Carmen Blanco-Aparicio

Carmen Blanco-Aparicio

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Carmen Blanco-Aparicio

Carmen Blanco-Aparicio

Publications by authors named "Carmen Blanco-Aparicio"

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The mTOR pathway is necessary for survival of mice with short telomeres.

Nat Commun 2020 Mar 3;11(1):1168. Epub 2020 Mar 3.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, E-28029, Madrid, Spain.

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http://dx.doi.org/10.1038/s41467-020-14962-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054554PMC
March 2020

Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer.

Oncogene 2020 Feb 10. Epub 2020 Feb 10.

Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons Ireland, Smurfit Building Beaumont Hospital, Beaumont, Dublin, Ireland.

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http://dx.doi.org/10.1038/s41388-020-1202-yDOI Listing
February 2020

Screening protocol for the identification of modulators by immunofluorescent cell-based assay.

Chem Biol Drug Des 2020 Jan 20;95(1):66-78. Epub 2019 Sep 20.

Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1111/cbdd.13616DOI Listing
January 2020

Multiple cancer pathways regulate telomere protection.

EMBO Mol Med 2019 07 13;11(7):e10292. Epub 2019 Jun 13.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.15252/emmm.201910292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609915PMC
July 2019

Identification of novel PI3K inhibitors through a scaffold hopping strategy.

Bioorg Med Chem Lett 2017 11 30;27(21):4794-4799. Epub 2017 Sep 30.

Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, E-28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.09.059DOI Listing
November 2017

Modulation of telomere protection by the PI3K/AKT pathway.

Nat Commun 2017 11 2;8(1):1278. Epub 2017 Nov 2.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, Madrid, E-28029, Spain.

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http://dx.doi.org/10.1038/s41467-017-01329-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668434PMC
November 2017

Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts.

Cancer Cell 2017 11;32(5):590-607.e4

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid, 28029, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.10.006DOI Listing
November 2017

Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.

Oncotarget 2017 Aug 22;8(35):58872-58886. Epub 2017 Jul 22.

Instituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas, Seville, Spain.

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http://dx.doi.org/10.18632/oncotarget.19438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601700PMC
August 2017

The role of PIM1/PIM2 kinases in tumors of the male reproductive system.

Sci Rep 2016 11 30;6:38079. Epub 2016 Nov 30.

Instituto de Biomedicina de Sevilla, IBIS/Hospital Universitario Virgen del Rocío/Universidad de Sevilla/Consejo Superior de Investigaciones Científicas, Avda. Manuel Siurot s/n 41013, Seville, Spain.

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http://dx.doi.org/10.1038/srep38079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128923PMC
November 2016

