Carl Nathan

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J Exp Med 2020 05;217(5)

Executive Editor, Journal of Experimental Medicine.

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http://dx.doi.org/10.1084/jem.20200567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105390PMC
May 2020

Resisting antimicrobial resistance.

Authors:
Carl Nathan

Nat Rev Microbiol 2020 05;18(5):259-260

Weill Cornell Medicine, New York, USA.

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http://dx.doi.org/10.1038/s41579-020-0348-5DOI Listing
May 2020

Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis.

Protein Sci 2020 03 20;29(3):744-757. Epub 2020 Jan 20.

Department of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, Texas.

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http://dx.doi.org/10.1002/pro.3813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021004PMC
March 2020

JEM goes viral.

J Exp Med 2020 Feb;217(2)

Executive Editor, Journal of Experimental Medicine.

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http://dx.doi.org/10.1084/jem.20200046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041700PMC
February 2020

Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency.

N Engl J Med 2020 01;382(5):437-445

From St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University (S.B.D., D.H., N.H., S.B., F.R., B.B., R.F., E.J., J.B., L.A., S.B.-D., J.-L.C.), the Department of Microbiology and Immunology, Weill Cornell Medicine (R.B., C.N.), and Howard Hughes Medical Institute (J.-L.C.) - all in New York; the Pediatric Respiratory Diseases Research Center (D.M., S.A.M.), the Department of Clinical Immunology and Infectious Diseases (D.M., N. Mansouri), and the Clinical Tuberculosis and Epidemiology Research Center (D.M., M.M.), National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; the Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM Unité 1163 (A.-L.N., L.L.-D., E.J., J.B., L.A., S.B.-D., V.B., J.-L.C.), Paris University, Imagine Institute (A.-L.N., L.L.-D., E.J., J.B., L.A., S.B.-D., V.B., J.-L.C.), and the Study Center for Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris (AP-HP) (J.B.), and the Pediatric Immunology-Hematology Unit (J.-L.C.), Necker Hospital for Sick Children, Paris, and the Department of Pathology, Ambroise Paré Hospital, AP-HP, Boulogne-Billancourt (J.-F.E.) - all in France; the Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany (A.-L.N.); the Research Branch, Sidra Medicine (M.R., T.K., F.A.A., N. Marr), and the College of Health and Life Sciences, Hamad Bin Khalifa University (N. Marr), Doha, Qatar; and the Division of Pulmonary Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (N. Mansouri).

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http://dx.doi.org/10.1056/NEJMoa1910640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063989PMC
January 2020

Selective Phenylimidazole-Based Inhibitors of the Proteasome.

J Med Chem 2019 10 15;62(20):9246-9253. Epub 2019 Oct 15.

Department of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091493PMC
October 2019

Editorial Board: Expanding on the basis of cancer.

J Exp Med 2019 Aug 1;216(8):1725. Epub 2019 Jul 1.

Executive Editor, Journal of Experimental Medicine

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http://dx.doi.org/10.1084/jem.20191171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683983PMC
August 2019

Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in .

ACS Infect Dis 2019 07 3;5(7):1087-1104. Epub 2019 May 3.

Tsinghua-Peking Center for Life Sciences , Tsinghua University , Renhuan Building, Rm 311 , Haidian District, Beijing 100084 , P. R. China.

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http://dx.doi.org/10.1021/acsinfecdis.8b00325DOI Listing
July 2019

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.

J Antibiot (Tokyo) 2019 06 22;72(6):469-475. Epub 2019 Mar 22.

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1038/s41429-019-0167-yDOI Listing
June 2019

Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.

ACS Infect Dis 2019 02 17;5(2):272-280. Epub 2018 Dec 17.

TB Discovery Research , Infectious Disease Research Institute , 1616 Eastlake Avenue E , Suite 400, Seattle , Washington 98102 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.8b00256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371205PMC
February 2019

ATP hydrolysis-coupled peptide translocation mechanism of ClpB.

Proc Natl Acad Sci U S A 2018 10 26;115(41):E9560-E9569. Epub 2018 Sep 26.

Cryo-Electron Microscopy Structural Biology Laboratory, Van Andel Research Institute, Grand Rapids, MI 49503;

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http://dx.doi.org/10.1073/pnas.1810648115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187150PMC
October 2018

Evidence for dispensability of protein kinase R in host control of tuberculosis.

Eur J Immunol 2018 04 28;48(4):612-620. Epub 2018 Feb 28.

Immunology and Microbial Pathogenesis Program, Weill Graduate School of Medical Sciences of Cornell University, New York City, NY, USA.

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http://dx.doi.org/10.1002/eji.201747180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361384PMC
April 2018

The new face of JEM.

