Carlos A Zarate

Carlos A Zarate

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Carlos A Zarate

Carlos A Zarate

Publications by authors named "Carlos A Zarate"

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Ketamine-Induced Glutamatergic Mechanisms of Sleep and Wakefulness: Insights for Developing Novel Treatments for Disturbed Sleep and Mood.

Handb Exp Pharmacol 2019 ;253:337-358

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institute of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/164_2017_51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866161PMC
September 2019

Multimodal imaging reveals a complex pattern of dysfunction in corticolimbic pathways in major depressive disorder.

Hum Brain Mapp 2019 Sep 9;40(13):3940-3950. Epub 2019 Jun 9.

Section on the Neurobiology and Treatment of Mood Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/hbm.24679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677619PMC
September 2019

The influence of ketamine on drug discovery in depression.

Drug Discov Today 2019 Aug 2. Epub 2019 Aug 2.

Section on the Neurobiology and Treatment of Mood Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S13596446193028
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http://dx.doi.org/10.1016/j.drudis.2019.07.007DOI Listing
August 2019

Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects.

Mol Psychiatry 2019 Jul 27;24(7):1040-1052. Epub 2018 Feb 27.

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41380-018-0028-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111001PMC
July 2019

Effects of Ketamine on Brain Activity During Emotional Processing: Differential Findings in Depressed Versus Healthy Control Participants.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 07 25;4(7):610-618. Epub 2019 Jan 25.

Section on Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.bpsc.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612456PMC
July 2019

Glutamatergic Modulators in Depression.

Harv Rev Psychiatry 2018 Nov/Dec;26(6):307-319

From the Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1097/HRP.0000000000000183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102095PMC
June 2019

Impact of midazolam vs. saline on effect size estimates in controlled trials of ketamine as a rapid-acting antidepressant.

Neuropsychopharmacology 2019 06 17;44(7):1233-1238. Epub 2019 Jan 17.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41386-019-0317-8DOI Listing
June 2019

Depression in the Primary Care Setting. Reply.

N Engl J Med 2019 06;380(23):2279-2280

National Institute of Mental Health, Bethesda, MD

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http://dx.doi.org/10.1056/NEJMc1903259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736516PMC
June 2019

Correction to: Mapping anticipatory anhedonia: an fMRI study.

Brain Imaging Behav 2019 Jun 6. Epub 2019 Jun 6.

Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://link.springer.com/10.1007/s11682-019-00131-6
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http://dx.doi.org/10.1007/s11682-019-00131-6DOI Listing
June 2019

Prognosis and improved outcomes in major depression: a review.

Transl Psychiatry 2019 04 3;9(1):127. Epub 2019 Apr 3.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1038/s41398-019-0460-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447556PMC
April 2019

Mapping anticipatory anhedonia: an fMRI study.

Brain Imaging Behav 2019 Apr 27. Epub 2019 Apr 27.

Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s11682-019-00084-wDOI Listing
April 2019

()-hydroxynorketamine exerts mGlu receptor-dependent antidepressant actions.

Proc Natl Acad Sci U S A 2019 03 13;116(13):6441-6450. Epub 2019 Mar 13.

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201;

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http://dx.doi.org/10.1073/pnas.1819540116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442605PMC
March 2019

Prognosis and improved outcomes in major depression: a review.

Transl Psychiatry 2019 04 3;9(1):127. Epub 2019 Apr 3.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1038/s41398-019-0460-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447556PMC
April 2019

Disentangling the association of depression on the anti-fatigue effects of ketamine.

J Affect Disord 2019 02 6;244:42-45. Epub 2018 Oct 6.

Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183161
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http://dx.doi.org/10.1016/j.jad.2018.10.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226316PMC
February 2019

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ( 2R,6R)-hydroxynorketamine.

J Psychopharmacol 2018 Nov 29:269881118812095. Epub 2018 Nov 29.

1 Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1177/0269881118812095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541551PMC
November 2018

Depression in the Primary Care Setting.

N Engl J Med 2019 02;380(6):559-568

From the Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1056/NEJMcp1712493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727965PMC
February 2019

Ketamine normalizes brain activity during emotionally valenced attentional processing in depression.

