Publications by authors named "Carlos Flores"

100Publications

NanoCLUST: a species-level analysis of 16S rRNA nanopore sequencing data.

Bioinformatics 2020 Oct 18. Epub 2020 Oct 18.

Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, 38010, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btaa900DOI Listing
October 2020

Iso-damping fractional-order control for robust automated car-following.

J Adv Res 2020 Sep 17;25:181-189. Epub 2020 Jun 17.

California PATH Program of the Institute of Transportation Studies, University of California Berkeley, Richmond, CA 94804, United States.

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http://dx.doi.org/10.1016/j.jare.2020.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474189PMC
September 2020

Corrigendum: Bradykinin-Mediated Angioedema: An Update of the Genetic Causes and the Impact of Genomics.

Front Genet 2020 28;11:690. Epub 2020 Jul 28.

Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.3389/fgene.2020.00690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402326PMC
July 2020

Monitoring Lactate Dynamics in Individual Macrophages with a Genetically Encoded Probe.

Methods Mol Biol 2020 ;2184:19-30

Centro de Estudios Científicos-CECs, Valdivia, Chile.

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http://dx.doi.org/10.1007/978-1-0716-0802-9_2DOI Listing
January 2020

Sensitivity of different RT-qPCR solutions for SARS-CoV-2 detection.

Int J Infect Dis 2020 Oct 1;99:190-192. Epub 2020 Aug 1.

Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain; Research Unit, Hospital Universitario N. S. de Candelaria, Santa Cruz de Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Instituto de Tecnologías Biomédicas (ITB) Universidad de La Laguna, San Cristóbal de La Laguna, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2020.07.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395224PMC
October 2020

The impact of BMI on mental health: Further evidence from genetic markers.

Econ Hum Biol 2020 Aug 13;38:100895. Epub 2020 Jun 13.

Department of Economics and Center for Policy Research, Maxwell School of Citizenship and Public Affairs, Syracuse University; Research Fellow IZA, and GLO, 426 Eggers Hall, Syracuse, NY 13244, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ehb.2020.100895DOI Listing
August 2020

Fast SARS-CoV-2 detection by RT-qPCR in preheated nasopharyngeal swab samples.

Int J Infect Dis 2020 Aug 31;97:66-68. Epub 2020 May 31.

Genomics Division, Instituto Tecnológico y de Energías Renovables, 38600 Santa Cruz de Tenerife, Spain; Research Unit, Hospital Universitario N. S. de Candelaria, 38010 Santa Cruz de Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain; Instituto de Tecnologías Biomédicas (ITB) Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2020.05.099DOI Listing
August 2020

Admixture mapping of asthma in southwestern Europeans with North African ancestry influences.

Am J Physiol Lung Cell Mol Physiol 2020 05 18;318(5):L965-L975. Epub 2020 Mar 18.

Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.1152/ajplung.00344.2019DOI Listing
May 2020

Alimentary necrobacillosis in alpacas.

J Vet Diagn Invest 2020 Mar 18;32(2):339-343. Epub 2020 Feb 18.

California Animal Health and Food Safety Laboratory System, San Bernardino (Carvallo, Uzal) branches, University of California-Davis, Davis, CA.

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http://dx.doi.org/10.1177/1040638720906409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081513PMC
March 2020

Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study.

Lancet Respir Med 2020 03 23;8(3):258-266. Epub 2020 Jan 23.

Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain; Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Instituto de Tecnologías Biomédicas, Universidad de La Laguna, Santa Cruz de Tenerife, Spain. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(19)30368-6DOI Listing
March 2020

Cyanoflan: A cyanobacterial sulfated carbohydrate polymer with emulsifying properties.

Carbohydr Polym 2020 Feb 31;229:115525. Epub 2019 Oct 31.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; Faculdade de Ciências, Departamento de Biologia, Universidade do Porto, Rua do Campo Alegre, Edifício FC4, 4169-007 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2019.115525DOI Listing
February 2020

Bradykinin-Mediated Angioedema: An Update of the Genetic Causes and the Impact of Genomics.

Front Genet 2019 27;10:900. Epub 2019 Sep 27.

Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.3389/fgene.2019.00900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776636PMC
September 2019

Bacterial salivary microbiome associates with asthma among african american children and young adults.

Pediatr Pulmonol 2019 12 9;54(12):1948-1956. Epub 2019 Sep 9.

Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology, and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.1002/ppul.24504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851413PMC
December 2019

Genomics and the Acute Respiratory Distress Syndrome: Current and Future Directions.

Int J Mol Sci 2019 Aug 16;20(16). Epub 2019 Aug 16.

Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife 38010, Spain.

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http://dx.doi.org/10.3390/ijms20164004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721149PMC
August 2019

Characterization and antitumor activity of the extracellular carbohydrate polymer from the cyanobacterium Synechocystis ΔsigF mutant.

Int J Biol Macromol 2019 Sep 21;136:1219-1227. Epub 2019 Jun 21.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; IBMC - Instituto de Biologia Celular e Molecular, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; FCUP - Faculdade de Ciências, Departamento de Biologia, Universidade do Porto, Rua do Campo Alegre, Edifício FC4, 4169-007 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2019.06.152DOI Listing
September 2019

Looking Outwards: Isolation of Cyanobacterial Released Carbohydrate Polymers and Proteins.

J Vis Exp 2019 05 27(147). Epub 2019 May 27.

Bioengineering and Synthetic Microbiology Group, Instituto de Investigação e Inovação em Saude, Universidade do Porto; Instituto de Biologia Celular e Molecular, Universidade do Porto; Departamento de Biologia, Faculdade de Ciências, Universidade do Porto;

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http://dx.doi.org/10.3791/59590DOI Listing
May 2019

NanoDJ: a Dockerized Jupyter notebook for interactive Oxford Nanopore MinION sequence manipulation and genome assembly.

BMC Bioinformatics 2019 May 9;20(1):234. Epub 2019 May 9.

Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.1186/s12859-019-2860-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509807PMC
May 2019

Preschoolers with recurrent wheezing have a high prevalence of sleep disordered breathing.

J Asthma 2020 Jun 5;57(6):584-592. Epub 2019 Apr 5.

Department of Pediatric Pulmonology and Cardiology, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

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https://www.tandfonline.com/doi/full/10.1080/02770903.2019.1
Publisher Site
http://dx.doi.org/10.1080/02770903.2019.1599385DOI Listing
June 2020

Factors associated with HIV testing among men who have sex with men in Guatemala City.

Int J STD AIDS 2019 05 27;30(6):577-585. Epub 2019 Feb 27.

6 Center on Gender Equity and Health, Division of Infectious Diseases and Global Public Health, School of Medicine, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1177/0956462419826393DOI Listing
May 2019

Genomic Predictors of Asthma Phenotypes and Treatment Response.

Front Pediatr 2019 5;7. Epub 2019 Feb 5.

Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.3389/fped.2019.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370703PMC
February 2019

Association of mitochondrial variants A4336G of the tRNAGln gene and 8701G/A of the MT-ATP6 gene in Mexicans Mestizos with Parkinson disease.

Folia Neuropathol 2019 ;57(4):335-339

Subdirección de Enseñanza e Investigación, Centro Médico Nacional "20 de Noviembre", Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Ciudad de México, México.

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http://dx.doi.org/10.5114/fn.2019.89859DOI Listing
July 2020

The alternative sigma factor SigF is a key player in the control of secretion mechanisms in Synechocystis sp. PCC 6803.

Environ Microbiol 2019 01 3;21(1):343-359. Epub 2018 Dec 3.

Bioengineering and Synthetic Microbiology Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

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http://doi.wiley.com/10.1111/1462-2920.14465
Publisher Site
http://dx.doi.org/10.1111/1462-2920.14465DOI Listing
January 2019

Role of genomics in asthma exacerbations.

Curr Opin Pulm Med 2019 01;25(1):101-112

Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics.

