Carl W Cotman

Carl W Cotman

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Carl W Cotman

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Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity.

Learn Mem 2019 Dec 15;26(12):485-492. Epub 2019 Nov 15.

Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92617, USA.

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http://dx.doi.org/10.1101/lm.050278.119DOI Listing
December 2019

What are the earlier life contributions to reserve and resilience?

Neurobiol Aging 2019 Nov 30;83:135-139. Epub 2019 Apr 30.

Institute for Brain Aging and Dementia, University of California, Irvine, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.04.014DOI Listing
November 2019

Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline.

Neurobiol Aging 2019 06 20;78:142-154. Epub 2019 Feb 20.

Institute for Memory Impairments and Neurological Disorders, University of California-Irvine, Irvine, CA, USA; Department of Neurology, University of California-Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.012DOI Listing
June 2019

Inhibition of LTP-Induced Translation by IL-1β Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites.

ACS Chem Neurosci 2019 03 4;10(3):1197-1203. Epub 2019 Feb 4.

Institute for Memory Impairments and Neurological Disorders , University of California, Irvine , Irvine , California 92697 , United States.

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http://dx.doi.org/10.1021/acschemneuro.8b00511DOI Listing
March 2019

TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse.

Neurochem Res 2019 Jan 4;44(1):49-60. Epub 2018 Apr 4.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1007/s11064-018-2517-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170724PMC
January 2019

Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines.

Brain Pathol 2018 05;28(3):427-430

Department of Neurology, University of Bonn, 53127 Bonn, Germany.

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http://doi.wiley.com/10.1111/bpa.12573
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http://dx.doi.org/10.1111/bpa.12573DOI Listing
May 2018

IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation.

J Neuroinflammation 2018 Apr 30;15(1):127. Epub 2018 Apr 30.

Institute for Memory Impairments and Neurological Disorders, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1186/s12974-018-1158-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925843PMC
April 2018

On the road towards the global analysis of human synapses.

Neural Regen Res 2017 Oct;12(10):1586-1589

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.

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http://dx.doi.org/10.4103/1673-5374.217321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696829PMC
October 2017

Cytokines and cytokine networks target neurons to modulate long-term potentiation.

Cytokine Growth Factor Rev 2017 Apr 29;34:27-33. Epub 2017 Mar 29.

Institute for Memory Impairments and Neurological Disorders, University of California-Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.cytogfr.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491344PMC
April 2017

Pattern separation and goal-directed behavior in the aged canine.

Learn Mem 2017 03 15;24(3):123-131. Epub 2017 Feb 15.

UC Institute for Memory Impairments and Neurological Disorders (UCI MIND), University of California, Irvine, California 92697, USA.

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http://dx.doi.org/10.1101/lm.043422.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311386PMC
March 2017

IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking.

J Neuroinflammation 2017 02 2;14(1):29. Epub 2017 Feb 2.

Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1186/s12974-017-0803-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290618PMC
February 2017

Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise.

J Neuroinflammation 2016 11 10;13(1):289. Epub 2016 Nov 10.

Zentrum für Klinische Transfusionsmedizin (ZKT) and Institute of Clinical and Experimental Transfusion Medicine (IKET), University Hospital Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1186/s12974-016-0758-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105243PMC
November 2016

Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.

Neurobiol Aging 2016 Jan 30;37:171-178. Epub 2015 Sep 30.

Institute for Memory Impairments and Neurological Disorders, University of California-Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.09.015DOI Listing
January 2016

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus.

Proc Natl Acad Sci U S A 2015 Sep 24;112(36):E5078-87. Epub 2015 Aug 24.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697;

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http://dx.doi.org/10.1073/pnas.1514486112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568670PMC
September 2015

Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease.

Neurobiol Aging 2014 Sep 2;35(9):1961-72. Epub 2014 Apr 2.

Institute for Mental Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA; Departments of Neurology and Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067010PMC
September 2014

Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design.

Neuroepidemiology 2013 15;41(3-4):198-207. Epub 2013 Oct 15.

