Publications by authors named "Carla Arnau Del Valle"

4 Publications

  • Page 1 of 1

Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose Bengal.

Front Med (Lausanne) 2021 24;8:641646. Epub 2021 May 24.

Departamento de Química Inorgánica y Orgánica, Universitat Jaume I, Castellón, Spain.

New strategies to fight bacteria and fungi are necessary in view of the problem of iatrogenic and nosocomial infections combined with the growing threat of increased antimicrobial resistance. Recently, our group has prepared and described two new readily available materials based on the combination of Rose Bengal (singlet oxygen photosensitizer) and commercially available cationic polystyrene (macroporous resin Amberlite® IRA 900 or gel-type resin IRA 400). These materials showed high efficacy in the antimicrobial photodynamic inactivation (aPDI) of . Here, we present the photobactericidal effect of these polymers against an extended group of pathogens like , and the opportunistic yeast using green light. The most interesting finding is that the studied materials are able to reduce the population of both Gram-positive and Gram-negative bacteria with good activity, although, for , in a moderate manner. In view of the results achieved and especially considering the inexpensiveness of these two types of photoactive polymers, we believe that they could be used as the starting point for the development of coatings for self-disinfecting surfaces.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2021.641646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180575PMC
May 2021

A cost-effective combination of Rose Bengal and off-the-shelf cationic polystyrene for the photodynamic inactivation of Pseudomonas aeruginosa.

Mater Sci Eng C Mater Biol Appl 2020 Dec 24;117:111302. Epub 2020 Jul 24.

Universitat Jaume I, Departamento de Química Inorgánica y Orgánica, Avda. Sos Baynat s/n, 12071 Castellón, Spain. Electronic address:

Two new photoactive materials have been prepared, characterized and tested against Pseudomonas aeruginosa bacteria (planktonic suspension). The synthesis of the polymeric photosensitizers can be made at a multigram scale, in few minutes, starting from inexpensive and readily available materials, such as Rose Bengal (photosensitizer) and ion exchange resins Amberlite® IRA 900 (macroporous) or IRA 400 (gel-type) as cationic polystyrene supports. The most notable feature of these systems is their notable bactericidal activity in the dark (4-5 log CFU/mL reduction of the population of P. aeruginosa) which becomes enhanced upon irradiation with visible light (to reach a total reduction of 8 log CFU/mL for the macroporous polymer at a fluence of 120 J/cm using green light of 515 nm).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2020.111302DOI Listing
December 2020

Photoactive Hexanuclear Molybdenum Nanoclusters Embedded in Molecular Organogels.

Inorg Chem 2019 Jul 5;58(14):8900-8905. Epub 2019 Jul 5.

Departamento de Química Inorgánica y Orgánica , Universitat Jaume I , Avenida Sos Baynat s/n , Castellón 12071 , Spain.

Hexanuclear molybdenum clusters are attractive species because of their outstanding photonic properties, and in the past they have been attached to a variety of supports such as organic polymers and inorganic nanoparticles, as described in the recent literature. Here, a cluster of the formula TBA[MoIAc] (TBA = tetrabutylammonium; Ac = acetate) has been supported on molecular organogels for the first time, resulting in a new soft material with remarkable photoactivity. Electron and confocal microscopic analyses showed the alignment of the nanoclusters to 1D self-assembled fibers formed by the organic gelator, and emission spectroscopy corroborated the interaction of the emissive clusters with such fibrillary structures. The new hybrid system is a deep-red emissive material (phosphorescence maximum at ca. 680 nm), with chromatic coordinates = 0.725 and = 0.274, capable of efficiently generating singlet oxygen (O) upon illumination with white light, as demonstrated by the photooxygenation of 9,10-dimethylanthracene and 1,5-dihydroxynaphthalene. The organogels can been made in dichloromethane and toluene and in both solvents display phosphorescence emission and photocatalytic properties.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.inorgchem.9b00916DOI Listing
July 2019

Superior performance of macroporous over gel type polystyrene as a support for the development of photo-bactericidal materials.

J Mater Chem B 2017 Aug 20;5(30):6058-6064. Epub 2017 Jul 20.

Universitat Jaume I, Departamento de Química Inorgánica y Orgánica, Avda. Sos Baynat s/n, 12071, Castellón, Spain.

A hexanuclear molybdenum cluster [MoIAc] (1) has been ionically bound onto macroporous (P) and gel-type (P) resins and their performance as materials for the photodynamic inactivation of microorganisms has been studied. It has been found that [email protected] in combination with light is able to reduce 99.999999% of the population of Gram-positive Staphylococcus aureus whereas the activity of [email protected] is limited to a 99.99% reduction at the same light dose. The same trend is observed with Gram-negative Pseudomonas aeruginosa. A comprehensive study of both materials has been performed using confocal laser scanning microscopy, thermogravimetric analysis, nitrogen porosimetry, steady state and time resolved fluorometries and diffuse reflectance spectroscopy. The photochemical generation of singlet oxygen (O) has been assessed using 9,10-dimethylanthracene as a trap for this reactive oxygen species. It can be concluded that the nature of the polymeric support is of paramount importance for the development of surfaces with bactericidal properties.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c7tb01478cDOI Listing
August 2017
-->