Neuroimage Clin 2018 5;20:92-101. Epub 2018 Jul 5.

Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2018.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070691PMC
January 2019

Neurophysiological Changes Associated with Antidepressant Response to Ketamine Not Observed in a Negative Trial of Scopolamine in Major Depressive Disorder.

Int J Neuropsychopharmacol 2019 01;22(1):10-18

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1093/ijnp/pyy051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313153PMC
January 2019

Disentangling the association of depression on the anti-fatigue effects of ketamine.

J Affect Disord 2019 02 6;244:42-45. Epub 2018 Oct 6.

Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183161
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http://dx.doi.org/10.1016/j.jad.2018.10.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226316PMC
February 2019

Synaptic potentiation and rapid antidepressant response to ketamine in treatment-resistant major depression: A replication study.

Psychiatry Res Neuroimaging 2019 01 12;283:64-66. Epub 2018 Sep 12.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1016/j.pscychresns.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410365PMC
January 2019

Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects.

Psychopharmacology (Berl) 2018 Oct 16;235(10):3017-3030. Epub 2018 Aug 16.

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00213-018-4992-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193489PMC
October 2018

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ( 2R,6R)-hydroxynorketamine.

J Psychopharmacol 2018 Nov 29:269881118812095. Epub 2018 Nov 29.

1 Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1177/0269881118812095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541551PMC
November 2018

Default Mode Connectivity in Major Depressive Disorder Measured Up to 10 Days After Ketamine Administration.

Biol Psychiatry 2018 10 15;84(8):582-590. Epub 2018 Feb 15.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

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https://linkinghub.elsevier.com/retrieve/pii/S00063223183008
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http://dx.doi.org/10.1016/j.biopsych.2018.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093808PMC
October 2018

Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects.

Psychopharmacology (Berl) 2018 Oct 16;235(10):3017-3030. Epub 2018 Aug 16.

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00213-018-4992-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193489PMC
October 2018

Are 24-hour motor activity patterns associated with continued rapid response to ketamine?

Neuropsychiatr Dis Treat 2018 16;14:2739-2748. Epub 2018 Oct 16.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA,

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https://www.dovepress.com/are-24-hour-motor-activity-pattern
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http://dx.doi.org/10.2147/NDT.S172089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200084PMC
October 2018

7T H-MRS in major depressive disorder: a Ketamine Treatment Study.

Neuropsychopharmacology 2018 08 5;43(9):1908-1914. Epub 2018 Apr 5.

Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41386-018-0057-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046051PMC
August 2018

7T H-MRS in major depressive disorder: a Ketamine Treatment Study.

Neuropsychopharmacology 2018 08 5;43(9):1908-1914. Epub 2018 Apr 5.

Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41386-018-0057-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046051PMC
August 2018

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.

Pharmacol Rev 2018 07;70(3):621-660

Departments of Psychiatry (P.Z., L.M.R., J.N.H., P.G., T.D.G.), Pharmacology (E.F.R.P., E.X.A., T.D.G.), Anatomy and Neurobiology (T.D.G.), Epidemiology and Public Health, Division of Translational Toxicology (E.F.R.P., E.X.A.), Medicine (E.X.A.), and Program in Neuroscience (L.M.R.) and Toxicology (J.N.H.), University of Maryland School of Medicine, Baltimore, Maryland; Biomedical Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland (R.M.); Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Intramural Research Program, National Institutes of Health, Rockville, Maryland (P.J.M., C.J.T.); and Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)

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http://dx.doi.org/10.1124/pr.117.015198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020109PMC
July 2018

Features of dissociation differentially predict antidepressant response to ketamine in treatment-resistant depression.

J Affect Disord 2018 May 17;232:310-315. Epub 2018 Feb 17.

National Institutes of Health, National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, Building 10/CRC, 10 Center Dr., Unit 7 Southeast, Room 7-5342, Bethesda, MD 20892, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01650327173247
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http://dx.doi.org/10.1016/j.jad.2018.02.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858990PMC
May 2018

daTALbase: A Database for Genomic and Transcriptomic Data Related to TAL Effectors.