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Authors:
William H Goodson Leroy Lowe David O Carpenter Michael Gilbertson Abdul Manaf Ali Adela Lopez de Cerain Salsamendi Ahmed Lasfar Amancio Carnero Amaya Azqueta Amedeo Amedei Amelia K Charles Andrew R Collins Andrew Ward Anna C Salzberg Annamaria Colacci Ann-Karin Olsen Arthur Berg Barry J Barclay Binhua P Zhou Carmen Blanco-Aparicio Carolyn J Baglole Chenfang Dong Chiara Mondello Chia-Wen Hsu Christian C Naus Clement Yedjou Colleen S Curran Dale W Laird Daniel C Koch Danielle J Carlin Dean W Felsher Debasish Roy Dustin G Brown Edward Ratovitski Elizabeth P Ryan Emanuela Corsini Emilio Rojas Eun-Yi Moon Ezio Laconi Fabio Marongiu Fahd Al-Mulla Ferdinando Chiaradonna Firouz Darroudi Francis L Martin Frederik J Van Schooten Gary S Goldberg Gerard Wagemaker Gladys N Nangami Gloria M Calaf Graeme Williams Gregory T Wolf Gudrun Koppen Gunnar Brunborg H Kim Lyerly Harini Krishnan Hasiah Ab Hamid Hemad Yasaei Hideko Sone Hiroshi Kondoh Hosni K Salem Hsue-Yin Hsu Hyun Ho Park Igor Koturbash Isabelle R Miousse A Ivana Scovassi James E Klaunig Jan Vondráček Jayadev Raju Jesse Roman John Pierce Wise Jonathan R Whitfield Jordan Woodrick Joseph A Christopher Josiah Ochieng Juan Fernando Martinez-Leal Judith Weisz Julia Kravchenko Jun Sun Kalan R Prudhomme Kannan Badri Narayanan Karine A Cohen-Solal Kim Moorwood Laetitia Gonzalez Laura Soucek Le Jian Leandro S D'Abronzo Liang-Tzung Lin Lin Li Linda Gulliver Lisa J McCawley Lorenzo Memeo Louis Vermeulen Luc Leyns Luoping Zhang Mahara Valverde Mahin Khatami Maria Fiammetta Romano Marion Chapellier Marc A Williams Mark Wade Masoud H Manjili Matilde E Lleonart Menghang Xia Michael J Gonzalez Michalis V Karamouzis Micheline Kirsch-Volders Monica Vaccari Nancy B Kuemmerle Neetu Singh Nichola Cruickshanks Nicole Kleinstreuer Nik van Larebeke Nuzhat Ahmed Olugbemiga Ogunkua P K Krishnakumar Pankaj Vadgama Paola A Marignani Paramita M Ghosh Patricia Ostrosky-Wegman Patricia A Thompson Paul Dent Petr Heneberg Philippa Darbre Po Sing Leung Pratima Nangia-Makker Qiang Shawn Cheng R Brooks Robey Rabeah Al-Temaimi Rabindra Roy Rafaela Andrade-Vieira Ranjeet K Sinha Rekha Mehta Renza Vento Riccardo Di Fiore Richard Ponce-Cusi Rita Dornetshuber-Fleiss Rita Nahta Robert C Castellino Roberta Palorini Roslida Abd Hamid Sabine A S Langie Sakina E Eltom Samira A Brooks Sandra Ryeom Sandra S Wise Sarah N Bay Shelley A Harris Silvana Papagerakis Simona Romano Sofia Pavanello Staffan Eriksson Stefano Forte Stephanie C Casey Sudjit Luanpitpong Tae-Jin Lee Takemi Otsuki Tao Chen Thierry Massfelder Thomas Sanderson Tiziana Guarnieri Tove Hultman Valérian Dormoy Valerie Odero-Marah Venkata Sabbisetti Veronique Maguer-Satta W Kimryn Rathmell Wilhelm Engström William K Decker William H Bisson Yon Rojanasakul Yunus Luqmani Zhenbang Chen Zhiwei Hu

Carcinogenesis 2015 Jun;36 Suppl 1:S254-96

Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480130PMC
June 2015

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

Carcinogenesis 2014 Dec 24;35(12):2822-30. Epub 2014 Oct 24.

Tumour Suppression Group, Experimental Therapeutics Program and Confocal Microscopy Unit, Spanish National Cancer Research Centre (CNIO), Madrid, E28029, Spain

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http://dx.doi.org/10.1093/carcin/bgu220DOI Listing
December 2014

Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.

Front Oncol 2014 15;4:109. Epub 2014 May 15.

Biology Section, Experimental Therapeutics Programme, Spanish National Cancer Research Centre (CNIO) , Madrid , Spain.

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http://dx.doi.org/10.3389/fonc.2014.00109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030178PMC
June 2014

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis.

BMC Cancer 2014 Apr 23;14:281. Epub 2014 Apr 23.

Instituto de Biomedicina de Sevilla, IBIS/Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Sevilla, Spain.

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http://dx.doi.org/10.1186/1471-2407-14-281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023704PMC
April 2014

The PIM family of serine/threonine kinases in cancer.

Med Res Rev 2014 Jan 10;34(1):136-59. Epub 2013 Apr 10.

Experimental Therapeutics Programme, Spanish National Cancer Research Centre, Madrid, Spain.

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http://dx.doi.org/10.1002/med.21284DOI Listing
January 2014

Pim kinases in cancer: diagnostic, prognostic and treatment opportunities.

Biochem Pharmacol 2013 Mar 5;85(5):629-643. Epub 2012 Oct 5.

Instituto de Biomedicina de Sevilla (IBiS), HUVR/CSIC/Universidad de Sevilla, Sevilla, Spain; Consejo Superior de Investigaciones Cientificas, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2012.09.018DOI Listing
March 2013

The essential role of PIM kinases in sarcoma growth and bone invasion.

Carcinogenesis 2012 Aug 22;33(8):1479-86. Epub 2012 May 22.

Experimental Therapeutics Programme, Spanish National Cancer Research Centre Madrid, Spain.

