Carmen Martin-Ruiz

Carmen Martin-Ruiz

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Carmen Martin-Ruiz

Carmen Martin-Ruiz

Publications by authors named "Carmen Martin-Ruiz"

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62Publications

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Inflammation in mild cognitive impairment due to Parkinson's disease, Lewy body disease, and Alzheimer's disease.

Authors:
Eleanor King John O'Brien Paul Donaghy Caroline H Williams-Gray Rachael A Lawson Christopher M Morris Nicola Barnett Kirsty Olsen Carmen Martin-Ruiz David Burn Alison J Yarnall John-Paul Taylor Gordan Duncan Tien K Khoo Alan Thomas

Int J Geriatr Psychiatry 2019 Aug 16;34(8):1244-1250. Epub 2019 May 16.

Institute of Neuroscience, Campus for Aging and Vitality, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/gps.5124DOI Listing
August 2019

A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Authors:
Joris Deelen Daniel S Evans Dan E Arking Niccolò Tesi Marianne Nygaard Xiaomin Liu Mary K Wojczynski Mary L Biggs Ashley van der Spek Gil Atzmon Erin B Ware Chloé Sarnowski Albert V Smith Ilkka Seppälä Heather J Cordell Janina Dose Najaf Amin Alice M Arnold Kristin L Ayers Nir Barzilai Elizabeth J Becker Marian Beekman Hélène Blanché Kaare Christensen Lene Christiansen Joanna C Collerton Sarah Cubaynes Steven R Cummings Karen Davies Birgit Debrabant Jean-François Deleuze Rachel Duncan Jessica D Faul Claudio Franceschi Pilar Galan Vilmundur Gudnason Tamara B Harris Martijn Huisman Mikko A Hurme Carol Jagger Iris Jansen Marja Jylhä Mika Kähönen David Karasik Sharon L R Kardia Andrew Kingston Thomas B L Kirkwood Lenore J Launer Terho Lehtimäki Wolfgang Lieb Leo-Pekka Lyytikäinen Carmen Martin-Ruiz Junxia Min Almut Nebel Anne B Newman Chao Nie Ellen A Nohr Eric S Orwoll Thomas T Perls Michael A Province Bruce M Psaty Olli T Raitakari Marcel J T Reinders Jean-Marie Robine Jerome I Rotter Paola Sebastiani Jennifer Smith Thorkild I A Sørensen Kent D Taylor André G Uitterlinden Wiesje van der Flier Sven J van der Lee Cornelia M van Duijn Diana van Heemst James W Vaupel David Weir Kenny Ye Yi Zeng Wanlin Zheng Henne Holstege Douglas P Kiel Kathryn L Lunetta P Eline Slagboom Joanne M Murabito

Nat Commun 2019 Aug 14;10(1):3669. Epub 2019 Aug 14.

NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA.

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http://dx.doi.org/10.1038/s41467-019-11558-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694136PMC
August 2019

Smoking does not accelerate leucocyte telomere attrition: a meta-analysis of 18 longitudinal cohorts.

Authors:
Melissa Bateson Abraham Aviv Laila Bendix Athanase Benetos Yoav Ben-Shlomo Stig E Bojesen Cyrus Cooper Rachel Cooper Ian J Deary Sara Hägg Sarah E Harris Jeremy D Kark Florian Kronenberg Diana Kuh Carlos Labat Carmen M Martin-Ruiz Craig Meyer Børge G Nordestgaard Brenda W J H Penninx Gillian V Pepper Dóra Révész M Abdullah Said John M Starr Holly Syddall William Murray Thomson Pim van der Harst Mary Whooley Thomas von Zglinicki Peter Willeit Yiqiang Zhan Daniel Nettle

R Soc Open Sci 2019 Jun 5;6(6):190420. Epub 2019 Jun 5.

Centre for Behaviour and Evolution and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1098/rsos.190420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599800PMC
June 2019

Peripheral inflammation in mild cognitive impairment with possible and probable Lewy body disease and Alzheimer's disease.

Authors:
Eleanor King John Tiernan O'Brien Paul Donaghy Christopher Morris Nicola Barnett Kirsty Olsen Carmen Martin-Ruiz John Paul Taylor Alan J Thomas

Int Psychogeriatr 2019 04 11;31(4):551-560. Epub 2019 Mar 11.

Institute of Neuroscience, Campus for Ageing and Vitality,Newcastle University,Newcastle upon Tyne,UK.

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http://dx.doi.org/10.1017/S1041610218001126DOI Listing
April 2019

Telomere length is associated with childhood trauma in patients with severe mental disorders.

Authors:
Monica Aas Torbjørn Elvsåshagen Lars T Westlye Tobias Kaufmann Lavinia Athanasiu Srdjan Djurovic Ingrid Melle Dennis van der Meer Carmen Martin-Ruiz Nils Eiel Steen Ingrid Agartz Ole A Andreassen

Transl Psychiatry 2019 03 21;9(1):97. Epub 2019 Mar 21.

