Publications by authors named "Carlos Diéguez"

100Publications

Unraveling the Role of Leptin in Liver Function and Its Relationship with Liver Diseases.

Int J Mol Sci 2020 Dec 9;21(24). Epub 2020 Dec 9.

Hepatic Regenerative Medicine Group, Madrid Institute for Advanced Studies in Food (IMDEA-Food), CEI-UAM+CSIC, 28049 Madrid, Spain.

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December 2020

Circulating LEAP-2 is associated with puberty in girls.

Int J Obes (Lond) 2020 Nov 2. Epub 2020 Nov 2.

CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Santiago de Compostela, 15706, Spain.

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November 2020

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points.

J Hepatol 2021 Feb 20;74(2):469-471. Epub 2020 Oct 20.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Galician Agency of Innovation (GAIN), Santiago de Compostela, Spain. Electronic address:

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February 2021

Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty.

Cell Metab 2020 Dec 19;32(6):951-966.e8. Epub 2020 Oct 19.

Instituto Maimónides de Investigation Biomédica de Córdoba (IMIBIC), Department of Cell Biology, Physiology and Immunology, University of Córdoba and Hospital Universitario Reina Sofia, 14004 Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 14004 Córdoba, Spain; Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine and Turku Center for Disease Modeling, University of Turku, Turku, Finland. Electronic address:

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December 2020

Reprint of: Recent Updates on Obesity Treatments: Available Drugs and Future Directions.

Neuroscience 2020 11;447:191-215

NeurObesity Group, Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 15706, Spain. Electronic address:

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November 2020

Nicotine' actions on energy balance: Friend or foe?

Pharmacol Ther 2020 Sep 26:107693. Epub 2020 Sep 26.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain. Electronic address:

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September 2020

AMPK-Dependent Mechanisms but Not Hypothalamic Lipid Signaling Mediates GH-Secretory Responses to GHRH and Ghrelin.

Cells 2020 08 21;9(9). Epub 2020 Aug 21.

CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 15782 Santiago de Compostela, Spain.

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August 2020

Editorial: Hypocretins/Orexins.

Front Endocrinol (Lausanne) 2020 2;11:357. Epub 2020 Jun 2.

Department of Physiology, CIMUS, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

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June 2020

Recent Updates on Obesity Treatments: Available Drugs and Future Directions.

Neuroscience 2020 06 29;437:215-239. Epub 2020 Apr 29.

NeurObesity Group, Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 15706, Spain. Electronic address:

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June 2020

Levels of the Novel Endogenous Antagonist of Ghrelin Receptor, Liver-Enriched Antimicrobial Peptide-2, in Patients with Rheumatoid Arthritis.

Nutrients 2020 Apr 6;12(4). Epub 2020 Apr 6.

SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), the NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain.

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April 2020

Temperature but not leptin prevents semi-starvation induced hyperactivity in rats: implications for anorexia nervosa treatment.

Sci Rep 2020 03 24;10(1):5300. Epub 2020 Mar 24.

Department Psicología Clínica y Psicobiología, Facultad de Psicología, Universidad de Santiago, Campus Vida, 15782, Santiago de Compostela, Spain.

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March 2020

Oral Pharmacological Activation of Hypothalamic Guanylate Cyclase 2C Receptor Stimulates Brown Fat Thermogenesis to Reduce Body Weight.

Neuroendocrinology 2020 17;110(11-12):1042-1054. Epub 2020 Jan 17.

Department of Physiology, CIMUS, Universidade de Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain,

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January 2020

HYPOTHesizing about central comBAT against obesity.

J Physiol Biochem 2020 May 16;76(2):193-211. Epub 2019 Dec 16.

Department of Physiology, Pharmacy School, Complutense University of Madrid, 28040, Madrid, Spain.

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May 2020

Glucagon Control on Food Intake and Energy Balance.

Int J Mol Sci 2019 Aug 11;20(16). Epub 2019 Aug 11.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain.

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August 2019

Glucagon, GLP-1 and Thermogenesis.

Int J Mol Sci 2019 Jul 13;20(14). Epub 2019 Jul 13.

Department of Physiology, Pharmacy School, Complutense University of Madrid, 28040 Madrid, Spain.