Mol Plant Microbe Interact 2018 04 14;31(4):471-480. Epub 2018 Feb 14.

1 IRD, Cirad, Université Montpellier, IPME, Montpellier (34000), France.

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https://apsjournals.apsnet.org/doi/10.1094/MPMI-06-17-0153-F
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http://dx.doi.org/10.1094/MPMI-06-17-0153-FIDOI Listing
April 2018

Parsing the heterogeneity of depression: An exploratory factor analysis across commonly used depression rating scales.

J Affect Disord 2018 04 5;231:51-57. Epub 2018 Feb 5.

Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.jad.2018.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852677PMC
April 2018

Glutamatergic Signaling Drives Ketamine-Mediated Response in Depression: Evidence from Dynamic Causal Modeling.

Int J Neuropsychopharmacol 2018 Apr 13. Epub 2018 Apr 13.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1093/ijnp/pyy041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070027PMC
April 2018

Using Neuroimaging to Decipher the Mechanism of Action of Ketamine: A Pathway to Novel Therapeutics?

Biol Psychiatry Cogn Neurosci Neuroimaging 2017 10 5;2(7):549-551. Epub 2017 Oct 5.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

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https://linkinghub.elsevier.com/retrieve/pii/S24519022173014
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http://dx.doi.org/10.1016/j.bpsc.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251409PMC
October 2017

What Should be Done When Elderly Patients with Major Depression Have Failed to Respond to All Treatments?

Authors:
Carlos A Zarate

Am J Geriatr Psychiatry 2017 11 30;25(11):1210-1212. Epub 2017 Aug 30.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2017.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654661PMC
November 2017

Using Neuroimaging to Decipher the Mechanism of Action of Ketamine: A Pathway to Novel Therapeutics?

Biol Psychiatry Cogn Neurosci Neuroimaging 2017 10 5;2(7):549-551. Epub 2017 Oct 5.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

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https://linkinghub.elsevier.com/retrieve/pii/S24519022173014
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http://dx.doi.org/10.1016/j.bpsc.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251409PMC
October 2017

Ketamine and Psychosis History: Antidepressant Efficacy and Psychotomimetic Effects Postinfusion.

Biol Psychiatry 2017 09 22;82(5):e35-e36. Epub 2017 Jan 22.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.08.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859935PMC
September 2017

Motor-Activity Markers of Circadian Timekeeping Are Related to Ketamine's Rapid Antidepressant Properties.

Biol Psychiatry 2017 09 28;82(5):361-369. Epub 2017 Mar 28.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.biopsych.2017.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546993PMC
September 2017

Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites.

Org Lett 2017 09 22;19(17):4572-4575. Epub 2017 Aug 22.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health , Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/acs.orglett.7b02177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641405PMC
September 2017

A Double-Blind, Placebo-Controlled, Pilot Study of Riluzole Monotherapy for Acute Bipolar Depression.

J Clin Psychopharmacol 2017 Jun;37(3):355-358

From the Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1097/JCP.0000000000000693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392145PMC
June 2017

New targets for rapid antidepressant action.

Prog Neurobiol 2017 05 23;152:21-37. Epub 2015 Dec 23.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.pneurobio.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919246PMC
May 2017

Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine.

Biol Psychiatry 2017 05 12;81(10):886-897. Epub 2016 May 12.

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.biopsych.2016.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107161PMC
May 2017

Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine.

Biol Psychiatry 2017 04 30;81(8):e69-e71. Epub 2016 Sep 30.

Department of Psychiatry, National Institute on Aging, National Institutes of Health, Baltimore; Department of Division of Translational Toxicology, Pharmacology, National Institute on Aging, National Institutes of Health, Baltimore; Department of Anatomy and Neurobiology, National Institute on Aging, National Institutes of Health, Baltimore. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.08.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359040PMC
April 2017

Genetic Studies on the Tripartite Glutamate Synapse in the Pathophysiology and Therapeutics of Mood Disorders.