NORMENT K.G Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/s41398-019-0432-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428889PMC
March 2019

Plasma Vitamin B12, Supplementation and Mortality.

Authors:
Nuno Mendonça Carol Jagger Antoneta Granic Carmen Martin-Ruiz John C Mathers Chris J Seal Tom R Hill

J Gerontol A Biol Sci Med Sci 2019 01;74(1):138

Faculty of Medical Sciences, Institute of Cellular Medicine, Newcastle upon Tyne.

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http://dx.doi.org/10.1093/gerona/gly200DOI Listing
January 2019

Elevated Total Homocysteine in All Participants and Plasma Vitamin B12 Concentrations in Women Are Associated With All-Cause and Cardiovascular Mortality in the Very Old: The Newcastle 85+ Study.

Authors:
Nuno Mendonça Carol Jagger Antoneta Granic Carmen Martin-Ruiz John C Mathers Chris J Seal Tom R Hill

J Gerontol A Biol Sci Med Sci 2018 08;73(9):1258-1264

Institute of Cellular Medicine, Newcastle upon Tyne, UK.

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https://academic.oup.com/biomedgerontology/article/73/9/1258
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http://dx.doi.org/10.1093/gerona/gly035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093381PMC
August 2018

Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias.

Authors:
Eleanor King John Tiernan O'Brien Paul Donaghy Christopher Morris Nicola Barnett Kirsty Olsen Carmen Martin-Ruiz John-Paul Taylor Alan J Thomas

J Neurol Neurosurg Psychiatry 2018 04 16;89(4):339-345. Epub 2017 Dec 16.

Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/jnnp-2017-317134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869446PMC
April 2018

A new model of exercise referral scheme in primary care: is the effect on adherence to physical activity sustainable in the long term? A 15-month randomised controlled trial.

Authors:
Carme Martín-Borràs Maria Giné-Garriga Anna Puig-Ribera Carlos Martín Mercè Solà Antonio I Cuesta-Vargas

BMJ Open 2018 03 3;8(3):e017211. Epub 2018 Mar 3.

Department of Physical Therapy, Universidad de Málaga, Málaga, Spain.

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http://dx.doi.org/10.1136/bmjopen-2017-017211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855315PMC
March 2018

The epigenetic clock and telomere length are independently associated with chronological age and mortality.

Authors:
Riccardo E Marioni Sarah E Harris Sonia Shah Allan F McRae Thomas von Zglinicki Carmen Martin-Ruiz Naomi R Wray Peter M Visscher Ian J Deary

Int J Epidemiol 2018 02;47(1):356

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http://dx.doi.org/10.1093/ije/dyx233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837660PMC
February 2018

Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936.

Authors:
Sarah E Harris Valentina Riggio Louise Evenden Tamara Gilchrist Sarah McCafferty Lee Murphy Nicola Wrobel Adele M Taylor Janie Corley Alison Pattie Simon R Cox Carmen Martin-Ruiz James Prendergast John M Starr Riccardo E Marioni Ian J Deary

Aging (Albany NY) 2017 12;9(12):2489-2503

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.

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http://dx.doi.org/10.18632/aging.101333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764388PMC
December 2017

Grip strength and inflammatory biomarker profiles in very old adults.

Authors:
Antoneta Granic Karen Davies Carmen Martin-Ruiz Carol Jagger Thomas B L Kirkwood Thomas von Zglinicki Avan Aihie Sayer

Age Ageing 2017 11;46(6):976-982

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/ageing/afx088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860623PMC
November 2017

Homocysteine, Tryptophan, and Cognition in the Very Old.

Authors:
Nuno Mendonça Antoneta Granic John C Mathers Carmen Martin-Ruiz Keith A Wesnes Chris J Seal Carol Jagger Tom R Hill

J Am Med Dir Assoc 2017 10 23;18(10):895-896. Epub 2017 Aug 23.

School of Agriculture Food and Rural Development, Newcastle University, Newcastle-upon-Tyne, United Kingdom; Newcastle University Institute for Aging, Newcastle-upon-Tyne, United Kingdom; Human Nutrition Research Center, Newcastle University, Newcastle-upon-Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jamda.2017.07.010DOI Listing
October 2017

Parietal white matter lesions in Alzheimer's disease are associated with cortical neurodegenerative pathology, but not with small vessel disease.

Authors:
Kirsty E McAleese Lauren Walker Sophie Graham Elisa L J Moya Mary Johnson Daniel Erskine Sean J Colloby Madhurima Dey Carmen Martin-Ruiz John-Paul Taylor Alan J Thomas Ian G McKeith Charles De Carli Johannes Attems

Acta Neuropathol 2017 Sep 21;134(3):459-473. Epub 2017 Jun 21.

Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1007/s00401-017-1738-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563333PMC
September 2017

One-Carbon Metabolism Biomarkers and Cognitive Decline in the Very Old: The Newcastle 85+ Study.

Authors:
Nuno Mendonça Antoneta Granic John C Mathers Carmen Martin-Ruiz Keith A Wesnes Chris J Seal Carol Jagger Tom R Hill

J Am Med Dir Assoc 2017 Sep 21;18(9):806.e19-806.e27. Epub 2017 Jun 21.

School of Agriculture, Food, and Rural Development, Newcastle University, Newcastle-upon-Tyne, UK; Newcastle University Institute for Ageing, Newcastle-upon-Tyne, UK; Human Nutrition Research Centre, Newcastle University, Newcastle-upon-Tyne, UK; Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1016/j.jamda.2017.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576913PMC
September 2017

Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling.

Authors:
Daniel Nettle Clare Andrews Sophie Reichert Tom Bedford Claire Kolenda Craig Parker Carmen Martin-Ruiz Pat Monaghan Melissa Bateson

Sci Rep 2017 01 17;7:40794. Epub 2017 Jan 17.

Centre for Behaviour and Evolution &Institute of Neuroscience, Newcastle University, Newcastle, NE2 4HH, UK.

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http://dx.doi.org/10.1038/srep40794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240102PMC
January 2017

Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study.

Authors:
Simon H S Pearce Salman Razvi Mohammad E Yadegarfar Carmen Martin-Ruiz Andrew Kingston Joanna Collerton Theo J Visser Tom B Kirkwood Carol Jagger

J Clin Endocrinol Metab 2016 11 23;101(11):4385-4394. Epub 2016 Aug 23.

Institute of Genetic Medicine (S.H.S.P., S.R.), Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom; Institute of Health and Society (M.E.Y., C.M.-R., A.K., J.C., T.B.K., C.J.), Newcastle University, Newcastle upon Tyne NE2 4AX, United Kingdom; and Department of Internal Medicine (T.J.V.), Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1210/jc.2016-1935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095241PMC
November 2016

Brood size moderates associations between relative size, telomere length, and immune development in European starling nestlings.

Authors:
Daniel Nettle Clare Andrews Sophie Reichert Tom Bedford Annie Gott Craig Parker Claire Kolenda Carmen Martin-Ruiz Pat Monaghan Melissa Bateson

Ecol Evol 2016 Nov 17;6(22):8138-8148. Epub 2016 Oct 17.

Institute of Neuroscience and Centre for Behaviour & Evolution Newcastle University Henry Wellcome Building Newcastle UK.

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http://dx.doi.org/10.1002/ece3.2551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108265PMC
November 2016

Intakes of Folate and Vitamin B12 and Biomarkers of Status in the Very Old: The Newcastle 85+ Study.

Authors:
Nuno Mendonça John C Mathers Ashley J Adamson Carmen Martin-Ruiz Chris J Seal Carol Jagger Tom R Hill

Nutrients 2016 Sep 28;8(10). Epub 2016 Sep 28.

School of Agriculture Food and Rural Development, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.

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http://dx.doi.org/10.3390/nu8100604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083992PMC
September 2016

CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study.

Authors:
Ioakim Spyridopoulos Carmen Martin-Ruiz Catharien Hilkens Mohammad E Yadegarfar John Isaacs Carol Jagger Tom Kirkwood Thomas von Zglinicki

Aging Cell 2016 Apr 22;15(2):389-92. Epub 2015 Dec 22.

Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1111/acel.12430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783336PMC
April 2016

The epigenetic clock and telomere length are independently associated with chronological age and mortality.

Authors:
Riccardo E Marioni Sarah E Harris Sonia Shah Allan F McRae Thomas von Zglinicki Carmen Martin-Ruiz Naomi R Wray Peter M Visscher Ian J Deary

Int J Epidemiol 2016 Apr 13. Epub 2016 Apr 13.

Department of Psychology, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1093/ije/dyw041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864882PMC
April 2016

Reactive oxygen species production and mitochondrial dysfunction in white blood cells are not valid biomarkers of ageing in the very old.

Authors:
Laura Wiley Deepthi Ashok Carmen Martin-Ruiz Duncan C S Talbot Joanna Collerton Andrew Kingston Karen Davies Patrick F Chinnery Michael Catt Carol Jagger Thomas B L Kirkwood Thomas von Zglinicki

PLoS One 2014 10;9(3):e91005. Epub 2014 Mar 10.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091005PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948743PMC
March 2016

Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921.

Authors:
Sarah E Harris Riccardo E Marioni Carmen Martin-Ruiz Alison Pattie Alan J Gow Simon R Cox Janie Corley Thomas von Zglinicki John M Starr Ian J Deary

Mech Ageing Dev 2016 Mar 10;154:43-8. Epub 2016 Feb 10.