Memory Disorders Research Group, Danish Dementia Research Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000354632DOI Listing
August 2014

Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production.

Neurobiol Aging 2014 May 30;35(5):1002-11. Epub 2013 Oct 30.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.10.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939046PMC
May 2014

Exercise enhances memory consolidation in the aging brain.

Front Aging Neurosci 2014 3;6. Epub 2014 Feb 3.

Institute for Memory Impairments and Neurological Disorders, University of California Irvine, CA, USA.

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http://dx.doi.org/10.3389/fnagi.2014.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910002PMC
February 2014

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease.

Neurobiol Dis 2013 Sep 30;57:47-55. Epub 2012 Jun 30.

Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine CA 92697-4260, USA.

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http://dx.doi.org/10.1016/j.nbd.2012.06.011DOI Listing
September 2013

Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment.

J Alzheimers Dis 2012 ;32(4):1011-8

Center for Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.3233/JAD-2012-121078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951984PMC
August 2013

A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap.

Neurobiol Aging 2013 Jul 20;34(7):1891-901. Epub 2013 Feb 20.

Institute for Memory Impairments and Neurological Disorders, University of California-Irvine, CA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650917PMC
July 2013

Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease.

Neurobiol Aging 2013 Jun 27;34(6):1653-61. Epub 2012 Dec 27.

Institute for Mental Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022280PMC
June 2013

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.

Hum Mol Genet 2012 Aug 3;21(15):3500-12. Epub 2012 May 3.

Department of Neurology, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1093/hmg/dds161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392107PMC
August 2012

Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ɛ4 carriers.

Alzheimers Dement 2012 Jul 9;8(4):352-6. Epub 2012 Jan 9.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, USA.

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http://dx.doi.org/10.1016/j.jalz.2011.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360109PMC
July 2012

Novel late-onset Alzheimer disease loci variants associate with brain gene expression.

Authors:
Mariet Allen Fanggeng Zou High Seng Chai Curtis S Younkin Julia Crook V Shane Pankratz Minerva M Carrasquillo Christopher N Rowley Asha A Nair Sumit Middha Sooraj Maharjan Thuy Nguyen Li Ma Kimberly G Malphrus Ryan Palusak Sarah Lincoln Gina Bisceglio Constantin Georgescu Debra Schultz Fariborz Rakhshan Christopher P Kolbert Jin Jen Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg Ronald C Petersen Neill R Graff-Radford Dennis W Dickson Steven G Younkin Nilüfer Ertekin-Taner Liana G Apostolova Steven E Arnold Clinton T Baldwin Robert Barber Michael M Barmada Thomas Beach Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Jacqueline Buros Joseph D Buxbaum Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Paul K Crane Carlos Cruchaga Jeffrey L Cummings Philip L De Jager Charles DeCarli Steven T DeKosky F Yesim Demirci Ramon Diaz-Arrastia Malcolm Dick Beth A Dombroski Ranjan Duara William D Ellis Denis Evans Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Tatiana M Foroud Matthew Frosch Douglas R Galasko Paul J Gallins Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass Alison M Goate Robert C Green John H Growdon Hakon Hakonarson Ronald L Hamilton John Hardy Lindy E Harrell Elizabeth Head Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun M Ilyas Kamboh Jason Karlawish Anna Karydas John S K Kauwe Jeffrey A Kaye Nancy Kennedy Ronald Kim Edward H Koo Neil W Kowall Patricia Kramer Walter A Kukull James J Lah Eric B Larson Allan I Levey Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Amanda J Myers Adam C Naj Petra Nowotny Joseph E Parisi Daniel P Perl Elaine Peskind Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Ruchita A Rajbhandary Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Peter St George-Hyslop Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Badri Narayan Vardarajan Harry V Vinters Jean Paul Vonsattel Li-San Wang Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer

Neurology 2012 Jul 20;79(3):221-8. Epub 2012 Jun 20.

Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA.

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http://dx.doi.org/10.1212/WNL.0b013e3182605801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398432PMC
July 2012

Clinical trials: new opportunities.