J Exp Med 2017 Dec;214(12):3467

Executive Editor, Journal of Experimental Medicine

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http://dx.doi.org/10.1084/jem.20172072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716050PMC
December 2017

Introduction of Laurie H. Glimcher, MD.

Authors:
Carl F Nathan

J Clin Invest 2017 10 2;127(10):3575. Epub 2017 Oct 2.

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http://dx.doi.org/10.1172/JCI97404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617670PMC
October 2017

Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between and .

mBio 2017 09 12;8(5). Epub 2017 Sep 12.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01183-17
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http://dx.doi.org/10.1128/mBio.01183-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596344PMC
September 2017

Kunkel Lecture: Fundamental immunodeficiency and its correction.

Authors:
Carl Nathan

J Exp Med 2017 Aug 12;214(8):2175-2191. Epub 2017 Jul 12.

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY

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http://www.jem.org/lookup/doi/10.1084/jem.20170637
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http://dx.doi.org/10.1084/jem.20170637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551579PMC
August 2017

JEM Advisory Editorial Board: Increasing diversity.

J Exp Med 2017 Aug;214(8):2169

Executive Editor, The Journal of Experimental Medicine.

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http://dx.doi.org/10.1084/jem.20171220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551585PMC
August 2017

Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

ACS Infect Dis 2017 02 5;3(2):176-181. Epub 2016 Dec 5.

Department of Chemistry, Brown University , 324 Brook Street, Box H, Providence, Rhode Island 02912, United States.

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http://dx.doi.org/10.1021/acsinfecdis.6b00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410965PMC
February 2017

Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.

Biochemistry 2017 Jan 27;56(1):324-333. Epub 2016 Dec 27.

Van Andel Research Institute , Grand Rapids, Michigan 49503, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b01107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745808PMC
January 2017

A time of change.

J Exp Med 2017 Jan;214(1):1-2

Executive Editor, The Journal of Experimental Medicine.

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http://dx.doi.org/10.1084/jem.20162116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206507PMC
January 2017

Targeting Phenotypically Tolerant Mycobacterium tuberculosis.

Microbiol Spectr 2017 01;5(1)

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065.

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http://dx.doi.org/10.1128/microbiolspec.TBTB2-0031-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367488PMC
January 2017

Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK.

Proc Natl Acad Sci U S A 2016 12 21;113(49):E7947-E7956. Epub 2016 Nov 21.

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10021;

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http://dx.doi.org/10.1073/pnas.1617644113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150378PMC
December 2016

Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors.

ChemMedChem 2016 10 25;11(19):2127-2131. Epub 2016 Aug 25.

Department of Microbiology & Immunology, Weill Cornell Medical College, 1300 York Avenue, Box 62, New York, NY, 10065, USA.

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http://dx.doi.org/10.1002/cmdc.201600384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760267PMC
October 2016

Macrophages' Choice: Take It In or Keep It Out.

Authors:
Carl Nathan

Immunity 2016 10;45(4):710-711

Department of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.10.002DOI Listing
October 2016

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.

J Med Chem 2016 07 17;59(13):6027-44. Epub 2016 Jun 17.

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947980PMC
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Human studies at JEM: Immunology and beyond.

J Exp Med 2016 Apr 14;213(4):467-8. Epub 2016 Mar 14.

Editors, The Journal of Experimental Medicine

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http://dx.doi.org/10.1084/jem.20160211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821652PMC
April 2016

Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis.

PLoS One 2015 15;10(5):e0126211. Epub 2015 May 15.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126211PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433263PMC
March 2016

A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis.

Methods Mol Biol 2015 ;1285:293-315

Department of Microbiology and Immunology, Weill Cornell Medical College, Belfer 1126, 413 East 69th St., New York, NY, 10065, USA,

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http://dx.doi.org/10.1007/978-1-4939-2450-9_18DOI Listing
December 2015

Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.

Tuberculosis (Edinb) 2015 Dec 19;95(6):689-694. Epub 2015 Oct 19.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2015.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667687PMC
December 2015

Cooperative development of antimicrobials: looking back to look ahead.

Authors:
Carl Nathan

Nat Rev Microbiol 2015 10;13(10):651-7

Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 New York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nrmicro3523DOI Listing
October 2015

E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.

Proc Natl Acad Sci U S A 2015 Oct 1;112(43):E5834-43. Epub 2015 Oct 1.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1510932112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629369PMC
October 2015

IMMUNOLOGY. From transient infection to chronic disease.

Authors:
Carl Nathan

Science 2015 Oct;350(6257):161

Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.aad4141DOI Listing
October 2015

Video podcast: Tuberculosis.