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http://dx.doi.org/10.1097/MCP.0000000000000533DOI Listing
January 2019

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 09;50(9):1343

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41588-018-0197-6DOI Listing
September 2018

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 08 16;50(8):1072-1080. Epub 2018 Jul 16.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41588-018-0157-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068780PMC
August 2018

Frequency of Technical Complications in Fixed Implant Prosthesis: The Effect of Prosthesis Screw Emergence Correction by Computer-Aided Design/Computer-Aided Manufacturing.

J Oral Implantol 2018 Dec 5;44(6):427-431. Epub 2018 Jun 5.

2   University Institute for Regenerative Medicine and Oral Implantology-UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria, Spain.

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http://dx.doi.org/10.1563/aaid-joi-D-17-00229DOI Listing
December 2018

Assessing Asthma Medication Responses in U.S. Minority Children by Whole-Genome Sequencing.

Am J Respir Crit Care Med 2018 06;197(12):1513-1514

1 Instituto Tecnológico y de Energías Renovables Tenerife, Spain.

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http://dx.doi.org/10.1164/rccm.201803-0457EDDOI Listing
June 2018

[Orf virus in human, confirmation in case report from Chile].

Rev Chilena Infectol 2017 Dec;34(6):607-609

Facultad de Ciencias, Universidad Mayor, Santiago, Chile.

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http://dx.doi.org/10.4067/S0716-10182017000600607DOI Listing
December 2017

The road to precision medicine in sepsis: blood transcriptome endotypes.

Lancet Respir Med 2017 10 29;5(10):767-768. Epub 2017 Aug 29.

CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario Dr Negrín, Gran Canaria, Spain; Keenan Research Center for Biomedical Science at the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S2213-2600(17)30297-7DOI Listing
October 2017

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Authors:
Philip C Haycock Stephen Burgess Aayah Nounu Jie Zheng George N Okoli Jack Bowden Kaitlin Hazel Wade Nicholas J Timpson David M Evans Peter Willeit Abraham Aviv Tom R Gaunt Gibran Hemani Massimo Mangino Hayley Patricia Ellis Kathreena M Kurian Karen A Pooley Rosalind A Eeles Jeffrey E Lee Shenying Fang Wei V Chen Matthew H Law Lisa M Bowdler Mark M Iles Qiong Yang Bradford B Worrall Hugh Stephen Markus Rayjean J Hung Chris I Amos Amanda B Spurdle Deborah J Thompson Tracy A O'Mara Brian Wolpin Laufey Amundadottir Rachael Stolzenberg-Solomon Antonia Trichopoulou N Charlotte Onland-Moret Eiliv Lund Eric J Duell Federico Canzian Gianluca Severi Kim Overvad Marc J Gunter Rosario Tumino Ulrika Svenson Andre van Rij Annette F Baas Matthew J Bown Nilesh J Samani Femke N G van t'Hof Gerard Tromp Gregory T Jones Helena Kuivaniemi James R Elmore Mattias Johansson James Mckay Ghislaine Scelo Robert Carreras-Torres Valerie Gaborieau Paul Brennan Paige M Bracci Rachel E Neale Sara H Olson Steven Gallinger Donghui Li Gloria M Petersen Harvey A Risch Alison P Klein Jiali Han Christian C Abnet Neal D Freedman Philip R Taylor John M Maris Katja K Aben Lambertus A Kiemeney Sita H Vermeulen John K Wiencke Kyle M Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew-Kee Low Krina T Zondervan Grant W Montgomery Dale R Nyholt David A van Heel Karen Hunt Dan E Arking Foram N Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand Mary E Comeau W Mark Brown Edwin K Silverman John E Hokanson Michael H Cho Jennie Hui Manuel A Ferreira Philip J Thompson Alanna C Morrison Janine F Felix Nicholas L Smith Angela M Christiano Lynn Petukhova Regina C Betz Xing Fan Xuejun Zhang Caihong Zhu Carl D Langefeld Susan D Thompson Feijie Wang Xu Lin David A Schwartz Tasha Fingerlin Jerome I Rotter Mary Frances Cotch Richard A Jensen Matthias Munz Henrik Dommisch Arne S Schaefer Fang Han Hanna M Ollila Ryan P Hillary Omar Albagha Stuart H Ralston Chenjie Zeng Wei Zheng Xiao-Ou Shu Andre Reis Steffen Uebe Ulrike Hüffmeier Yoshiya Kawamura Takeshi Otowa Tsukasa Sasaki Martin Lloyd Hibberd Sonia Davila Gang Xie Katherine Siminovitch Jin-Xin Bei Yi-Xin Zeng Asta Försti Bowang Chen Stefano Landi Andre Franke Annegret Fischer David Ellinghaus Carlos Flores Imre Noth Shwu-Fan Ma Jia Nee Foo Jianjun Liu Jong-Won Kim David G Cox Olivier Delattre Olivier Mirabeau Christine F Skibola Clara S Tang Merce Garcia-Barcelo Kai-Ping Chang Wen-Hui Su Yu-Sun Chang Nicholas G Martin Scott Gordon Tracey D Wade Chaeyoung Lee Michiaki Kubo Pei-Chieng Cha Yusuke Nakamura Daniel Levy Masayuki Kimura Shih-Jen Hwang Steven Hunt Tim Spector Nicole Soranzo Ani W Manichaikul R Graham Barr Bratati Kahali Elizabeth Speliotes Laura M Yerges-Armstrong Ching-Yu Cheng Jost B Jonas Tien Yin Wong Isabella Fogh Kuang Lin John F Powell Kenneth Rice Caroline L Relton Richard M Martin George Davey Smith