J Gerontol A Biol Sci Med Sci 2012 Jun 8;67(7):773-80. Epub 2012 May 8.

Center for BrainHealth, The University of Texas at Dallas, USA.

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http://dx.doi.org/10.1093/gerona/gls126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708514PMC
June 2012

BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog.

Neurobiol Aging 2012 Mar 5;33(3):546-54. Epub 2010 May 5.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935515PMC
March 2012

Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs.

Age (Dordr) 2012 Feb 19;34(1):67-73. Epub 2011 Feb 19.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1226 Gillespie NRF, Irvine, CA 92697-4540, USA.

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http://link.springer.com/10.1007/s11357-011-9219-3
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http://dx.doi.org/10.1007/s11357-011-9219-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260365PMC
February 2012

Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain.

PLoS One 2011 13;6(9):e24652. Epub 2011 Sep 13.

Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024652PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172245PMC
February 2012

Caspase-3 activation as a bifurcation point between plasticity and cell death.

Neurosci Bull 2012 Feb;28(1):14-24

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California 92697-4540, USA.

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http://link.springer.com/10.1007/s12264-012-1057-5
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http://dx.doi.org/10.1007/s12264-012-1057-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838299PMC
February 2012

Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines.

Neurobiol Aging 2012 Jan 30;33(1):108-20. Epub 2010 Apr 30.

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, United States.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932860PMC
January 2012

β-Amyloid impairs axonal BDNF retrograde trafficking.

Neurobiol Aging 2011 May 21;32(5):821-33. Epub 2009 Jun 21.

Institute for Brain Aging and Dementia, University of California, Irvine, 1226 Gillespie NRF, Irvine, CA 92697, United States.

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http://dx.doi.org/10.1016/j.neurobiolaging.2009.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038182PMC
May 2011

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:
Adam C Naj Gyungah Jun Gary W Beecham Li-San Wang Badri Narayan Vardarajan Jacqueline Buros Paul J Gallins Joseph D Buxbaum Gail P Jarvik Paul K Crane Eric B Larson Thomas D Bird Bradley F Boeve Neill R Graff-Radford Philip L De Jager Denis Evans Julie A Schneider Minerva M Carrasquillo Nilufer Ertekin-Taner Steven G Younkin Carlos Cruchaga John S K Kauwe Petra Nowotny Patricia Kramer John Hardy Matthew J Huentelman Amanda J Myers Michael M Barmada F Yesim Demirci Clinton T Baldwin Robert C Green Ekaterina Rogaeva Peter St George-Hyslop Steven E Arnold Robert Barber Thomas Beach Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Jeffrey L Cummings Charles DeCarli Steven T DeKosky Ramon Diaz-Arrastia Malcolm Dick Dennis W Dickson William G Ellis Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Nancy Johnson Jason Karlawish Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall James J Lah Allan I Levey Andrew P Lieberman Oscar L Lopez Wendy J Mack Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Joseph E Parisi Daniel P Perl Elaine Peskind Ronald C Petersen Wayne W Poon Joseph F Quinn Ruchita A Rajbhandary Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Roger N Rosenberg Mary Sano Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer Laura B Cantwell Beth A Dombroski Duane Beekly Kathryn L Lunetta Eden R Martin M Ilyas Kamboh Andrew J Saykin Eric M Reiman David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg

Nat Genet 2011 May 3;43(5):436-41. Epub 2011 Apr 3.

The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.

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http://dx.doi.org/10.1038/ng.801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090745PMC
May 2011

Mild stress facilitates learning and exercise improves retention in aged mice.

Exp Gerontol 2011 Jan 15;46(1):53-9. Epub 2010 Oct 15.

Institute for Brain Aging and Dementia, University of California Irvine, 1226 Gillespie NRF, Irvine, CA 92697-4540, United States.

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http://dx.doi.org/10.1016/j.exger.2010.10.001DOI Listing
January 2011

Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia.