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK; Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.

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http://dx.doi.org/10.1016/j.mad.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798845PMC
March 2016

Reproducibility of telomere length assessment: an international collaborative study.

Authors:
Carmen M Martin-Ruiz Duncan Baird Laureline Roger Petra Boukamp Damir Krunic Richard Cawthon Martin M Dokter Pim van der Harst Sofie Bekaert Tim de Meyer Goran Roos Ulrika Svenson Veryan Codd Nilesh J Samani Liane McGlynn Paul G Shiels Karen A Pooley Alison M Dunning Rachel Cooper Andrew Wong Andrew Kingston Thomas von Zglinicki

Int J Epidemiol 2015 Oct 19;44(5):1673-83. Epub 2014 Sep 19.

Newcastle University Institute for Ageing, Newcastle University, Newcastle, UK,

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http://dx.doi.org/10.1093/ije/dyu191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681105PMC
October 2015

Reproducibility of Telomere Length Assessment--An International Collaborative Study.

Authors:
Carmen M Martin-Ruiz Duncan Baird Laureline Roger Petra Boukamp Damir Krunic Richard Cawthon Martin M Dokter Pim van der Harst Sofie Bekaert Tim de Meyer Goran Roos Ulrika Svenson Veryan Codd Nilesh J Samani Liane McGlynn Paul G Shiels Karen A Pooley Alison M Dunning Rachel Cooper Andrew Wong Andrew Kingston Thomas von Zglinicki

Int J Epidemiol 2015 Oct 24;44(5):1749-54. Epub 2015 Sep 24.

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http://dx.doi.org/10.1093/ije/dyv171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312091PMC
October 2015

Reproducibility of telomere length assessment: Authors' Response to Damjan Krstajic and Ljubomir Buturovic.

Authors:
Carmen M Martin-Ruiz Duncan Baird Laureline Roger Petra Boukamp Damir Krunic Richard Cawthon Martin M Dokter Pim Van Der Harst Sofie Bekaert Tim De Meyer Goran Roos Ulrika Svenson Veryan Codd Nilesh J Samani Liane Mcglynn Paul G Shiels Karen A Pooley Alison M Dunning Rachel Cooper Andrew Wong Andrew Kingston Thomas Von Zglinicki

Int J Epidemiol 2015 Oct 24;44(5):1739-41. Epub 2015 Sep 24.

Institute for Ageing and Health, Newcastle University, Newcastle, UK,

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http://dx.doi.org/10.1093/ije/dyv170DOI Listing
October 2015

Is Southern blotting necessary to measure telomere length reproducibly? Authors' Response to: Commentary: The reliability of telomere length measurements.

Authors:
Carmen M Martin-Ruiz Duncan Baird Laureline Roger Petra Boukamp Damir Krunic Richard Cawthon Martin M Dokter Pim Van Der Harst Sofie Bekaert Tim De Meyer Goran Roos Ulrika Svenson Veryan Codd Nilesh J Samani Liane Mcglynn Paul G Shiels Karen A Pooley Alison M Dunning Rachel Cooper Andrew Wong Andrew Kingston Thomas Von Zglinicki

Int J Epidemiol 2015 Oct 24;44(5):1686-7. Epub 2015 Sep 24.

Institute for Ageing and Health, Newcastle University, Newcastle, UK,

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http://dx.doi.org/10.1093/ije/dyv169DOI Listing
October 2015

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians.

Authors:
Yasumichi Arai Carmen M Martin-Ruiz Michiyo Takayama Yukiko Abe Toru Takebayashi Shigeo Koyasu Makoto Suematsu Nobuyoshi Hirose Thomas von Zglinicki

EBioMedicine 2015 Oct 29;2(10):1549-58. Epub 2015 Jul 29.

Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle University, UK.

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http://dx.doi.org/10.1016/j.ebiom.2015.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634197PMC
October 2015

Age-related frailty and its association with biological markers of ageing.

Authors:
Arnold Mitnitski Joanna Collerton Carmen Martin-Ruiz Carol Jagger Thomas von Zglinicki Kenneth Rockwood Thomas B L Kirkwood

BMC Med 2015 Jul 13;13:161. Epub 2015 Jul 13.

Institute for Cell and Molecular Biosciences and Newcastle University Institute for Ageing, Newcastle upon Tyne, NE4 5PL, UK.

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http://dx.doi.org/10.1186/s12916-015-0400-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499935PMC
July 2015

Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes.

Authors:
Lauren Walker Kirsty E McAleese Alan J Thomas Mary Johnson Carmen Martin-Ruiz Craig Parker Sean J Colloby Kurt Jellinger Johannes Attems

Acta Neuropathol 2015 May 11;129(5):729-48. Epub 2015 Mar 11.

