Carmen Behrens

Carmen Behrens

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Carmen Behrens

Carmen Behrens

Publications by authors named "Carmen Behrens"

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Development and Validation of a Predictive Radiomics Model for Clinical Outcomes in Stage I Non-small Cell Lung Cancer.

Int J Radiat Oncol Biol Phys 2018 11 15;102(4):1090-1097. Epub 2017 Nov 15.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.10.046DOI Listing
November 2018

Immunohistochemical and Image Analysis-Based Study Shows That Several Immune Checkpoints are Co-expressed in Non-Small Cell Lung Carcinoma Tumors.

J Thorac Oncol 2018 06 8;13(6):779-791. Epub 2018 Mar 8.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.03.002DOI Listing
June 2018

Major pathologic response and RAD51 predict survival in lung cancer patients receiving neoadjuvant chemotherapy.

Cancer Med 2018 06 19;7(6):2405-2414. Epub 2018 Apr 19.

Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/cam4.1505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010873PMC
June 2018

Programmed Death Cell Ligand 1 (PD-L1) Is Associated With Survival in Stage I Non-Small Cell Lung Cancer.

Semin Thorac Cardiovasc Surg 2017 Autumn;29(3):408-415. Epub 2017 May 26.

MD Anderson Cancer Center, Department of Translational Molecular Pathology, Houston, Texas.

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http://dx.doi.org/10.1053/j.semtcvs.2017.05.008DOI Listing
December 2017

GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma.

Cancer Res 2017 08 26;77(16):4448-4459. Epub 2017 Jun 26.

Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559311PMC
August 2017

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.

Cell Rep 2017 05;19(8):1669-1684

Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531293PMC
May 2017

An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer.

Clin Cancer Res 2016 Oct 28;22(19):4880-4889. Epub 2016 Jun 28.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492382PMC
October 2016

The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells.

Nat Commun 2016 Sep 26;7:12961. Epub 2016 Sep 26.

Creative Research Initiative Center for Concurrent Control of Emphysema and Lung Cancer, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

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http://dx.doi.org/10.1038/ncomms12961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052689PMC
September 2016

Interleukin-11 Receptor Is a Candidate Target for Ligand-Directed Therapy in Lung Cancer: Analysis of Clinical Samples and BMTP-11 Preclinical Activity.

Am J Pathol 2016 08 16;186(8):2162-2170. Epub 2016 Jun 16.

University of New Mexico Comprehensive Cancer Center, University of New Mexico School of Medicine, Albuquerque, New Mexico; Division of Molecular Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973658PMC
August 2016

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma.

Clin Cancer Res 2016 07 5;22(14):3630-42. Epub 2016 Feb 5.

Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947453PMC
July 2016

Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations.

Cancer Res 2016 Feb 16;76(3):675-85. Epub 2015 Dec 16.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer, Houston, Texas. Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738155PMC
February 2016

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma.

Am J Cancer Res 2015 15;5(10):3135-48. Epub 2015 Sep 15.

School of Molecular and Cellular Biology, University of Leeds Leeds, LS2 9JT, UK ; Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center Unit 1000, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656736PMC
December 2015

LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells.

Sci Rep 2015 Sep 7;5:13846. Epub 2015 Sep 7.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, U.S.A.

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http://dx.doi.org/10.1038/srep13846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561374PMC
September 2015

Activation of insulin-like growth factor 1 receptor in patients with non-small cell lung cancer.

Oncotarget 2015 Jun;6(18):16746-56

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599304PMC
http://dx.doi.org/10.18632/oncotarget.3796DOI Listing
June 2015

CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110.

Cancer Res 2015 May 25;75(10):2029-38. Epub 2015 Mar 25.

Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. The Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

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http://cancerres.aacrjournals.org/content/early/2015/04/30/0
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http://cancerres.aacrjournals.org/content/early/2015/03/25/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-1494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433598PMC
May 2015

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.

Proc Natl Acad Sci U S A 2014 Oct 29;111(41):14788-93. Epub 2014 Sep 29.

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, and Pharmacology, Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235;

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http://dx.doi.org/10.1073/pnas.1410419111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205603PMC
October 2014

Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway.

Clin Cancer Res 2014 Aug 6;20(15):4154-66. Epub 2014 Jun 6.

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, Pharmacology, and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438754PMC
August 2014

Prognostic implications of tumoral expression of insulin like growth factors 1 and 2 in patients with non-small-cell lung cancer.

Clin Lung Cancer 2014 May 1;15(3):213-21. Epub 2014 Jan 1.

Department of Thoracic/Head & Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX; College of Pharmacy, Seoul National University, Seoul, South Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15257304130026
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http://dx.doi.org/10.1016/j.cllc.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572464PMC
May 2014

Membrane carbonic anhydrase IX expression and relapse risk in resected stage I-II non-small-cell lung cancer.

J Thorac Oncol 2014 May;9(5):675-84

*Division of Medical Oncology, University of Ottawa, Ottawa, Ontario, Canada; and Departments of †Pathiology, ‡Biostatistics, §Thoracic and Cardiovascular Surgery, ||Thoracic/Head and Neck Medical Oncology, and ¶Translational Molecular Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1097/JTO.0000000000000148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084898PMC
May 2014

Prediction of survival in resected non-small cell lung cancer using a protein expression-based risk model: implications for personalized chemoprevention and therapy.

Clin Cancer Res 2014 Apr 23;20(7):1946-54. Epub 2013 Dec 23.

Authors' Affiliations: Departments of Thoracic/Head and Neck Medical Oncology, Biostatistics, Pathology, and Thoracic and Cardiovascular Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas; Levine Cancer Center; Philips Digital Pathology; and Department of Pathology, University of San Francisco Xavier de Chuquisaca Sucre-Bolivia, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018222PMC
April 2014

Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer.