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July 2019

Updating gender differences in the control of homeostatic and hedonic food intake: Implications for binge eating disorder.

Mol Cell Endocrinol 2019 11 15;497:110508. Epub 2019 Jul 15.

Department of Physiology, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Santiago de Compostela, Spain. Electronic address:

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November 2019

ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents.

Nutrients 2019 Jun 14;11(6). Epub 2019 Jun 14.

Endocrine Physiopathology Group, Instituto Investigación Sanitaria Santiago de Compostela (IDIS), Complejo Hospitalario Universitario Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, Spain.

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June 2019

Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice.

Nutrients 2019 Mar 30;11(4). Epub 2019 Mar 30.

Department of Physiology, CIMUS, Universidade de Santiago de Compostela - Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain.

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March 2019

Exciting advances in GPCR-based drugs discovery for treating metabolic disease and future perspectives.

Expert Opin Drug Discov 2019 05 1;14(5):421-431. Epub 2019 Mar 1.

d Neurotransmission et signalisation laboratoire , Inserm UMR-S 839 , Paris , France.

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May 2019

Ghrelin and food reward.

Neuropharmacology 2019 04 5;148:131-138. Epub 2019 Jan 5.

Inserm UMR-S 839, 75005, Paris, France; Sorbonne Université, Sciences and Engineering Faculty, 75005 Paris, France; Institut du Fer a Moulin, 75005, Paris, France.

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April 2019

p107 Deficiency Increases Energy Expenditure by Inducing Brown-Fat Thermogenesis and Browning of White Adipose Tissue.

Mol Nutr Food Res 2019 01 14;63(2):e1801096. Epub 2018 Nov 14.

Centro de Investigación en Medicina Molecular (CIMUS), Universidade de Santiago de Compostela and Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), 15782, Santiago de Compostela, Spain.

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January 2019

Protamine nanocapsules as carriers for oral peptide delivery.

J Control Release 2018 12 18;291:157-168. Epub 2018 Oct 18.

NanobioFar Group, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain. Electronic address:

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December 2018

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress.

Cell Rep 2018 10;25(2):413-423.e5

Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, 15706, Spain. Electronic address:

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October 2018

Unravelling the role and mechanism of adipokine and gastrointestinal signals in animal models in the nonhomeostatic control of energy homeostasis: Implications for binge eating disorder.

Eur Eat Disord Rev 2018 11 2;26(6):551-568. Epub 2018 Oct 2.

Department of Physiology, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Santiago de Compostela, Spain.

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November 2018

Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty.

Sci Rep 2018 09 28;8(1):14541. Epub 2018 Sep 28.

Fisiopatología Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Santiago de Compostela, Spain.

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September 2018

Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender.

Int J Mol Sci 2018 Sep 25;19(10). Epub 2018 Sep 25.

Departamento de Fisioloxía, Centro de Investigación en Medicina Molecular (CIMUS), Universidade de Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), 15782 Santiago de Compostela, Spain.

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September 2018

Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors.

Int J Mol Sci 2018 Aug 29;19(9). Epub 2018 Aug 29.

Department of Physiology/Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.

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August 2018

Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice.

Metabolism 2018 10 31;87:87-97. Epub 2018 Jul 31.

Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain; FiDiPro Program, Institute of Biomedicine, University of Turku, Turku, Finland. Electronic address:

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October 2018

Ghrelin and LEAP-2: Rivals in Energy Metabolism.

Trends Pharmacol Sci 2018 08 29;39(8):685-694. Epub 2018 Jun 29.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain. Electronic address:

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August 2018

Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake.

Genes (Basel) 2018 Jul 17;9(7). Epub 2018 Jul 17.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

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July 2018

mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol.

J Endocrinol 2018 09 18;238(3):177-186. Epub 2018 Jun 18.

Department of PhysiologyCiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain

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September 2018

Food Addiction and Binge Eating: Lessons Learned from Animal Models.

Nutrients 2018 Jan 11;10(1). Epub 2018 Jan 11.

Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 15786 Santiago de Compostela, Spain.

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January 2018

Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis.

Mol Metab 2018 02 15;8:132-143. Epub 2017 Dec 15.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain. Electronic address:

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February 2018

Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake.