Institute of Neuroscience and Institute for Ageing, Newcastle University, Campus for Ageing and Vitality, NE4 5PL, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00401-015-1406-3DOI Listing
May 2015

RIPOSTE: a framework for improving the design and analysis of laboratory-based research.

Authors:
Nicholas Gd Masca Elizabeth Ma Hensor Victoria R Cornelius Francesca M Buffa Helen M Marriott James M Eales Michael P Messenger Amy E Anderson Chris Boot Catey Bunce Robert D Goldin Jessica Harris Rod F Hinchliffe Hiba Junaid Shaun Kingston Carmen Martin-Ruiz Christopher P Nelson Janet Peacock Paul T Seed Bethany Shinkins Karl J Staples Jamie Toombs Adam Ka Wright M Dawn Teare

Elife 2015 May 7;4. Epub 2015 May 7.

Sheffield School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.7554/eLife.05519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461852PMC
May 2015

Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients.

Authors:
Jedrzej Hoffmann Evgeniya V Shmeleva Stephen E Boag Karel Fiser Alan Bagnall Santosh Murali Ian Dimmick Hanspeter Pircher Carmen Martin-Ruiz Mohaned Egred Bernard Keavney Thomas von Zglinicki Rajiv Das Stephen Todryk Ioakim Spyridopoulos

Circ Res 2015 Jan 10;116(1):87-98. Epub 2014 Nov 10.

From the Institute of Genetic Medicine (J.H., E.V.S., S.E.B., S.M., B.K., I.S.), Institute of Aging and Health (C.M.-R., T.v.Z.), and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (A.B., M.E., R.D., S.T.), Department of Cardiology, Freeman Hospital, Newcastle upon Tyne, United Kingdom (A.B., M.E., R.D., I.S.); Flow Cytometry Core Facility, International Center for Life, Newcastle upon Tyne, United Kingdom (I.D.); Department of Immunology, Institute of Medical Microbiology and Hygiene, Freiburg University, Germany (H.P.); CLIP-Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic (K.F.); University Hospital Motol, Prague, Czech Republic (K.F.); Institute of Cardiovascular Sciences, The University of Manchester, United Kingdom (B.K.); and Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom (S.M., S.T.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.30439
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.116.304393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280279PMC
January 2015

Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort.

Authors:
Stefano Masi Francesco D'Aiuto Carmen Martin-Ruiz Tauseef Kahn Andrew Wong Arjun K Ghosh Peter Whincup Diana Kuh Alan Hughes Thomas von Zglinicki Rebecca Hardy John Eric Deanfield

Eur Heart J 2014 Dec 22;35(46):3296-303. Epub 2014 Jun 22.

Vascular Physiology Unit, Institute of Cardiovascular Science, University College London, London, UK National Centre for Cardiovascular Prevention and Outcomes, University College London, 170 Tottenham Court Road, W1T 7HA London, UK

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http://dx.doi.org/10.1093/eurheartj/ehu226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258223PMC
December 2014

Utility of NT-proBNP as a rule-out test for left ventricular dysfunction in very old people with limiting dyspnoea: the Newcastle 85+ Study.

Authors:
Joanna Collerton Andrew Kingston Fahad Yousaf Karen Davies Antoinette Kenny Dermot Neely Carmen Martin-Ruiz Guy MacGowan Louise Robinson Thomas B L Kirkwood Bernard Keavney

BMC Cardiovasc Disord 2014 Sep 26;14:128. Epub 2014 Sep 26.

Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1186/1471-2261-14-128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189162PMC
September 2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Authors:
Joris Deelen Marian Beekman Hae-Won Uh Linda Broer Kristin L Ayers Qihua Tan Yoichiro Kamatani Anna M Bennet Riin Tamm Stella Trompet Daníel F Guðbjartsson Friederike Flachsbart Giuseppina Rose Alexander Viktorin Krista Fischer Marianne Nygaard Heather J Cordell Paolina Crocco Erik B van den Akker Stefan Böhringer Quinta Helmer Christopher P Nelson Gary I Saunders Maris Alver Karen Andersen-Ranberg Marie E Breen Ruud van der Breggen Amke Caliebe Miriam Capri Elisa Cevenini Joanna C Collerton Serena Dato Karen Davies Ian Ford Jutta Gampe Paolo Garagnani Eco J C de Geus Jennifer Harrow Diana van Heemst Bastiaan T Heijmans Femke-Anouska Heinsen Jouke-Jan Hottenga Albert Hofman Bernard Jeune Palmi V Jonsson Mark Lathrop Doris Lechner Carmen Martin-Ruiz Susan E Mcnerlan Evelin Mihailov Alberto Montesanto Simon P Mooijaart Anne Murphy Ellen A Nohr Lavinia Paternoster Iris Postmus Fernando Rivadeneira Owen A Ross Stefano Salvioli Naveed Sattar Stefan Schreiber Hreinn Stefánsson David J Stott Henning Tiemeier André G Uitterlinden Rudi G J Westendorp Gonneke Willemsen Nilesh J Samani Pilar Galan Thorkild I A Sørensen Dorret I Boomsma J Wouter Jukema Irene Maeve Rea Giuseppe Passarino Anton J M de Craen Kaare Christensen Almut Nebel Kári Stefánsson Andres Metspalu Patrik Magnusson Hélène Blanché Lene Christiansen Thomas B L Kirkwood Cornelia M van Duijn Claudio Franceschi Jeanine J Houwing-Duistermaat P Eline Slagboom

Hum Mol Genet 2014 Aug 31;23(16):4420-32. Epub 2014 Mar 31.