JAMA Oncol 2017 May;3(5):636-651

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.

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http://dx.doi.org/10.1001/jamaoncol.2016.5945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638008PMC
May 2017

The effect of radiation dose reduction on computer-aided detection (CAD) performance in a low-dose lung cancer screening population.

Med Phys 2017 Apr 14;44(4):1337-1346. Epub 2017 Mar 14.

Department of Radiological Sciences, University of California Los Angeles David Geffen School of Medicine, 924 Westwood Blvd, Los Angeles, California, 90024, USA.

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http://dx.doi.org/10.1002/mp.12128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719865PMC
April 2017

Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome.

Mol Cell Pediatr 2016 Dec 21;3(1):37. Epub 2016 Nov 21.

Centro de Estudios Científicos (CECs), Avenida Arturo Prat 514, 511046, Valdivia, Chile.

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http://dx.doi.org/10.1186/s40348-016-0065-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116442PMC
December 2016

ClC-2 and intestinal chloride secretion.

Authors:
Carlos A Flores

Am J Physiol Gastrointest Liver Physiol 2016 10;311(4):G775

Centro de Estudios Científicos (CECs), Valdivia, Chile

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http://dx.doi.org/10.1152/ajpgi.00310.2016DOI Listing
October 2016

Genomic Insights Into Sepsis Course Using Whole Exome Sequencing.

EBioMedicine 2016 Oct 24;12:18-19. Epub 2016 Sep 24.

Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna (ULL), Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.1016/j.ebiom.2016.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078624PMC
October 2016

Ischaemic stroke induced by neurocysticerosis, presenting as a clinical and radiological dilemma.

BJR Case Rep 2016 28;2(3):20150254. Epub 2016 Jul 28.

Department of Radiology, Christiana Care Health System, Newark, DE, USA.

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http://dx.doi.org/10.1259/bjrcr.20150254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243351PMC
July 2016

What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression.

Curr Allergy Asthma Rep 2016 07;16(8):53

Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Carretera del Rosario 145, 38010, Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.1007/s11882-016-0635-4DOI Listing
July 2016

Pharmacological analysis of epithelial chloride secretion mechanisms in adult murine airways.

Eur J Pharmacol 2016 Jun 7;781:100-8. Epub 2016 Apr 7.

Centro de Estudios Científicos (CECs), Valdivia, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2016.04.007DOI Listing
June 2016

Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.

Pharmacogenet Genomics 2016 06;26(6):280-7

aAllergy service, Infanta Leonor Hospital bResearch Unit and Biomedical Research Center in Respiratory Diseases, Carlos III Health Institute, Tenerife cAllergy Unit dResearch Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga Departments of ePharmacology fBiochemistry and Molecular Biology, University of Extremadura, Cáceres, Spain gINSERM U-954, University of Lorraine and University Hospital Center (CHU) of Nancy, Nancy, France.