J Alzheimers Dis 2010 ;20 Suppl 2:S293-310

Mitochondrial and Molecular Medicine and Genetics, University of California Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.3233/JAD-2010-100351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175722PMC
September 2010

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

Authors:
Vivianna M Van Deerlin Patrick M A Sleiman Maria Martinez-Lage Alice Chen-Plotkin Li-San Wang Neill R Graff-Radford Dennis W Dickson Rosa Rademakers Bradley F Boeve Murray Grossman Steven E Arnold David M A Mann Stuart M Pickering-Brown Harro Seelaar Peter Heutink John C van Swieten Jill R Murrell Bernardino Ghetti Salvatore Spina Jordan Grafman John Hodges Maria Grazia Spillantini Sid Gilman Andrew P Lieberman Jeffrey A Kaye Randall L Woltjer Eileen H Bigio Marsel Mesulam Safa Al-Sarraj Claire Troakes Roger N Rosenberg Charles L White Isidro Ferrer Albert Lladó Manuela Neumann Hans A Kretzschmar Christine Marie Hulette Kathleen A Welsh-Bohmer Bruce L Miller Ainhoa Alzualde Adolfo Lopez de Munain Ann C McKee Marla Gearing Allan I Levey James J Lah John Hardy Jonathan D Rohrer Tammaryn Lashley Ian R A Mackenzie Howard H Feldman Ronald L Hamilton Steven T Dekosky Julie van der Zee Samir Kumar-Singh Christine Van Broeckhoven Richard Mayeux Jean Paul G Vonsattel Juan C Troncoso Jillian J Kril John B J Kwok Glenda M Halliday Thomas D Bird Paul G Ince Pamela J Shaw Nigel J Cairns John C Morris Catriona Ann McLean Charles DeCarli William G Ellis Stefanie H Freeman Matthew P Frosch John H Growdon Daniel P Perl Mary Sano David A Bennett Julie A Schneider Thomas G Beach Eric M Reiman Bryan K Woodruff Jeffrey Cummings Harry V Vinters Carol A Miller Helena C Chui Irina Alafuzoff Päivi Hartikainen Danielle Seilhean Douglas Galasko Eliezer Masliah Carl W Cotman M Teresa Tuñón M Cristina Caballero Martínez David G Munoz Steven L Carroll Daniel Marson Peter F Riederer Nenad Bogdanovic Gerard D Schellenberg Hakon Hakonarson John Q Trojanowski Virginia M-Y Lee

Nat Genet 2010 Mar 14;42(3):234-9. Epub 2010 Feb 14.

[1] Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. [2] These authors contributed equally to this work.

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http://dx.doi.org/10.1038/ng.536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828525PMC
March 2010

Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells.

Proc Natl Acad Sci U S A 2009 Nov 9;106(45):19150-5. Epub 2009 Nov 9.

Department of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0909293106
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http://dx.doi.org/10.1073/pnas.0909293106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776427PMC
November 2009

Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice.

Alzheimers Dement 2009 Jul;5(4):287-94

Institute for Brain Aging and Dementia, University of California, Irvine, CA, USA.

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http://dx.doi.org/10.1016/j.jalz.2009.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105011PMC
July 2009

Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.

Neurochem Res 2009 Apr 10;34(4):755-63. Epub 2008 Oct 10.

Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1007/s11064-008-9850-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790461PMC
April 2009

Axonal mRNA in uninjured and regenerating cortical mammalian axons.

J Neurosci 2009 Apr;29(15):4697-707

Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697-4540, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.6130-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632375PMC
April 2009

The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches.

J Alzheimers Dis 2008 Dec;15(4):685-707

Institute for Brain Aging & Dementia, Department of Neurology, University of California, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.3233/jad-2008-15413DOI Listing
December 2008

Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines.

J Comp Neurol 2008 Nov;511(2):257-70

Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697-4540, USA.

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http://dx.doi.org/10.1002/cne.21821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105010PMC
November 2008

Gene expression changes in the course of normal brain aging are sexually dimorphic.