Neuropsychopharmacology 2017 Mar 11;42(4):787-800. Epub 2016 Aug 11.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/npp.2016.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312057PMC
March 2017

Case series: Antidepressant effects of low-affinity and low-trapping NMDA receptor antagonists did not predict response to ketamine in seven subjects.

J Psychiatr Res 2017 03 22;86:55-57. Epub 2016 Nov 22.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2016.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272869PMC
March 2017

Ketamine and Beyond: Investigations into the Potential of Glutamatergic Agents to Treat Depression.

Drugs 2017 Mar;77(4):381-401

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10/CRC, Room 7-5545, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s40265-017-0702-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342919PMC
March 2017

Deriving frequency-dependent spatial patterns in MEG-derived resting state sensorimotor network: A novel multiband ICA technique.

Hum Brain Mapp 2017 02 22;38(2):779-791. Epub 2016 Oct 22.

Magnetoencephalography Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/hbm.23417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224967PMC
February 2017

Mood Therapeutics: Novel Pharmacological Approaches for Treating Depression.

Expert Rev Clin Pharmacol 2017 Feb 16;10(2):153-166. Epub 2017 Jan 16.

a Experimental Therapeutics and Pathophysiology Branch , NIMH-NIH , Bethesda , Maryland , USA.

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http://dx.doi.org/10.1080/17512433.2017.1253472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552063PMC
February 2017

Increased Brain Lactate During Depressive Episodes and Reversal Effects by Lithium Monotherapy in Drug-Naive Bipolar Disorder: A 3-T 1H-MRS Study.

J Clin Psychopharmacol 2017 Feb;37(1):40-45

From the *Laboratory of Neuroscience (LIM-27), Institute and Department of Psychiatry, University of São Paulo; †Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo, São Paulo, Brazil; ‡Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, NIH, Bethesda, MD; and §Laboratory of Magnetic Resonance in Neuroradiology (LIM-44), Institute and Department of Radiology, University of São Paulo, São Paulo; ‖Department of Clinical Medicine and Translational Psychiatry Research Group Faculty of Medicine, Federal University of Ceara, Fortaleza; and ¶Laboratory of Psychiatric Neuroimaging (LIM-21), Institute and Department of Psychiatry, University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1097/JCP.0000000000000616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182117PMC
February 2017

Increased Activity or Energy as a Primary Criterion for the Diagnosis of Bipolar Mania in DSM-5: Findings From the STEP-BD Study.

Am J Psychiatry 2017 Jan 13;174(1):70-76. Epub 2016 Aug 13.

From the Section on the Neurobiology and Treatment of Mood Disorders, NIMH, Bethesda, Md.; the Department of Psychiatry and Behavioral Sciences, Health Sciences Center, University of New Mexico, Albuquerque; VA Palo Alto Health Care System and the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, Calif.

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http://dx.doi.org/10.1176/appi.ajp.2016.15091132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5205570PMC
January 2017

Change in cytokine levels is not associated with rapid antidepressant response to ketamine in treatment-resistant depression.

J Psychiatr Res 2017 01 30;84:113-118. Epub 2016 Sep 30.

Experimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, NIH, 10 Center Drive, Room 7-5432, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2016.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125870PMC
January 2017

Functional connectivity during masked and unmasked face emotion processing in bipolar disorder.

Psychiatry Res Neuroimaging 2016 Dec 24;258:1-9. Epub 2016 Oct 24.

Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.pscychresns.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135603PMC
December 2016

Symptomatology and predictors of antidepressant efficacy in extended responders to a single ketamine infusion.

J Affect Disord 2017 Jan 26;208:560-566. Epub 2016 Oct 26.

National Institutes of Health, National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, Building 10/CRC, 10 Center Dr., Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2016.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154889PMC
January 2017

Ketamine Mechanism of Action: Separating the Wheat from the Chaff.

Neuropsychopharmacology 2017 01;42(1):368-369

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA E-mail:

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http://dx.doi.org/10.1038/npp.2016.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143504PMC
January 2017

Functional connectivity during masked and unmasked face emotion processing in bipolar disorder.