Neuropharmacology 2018 03 2;130:62-70. Epub 2017 Dec 2.

Instituto de Salud Carlos III, CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Spain; Department of Physiology, CIMUS - University of Santiago de Compostela, Santiago de Compostela 15782 Spain; Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Spain.

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March 2018

GPR55 and the regulation of glucose homeostasis.

Int J Biochem Cell Biol 2017 07 27;88:204-207. Epub 2017 Apr 27.

Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain; Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. Electronic address:

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July 2017

Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.

Redox Biol 2017 08 15;12:854-863. Epub 2017 Apr 15.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain. Electronic address:

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August 2017

Rational design of polyarginine nanocapsules intended to help peptides overcoming intestinal barriers.

J Control Release 2017 Oct 21;263:4-17. Epub 2017 Feb 21.

Department of Pharmacy and Pharmaceutical Technology, CIMUS Research Institute, IDIS research Institute, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address:

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October 2017

GPR55: a new promising target for metabolism?

J Mol Endocrinol 2017 04 14;58(3):R191-R202. Epub 2017 Feb 14.

Instituto de Investigaciones Sanitarias (IDIS)CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.

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April 2017

Current Understanding of the Hypothalamic Ghrelin Pathways Inducing Appetite and Adiposity.

Trends Neurosci 2017 03 17;40(3):167-180. Epub 2017 Jan 17.

Department of Physiology, School of Medicine-CiMUS, Instituto de Investigación Sanitaria (IDIS), University of Santiago de Compostela, Av de Barcelona s/n Santiago de Compostela (A Coruña), 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain. Electronic address:

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March 2017

Thyroid hormones induce browning of white fat.

J Endocrinol 2017 02 2;232(2):351-362. Epub 2016 Dec 2.

Department of PhysiologyCIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain

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February 2017

Contribution of adaptive thermogenesis to the hypothalamic regulation of energy balance.

Biochem J 2016 Nov;473(22):4063-4082

Department of Physiology, School of Medicine-CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela (A Coruña) 15782, Spain.

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November 2016

The interaction of protamine nanocapsules with the intestinal epithelium: A mechanistic approach.

J Control Release 2016 12 6;243:109-120. Epub 2016 Oct 6.

Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, Belgium. Electronic address:

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December 2016

Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance.

Neuroendocrinology 2017 11;104(4):398-411. Epub 2016 Oct 11.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.

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May 2017

Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty.

Mol Metab 2016 Oct 11;5(10):844-857. Epub 2016 Aug 11.

Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain; Hospital Universitario Reina Sofia (HURS), 14004 Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Córdoba, Spain. Electronic address:

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October 2016

Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity.

Diabetes 2017 Jan 15;66(1):87-99. Epub 2016 Sep 15.

Department of Physiology, Centro Singular de Investigación en Medicina Molecular e Enfermidades Crónicas, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain

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January 2017

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance.

Cell Rep 2016 08 11;16(8):2231-2242. Epub 2016 Aug 11.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain. Electronic address:

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August 2016

Acute stimulation of brain mu opioid receptors inhibits glucose-stimulated insulin secretion via sympathetic innervation.

Neuropharmacology 2016 11 7;110(Pt A):322-332. Epub 2016 Aug 7.

Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain; Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. Electronic address:

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November 2016

Hypothalamus and thermogenesis: Heating the BAT, browning the WAT.

Mol Cell Endocrinol 2016 12 4;438:107-115. Epub 2016 Aug 4.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, 15706, Spain. Electronic address:

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December 2016

Antiobesity efficacy of GLP-1 receptor agonist liraglutide is associated with peripheral tissue-specific modulation of lipid metabolic regulators.

Biofactors 2016 Nov 23;42(6):600-611. Epub 2016 May 23.

UGC Salud Mental, Instituto De Investigación Biomédica De Málaga (IBIMA), Universidad De Málaga-Hospital Universitario Regional De Málaga, Avda. Carlos Haya 82, Pabellón De Gobierno, Málaga, Spain.

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November 2016

Hypothalamic AMPK: a canonical regulator of whole-body energy balance.