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http://dx.doi.org/10.1097/FPC.0000000000000216DOI Listing
June 2016

Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene.

J Allergy Clin Immunol 2016 Mar 24;137(3):964-6. Epub 2015 Nov 24.

Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Applied Genomics Group (G2A), Genetics Laboratory, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (CIBICAN), Universidad de La Laguna, Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.09.051DOI Listing
March 2016

Erratum to: Injurious mechanical ventilation affects neuronal activation in ventilated rats.

Crit Care 2015 Oct 27;19:379. Epub 2015 Oct 27.

CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, C/ Sinesio Delgado 6, Madrid, 28029, Spain.

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http://dx.doi.org/10.1186/s13054-015-1076-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624182PMC
October 2015

Altered Profile of Circulating Endothelial-Derived Microparticles in Ventilator-Induced Lung Injury.

Crit Care Med 2015 Dec;43(12):e551-9

1CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. 2Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain. 3Department of Anatomy, Pathology and Histology, University of La Laguna, Tenerife, Spain. 4Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain. 5Department of Immunology, Hospital San Espases, Palma de Mallorca, Spain. 6Department of Clinical Biochemistry, Hospital Universitario NS de Candelaria, Tenerife, Spain. 7Research Unit, Hospital Universitario NS de Candelaria, Tenerife, Spain. 8Institute of Medical Science, University of Toronto, Toronto, ON, Canada. 9Respiratory and Critical Care Research Group, Toronto General Research Institute, University Health Network, Toronto, ON, Canada. 10Keenan Research Center for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. 11Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/CCM.0000000000001280DOI Listing
December 2015

Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury.

PLoS One 2015 6;10(7):e0132296. Epub 2015 Jul 6.

CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Santa Cruz de Tenerife, Spain; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132296PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492998PMC
April 2016

Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent.

J Allergy Clin Immunol 2015 Oct 27;136(4):1116-8.e9. Epub 2015 May 27.

CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Applied Genomics Group (G2A), Genetics Laboratory, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Tenerife, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699578PMC
October 2015

Variability in CT lung-nodule volumetry: Effects of dose reduction and reconstruction methods.

Med Phys 2015 May;42(5):2679-89

Department of Radiological Sciences, University of California Los Angeles, Los Angeles, California 90024.

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http://dx.doi.org/10.1118/1.4918919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148179PMC
May 2015

IonGAP: integrative bacterial genome analysis for Ion Torrent sequence data.

Bioinformatics 2015 Sep 6;31(17):2870-3. Epub 2015 May 6.

Applied Genomics Group (G2A), Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (CIBICAN), Universidad de La Laguna, Santa Cruz de Tenerife, Spain, Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain, CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btv283DOI Listing
September 2015

Host genetics shapes adult sepsis survival.

Authors:
Carlos Flores

Lancet Respir Med 2015 Jan 18;3(1):7-8. Epub 2014 Dec 18.

Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Carretera del Rosario, 38010 Santa Cruz de Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Applied Genomics Group (G2A), Genetics Laboratory, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Tenerife, Spain. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(14)70307-8DOI Listing
January 2015

Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury.

Crit Care 2014 Oct 21;18(5):568. Epub 2014 Oct 21.

Keenan Research Center for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.

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http://dx.doi.org/10.1186/s13054-014-0568-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220065PMC
October 2014

The Gos28 SNARE protein mediates intra-Golgi transport of rhodopsin and is required for photoreceptor survival.

J Biol Chem 2014 Nov 26;289(47):32392-409. Epub 2014 Sep 26.

From the Department of Ophthalmology and Visual Sciences, Department of Genetics and The McPherson Eye Research Institute, University of Wisconsin, Madison, Wisconsin 53792

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http://dx.doi.org/10.1074/jbc.M114.585166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239595PMC
November 2014

HLA-DRB1*15:01 allele protects from asthma susceptibility.

J Allergy Clin Immunol 2014 Nov 14;134(5):1201-3. Epub 2014 Jul 14.

CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Applied Genomics Group (G2A), Genetics Laboratory, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Tenerife, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.05.031DOI Listing
November 2014

GADD45a promoter regulation by a functional genetic variant associated with acute lung injury.

PLoS One 2014 18;9(6):e100169. Epub 2014 Jun 18.

Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100169PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062486PMC
October 2015

Assessment of planctomycetes cell viability after pollutants exposure.

Antonie Van Leeuwenhoek 2014 Aug 6;106(2):399-411. Epub 2014 Jun 6.

Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, FC4 Rua do Campo Alegre s/nº, 4169-007, Porto, Portugal.

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http://dx.doi.org/10.1007/s10482-014-0206-4DOI Listing
August 2014

The vitamin D status of prison inmates.

PLoS One 2014 5;9(3):e90623. Epub 2014 Mar 5.

Department of Family and Community Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944727PMC
November 2014

Assessing the quality of studies supporting genetic susceptibility and outcomes of ARDS.

Front Genet 2014 6;5:20. Epub 2014 Feb 6.

CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III Madrid, Spain ; Research Unit, Hospital Universitario N.S. de Candelaria Santa Cruz de Tenerife, Spain ; Applied Genomics Group (G2A), Genetics Laboratory, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.3389/fgene.2014.00020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915143PMC
February 2014

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.

Lancet Respir Med 2013 Jun 17;1(4):309-317. Epub 2013 Apr 17.

Section of Pulmonary and Critical Care Medicine (Prof I Noth MD, S-F Ma PhD, M Barber PhD, Y Huang MS, S M Broderick BS, R Vij MD) and Section of Genetic Medicine (Prof D Nicolae PhD), University of Chicago, Chicago, IL, USA; Dorothy P and Richard P Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA (Y Zhang PhD, J Scuirba BS, T J Richards PhD, B M Juan-Guardela MD, Prof N Kaminski MD); CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain (C Flores PhD); Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Tenerife, Spain (C Flores); Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, IL, USA (M S Wade MS, Prof J G N Garcia MD); Department of Twin Research and Genetic Epidemiology, King's College London, London, UK (P Hysi PhD); Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA (M K Han MD, Prof F J Martinez MD); InterMune, Brisbane, CA, USA (K Kossen PhD, S D Seiwert PhD); and Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Pennsylvania, PA, USA (J D Christie MD).

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http://dx.doi.org/10.1016/S2213-2600(13)70045-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894577PMC
June 2013

Prognostic factors in pediatric sepsis study, from the Spanish Society of Pediatric Intensive Care.

Pediatr Infect Dis J 2014 Feb;33(2):152-7

From the *Pediatric Intensive Care Unit Service, Hospital de Sant Joan de Déu, Barcelona; †Pediatric Intensive Care Unit Service, Hospital Carlos Haya, Málaga; ‡Pediatric Intensive Care Unit Service, Hospital Universitario de Salamanca, Salamanca; §Pediatric Intensive Care Unit Service, Hospital Parc Taulí, Sabadell; ¶Pediatric Intensive Care Unit Service, Hospital Virgen de la Salud, Toledo; ‖Pediatric Intensive Care Unit Service, Hospital Puerta del Mar, Cádiz; and **Pediatric Intensive Care Unit Service, Hospital Gregorio Marañón, Madrid, Spain.

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http://pdfs.journals.lww.com/pidj/2014/02000/Prognostic_Fact
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http://dx.doi.org/10.1097/01.inf.0000435502.36996.72DOI Listing
February 2014

Assessing the validity of asthma associations for eight candidate genes and age at diagnosis effects.

PLoS One 2013 9;8(9):e73157. Epub 2013 Sep 9.

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain ; Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073157PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767824PMC
June 2014

Disruption of CDH2/N-cadherin-based adherens junctions leads to apoptosis of ependymal cells and denudation of brain ventricular walls.

J Neuropathol Exp Neurol 2013 Sep;72(9):846-60

Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.

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http://dx.doi.org/10.1097/NEN.0b013e3182a2d5feDOI Listing
September 2013