Proc Natl Acad Sci U S A 2008 Oct 1;105(40):15605-10. Epub 2008 Oct 1.

Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1073/pnas.0806883105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563070PMC
October 2008

Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction.

Neurobiol Aging 2008 Sep 27;29(9):1380-93. Epub 2007 Apr 27.

University of California Irvine, Institute for Brain Aging and Dementia, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052889PMC
September 2008

Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction.

Free Radic Biol Med 2008 Apr 18;44(7):1465-74. Epub 2008 Jan 18.

Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597696PMC
April 2008

Voluntary running attenuates age-related deficits following SCI.

Exp Neurol 2008 Mar 13;210(1):207-16. Epub 2007 Nov 13.

Reeve-Irvine Research Center, Department of Anatomy and Neurobiology, School of Medicine, University of California at Irvine, Irvine, CA 92697-4292, USA.

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http://dx.doi.org/10.1016/j.expneurol.2007.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387276PMC
March 2008

Region specific neuron loss in the aged canine hippocampus is reduced by enrichment.

Neurobiol Aging 2008 Jan 7;29(1):39-50. Epub 2006 Nov 7.

Institute for Brain Aging and Dementia, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2006.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198929PMC
January 2008

Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons.

Brain Res 2008 Jan 26;1188:189-97. Epub 2007 Oct 26.

Neuro-Behavioral Biology Center, Institute of Science and Technology for Development, Mahidol University, Salaya Campus Nakorn Pathom, Thailand.

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http://dx.doi.org/10.1016/j.brainres.2007.10.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409119PMC
January 2008

Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse.

Behav Brain Res 2007 Dec 10;184(2):124-32. Epub 2007 Jul 10.

Institute for Brain Aging & Dementia, University of California at Irvine, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1016/j.bbr.2007.06.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2215770PMC
December 2007

Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function.

Neurobiol Learn Mem 2007 Sep 22;88(2):249-59. Epub 2007 Jun 22.

Institute for Brain Aging and Dementia, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1016/j.nlm.2007.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173881PMC
September 2007

Exercise builds brain health: key roles of growth factor cascades and inflammation.

Trends Neurosci 2007 Sep 31;30(9):464-72. Epub 2007 Aug 31.

University of California, Irvine Institute for Brain Aging and Dementia, 1113 Gillespie Building, Irvine, CA 92617-4540, USA.

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http://dx.doi.org/10.1016/j.tins.2007.06.011DOI Listing
September 2007

Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains.

Neurobiol Dis 2007 Apr 3;26(1):165-73. Epub 2007 Jan 3.

Institute for Brain Aging and Dementia, 1113 Gillespie Neuroscience Research Facility, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.nbd.2006.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2198925PMC
April 2007

Physical activity and the maintenance of cognition: learning from animal models.

Alzheimers Dement 2007 Apr;3(2 Suppl):S30-7

Institute for Brain Aging and Dementia, University of California, Irvine, CA, USA.

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http://dx.doi.org/10.1016/j.jalz.2007.01.013DOI Listing
April 2007

External force-assisted cell positioning inside microfluidic devices.

Biomed Microdevices 2007 Feb;9(1):15-23

Department of Chemistry, Kongju National University, 182 Shinkwandong, Kongju, 314-701, Korea.

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http://dx.doi.org/10.1007/s10544-006-9002-xDOI Listing
February 2007

Effects of melatonin and age on gene expression in mouse CNS using microarray analysis.

Neurochem Int 2007 Jan 21;50(2):336-44. Epub 2006 Nov 21.

Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697-1825, USA.

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http://dx.doi.org/10.1016/j.neuint.2006.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868445PMC
January 2007

Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia.

Neurobiol Learn Mem 2006 Sep 17;86(2):197-204. Epub 2006 Apr 17.

Department of Pharmacology, University of Toronto, 1265 Military Trail, Scarborough, Ont., Canada M1C 1A4.

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http://dx.doi.org/10.1016/j.nlm.2006.02.005DOI Listing
September 2006

Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.