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http://dx.doi.org/10.1093/carcin/bgs176DOI Listing
August 2012

Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation.

Cell Cycle 2011 Aug 15;10(16):2751-62. Epub 2011 Aug 15.

Experimental Therapeutics Programme, Instituto de Biomedicina de Sevilla/HUVR, Sevilla, Spain.

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http://dx.doi.org/10.4161/cc.10.16.16422DOI Listing
August 2011

Spinophilin loss contributes to tumorigenesis in vivo.

Cell Cycle 2011 Jun 15;10(12):1948-55. Epub 2011 Jun 15.

Experimental Therapeutics Program, Spanish National Cancer Research Center, Madrid, Spain.

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http://dx.doi.org/10.4161/cc.10.12.15798DOI Listing
June 2011

Inhibiting PI3K as a therapeutic strategy against cancer.

Clin Transl Oncol 2009 Sep;11(9):572-9

Medical Oncology, Hospital Universitario Virgen del Rocío, Sevilla, Spain.

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http://dx.doi.org/10.1007/s12094-009-0407-xDOI Listing
September 2009

Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation.

Cancer Res 2008 Dec;68(23):9643-53

Experimental Therapeutics Program and Biotechnology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1539DOI Listing
December 2008

Genetic modelling of the PTEN/AKT pathway in cancer research.

Clin Transl Oncol 2008 Oct;10(10):618-27

Experimental Therapeutics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1007/s12094-008-0262-1DOI Listing
October 2008

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications.

Curr Cancer Drug Targets 2008 May;8(3):187-98

Experimental Therapeutics Programme, Spanish National Cancer Centre (CNIO), C/Melchor Fernandez Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.2174/156800908784293659DOI Listing
May 2008

MAP17 enhances the malignant behavior of tumor cells through ROS increase.

Carcinogenesis 2007 Oct 4;28(10):2096-104. Epub 2007 Jun 4.

Experimental Therapeutics Program, Centro Nacional de Investigaciones Oncológicas, Melchor Fernandez Almagro, 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1093/carcin/bgm124DOI Listing
October 2007

MAP17 overexpression is a common characteristic of carcinomas.

Carcinogenesis 2007 Aug 9;28(8):1646-52. Epub 2007 Apr 9.

Experimental Therapeutics Program, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.1093/carcin/bgm083DOI Listing
August 2007

PTEN, more than the AKT pathway.

Carcinogenesis 2007 Jul 6;28(7):1379-86. Epub 2007 Mar 6.

Experimental Therapeutics Programme, Spanish National Cancer Centre (CNIO), C/Melchor Fernandez Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1093/carcin/bgm052DOI Listing
July 2007

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

Carcinogenesis 2007 Jul 19;28(7):1418-25. Epub 2007 Mar 19.

Experimental Therapeutics Programme, Spanish National Cancer Centre (CNIO), C/Melchor Fernandez Almagro3, Madrid, Spain.

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http://dx.doi.org/10.1093/carcin/bgm059DOI Listing
July 2007

Levels of p27(kip1) determine Aplidin sensitivity.

Mol Cancer Ther 2007 Apr;6(4):1310-6

Experimental Therapeutics Programme, Spanish National Cancer Center, Madrid, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0729DOI Listing
April 2007

Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer.

Carcinogenesis 2007 Mar 17;28(3):584-94. Epub 2006 Oct 17.

Experimental Therapeutics Programme, Spanish National Cancer Center (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1093/carcin/bgl190DOI Listing
March 2007

Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker.

Cancer Lett 2005 Aug;226(2):169-84

Unitat de Bioquímica, Departament de Biologia, Facultat de Ciències, Universitat de Girona, Campus de Montilivi, 17071 Girona, Spain.

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http://dx.doi.org/10.1016/j.canlet.2005.01.025DOI Listing
August 2005

Regulation of MAPK cascades by protein tyrosine phosphatases.

Methods Mol Biol 2004 ;250:103-12

Instituto de Investigaciones Citológicas, Valencia, Spain.

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http://dx.doi.org/10.1385/1-59259-671-1:103DOI Listing
April 2004

Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.

J Biol Chem 2002 Jan 15;277(4):2629-36. Epub 2001 Nov 15.

Instituto de Investigaciones Citológicas, Amadeo de Saboya, 4, 46010 Valencia, Spain.

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http://dx.doi.org/10.1074/jbc.M108874200DOI Listing
January 2002