Clin Cancer Res 2014 Mar 31;20(6):1610-22. Epub 2014 Jan 31.

Authors' Affiliations: Departments of Cell Biology; Pathology; Molecular Biology; Plastic Surgery; and Clinical Sciences; Simmons Comprehensive Cancer Center; Hamon Center for Therapeutic Oncology; Departments of Internal Medicine; Pharmacology; and Radiation Oncology, UT Southwestern Medical Center, Dallas; Departments of Thoracic/Head and Neck Medical Oncology; and Translational Molecular Pathology; The University of Texas MD Anderson Cancer Center, Houston, Texas; and Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-2589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961755PMC
March 2014

Identification of a subset of human non-small cell lung cancer patients with high PI3Kβ and low PTEN expression, more prevalent in squamous cell carcinoma.

Clin Cancer Res 2014 Feb 27;20(3):595-603. Epub 2013 Nov 27.

Authors' Affiliations: AstraZeneca R&D; Former AstraZeneca, Macclesfield, Cheshire, United Kingdom; Departments of Translational Molecular Pathology and Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; AstraZeneca, Asia and Emerging Markets iMed, Shanghai, China; Novartis Institutes for BioMedical Research, Basel, Switzerland; and Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503252PMC
February 2014

A reevaluation of CD22 expression in human lung cancer.

Cancer Res 2014 Jan;74(1):263-71

Authors' Affiliations: Cancer Immunobiology Center and Hamon Center for Therapeutic Oncology Research; Departments of Immunology, Internal Medicine, Microbiology, Pathology, and Pharmacology, University of Texas Southwestern Medical Center, Dallas; Departments of Thoracic/Head and Neck Medical Oncology and Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston; Bio-Synthesis Inc., Lewisville, Texas; and Department of Immunology, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903042PMC
January 2014

EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma.

Clin Cancer Res 2013 Dec 4;19(23):6556-65. Epub 2013 Oct 4.

Authors' Affiliations: Departments of Thoracic/Head and Neck Medical Oncology, Pathology, Biostatistics, Thoracic Surgery, and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and The University of Ottawa, Ottawa, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890101PMC
December 2013

Validation of a proliferation-based expression signature as prognostic marker in early stage lung adenocarcinoma.

Clin Cancer Res 2013 Nov 18;19(22):6261-71. Epub 2013 Sep 18.

Authors' Affiliations: Departments of Translational Molecular Pathology, Thoracic/Head and Neck, Pathology, and Thoracic and Cardiovascular Surgery, The University of Texas, MD Anderson Cancer Center, Houston, Texas; Myriad Genetics, Inc., Salt Lake City, Utah; and Istituto Europeo di Oncologia, Milan, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834029PMC
November 2013

A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients.

Clin Cancer Res 2013 Mar 28;19(6):1577-86. Epub 2013 Jan 28.

Quantitative Biomedical Research Center, Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619002PMC
March 2013

Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer.

Mol Endocrinol 2012 Aug 14;26(8):1443-54. Epub 2012 Jun 14.

Department of Biochemistry, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do 220-701, Republic of Korea.

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http://dx.doi.org/10.1210/me.2011-1382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404298PMC
August 2012

Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer.

Cancer 2012 May 22;118(9):2454-65. Epub 2011 Sep 22.

Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://doi.wiley.com/10.1002/cncr.26492
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http://dx.doi.org/10.1002/cncr.26492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298843PMC
May 2012

Thymomas I: a clinicopathologic correlation of 250 cases with emphasis on the World Health Organization schema.

Am J Clin Pathol 2012 Mar;137(3):444-50

Department of Pathology, M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1309/AJCP76KEGWQKWOKADOI Listing
March 2012

Robust gene expression signature from formalin-fixed paraffin-embedded samples predicts prognosis of non-small-cell lung cancer patients.

Clin Cancer Res 2011 Sep 8;17(17):5705-14. Epub 2011 Jul 8.

Department of Clinical Sciences, Simmons Cancer Center, Internal Medicine, Pharmacology, and Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-11-0196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166982PMC
September 2011

Inhibitor of differentiation-1 as a novel prognostic factor in NSCLC patients with adenocarcinoma histology and its potential contribution to therapy resistance.

Clin Cancer Res 2011 Jun 3;17(12):4155-66. Epub 2011 May 3.

Departments of Oncology, Pathology, and Thoracic Surgery, Clínica Universidad de Navarra; Division of Oncology, Center for Applied Medical Research (CIMA), Pamplona, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-3381DOI Listing
June 2011

Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis.

Clin Cancer Res 2011 Apr 21;17(8):2434-43. Epub 2011 Jan 21.

Departmentsof Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078948PMC
April 2011

A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis.

Clin Cancer Res 2011 Mar 16;17(6):1490-501. Epub 2010 Dec 16.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079395PMC
March 2011

Exponential decay nonlinear regression analysis of patient survival curves: preliminary assessment in non-small cell lung cancer.

Lung Cancer 2011 Feb;71(2):217-23

Department of Thoracic/Head & Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.

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http://dx.doi.org/10.1016/j.lungcan.2010.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962880PMC
February 2011

Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer.

PLoS Med 2010 Dec 14;7(12):e1000378. Epub 2010 Dec 14.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1000378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001894PMC
December 2010

Prognostic significance of RNA-dependent protein kinase on non-small cell lung cancer patients.

Clin Cancer Res 2010 Nov 7;16(22):5522-8. Epub 2010 Oct 7.

Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070287PMC
November 2010