Psychiatry Res Neuroimaging 2016 Dec 24;258:1-9. Epub 2016 Oct 24.

Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.pscychresns.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135603PMC
December 2016

GSK-3: A key regulatory target for ketamine's rapid antidepressant effects mediated by enhanced AMPA to NMDA throughput.

Bipolar Disord 2016 12 29;18(8):702-705. Epub 2016 Nov 29.

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/bdi.12452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222739PMC
December 2016

Familial aggregation and heritability of the melancholic and atypical subtypes of depression.

J Affect Disord 2016 Nov 14;204:241-6. Epub 2016 Jun 14.

Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2016.06.040DOI Listing
November 2016

Recognition of emotional facial expressions in anxious and nonanxious depression.

Compr Psychiatry 2016 10 14;70:1-8. Epub 2016 Jun 14.

Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1016/j.comppsych.2016.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023953PMC
October 2016

Underrepresented Minorities in Science: ACNP Strives to Increase Minority Representation and Inclusion.

Neuropsychopharmacology 2016 09;41(10):2421-3

Experimental Therapeutics & Pathophysiology Branch & Section of Neurobiology and Treatment of Mood Disorders, Division of Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/npp.2016.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987859PMC
September 2016

Preliminary differences in resting state MEG functional connectivity pre- and post-ketamine in major depressive disorder.

Psychiatry Res Neuroimaging 2016 Aug 23;254:56-66. Epub 2016 Jun 23.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.pscychresns.2016.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992587PMC
August 2016

Amygdala response to explicit sad face stimuli at baseline predicts antidepressant treatment response to scopolamine in major depressive disorder.

Psychiatry Res Neuroimaging 2016 Aug 20;254:67-73. Epub 2016 Jun 20.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA; Neuroscience Biomarkers Division, Janssen Research and Development, San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.pscychresns.2016.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711385PMC
August 2016

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Biol Psychiatry 2016 07;80(2):84-86

Department of Psychiatry, University Neuropsychiatric Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.biopsych.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150945PMC
July 2016

The McLean-Harvard First-Episode Project: Early Course in 114 Cases of First-Episode Nonaffective Psychoses.

J Clin Psychiatry 2016 06;77(6):781-8

International Consortium for Bipolar & Psychotic Disorders Research, McLean Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.4088/JCP.14m09414DOI Listing
June 2016

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Biol Psychiatry 2016 07;80(2):84-86

Department of Psychiatry, University Neuropsychiatric Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.biopsych.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150945PMC
July 2016

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Biol Psychiatry 2016 07;80(2):84-86

Department of Psychiatry, University Neuropsychiatric Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.biopsych.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150945PMC
July 2016

Safety of research into severe and treatment-resistant mood disorders: analysis of outcome data from 12 years of clinical trials at the US National Institute of Mental Health.

Lancet Psychiatry 2016 May 10;3(5):436-42. Epub 2016 Mar 10.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/S2215-0366(16)00006-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860062PMC
May 2016

An assessment of the anti-fatigue effects of ketamine from a double-blind, placebo-controlled, crossover study in bipolar disorder.

J Affect Disord 2016 Apr 19;194:115-9. Epub 2016 Jan 19.

Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, 10 Center Drive, Rm 4N222, MSC 1381 Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769920PMC
April 2016

Lithium and Valproate Levels Do Not Correlate with Ketamine's Antidepressant Efficacy in Treatment-Resistant Bipolar Depression.

Neural Plast 2015 7;2015:858251. Epub 2015 Jun 7.

National Institute of Mental Health, National Institutes of Health, Experimental Therapeutics and Pathophysiology Branch, 10 Center Drive, Building 10/CRC, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1155/2015/858251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475570PMC
March 2016

A randomized, placebo-controlled pilot trial of the delta opioid receptor agonist AZD2327 in anxious depression.

Psychopharmacology (Berl) 2016 Mar 4;233(6):1119-30. Epub 2016 Jan 4.

Experimental Therapeutics and Pathophysiology Branch, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, 10 Center Drive CRC, Room 7-5545, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00213-015-4195-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103283PMC
March 2016

Novel Glutamatergic Treatments for Severe Mood Disorders.