Department of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing,

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http://dx.doi.org/10.1093/hmg/ddu139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103672PMC
August 2014

Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study.

Authors:
Joanna Collerton Hannah E Gautrey Sanne D van Otterdijk Karen Davies Carmen Martin-Ruiz Thomas von Zglinicki Thomas B L Kirkwood Carol Jagger John C Mathers Gordon Strathdee

Biogerontology 2014 Aug 26;15(4):317-28. Epub 2014 Apr 26.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

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August 2014

Biomarkers of healthy ageing: expectations and validation.

Authors:
Carmen Martin-Ruiz Thomas von Zglinicki

Proc Nutr Soc 2014 Aug 9;73(3):422-9. Epub 2014 May 9.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality,Newcastle upon Tyne NE4 5PL,UK.

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http://www.journals.cambridge.org/abstract_S0029665114000147
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August 2014

Inflammation, telomere length, and grip strength: a 10-year longitudinal study.

Authors:
Daniel Baylis Georgia Ntani Mark H Edwards Holly E Syddall David B Bartlett Elaine M Dennison Carmen Martin-Ruiz Thomas von Zglinicki Diana Kuh Janet M Lord Avan Aihie Sayer Cyrus Cooper

Calcif Tissue Int 2014 Jul 25;95(1):54-63. Epub 2014 May 25.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1007/s00223-014-9862-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098723PMC
July 2014

Telomere length and physical performance at older ages: an individual participant meta-analysis.

Authors:
Michael P Gardner Carmen Martin-Ruiz Rachel Cooper Rebecca Hardy Avan Aihie Sayer Cyrus Cooper Ian J Deary John Gallacher Sarah E Harris Paul G Shiels John M Starr Diana Kuh Thomas von Zglinicki Yoav Ben-Shlomo

PLoS One 2013 26;8(7):e69526. Epub 2013 Jul 26.

School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724915PMC
April 2014

Gender and telomere length: systematic review and meta-analysis.

Authors:
Michael Gardner David Bann Laura Wiley Rachel Cooper Rebecca Hardy Dorothea Nitsch Carmen Martin-Ruiz Paul Shiels Avan Aihie Sayer Michelangela Barbieri Sofie Bekaert Claus Bischoff Angela Brooks-Wilson Wei Chen Cyrus Cooper Kaare Christensen Tim De Meyer Ian Deary Geoff Der Ana Diez Roux Annette Fitzpatrick Anjum Hajat Julius Halaschek-Wiener Sarah Harris Steven C Hunt Carol Jagger Hyo-Sung Jeon Robert Kaplan Masayuki Kimura Peter Lansdorp Changyong Li Toyoki Maeda Massimo Mangino Tim S Nawrot Peter Nilsson Katarina Nordfjall Giuseppe Paolisso Fu Ren Karl Riabowol Tony Robertson Goran Roos Jan A Staessen Tim Spector Nelson Tang Brad Unryn Pim van der Harst Jean Woo Chao Xing Mohammad E Yadegarfar Jae Yong Park Neal Young Diana Kuh Thomas von Zglinicki Yoav Ben-Shlomo

Exp Gerontol 2014 Mar 21;51:15-27. Epub 2013 Dec 21.

School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol, UK. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2013.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523138PMC
March 2014

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old.

Authors:
Joanna Collerton Deepthi Ashok Carmen Martin-Ruiz Angela Pyle Gavin Hudson Mohammad Yadegarfar Karen Davies Carol Jagger Thomas von Zglinicki Thomas B L Kirkwood Patrick F Chinnery

Neurobiol Aging 2013 Dec 30;34(12):2889.e1-4. Epub 2013 Apr 30.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906612PMC
December 2013

Childhood growth, IQ and education as predictors of white blood cell telomere length at age 49-51 years: the Newcastle Thousand Families Study.

Authors:
Mark S Pearce Kay D Mann Carmen Martin-Ruiz Louise Parker Martin White Thomas von Zglinicki Jean Adams

PLoS One 2012 6;7(7):e40116. Epub 2012 Jul 6.