Immunol Rev 2015 Mar;264(1)

Immunological Reviews.

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http://dx.doi.org/10.1111/imr.12262DOI Listing
March 2015

What can immunology contribute to the control of the world's leading cause of death from bacterial infection?

Authors:
Carl Nathan

Immunol Rev 2015 Mar;264(1):2-5

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1111/imr.12277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339219PMC
March 2015

TB drug development: immunology at the table.

Immunol Rev 2015 Mar;264(1):308-18

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1111/imr.12275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339218PMC
March 2015

Antibiotic resistance--problems, progress, and prospects.

N Engl J Med 2014 Nov 1;371(19):1761-3. Epub 2014 Oct 1.

From the Department of Microbiology and Immunology, Weill Cornell Medical College, New York (C.N.); and the Department of Medical Sciences, Uppsala University, Uppsala, Sweden (O.C.).

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http://www.nejm.org/doi/10.1056/NEJMp1408040
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http://dx.doi.org/10.1056/NEJMp1408040DOI Listing
November 2014

Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.

Nat Commun 2014 Jun 30;5:4306. Epub 2014 Jun 30.

1] Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA [2] Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms5306DOI Listing
June 2014

Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis.

J Med Chem 2014 May 24;57(9):3755-72. Epub 2014 Apr 24.

Tsinghua-Peking Center for Life Sciences and ‡Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University , Haidian Dist., Beijing 100084, P. R. China.

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http://dx.doi.org/10.1021/jm4019228DOI Listing
May 2014

Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome.

ACS Med Chem Lett 2014 Apr 3;5(4):405-10. Epub 2014 Feb 3.

Department of Microbiology & Immunology and Department of Biochemistry, Weill Cornell Medical College , 1300 York Avenue, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/ml400531dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027612PMC
April 2014

Benzimidazole-based compounds kill Mycobacterium tuberculosis.

Eur J Med Chem 2014 Mar 31;75:336-53. Epub 2014 Jan 31.

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nanwei Road, Xuanwu District, Beijing 100050, PR China; Tsinghua-Peking Center for Life Sciences and School of Medicine, Tsinghua University, Haidian Dist., Beijing 100084, PR China; Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Haidian Dist., Beijing 100084, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.01.039DOI Listing
March 2014

Drug-resistant tuberculosis: a new shot on goal.

Authors:
Carl Nathan

Nat Med 2014 Feb;20(2):121-3

Department of Microbiology and Immunology, Weill Cornell Medical College, and the Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.3470DOI Listing
February 2014

Nitrite impacts the survival of Mycobacterium tuberculosis in response to isoniazid and hydrogen peroxide.

Microbiologyopen 2013 Dec 8;2(6):901-11. Epub 2013 Sep 8.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York; Graduate Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University, New York, New York.

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http://dx.doi.org/10.1002/mbo3.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892337PMC
December 2013

Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.

Proc Natl Acad Sci U S A 2013 Dec 18;110(49):E4790-7. Epub 2013 Nov 18.

Departments of Immunology and Microbiology and Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10065.

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http://dx.doi.org/10.1073/pnas.1320118110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856836PMC
December 2013

Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.

Biochemistry 2013 Dec 26;52(51):9375-84. Epub 2013 Nov 26.

Department of Microbiology and Immunology and ‡Department of Pharmacology, Weill Cornell Medical College , New York, New York 10065, United States.

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http://dx.doi.org/10.1021/bi401077fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894633PMC
December 2013

Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):E4256-65. Epub 2013 Oct 21.

Department of Microbiology and Immunology and Genomics Resources Core Facility, Weill Cornell Medical College, New York, NY 10065.

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http://dx.doi.org/10.1073/pnas.1316894110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831502PMC
November 2013

A journey in science: promise, purpose, privilege.

Authors:
Carl Nathan

Mol Med 2013 Oct 3;19(1):305-13. Epub 2013 Oct 3.

Weill Cornell Medical College, New York, New York, United States of America.

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http://dx.doi.org/10.2119/molmed.2013.00063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789094PMC
October 2013

Perspective: Graduation time.

Nature 2013 Oct;502(7470):S7

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1038/502S7aDOI Listing
October 2013

SARM is required for neuronal injury and cytokine production in response to central nervous system viral infection.

J Immunol 2013 Jul 7;191(2):875-83. Epub 2013 Jun 7.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.1300374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710687PMC
July 2013

Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase.

J Biol Chem 2013 Jul 11;288(30):21688-702. Epub 2013 Jun 11.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, USA.

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http://dx.doi.org/10.1074/jbc.M113.465419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724628PMC
July 2013

N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.