Vaccine 2006 Apr 19;24(15):2824-34. Epub 2006 Jan 19.

Institute for Brain Aging & Dementia, Department of Neurology, University of California, 1259 Gillespie Neuroscience Research Facility, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1016/j.vaccine.2005.12.058DOI Listing
April 2006

The role of neurotrophins in brain aging: a perspective in honor of Regino Perez-Polo.

Authors:
Carl W Cotman

Neurochem Res 2005 Jun-Jul;30(6-7):877-81

Institute for Brain Aging and Dementia, University of California, 1113 Gillespic NRF, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1007/s11064-005-6960-yDOI Listing
January 2006

Nutritional management of brain aging in dogs.

J Am Vet Med Assoc 2005 Sep;227(5):722-8

Technical Information Services, Hill's Pet Nutrition Inc, PO Box 148, Topeka, KS 66601, USA.

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http://dx.doi.org/10.2460/javma.2005.227.722DOI Listing
September 2005

Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.

Acta Neuropathol 2005 Aug 29;110(2):135-44. Epub 2005 Jun 29.

Department of Biology, Boise State University, Boise, Idaho, USA.

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http://dx.doi.org/10.1007/s00401-005-1027-3DOI Listing
August 2005

A microfluidic culture platform for CNS axonal injury, regeneration and transport.

Nat Methods 2005 Aug;2(8):599-605

Department of Biomedical Engineering, University of California, Irvine, 204 Rockwell Engineering, Irvine, California 92697, USA.

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http://dx.doi.org/10.1038/nmeth777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1558906PMC
August 2005

Exercise-induced gene expression changes in the rat spinal cord.

Gene Expr 2005 ;12(2):107-21

Institute for Brain Aging and Dementia, 1113 Gillespie N.R.F., University of California Irvine, Irvine, CA 92697, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009109PMC
http://dx.doi.org/10.3727/000000005783992115DOI Listing
June 2005

Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats.

Neurobiol Aging 2005 May;26(5):749-63

Department of Neurology, Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2004.06.015DOI Listing
May 2005

The exercise-induced expression of BDNF within the hippocampus varies across life-span.

Neurobiol Aging 2005 Apr;26(4):511-20

Institute for Brain Aging and Dementia, University of California, 1125 Gillespie N.R.F, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2004.05.006DOI Listing
April 2005

Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.

J Neurosci 2005 Apr;25(17):4217-21

Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697-4540, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0496-05.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725122PMC
April 2005

A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog.

Prog Neuropsychopharmacol Biol Psychiatry 2005 Mar;29(3):361-9

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.pnpbp.2004.12.002DOI Listing
March 2005

The role of caspase cleavage of tau in Alzheimer disease neuropathology.

J Neuropathol Exp Neurol 2005 Feb;64(2):104-12

Institute for Brain Aging and Dementia, University of California, Irvine, 92697, USA.

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http://dx.doi.org/10.1093/jnen/64.2.104DOI Listing
February 2005

Patterned cell culture inside microfluidic devices.

Lab Chip 2005 Jan 26;5(1):102-7. Epub 2004 Jul 26.

Department of Biomedical Engineering, University of California at Irvine, 204 Rockwell Engineering Center, Irvine, CA 92697-2715, USA.

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http://dx.doi.org/10.1039/b403091eDOI Listing
January 2005

Voluntary wheel running improves recovery from a moderate spinal cord injury.

J Neurotrauma 2005 Jan;22(1):157-71

Institute for Brain Aging and Dementia, University of California, Irvine, California 92697-4540, USA.

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http://dx.doi.org/10.1089/neu.2005.22.157DOI Listing
January 2005

Activation of complement pathways after contusion-induced spinal cord injury.

J Neurotrauma 2004 Dec;21(12):1831-46

Department of Physical Medicine and Rehabilitation, and the Reeve-Irvine Center, University of California, Irvine, California 92696-4540, USA.

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http://dx.doi.org/10.1089/neu.2004.21.1831DOI Listing
December 2004