Institute of Health & Society, Newcastle University, Newcastle Upon Tyne, England, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391235PMC
March 2013

High-throughput 13-parameter immunophenotyping identifies shifts in the circulating T-cell compartment following reperfusion in patients with acute myocardial infarction.

Authors:
Jedrzej Hoffmann Karel Fiser Jolanta Weaver Ian Dimmick Monika Loeher Hanspeter Pircher Carmen Martin-Ruiz Murugapathy Veerasamy Bernard Keavney Thomas von Zglinicki Ioakim Spyridopoulos

PLoS One 2012 16;7(10):e47155. Epub 2012 Oct 16.

Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473067PMC
March 2013

Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936.

Authors:
Sarah E Harris Carmen Martin-Ruiz Thomas von Zglinicki John M Starr Ian J Deary

Neurobiol Aging 2012 Jul 30;33(7):1486.e3-8. Epub 2010 Dec 30.

Centre for Cognitive Ageing and Cognitive Epidemiology, Medical Genetics Section, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.11.013DOI Listing
July 2012

Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study.

Authors:
Joanna Collerton Carmen Martin-Ruiz Karen Davies Catharien M Hilkens John Isaacs Claire Kolenda Craig Parker Michael Dunn Michael Catt Carol Jagger Thomas von Zglinicki Thomas B L Kirkwood

Mech Ageing Dev 2012 Jun 1;133(6):456-66. Epub 2012 Jun 1.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, United Kingdom.

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http://dx.doi.org/10.1016/j.mad.2012.05.005DOI Listing
June 2012

A senescent cell bystander effect: senescence-induced senescence.

Authors:
Glyn Nelson James Wordsworth Chunfang Wang Diana Jurk Conor Lawless Carmen Martin-Ruiz Thomas von Zglinicki

Aging Cell 2012 Apr 9;11(2):345-9. Epub 2012 Feb 9.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1474-9726.2012.00795.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488292PMC
April 2012

Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study.

Authors:
Carmen Martin-Ruiz Carol Jagger Andrew Kingston Joanna Collerton Michael Catt Karen Davies Mick Dunn Catharien Hilkens Bernard Keavney Simon H S Pearce Wendy P J den Elzen Duncan Talbot Laura Wiley John Bond John C Mathers Martin P Eccles Louise Robinson Oliver James Thomas B L Kirkwood Thomas von Zglinicki

Mech Ageing Dev 2011 Oct 16;132(10):496-502. Epub 2011 Aug 16.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

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http://dx.doi.org/10.1016/j.mad.2011.08.001DOI Listing
October 2011

Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study.

Authors:
Wendy P J Den Elzen Carmen Martin-Ruiz Thomas von Zglinicki Rudi G J Westendorp Thomas B L Kirkwood Jacobijn Gussekloo

Age Ageing 2011 Jul 27;40(4):494-500. Epub 2011 May 27.

Department of Public Health and Primary Care, Leiden University Medical Centre, The Netherlands.

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http://dx.doi.org/10.1093/ageing/afr048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114621PMC
July 2011

Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs.

Authors:
Carol Jagger Joanna C Collerton Karen Davies Andrew Kingston Louise A Robinson Martin P Eccles Thomas von Zglinicki Carmen Martin-Ruiz Oliver F W James Tom B L Kirkwood John Bond

BMC Geriatr 2011 May 4;11:21. Epub 2011 May 4.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL UK.

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http://dx.doi.org/10.1186/1471-2318-11-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097155PMC
May 2011

Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study.

Authors:
Joanna Collerton Karen Davies Carol Jagger Andrew Kingston John Bond Martin P Eccles Louise A Robinson Carmen Martin-Ruiz Thomas von Zglinicki Oliver F W James Thomas B L Kirkwood

BMJ 2009 Dec 22;339:b4904. Epub 2009 Dec 22.

Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL.

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http://www.bmj.com/cgi/doi/10.1136/bmj.b4904
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http://dx.doi.org/10.1136/bmj.b4904DOI Listing
December 2009

Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations.

Authors:
Elena Domínguez-Garrido Diana Martínez-Redondo Carmen Martín-Ruiz Aurora Gómez-Durán Eduardo Ruiz-Pesini Pilar Madero Manuel Tamparillas Julio Montoya Thomas von Zglinicki Carmen Díez-Sánchez Manuel J López-Pérez

Biogerontology 2009 Aug 18;10(4):435-42. Epub 2008 Oct 18.

Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain.

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http://dx.doi.org/10.1007/s10522-008-9186-yDOI Listing
August 2009

DNA damage response and cellular senescence in tissues of aging mice.

Authors:
Chunfang Wang Diana Jurk Mandy Maddick Glyn Nelson Carmen Martin-Ruiz Thomas von Zglinicki

Aging Cell 2009 Jun 9;8(3):311-23. Epub 2009 Apr 9.