Curr Behav Neurosci Rep 2015 Dec 9;2(4):198-208. Epub 2015 Oct 9.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD U.S.A., 20892.

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http://dx.doi.org/10.1007/s40473-015-0050-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725605PMC
December 2015

Development of a clinician-administered National Institutes of Health-Brief Fatigue Inventory: A measure of fatigue in the context of depressive disorders.

J Psychiatr Res 2015 Sep 24;68:99-105. Epub 2015 Jun 24.

Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2015.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522041PMC
September 2015

The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition.

J Pharmacol Exp Ther 2015 Oct 11;355(1):76-85. Epub 2015 Aug 11.

Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)

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http://jpet.aspetjournals.org/content/355/1/76.full.pdf
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.115.22566
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http://dx.doi.org/10.1124/jpet.115.225664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576668PMC
October 2015

Ketamine for depression: evidence, challenges and promise.

World Psychiatry 2015 Oct;14(3):348-50

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1002/wps.20269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592658PMC
October 2015

Group differences in MEG-ICA derived resting state networks: Application to major depressive disorder.

Neuroimage 2015 Sep 30;118:1-12. Epub 2015 May 30.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2015.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555091PMC
September 2015

Development of a clinician-administered National Institutes of Health-Brief Fatigue Inventory: A measure of fatigue in the context of depressive disorders.

J Psychiatr Res 2015 Sep 24;68:99-105. Epub 2015 Jun 24.

Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00223956150018
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http://dx.doi.org/10.1016/j.jpsychires.2015.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522041PMC
September 2015

Development of a clinician-administered National Institutes of Health-Brief Fatigue Inventory: A measure of fatigue in the context of depressive disorders.

J Psychiatr Res 2015 Sep 24;68:99-105. Epub 2015 Jun 24.

Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00223956150018
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http://dx.doi.org/10.1016/j.jpsychires.2015.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522041PMC
September 2015

Development of a clinician-administered National Institutes of Health-Brief Fatigue Inventory: A measure of fatigue in the context of depressive disorders.

J Psychiatr Res 2015 Sep 24;68:99-105. Epub 2015 Jun 24.

Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00223956150018
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http://dx.doi.org/10.1016/j.jpsychires.2015.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522041PMC
September 2015

Regulation of leukocyte tricarboxylic acid cycle in drug-naïve Bipolar Disorder.

Neurosci Lett 2015 Sep 20;605:65-8. Epub 2015 Aug 20.

Laboratory of Neuroscience, LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Brazil; Laboratory of Psychiatric Neuroimaging, LIM-21, Department and Institute of Psychiatry, University of Sao Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116385PMC
September 2015

Potential Pathways Involved in the Rapid Antidepressant Effects of Nitrous Oxide.

Biol Psychiatry 2015 Jul;78(1):2-4

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Intramural Research Program, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.biopsych.2015.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116381PMC
July 2015

Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review.

Ther Adv Chronic Dis 2015 May;6(3):97-114

National Institutes of Health/National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, 10 Center Dr., Building 10/CRC, Room 7-5545, Bethesda, MD 20892, USA.

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http://journals.sagepub.com/doi/10.1177/2040622315579059
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http://dx.doi.org/10.1177/2040622315579059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416968PMC
May 2015

Pretreatment Differences in BOLD Response to Emotional Faces Correlate with Antidepressant Response to Scopolamine.

Int J Neuropsychopharmacol 2015 Mar 28;18(8). Epub 2015 Mar 28.

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute on Mental Health, National Institutes of Health, Bethesda, MD (Dr Furey, Ms Szczepanik, Dr Nugent, and Dr Zarate); Janssen Pharmaceuticals, LLC, of Johnson & Johnson, Inc., Titusville, NJ (Dr Drevets); Physical Medicine & Rehabilitation, Jewish Medical Center, Brooklyn Hospital Center, Brooklyn, NY (Dr Khanna).Registry number NCT00055575.

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http://dx.doi.org/10.1093/ijnp/pyv028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571629PMC
March 2015