Carlotta Costa

Carlotta Costa

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Carlotta Costa

Carlotta Costa

Publications by authors named "Carlotta Costa"

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The Strategy of PIKing a Target: What Is AKTually Most Effective?

Clin Cancer Res 2018 05 26;24(9):2029-2031. Epub 2018 Jan 26.

Division of Oncology and Pathology, Lund University Cancer Center, Lund, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3440DOI Listing
May 2018

Coamplification of protects -amplified breast cancers from targeted therapy.

Proc Natl Acad Sci U S A 2018 03 23;115(11):E2594-E2603. Epub 2018 Feb 23.

Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298;

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http://dx.doi.org/10.1073/pnas.1717820115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856537PMC
March 2018

The double life of p85.

Cancer Cell 2014 Oct;26(4):445-7

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.09.011DOI Listing
October 2014

mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.

Cancer Discov 2014 Jan 25;4(1):42-52. Epub 2013 Oct 25.

1Massachusetts General Hospital Cancer Center; 2Department of Medicine, Harvard Medical School; 3Division of Gastroenterology, Department of Medicine, Tufts Medical Center; 4Department of Pathology, Massachusetts General Hospital, Boston; and 5Radiation Oncology, Steele Lab for Tumor Biology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973435PMC
January 2014

Apoptosis in targeted therapy responses: the role of BIM.

Adv Pharmacol 2012 ;65:519-42

Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1016/B978-0-12-397927-8.00016-6DOI Listing
February 2013

MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors.

Cancer Res 2012 Jul 2;72(13):3228-37. Epub 2012 May 2.

Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02129, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515079PMC
July 2012

Phosphoinositide 3-kinase p110γ in immunity.

IUBMB Life 2011 Sep 28;63(9):707-13. Epub 2011 Jul 28.

Department of Genetic, Biology and Biochemistry and Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, Italy.

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http://dx.doi.org/10.1002/iub.516DOI Listing
September 2011

The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions.

Blood 2011 Jul 6;118(4):1099-108. Epub 2011 May 6.

Department of Genetic, Biology and Biochemistry, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1182/blood-2010-12-324756DOI Listing
July 2011

More than just kinases: the scaffolding function of PI3K.

Curr Top Microbiol Immunol 2010 ;346:171-81

Molecular Biotechnology Center, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1007/82_2010_57DOI Listing
January 2011

Dissection of the interplay between class I PI3Ks and Rac signaling in phagocytic functions.

ScientificWorldJournal 2010 Sep 14;10:1826-39. Epub 2010 Sep 14.

Department of Genetics, Biology, and Biochemistry, Molecular Biotechnology Center, University of Turin, Italy.

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http://dx.doi.org/10.1100/tsw.2010.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763975PMC
September 2010

The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.

Cancer Res 2008 Nov;68(21):8899-907

Department of Biomedical Sciences and Human Oncology, Center for Experimental Research and Medical Studies, University of Torino, Turin, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596920PMC
November 2008

Taming the PI3K team to hold inflammation and cancer at bay.

Pharmacol Ther 2008 May 5;118(2):192-205. Epub 2008 Mar 5.

Molecular Biotechnology Center, University of Torino, via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1016/j.pharmthera.2008.02.004DOI Listing
May 2008

Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma.

Proc Natl Acad Sci U S A 2007 Sep 24;104(36):14354-9. Epub 2007 Aug 24.

Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.

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http://dx.doi.org/10.1073/pnas.0703175104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952139PMC
September 2007

Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.

J Endocrinol 2007 Aug;194(2):243-56

Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Turin 10126, Italy.

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http://dx.doi.org/10.1677/JOE-07-0097DOI Listing
August 2007

CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.

J Immunol 2006 Nov;177(9):6143-51

Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, Turin, Italy.

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http://dx.doi.org/10.4049/jimmunol.177.9.6143DOI Listing
November 2006

Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing.

Thromb Haemost 2006 Jan;95(1):29-35

Dipartimento di Genetica, Biologia e Biochimica, University of Torino, Via Santena 5bis, 10126 Torino, Italy.

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January 2006

p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.

Blood 2005 Dec 16;106(12):3907-16. Epub 2005 Aug 16.

Center for Experimental Research and Medical Studies and Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1182/blood-2005-03-1204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895100PMC
December 2005