Ageing Research Laboratories, Institute for Ageing and Health and Center for Integrated Systems Biology of Ageing and Nutrition (CISBAN), Newcastle University, Newcastle upon Tyne NE4 6BE, UK.

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http://doi.wiley.com/10.1111/j.1474-9726.2009.00481.x
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http://dx.doi.org/10.1111/j.1474-9726.2009.00481.xDOI Listing
June 2009

Premature senescence of mesothelial cells is associated with non-telomeric DNA damage.

Authors:
Krzysztof Ksiazek João F Passos Sharon Olijslagers Gabriele Saretzki Carmen Martin-Ruiz Thomas von Zglinicki

Biochem Biophys Res Commun 2007 Oct 20;362(3):707-11. Epub 2007 Aug 20.

Department of Pathophysiology, University of Medical Sciences, Swiecickiego 6, 60781 Poznan, Poland.

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http://dx.doi.org/10.1016/j.bbrc.2007.08.047DOI Listing
October 2007

The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol.

Authors:
Joanna Collerton Karen Barrass John Bond Martin Eccles Carol Jagger Oliver James Carmen Martin-Ruiz Louise Robinson Thomas von Zglinicki Tom Kirkwood

BMC Geriatr 2007 Jun 26;7:14. Epub 2007 Jun 26.

Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.

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http://bmcgeriatr.biomedcentral.com/articles/10.1186/1471-23
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924857PMC
June 2007

No association between socio-economic status and white blood cell telomere length.

Authors:
Jean Adams Carmen Martin-Ruiz Mark S Pearce Martin White Louise Parker Thomas von Zglinicki

Aging Cell 2007 Feb 5;6(1):125-8. Epub 2006 Dec 5.

Institute of Health and Society, Newcastle University, 21 Claremont Place, Newcastle upon Tyne NE2 4AA, UK.

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http://dx.doi.org/10.1111/j.1474-9726.2006.00258.xDOI Listing
February 2007

Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85+ study.

Authors:
Joanna Collerton Carmen Martin-Ruiz Antoinette Kenny Karen Barrass Thomas von Zglinicki Tom Kirkwood Bernard Keavney

Eur Heart J 2007 Jan 10;28(2):172-6. Epub 2007 Jan 10.

Institute for Ageing and Health, Newcastle University, and Department of Cardiology, Freeman Hospital, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1093/eurheartj/ehl437DOI Listing
January 2007

Fat depot-specific characteristics are retained in strains derived from single human preadipocytes.

Authors:
Tamara Tchkonia Nino Giorgadze Tamar Pirtskhalava Thomas Thomou Matthew DePonte Ada Koo R Armour Forse Dharmaraj Chinnappan Carmen Martin-Ruiz Thomas von Zglinicki James L Kirkland

Diabetes 2006 Sep;55(9):2571-8

Department of Medicine, Boston University, Boston, MA 02118, USA.

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http://dx.doi.org/10.2337/db06-0540DOI Listing
September 2006

Telomere length predicts poststroke mortality, dementia, and cognitive decline.

Authors:
Carmen Martin-Ruiz Heather O Dickinson Barbara Keys Elise Rowan Rose Anne Kenny Thomas Von Zglinicki

Ann Neurol 2006 Aug;60(2):174-80

Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/ana.20869DOI Listing
August 2006

Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients.

Authors:
Katherine M Getliffe Carmen Martin Ruiz João F Passos Thomas von Zglinicki Chuka U Nwokolo

Eur J Gastroenterol Hepatol 2006 Feb;18(2):133-41

Department of Biological Sciences, University of Warwick, Coventry, UK.

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http://dx.doi.org/10.1097/00042737-200602000-00005DOI Listing
February 2006

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study.

Authors:
Carmen M Martin-Ruiz Jacobijn Gussekloo Diana van Heemst Thomas von Zglinicki Rudi G J Westendorp

Aging Cell 2005 Dec;4(6):287-90

Henry Wellcome Biogerontology Research Laboratory, University of Newcastle, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1474-9726.2005.00171.xDOI Listing
December 2005

Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span.

Authors:
Carmen Martin-Ruiz Gabriele Saretzki Joanne Petrie Juliane Ladhoff Jessie Jeyapalan Wenyi Wei John Sedivy Thomas von Zglinicki

J Biol Chem 2004 Apr 12;279(17):17826-33. Epub 2004 Feb 12.

Henry Wellcome Biogerontology Laboratory, School of Clinical Medical Sciences, University of Newcastle, General Hospital, Newcastle NE4 6BE, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M311980200DOI Listing
April 2004

Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia.

Authors:
Carmen M Martin-Ruiz Vahram H Haroutunian Philip Long Allan H Young Kenneth L Davis Elaine K Perry Jennifer A Court

Biol Psychiatry 2003 Dec;54(11):1222-33

Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/s0006-3223(03)00348-2DOI Listing
December 2003