). For the same duration, the frequency of optimal health increases with the intensity of LTPA.

Conclusions: The total amount of LTPA shows a graded and continuous association with better self-rated health. The benefits of LTPA on self-rated health increase with the intensity of the activity.
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http://dx.doi.org/10.1016/j.ypmed.2010.09.001DOI Listing
November 2010

Long-term outcome of focal segmental glomerulosclerosis after pediatric renal transplantation.

Pediatr Nephrol 2010 Mar 3;25(3):529-34. Epub 2009 Dec 3.

Department of Pediatric Nephrology, La Paz Children's Hospital, Paseo de la Castellana 261, 28046, Madrid, Spain.

Recurrence of focal segmental glomerulosclerosis (FSGS) after renal transplantation can limit graft survival. Despite new immunosuppressive agents, the incidence of recurrence remains relatively high. To identify risk factors for recurrence and efficacy of treatment, we reviewed the outcome of 23 grafts in 16 children with FSGS who had undergone transplantation between 1985 and 2007 at La Paz Children's Hospital. Recurrence was 56.3% after the first transplantation. We did not find significant differences in age at diagnosis, age at transplantation, age at end-stage renal disease (ESRD), progression to ESRD, bilateral nephrectomy of native kidneys prior to transplantation, use of induction therapy or of different immunosuppressive regimens between patients with and without recurrence. Plasmapheresis (PP) was carried out in seven of nine patients who had suffered recurrence, achieving remission in six of them. One patient received high doses of cyclosporin (CsA) and plasmapheresis, attaining remission. Graft survival was lower (P = 0.043) in patients with FSGS than in those with other ESRD etiologies (first year 75% vs 91%; fifth year 44% vs 78%). Recurrence of FSGS limited graft survival (first year 66% vs 85%; third year 20% vs 68%) (P = 0.07). In our experience, PP can be effective in treating FSGS recurrence, although its effect on long-term graft survival seems more limited.
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http://dx.doi.org/10.1007/s00467-009-1361-0DOI Listing
March 2010

Leisure-time physical activity in a southern European mediterranean country: adherence to recommendations and determining factors.

Rev Esp Cardiol 2009 Oct;62(10):1125-33

Consejería de Sanidad de Madrid, Madrid, España.

Introduction And Objectives: To determine whether adults in Madrid, Spain adhere to leisure-time physical activity (LTPA) recommendations and to identify factors associated with adherence.

Methods: A telephone survey of 12,037 individuals, representative of the Madrid population aged 18-64 years, was conducted. The LTPA level was quantified in metabolic equivalent (MET) hours per week from answers to a questionnaire on the frequency and duration of LTPA. This level was compared with the recommendation to engage in at least moderate activity >or=150 min/week or vigorous activity >or=60 min/week. Factors associated with adherence to the recommendation were identified using logistic regression analysis.

Results: The mean LTPA level was 17.3 MET-hours/ week (95% confidence interval [CI], 16.9-17.7 MET-hours/week) and 28.8% (95% CI, 28%-29.7%) adhered to the recommendation. The recommended level was achieved more frequently in men than women (odds ratio [OR]=2.41; 95% CI, 2.20-2.64). In comparison with younger individuals, adherence decreased gradually with age until 60-64 years, when the OR was 0.20 (95% CI, 0.15-0.25). Compared with less well-educated individuals, the university-educated were more likely to meet the recommendation (OR=2.28; 95% CI, 1.82-2.87). Obese individuals achieved it less frequently (OR=0.49; 95% CI, 0.40-0.61) than normal-weight individuals. Those whose job involved low-intensity physical activity achieved it more frequently than those with sedentary occupations (OR=1.21; 95% CI, 1.10-1.34).

Conclusions: The majority of adults in Madrid did not achieve the recommended LTPA level. Adherence was lower in women, older individuals, the less well-educated and the obese, while it was greater in those with a job involving low-intensity physical activity.
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http://dx.doi.org/10.1016/s1885-5857(09)73327-4DOI Listing
October 2009

Steroid-resistant nephrotic syndrome: long-term evolution after sequential therapy.

Pediatr Nephrol 2007 Nov 18;22(11):1875-80. Epub 2007 Sep 18.

Nefrología, Hospital Infantil La Paz, Paseo de la Castellana 261, Madrid 28046, Spain.

We present a retrospective study of 30 children of mean age 3.02 +/- 1.81 years with steroid-resistant nephrotic syndrome (SRNS) treated with intravenous injection of methylprednisolone plus orally administered prednisone; 24 children also received cyclophosphamide (CP). Sixteen were resistant to steroids from the beginning, and 14 after a mean of 11.26 +/- 16.61 months. The initial histological diagnosis was: 18 minimal change disease (MCD), 11 focal segmental glomerulosclerosis (FSGS) and one diffuse mesangial proliferative glomerulonephritis (DMPG). Total remission was achieved in 22 patients (73.3%), partial response in three (10%) and no response in five (16.6%), two of whom were brothers carrying an NPHS2 gene double mutation. There was no difference in response between the MCD and FSGS patients; the only patient with DMPG did not respond. Only initial resistance was a sign of bad prognosis. At follow-up (6.4 +/- 3.6 years from last pulse), 21/22 were still in remission, 14/21 were without treatment. Six patients required cyclosporine or mycophenolate mofetil because of steroid dependence. Two non-responders developed end-stage renal failure (ESRF); the remaining patients maintained normal glomerular filtration. The treatment was well tolerated. In conclusion, most of the patients treated with sequential therapy consisting of methylprednisolone (MP) (100%) and CP (80%) showed remission and preserved renal function, but 20% developed steroid dependence.
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http://dx.doi.org/10.1007/s00467-007-0567-2DOI Listing
November 2007

Labor induction with dinoprostone or oxytocine and postpartum disseminated intravascular coagulation: a hospital-based case-control study.

Am J Obstet Gynecol 2004 Nov;191(5):1637-43

Division of Pharmacoepidemiology and Pharmacovigilance, Agencia Española de Medicamentos y Productos Sanitarios, Madrid, Spain.

Objective: This study was undertaken to test the hypothesis of an association between pharmacologic agents used for labor induction, in particular dinoprostone, and postpartum disseminated intravascular coagulation (DIC).

Study Design: A retrospective hospital-based case-control study. Adjusted odds ratios (AOR) were calculated by a conditional logistic regression.

Results: Forty valid cases of postpartum DIC were compared against 197 matched controls. Labor was induced in 17% of controls, and 56% of cases (AOR = 7.2; 95% CI: 2.1-24.6). The association was observed for both dinoprostone (AOR = 6.7; 95% CI: 1.7-26.5) and oxytocin (AOR = 8.4; 95% CI: 1.4-50.9). Other risk factors identified were as follows: a maternal age older than 34 years (AOR = 9.5; 95% CI: 2.4-37.7), complications during pregnancy (AOR = 5.5; 95% CI: 1.3-22.8), and a gestational age of over 40 weeks (AOR = 3.5; 95% CI: 1.1-11.1). Such factors were shown to also have an interaction with the induction of labor. Oxytocin augmentation showed a negative association (AOR = 0.1; 95% CI: 0.02-0.4). The absolute risk attributable to induction was estimated in 5 per 10,000 deliveries.

Conclusion: The pharmacologic induction of labor is associated with an increased risk of postpartum DIC, regardless the substance used. Although the absolute risk seems to be quite low, the obstetricians should not neglect it, in particular for the special risk groups identified.
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http://dx.doi.org/10.1016/j.ajog.2004.03.021DOI Listing
November 2004
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