J Am Chem Soc 2013 Jul 25;135(27):9968-71. Epub 2013 Jun 25.

Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773049PMC
July 2013

Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2013 Jun 18;57(6):2834-7. Epub 2013 Mar 18.

Center for Global Health, Department of Medicine, Weill Cornell Medical College, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716123PMC
June 2013

Beyond oxidative stress: an immunologist's guide to reactive oxygen species.

Nat Rev Immunol 2013 May;13(5):349-61

Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nri3423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250048PMC
May 2013

Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R.

PLoS One 2012 16;7(2):e30512. Epub 2012 Feb 16.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281035PMC
August 2012

Fresh approaches to anti-infective therapies.

Authors:
Carl Nathan

Sci Transl Med 2012 Jun;4(140):140sr2

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scitranslmed.3003081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712344PMC
June 2012

Secretory products of macrophages: twenty-five years on.

Authors:
Carl Nathan

J Clin Invest 2012 Apr;122(4):1189-90

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314479PMC
http://dx.doi.org/10.1172/jci62930DOI Listing
April 2012

In vitro differentiation of human macrophages with enhanced antimycobacterial activity.

J Clin Invest 2011 Oct 12;121(10):3889-901. Epub 2011 Sep 12.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, USA.

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http://dx.doi.org/10.1172/JCI57235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195467PMC
October 2011

Is iNOS beginning to smoke?

Authors:
Carl Nathan

Cell 2011 Oct;147(2):257-8

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2011.09.031DOI Listing
October 2011

Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.

Tuberculosis (Edinb) 2011 Sep 20;91(5):343-7. Epub 2011 Jul 20.

Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.tube.2011.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172396PMC
September 2011

Identification of new inhibitors of protein kinase R guided by statistical modeling.

Bioorg Med Chem Lett 2011 Jul 13;21(13):4108-14. Epub 2011 May 13.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.04.149DOI Listing
July 2011

Making space for anti-infective drug discovery.

Authors:
Carl Nathan

Cell Host Microbe 2011 May;9(5):343-8

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.chom.2011.04.013DOI Listing
May 2011

Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis.

ACS Med Chem Lett 2011;2(11):849-854

Departments of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10065.

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http://dx.doi.org/10.1021/ml200157fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215101PMC
January 2011

Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity.

PLoS One 2010 Dec 10;5(12):e15120. Epub 2010 Dec 10.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000826PMC
December 2010

A protecting group-free synthesis of deazathiamine: a step toward inhibitor design.

Bioorg Med Chem Lett 2010 Nov 16;20(22):6472-4. Epub 2010 Sep 16.

Organic Synthesis Core Facility, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, PO Box 237, New York, NY 10065, United States.

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http://dx.doi.org/10.1016/j.bmcl.2010.09.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957563PMC
November 2010

Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.

Chem Biol 2010 Oct;17(10):1122-31

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10745521100034
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http://dx.doi.org/10.1016/j.chembiol.2010.08.009DOI Listing
October 2010

Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome.

Arch Biochem Biophys 2010 Sep 15;501(2):214-20. Epub 2010 Jun 15.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Ave., New York, NY 10065, United States.

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http://dx.doi.org/10.1016/j.abb.2010.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930046PMC
September 2010

Induction of ER stress in macrophages of tuberculosis granulomas.

PLoS One 2010 Sep 15;5(9):e12772. Epub 2010 Sep 15.

Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939897PMC
September 2010

Killing of non-replicating Mycobacterium tuberculosis by 8-hydroxyquinoline.

J Antimicrob Chemother 2010 Jul 30;65(7):1424-7. Epub 2010 Apr 30.

Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1093/jac/dkq145DOI Listing
July 2010

Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .

Biochemistry 2010 Mar;49(8):1616-27

Department of Microbiology and Immunology, Weill Cornell Medical College, New York,New York 10065, USA.

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http://dx.doi.org/10.1021/bi9016186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827632PMC
March 2010

Nonresolving inflammation.

Cell 2010 Mar;140(6):871-82

Department of Microbiology and Immunology, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2010.02.029DOI Listing
March 2010

SnapShot: Reactive Oxygen Intermediates (ROI).

Cell 2010 Mar;140(6):951-951.e2

Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2010.03.008DOI Listing
March 2010

N-iminoethyl-L-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition.

Neurochem Int 2010 Jan 13;56(2):345-51. Epub 2009 Nov 13.

Weill Cornell Medical College, Department of Neurology and Neuroscience, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.neuint.2009.11.006DOI Listing
January 2010

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.

J Exp Med 2010 Jan 21;207(1):117-28. Epub 2009 Dec 21.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1084/jem.20091568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812536PMC
January 2010