Nat Rev Endocrinol 2016 07 20;12(7):421-32. Epub 2016 May 20.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain.

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July 2016

Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice.

Endocrinology 2016 07 16;157(7):2735-49. Epub 2016 May 16.

Department of Physiology (O.A.-M., B.P., M.J.G.-R., M.G.-L., E.D.R., M.Q., A.S., C.V.A., M.L., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (O.A.-M., B.P., M.J.G.-R., M.Q., M.L., C.D., R.N.), Santiago de Compostela 15706, Spain; Department of Adipocyte Development and Nutrition (D.K., M.K., T.J.S.), German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, Germany; and German Center for Diabetes Research (T.J.S.), München-Neuherberg 85764, Germany.

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July 2016

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance.

Mol Metab 2016 Apr 10;5(4):271-282. Epub 2016 Feb 10.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain. Electronic address:

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April 2016

Glucagon-Like Peptide 1 Analogs and their Effects on Pancreatic Islets.

Trends Endocrinol Metab 2016 05 6;27(5):304-318. Epub 2016 Apr 6.

Instituto de Investigaciones Sanitarias (IDIS), CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain; Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. Electronic address:

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May 2016

Metformin: A Hopeful Promise in Aging Research.

Cold Spring Harb Perspect Med 2016 Mar 1;6(3):a025932. Epub 2016 Mar 1.

Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland 21224.

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March 2016

Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance.

Mol Metab 2015 Dec 22;4(12):961-70. Epub 2015 Oct 22.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706, Spain.

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December 2015

"Food Addiction" in Patients with Eating Disorders is Associated with Negative Urgency and Difficulties to Focus on Long-Term Goals.

Front Psychol 2016 2;7:61. Epub 2016 Feb 2.

Department of Psychiatry, University Hospital of Bellvitge-IDIBELLBarcelona, Spain; Ciber Fisiopatologia Obesidad y Nutrición, Instituto Salud Carlos IIIBarcelona, Spain; Department of Clinical Sciences, School of Medicine, University of BarcelonaBarcelona, Spain.

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February 2016

Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice.

Sci Rep 2015 Dec 10;5:17977. Epub 2015 Dec 10.

Department of Physiology/Research Center of Molecular Medicine and Chronic Diseases (CIMUS). University of Santiago de Compostela.

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December 2015

Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways.

Diabetes 2016 Feb 13;65(2):421-32. Epub 2015 Nov 13.

Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases, Universidade de Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain CIBER Fisiopatología de la Obesidad y Nutrición, Spain

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February 2016

The Adipokine Chemerin Induces Apoptosis in Cardiomyocytes.

Cell Physiol Biochem 2015 20;37(1):176-92. Epub 2015 Aug 20.

Cellular and Molecular Cardiology Research Unit and Department of Cardiology, Institute of Biomedical Research and University Clinical Hospital, Santiago de Compostela, Spain.

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May 2016

Orexins (hypocretins) and energy balance: More than feeding.

Mol Cell Endocrinol 2015 Dec 26;418 Pt 1:17-26. Epub 2015 Jul 26.

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) 15706, Spain. Electronic address:

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December 2015

Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women.

J Clin Endocrinol Metab 2015 Sep 14;100(9):E1188-96. Epub 2015 Jul 14.

