Publications by authors named "Carlos J Camacho"

70Publications

Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck.

Front Chem 2019 28;7:822. Epub 2019 Nov 28.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

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November 2019

Cross-docking benchmark for automated pose and ranking prediction of ligand binding.

Protein Sci 2020 01 28;29(1):298-305. Epub 2019 Nov 28.

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.

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January 2020

Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.

Proc Natl Acad Sci U S A 2019 07 15;116(31):15696-15705. Epub 2019 Jul 15.

Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261;

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July 2019

A network-centric approach to drugging TNF-induced NF-κB signaling.

Nat Commun 2019 02 26;10(1):860. Epub 2019 Feb 26.

Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

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February 2019

Predicting protein targets for drug-like compounds using transcriptomics.

PLoS Comput Biol 2018 12 7;14(12):e1006651. Epub 2018 Dec 7.

Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America.

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December 2018

Improving small molecule virtual screening strategies for the next generation of therapeutics.

Curr Opin Chem Biol 2018 06 17;44:87-92. Epub 2018 Jun 17.

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address:

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June 2018

Case series: Pyramidal cataracts, intact irides and nystagmus from three novel mutations.

Am J Ophthalmol Case Rep 2018 Jun 28;10:172-179. Epub 2018 Feb 28.

UPMC Eye Center, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.

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June 2018

AnchorQuery: Rapid online virtual screening for small-molecule protein-protein interaction inhibitors.

Protein Sci 2018 01 24;27(1):229-232. Epub 2017 Oct 24.

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.

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January 2018

Optimal affinity ranking for automated virtual screening validated in prospective D3R grand challenges.

J Comput Aided Mol Des 2018 01 16;32(1):287-297. Epub 2017 Sep 16.

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

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January 2018

Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase.

Sci Rep 2017 05 11;7(1):1789. Epub 2017 May 11.

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15206, USA.

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May 2017

Probing protein flexibility reveals a mechanism for selective promiscuity.

Elife 2017 04 22;6. Epub 2017 Apr 22.

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, United States.

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April 2017

Optimal strategies for virtual screening of induced-fit and flexible target in the 2015 D3R Grand Challenge.

J Comput Aided Mol Des 2016 09 29;30(9):695-706. Epub 2016 Aug 29.

Department of Computational and System Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

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September 2016

Extensive Citrullination Promotes Immunogenicity of HSP90 through Protein Unfolding and Exposure of Cryptic Epitopes.

J Immunol 2016 09 22;197(5):1926-36. Epub 2016 Jul 22.

Division of Rheumatology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136;

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September 2016

Fragment oriented molecular shapes.

J Mol Graph Model 2016 05 2;66:143-54. Epub 2016 Apr 2.

Department of Computational and Systems Biology, University of Pittsburgh, United States. Electronic address:

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May 2016

Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences.

Biochim Biophys Acta 2016 May 27;1861(5):391-401. Epub 2016 Feb 27.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA; Center for Free Radical and Antioxidant Health and Center for Medical Countermeasures against Radiation, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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May 2016