Carlos A Osorio-Martínez, PHD - UNIVERSIDAD SANTO TOMAS -  University Professor

Carlos A Osorio-Martínez

PHD

UNIVERSIDAD SANTO TOMAS

University Professor

BUCARAMANGA, SANTANDER | Colombia

Main Specialties: Chemistry

Additional Specialties: ORGANIC CHEMISTRY

ORCID logohttps://orcid.org/0000-0002-7630-8867


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Carlos A Osorio-Martínez, PHD - UNIVERSIDAD SANTO TOMAS -  University Professor

Carlos A Osorio-Martínez

PHD

Introduction

A detail-oriented organic chemist with approximately 8 years of experience in synthetic organic / organometallic chemistry. Team player with strong communication skills. Ability to establish a safe and healthy work environment.

Primary Affiliation: UNIVERSIDAD SANTO TOMAS - BUCARAMANGA, SANTANDER , Colombia

Specialties:

Additional Specialties:

Research Interests:


View Carlos A Osorio-Martínez’s Resume / CV

Education

Mar 2013
University of Guanajuato
PhD in Chemistry (Laureate Honors )
Thesis: Two applications of cross couplings catalyzed by transition metals: a) Synthesis of fluorescent macromolecules and b) Use of intermediates with orthogonal reactivity. Supervisors: Professor Eduardo Peña Cabrera (University of Guanajuato - Mexico)
Jul 2008
University of Alcala
Master
Thesis: Synthesis and characterization of dendrimers of carbosilane structure via "click chemistry". Supervisors: Professor Rafael Gómez Ramírez
Aug 2007
University of Guadalajara
Master´s Degree Forest Products Science
Thesis: Isolation and Characterization of Xylan of olote for application in the modification of cellulose fibers. Supervisors: Professor . Felipe de Jesús Ramírez Cano (University of Guadalajara- Mexico)
Apr 2003
Industrial University of Santande
Bachelor of Science- Chemistry

Experience

Aug 2018
Universidad del Atlantico - University Professor
Professor
Teaching applied organic chemistry, synthetic organic, organometallic chemistry
Jul 2016
Universidad de la Costa- University Professor
Professor
Teaching, research and extension processes in Chemistry areas for the careers of the University Engineering Faculties
Feb 2014
The National Agency for Research and Innovation (ANII)- University of the Republic (UdelaR)
Postdoctoral Researcher
Retrosynthetic analysis, synthesis, and spectroscopic characterization (NMR, IR, fluorescence, UV, GC-MS) fluorescent compounds for medical and pharmaceutical applications

Publications

5Publications

62Reads

152Profile Views

• Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent

RSC Adv., 2017,7, 7983-7989

RSC Advances

The potential use of amide-containing thiazoles, especially (2E,2Z)-3-allyl-4-[((E)-4-cinnamylpiperazin-1-yl)carbonyl]-2-[2-((E)-3-(furan-2-yl)propenylidene)hydrazono]-2,3-dihydrothiazole (1), as drugs for the treatment of Chagas disease has been recently described. The therapeutic application of 1 requires further pre-clinical studies, including in vivo biodistribution. In this sense, a BODIPY-fluorophore based probe for this drug (1-BODIPY) was developed and investigated for its potential as an in vivo tracer. The fluorescent tracer was synthesized, physicochemically and in vitro biologically characterised, and its in vivo biodistribution evaluated. The in vitro studies demonstrated that the fluorescent probe could simulate the in vivo behaviour of compound 1. Furthermore, the in vivo proof of concept showed that the 1-BODIPY biodistribution involves organs that are associated with the parasitic disease. These findings allow us to establish future administration routes and regimens in the treatment of Chagas disease with 1.

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January 2017

Reaction of amines with 8-methylthioBODIPY: dramatic optical and laser response to amine substitution.

Chem Asian J 2013 Nov 16;8(11):2691-700. Epub 2013 Aug 16.

Departamento de Química Física, Universidad del País Vasco (UPV/EHU) aptdo. 644, 48080 Bilbao (Spain).

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http://dx.doi.org/10.1002/asia.201300760DOI Listing
November 2013
14 Reads

8-Alkoxy- and 8-aryloxy-BODIPYs: straightforward fluorescent tagging of alcohols and phenols.

J Org Chem 2013 Jun 11;78(12):5867-77. Epub 2013 Jun 11.

Departamento de Quı́mica, Universidad de Guanajuato, Col. Noria Alta S/N, Guanajuato, Gto. 36050, Mexico.

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http://dx.doi.org/10.1021/jo400417hDOI Listing
June 2013
7 Reads
4.721 Impact Factor

8-AminoBODIPYs: cyanines or hemicyanines? The effect of the coplanarity of the amino group on their optical properties.

J Org Chem 2012 Jun 23;77(12):5434-8. Epub 2012 May 23.

Departamento de Química, Universidad de Guanajuato, Col. Noria Alta S/N, Guanajuato, GTO, 36050, Mexico.

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http://dx.doi.org/10.1021/jo300724mDOI Listing
June 2012
9 Reads
4.721 Impact Factor