Grupo Fisiopatología Endocrina (S.B.-F., C.F., L.M.S., C.C.), Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario, Departamento de Pediatría (S.B.-F.), Universitario de Santiago de Compostela, 15705 Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (S.B.-F., L.M.S., F.F.C., C.D., Z.A., R.B., C.B., R.d.l.T., J.C.F.-G., J.M.F.-R., G.F., J.G.-A., S.J.-M., F.J.T., F.F.-A., R.N.), Instituto Salud Carlos III, 28029 Madrid, Spain; Department of Physiology (C.F., C.D., R.N.), Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain; Department of Psychiatry (Z.A., S.J.-M., F.F.-A.), University Hospital of Bellvitge-Institut d"Investigació Biomèdica de Bellvitge, 08907 Barcelona, Spain; Department of Psychological, Personality, Evaluation, and Treatment (R.B.), University of Valencia, 46022 Valencia, Spain; Department of Basic Psychology, Clinic, and Psychobiology (C.B.), University Jaume I, 12071 Castelló, Spain; Human Pharmacology and Clinical Neurosciences Research Group (R.d.l.T.), Neuroscience Research Program, Hospital del Mar Medical Research Institute, Center for Genomic Regulation (X.E.), and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (X.E.), 08003 Barcelona, Spain; Department of Experimental and Health Sciences (R.d.l.T.), Universitat Pompeu Fabra Barcelona, 08950 Barcelona, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.C.F.-G., F.J.T.), Hospital Clínico Universitario Virgen de Victoria (IBIMA), 29010 Málaga, Spain; Department of Diabetes, Endocrinology, and Nutrition (J.M.F.-R.), Institut d'Investigació Biomèdica de Girona, Hospital Dr Josep Trueta, 17007 Girona, Spain; Department of Endocrinology and Nutrition (G.F., J.G.-A.), Clínica Universidad de Navarra, University of Navarra, Institut

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September 2015

Hypothalamic GLP-1: the control of BAT thermogenesis and browning of white fat.

Adipocyte 2015 Apr-Jun;4(2):141-5. Epub 2015 Jan 7.

Department of Physiology; CIMUS; University of Santiago de Compostela-Instituto de Investigación Sanitaria; and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) ; Santiago de Compostela, Spain.

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July 2015

Hypothalamic-autonomic control of energy homeostasis.

Endocrine 2015 Nov 19;50(2):276-91. Epub 2015 Jun 19.

NeurObesity Group, Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782, Santiago de Compostela, Spain.

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November 2015

24 h nesfatin-1 treatment promotes apoptosis in cardiomyocytes.

Endocrine 2016 Mar 5;51(3):551-5. Epub 2015 Jun 5.

Cellular and Molecular Cardiology Research Unit (7), Department of Cardiology, Institute of Biomedical Research (IDIS), Planta -2, Edificio de Consultas Externas, University of Santiago de Compostela Clinical Hospital, 15706, Santiago De Compostela, Spain.

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March 2016

What is the real relevance of endogenous ghrelin?

Peptides 2015 Aug 20;70:1-6. Epub 2015 May 20.

Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), University of Santiago de Compostela, Avda. Barcelona s/n, 15782 Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Santiago de Compostela (A Coruña) 15706, Spain. Electronic address:

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August 2015

Metabolic and Gonadotropic Impact of Sequential Obesogenic Insults in the Female: Influence of the Loss of Ovarian Secretion.

Endocrinology 2015 Aug 18;156(8):2984-98. Epub 2015 May 18.

Department of Cell Biology, Physiology, and Immunology (M.A.S.-G., F.R.-P., M.M.-L., S.L., V.H., J.M.C., J.P.C., R.M.L., M.J.V., J.R., A.R.-R., L.P., M.T.-S.), University of Córdoba, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, and Instituto Maimónides de Investigación Biomédica de Córdoba/Hospital Universitario Reina Sofía, 14004 Córdoba, Spain; and Department of Physiology (C.D.), University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.

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August 2015

Come to Where Insulin Resistance Is, Come to AMPK Country.

Cell Metab 2015 May;21(5):663-5

Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15706, Spain. Electronic address:

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May 2015

Regulation of NUCB2/nesfatin-1 production in rat's stomach and adipose tissue is dependent on age, testosterone levels and lactating status.

Mol Cell Endocrinol 2015 Aug 23;411:105-12. Epub 2015 Apr 23.

Grupo Fisiopatología Endocrina, Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS).; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain. Electronic address:

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August 2015

Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin.

PLoS One 2015 17;10(3):e0121087. Epub 2015 Mar 17.

Department of Medicine, Faculty of Health Sciences, University of A Coruña, A Coruña, Spain; Instituto de Investigación Biomedica (INIBIC), University Hospital A Coruña, A Coruña, Spain; Department of Endocrinology, University Hospital A Coruña, A Coruña, Spain.

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February 2016

Leptin, 20 years of searching for glucose homeostasis.

Life Sci 2015 Nov 2;140:4-9. Epub 2015 Mar 2.

Department of Physiology, CIMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 15706, Spain. Electronic address:

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November 2015