Publications by authors named "Carmela Borreggine"

4 Publications

  • Page 1 of 1

Cerebral amyloid angiopathy related inflammation: A little known but not to be underestimated disease.

Radiol Case Rep 2021 Sep 3;16(9):2514-2521. Epub 2021 Jul 3.

Department of Diagnostic Imaging, Tricase, Italy.

Cerebral amyloid angiopathy related inflammation (CAA-ri) is a rare encephalopathy resulting from perivascular inflammation after β-βamyloid (A) deposition in cerebral vessels leading to progressive dementia, focal neurological signs, seizures and intracerebral hemorrhages. This condition is characterized on magnetic resonance imaging (MRI) by patchy or confluent T2/fluid attenuation inversion recovery (FLAIR) hyperintensities in the cortex and subcortical white matter located mainly in the same areas of pre-existing multiple microhemorrhages. In this report of 2 cases of "probable" CAA-ri women aged 71 and 68, we propose a review on the pathophysiological, clinical, radiological, therapeutic and prognostic aspects of this little-known and poor outcome condition. Even though an apparently favorable initial evolution after steroid and/or immunosuppressive treatment, CAA-ri course is unpredictable and often associated with low survival rates. We suggest the importance of timely and proper clinico-radiological evaluation in suspected CAA-ri cases, in order to start an appropriate treatment even without the brain biopsy.
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http://dx.doi.org/10.1016/j.radcr.2021.05.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260958PMC
September 2021

Balò's concentric sclerosis in a case of cocaine-levamisole abuse.

SAGE Open Med Case Rep 2020 17;8:2050313X20940532. Epub 2020 Jul 17.

Department of Diagnostic Imaging, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

Baló's concentric sclerosis is a rare variant of multiple sclerosis. It belongs to the group of primary inflammatory central nervous system demyelinating diseases having no clear etiology. Peculiar radiological findings on magnetic resonance imaging are alternating rings of demyelinated and myelinated axons resembling an "onion bulb." We report on a case of a patient with cocaine abuse who presented with Balò's-like acute multifocal leukoencephalopathy supported by histological and radiological findings. The abuse of cocaine and its most frequent adulterant, levamisole, may induce ischemic or hemorrhagic stroke and metabolic or multifocal inflammatory leukoencephalopathy. Only a few studies described levamisole-induced leukoencephalopathy mimicking Balò round lesions. Nevertheless, it has not yet been established the correlation between them; it might also be possible that the cocaine/levamisole addiction represents just a coincidence in some of those patients affected by Balò sclerosis disease.
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http://dx.doi.org/10.1177/2050313X20940532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370552PMC
July 2020

Sporadic Burkitt's lymphoma/acute B-cell leukaemia presenting with progressive proptosis and orbital mass in a child.

Neuroradiol J 2016 Jun 22;29(3):231-5. Epub 2016 Mar 22.

Department of Diagnostic Imaging, Ospedali Riuniti, University of Foggia, Italy.

Burkitt's lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma that is found predominantly in children, with the highest incidence occurring in Africa. The sporadic form occurs in non-endemic areas and typically involves the ileo-caecum and the bowel, whereas orbital and paranasal sinus involvement is rare. Here, we present an unusual case of sporadic BL in a Caucasian male child with rapidly progressive painful proptosis of the right eye. Magnetic resonance imaging showed an oval-shaped, extraconal mass in the supero-lateral part of the right orbit that deformed and dislocated the eyeball antero-inferiorly. The patient underwent anterior orbitotomy, and a biopsy of the excised tissue revealed a starry-sky appearance characteristic of BL. Postoperative aggressive chemotherapy was initiated with a good response after one week.
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http://dx.doi.org/10.1177/1971400916639964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977928PMC
June 2016

Lentiform fork sign: a magnetic resonance finding in a case of acute metabolic acidosis.

Neuroradiol J 2014 Jun 17;27(3):288-92. Epub 2014 Jun 17.

Specialisation School in Radiodiagnostics, University of Foggia; Foggia, Italy.

We report a 33 year-old woman addicted to chronic unspecified solvents abuse with stupor, respiratory disorders, tetraplegia and severe metabolic acidosis. On admission an unenhanced cranial CT scan showed symmetrical hypodensities of both lentiform nuclei. MR imaging performed 12 hours after stupor demonstrates bilateral putaminal hemorrhagic necrosis, bilateral external capsule, corona radiata and deep cerebellar hyperintensities with right cingulate cortex involvement. DWI reflected bilateral putaminal hyperintensities with restricted water diffusion as to citotoxic edema and development of vasogenic edema in the external capsule recalling a fork. On day twenty, after specific treatments MRI demonstrated a bilateral putaminal marginal enhancement. Bilateral putaminal necrosis is a characteristic but non-specific radiological finding of methanol poisoning. Lentiform Fork sign is a rare MRI finding reported in literature in 22 patients with various conditions characterized by metabolic acidosis. Vasogenic edema may be due to the differences in metabolic vulnerability between neurons and astrocytes. We postulate that metabolic acidosis could have an important role to generate this sign.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202895PMC
http://dx.doi.org/10.15274/NRJ-2014-10041DOI Listing
June 2014
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