Carl H June

From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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December 2020

Chimeric Antigen Receptor T Cell Therapies: A Review of Cellular Kinetic-Pharmacodynamic Modeling Approaches.

Authors:

Anwesha Chaudhury Xu Zhu Lulu Chu Ardeshir Goliaei Carl H June Jeffrey D Kearns Andrew M Stein

J Clin Pharmacol 2020 Oct;60 Suppl 1:S147-S159

Pharmacometrics, Novartis Institutes of BioMedical Research, Cambridge, Massachusetts, USA.

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October 2020

Autologous CD4 T Lymphocytes Modified with a Tat-Dependent, Virus-Specific Endoribonuclease Gene in HIV-Infected Individuals.

Authors:

Jeffrey M Jacobson Julie K Jadlowsky Simon F Lacey Joseph A Fraietta Gabriela Plesa Hideto Chono Dong H Lee Irina Kulikovskaya Chelsie Bartoszek Fang Chen Lifeng Tian Alexander Dimitri Bruce L Levine Elizabeth A Veloso Wei-Ting Hwang Carl H June

Mol Ther 2021 02 11;29(2):626-635. Epub 2020 Nov 11.

Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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February 2021

Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children.

Blood Adv 2020 Oct;4(20):5174-5183

Division of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, PA.

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October 2020

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies.

Cell 2020 Oct 21;183(1):126-142.e17. Epub 2020 Sep 21.

Parker Institute for Cancer Immunotherapy, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

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October 2020

Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design.

Authors:

Saba Ghassemi Francisco J Martinez-Becerra Alyssa M Master Sarah A Richman David Heo John Leferovich Yitao Tu Juan Carlos García-Cañaveras Asma Ayari Yinan Lu Ai Wang Joshua D Rabinowitz Michael C Milone Carl H June Roddy S O'Connor

Mol Ther Methods Clin Dev 2020 Sep 9;18:595-606. Epub 2020 Jul 9.

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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September 2020

Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer.

Authors:

Andrew H Ko Alexander C Jordan Evan Tooker Simon F Lacey Renee B Chang Yan Li Alan P Venook Margaret Tempero Lloyd Damon Lawrence Fong Mark H O'Hara Bruce L Levine J Joseph Melenhorst Gabriela Plesa Carl H June Gregory L Beatty

Mol Ther 2020 11 21;28(11):2367-2378. Epub 2020 Jul 21.

Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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November 2020

Cancer immunotherapy comes of age and looks for maturity.

Authors:

Amanda Finck Saar I Gill Carl H June

Nat Commun 2020 07 3;11(1):3325. Epub 2020 Jul 3.

Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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July 2020

A rational mouse model to detect on-target, off-tumor CAR T cell toxicity.

Authors:

Mauro Castellarin Caroline Sands Tong Da John Scholler Kathleen Graham Elizabeth Buza Joseph A Fraietta Yangbing Zhao Carl H June

JCI Insight 2020 07 23;5(14). Epub 2020 Jul 23.

Center for Cellular Immunotherapies, Abramson Cancer Center, and.

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July 2020

Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of the epigenome.

Authors:

Qian Zhang Elena J Orlando Hong Y Wang Agata M Bogusz Xiaobin Liu Simon F Lacey Honore T Strauser Selene Nunez-Cruz Reza Nejati Paul Zhang Sarah Brooks Christopher Watt J Joseph Melenhorst Carl H June Stephen J Schuster Mariusz A Wasik

Blood 2020 Oct;136(17):1980-1983

Department of Pathology, University of Pennsylvania, Philadelphia, PA.

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October 2020

Enhanced cytotoxicity against solid tumors by bispecific antibody-armed CD19 CAR T cells: a proof-of-concept study.

Authors:

Archana Thakur John Scholler Dana L Schalk Carl H June Lawrence G Lum

J Cancer Res Clin Oncol 2020 Aug 24;146(8):2007-2016. Epub 2020 May 24.

Division of Hematology/Oncology, Department of Medicine, University of Virginia Cancer Center, 1335 Lee Street, West Complex 7191, Charlottesville, VA, 22908, USA.

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August 2020

Human chimeric antigen receptor macrophages for cancer immunotherapy.

Nat Biotechnol 2020 08 23;38(8):947-953. Epub 2020 Mar 23.

Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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August 2020

Cytokine release syndrome in severe COVID-19.

Authors:

John B Moore Carl H June

Science 2020 05 17;368(6490):473-474. Epub 2020 Apr 17.

Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.

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May 2020

Harnessing CAR T-cell Insights to Develop Treatments for Hyperinflammatory Responses in Patients with COVID-19.

Authors:

Sangya Agarwal Carl H June

Cancer Discov 2020 06 17;10(6):775-778. Epub 2020 Apr 17.

Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania.

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June 2020

Long-Term Outcomes From a Randomized Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells in Relapsed Chronic Lymphocytic Leukemia.

J Clin Oncol 2020 09 16;38(25):2862-2871. Epub 2020 Apr 16.

Cell Therapy and Transplant Program, Division of Hematology-Oncology, Department of Medicine, Philadelphia, PA.

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September 2020

4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling.

Authors:

Benjamin I Philipson Roddy S O'Connor Michael J May Carl H June Steven M Albelda Michael C Milone

Sci Signal 2020 03 31;13(625). Epub 2020 Mar 31.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA.

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March 2020

Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability.

Authors:

Sonia Guedan Aviv Madar Victoria Casado-Medrano Carolyn Shaw Anna Wing Fang Liu Regina M Young Carl H June Avery D Posey

J Clin Invest 2020 06;130(6):3087-3097

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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June 2020

CRISPR-engineered T cells in patients with refractory cancer.

Science 2020 02 6;367(6481). Epub 2020 Feb 6.

Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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February 2020

Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction.

Cancer Discov 2020 04 30;10(4):552-567. Epub 2020 Jan 30.

Division of Hematology/Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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April 2020

Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia.

Authors:

Xin He Zijie Feng Jian Ma Sunbin Ling Yan Cao Buddha Gurung Yuan Wu Bryson W Katona Kienan P O'Dwyer Don L Siegel Carl H June Xianxin Hua

Blood 2020 03;135(10):713-723

Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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March 2020

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering.

Authors:

Margaret M Billingsley Nathan Singh Pranali Ravikumar Rui Zhang Carl H June Michael J Mitchell

Nano Lett 2020 03 5;20(3):1578-1589. Epub 2020 Feb 5.

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

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March 2020

CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration.

Authors:

Christopher L Nobles Scott Sherrill-Mix John K Everett Shantan Reddy Joseph A Fraietta David L Porter Noelle Frey Saar I Gill Stephan A Grupp Shannon L Maude Donald L Siegel Bruce L Levine Carl H June Simon F Lacey J Joseph Melenhorst Frederic D Bushman

J Clin Invest 2020 02;130(2):673-685

Department of Microbiology.

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February 2020

Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia.

Authors:

Noelle V Frey Pamela A Shaw Elizabeth O Hexner Edward Pequignot Saar Gill Selina M Luger James K Mangan Alison W Loren Alexander E Perl Shannon L Maude Stephan A Grupp Nirav N Shah Joan Gilmore Simon F Lacey Jos J Melenhorst Bruce L Levine Carl H June David L Porter

J Clin Oncol 2020 02 9;38(5):415-422. Epub 2019 Dec 9.

Division of Hematology Oncology, Abramson Cancer Center, Cell Therapy and Transplant, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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February 2020