Carl Ernst

Carl Ernst

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Carl Ernst

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A roadmap for neurodevelopmental disease modeling for non-stem cell biologists.

Authors:
Carl Ernst

Stem Cells Transl Med 2020 Feb 13. Epub 2020 Feb 13.

Department of Human Genetics, McGill University and Douglas Hospital Research Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/sctm.19-0344DOI Listing
February 2020

Human iPSC-Derived Down Syndrome Astrocytes Display Genome-Wide Perturbations in Gene Expression, an Altered Adhesion Profile, and Increased Cellular Dynamics.

Hum Mol Genet 2020 Jan 15. Epub 2020 Jan 15.

Centre for Research in Neuroscience, Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal, QC, H3G 1A4, Canada.

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http://dx.doi.org/10.1093/hmg/ddaa003DOI Listing
January 2020

Dose in Brain Development.

Front Pediatr 2019 22;7:482. Epub 2019 Nov 22.

Department of Human Genetics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fped.2019.00482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882862PMC
November 2019

Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons.

Am J Hum Genet 2019 05 25;104(5):815-834. Epub 2019 Apr 25.

CHU-Sainte Justine Research Centre, University of Montreal, Montreal, QC H3T 1C5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507050PMC
May 2019

Umap and Bismap: quantifying genome and methylome mappability.

Nucleic Acids Res 2018 11;46(20):e120

Princess Margaret Cancer Centre, M5G 1L7, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/nar/gky677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237805PMC
November 2018

Disruption of GRIN2B Impairs Differentiation in Human Neurons.

Stem Cell Reports 2018 07 21;11(1):183-196. Epub 2018 Jun 21.

McGill University and Douglas Hospital Research Institute, Department of Psychiatry, 6875 LaSalle Boulevard, Frank Common Building, Room 2101.2, Verdun, Montreal, QC H4H 1R3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067152PMC
July 2018

Strategies to Advance Drug Discovery in Rare Monogenic Intellectual Disability Syndromes.

Int J Neuropsychopharmacol 2018 03;21(3):201-206

Department of Human Genetics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1093/ijnp/pyx090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836272PMC
March 2018

Strategies to Advance Drug Discovery in Rare Monogenic Intellectual Disability Syndromes.

Int J Neuropsychopharmacol 2018 03;21(3):201-206

Department of Human Genetics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1093/ijnp/pyx090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836272PMC
March 2018

DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects.

Genes (Basel) 2017 May 12;8(5). Epub 2017 May 12.

Department of Psychiatry, McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Verdun, QC H4H 1R3, Canada.

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http://dx.doi.org/10.3390/genes8050138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448012PMC
May 2017

A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing.

Stem Cells Transl Med 2017 03 1;6(3):886-896. Epub 2016 Dec 1.

McGill Group for Suicide Studies, Douglas Hospital Research Institute, Montreal, Quebec, H4H 1R3, Canada.

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http://doi.wiley.com/10.1002/sctm.16-0158
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http://dx.doi.org/10.1002/sctm.16-0158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442775PMC
March 2017

Medium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine.

BMC Genomics 2017 01 18;18(1):96. Epub 2017 Jan 18.

Department of Psychiatry, McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, 6875 boul. LaSalle, Verdun, QC, H4H 1R3, Canada.

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http://dx.doi.org/10.1186/s12864-017-3489-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242011PMC
January 2017

Lesch-Nyhan Syndrome: Models, Theories, and Therapies.

Mol Syndromol 2016 Nov 24;7(6):302-311. Epub 2016 Sep 24.

Department of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Que., Canada.

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http://dx.doi.org/10.1159/000449296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131334PMC
November 2016

Proliferation and Differentiation Deficits are a Major Convergence Point for Neurodevelopmental Disorders.

Authors:
Carl Ernst

Trends Neurosci 2016 05 28;39(5):290-299. Epub 2016 Mar 28.

Department of Psychiatry, McGill University, Montreal, QC, Canada; Department of Human Genetics, McGill University, Montreal, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; McGill Group for Suicide Studies, Douglas Hospital Research Institute, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2016.03.001DOI Listing
May 2016

Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling.

Science 2016 Feb;351(6275):849-54

Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1126/science.aab3103DOI Listing
February 2016

Investigation of genes important in neurodevelopment disorders in adult human brain.

Hum Genet 2015 Oct 21;134(10):1037-53. Epub 2015 Jul 21.

Department of Psychiatry, McGill University, Montreal, QC, H4H 1R3, Canada.

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http://dx.doi.org/10.1007/s00439-015-1584-zDOI Listing
October 2015

Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution.

BMC Genomics 2015 Sep 3;16:672. Epub 2015 Sep 3.

McGill Group for Suicide Studies, Douglas Mental Health University Institute, 6875 boul. Lasalle, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1186/s12864-015-1875-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559220PMC
September 2015

Biomarker discovery: quantification of microRNAs and other small non-coding RNAs using next generation sequencing.

BMC Med Genomics 2015 Jul 1;8:35. Epub 2015 Jul 1.

McGill Group for Suicide Studies (MGSS), Douglas Mental Health University Institute, McGill University, Frank B Common Pavilion, Room F-2101.2, 6875 LaSalle Boulevard, Montreal, QC, H4H 1R3, Canada.

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http://dx.doi.org/10.1186/s12920-015-0109-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487992PMC
July 2015

Comparative analysis of self-injury in people with psychopathology or neurodevelopmental disorders.

Pediatr Clin North Am 2015 Jun 7;62(3):619-31. Epub 2015 Apr 7.

Integrated Program in Neuroscience, McGill University, Montreal, Quebec H3A 0G4, Canada; McGill Group for Suicide Studies, Douglas Mental Health University Institute, Montreal, Quebec H4H 1R3, Canada; Department of Psychiatry, McGill University, Montreal, Quebec H3A 0G4, Canada; Department of Human Genetics, McGill University, Montreal, Quebec H3A 0G4, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00313955150002
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http://dx.doi.org/10.1016/j.pcl.2015.03.001DOI Listing
June 2015

Molecular convergence of neurodevelopmental disorders.

Am J Hum Genet 2014 Nov 9;95(5):490-508. Epub 2014 Oct 9.

Department of Psychiatry, McGill University, Montreal, QC H4H 1R3, Canada; McGill Group for Suicide Studies, Douglas Hospital Research Institute, Montreal, QC H4H 1R3, Canada; Department of Human Genetics, McGill University, Montreal, QC H4H 1R3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225591PMC
November 2014

Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families.

Am J Hum Genet 2014 Jun;94(6):870-83

Molecular Neurogenetics Unit and Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Departments of Neurology, Genetics, Psychiatry, and Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02141, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121471PMC
June 2014

BisQC: an operational pipeline for multiplexed bisulfite sequencing.

BMC Genomics 2014 Apr 16;15:290. Epub 2014 Apr 16.

Department of Psychiatry, McGill University, Douglas Hospital Research Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1186/1471-2164-15-290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234473PMC
April 2014

Identification and function of long non-coding RNA.

Front Cell Neurosci 2013 Oct 2;7:168. Epub 2013 Oct 2.

Douglas Hospital Research Institute Montreal, QC, Canada ; Department of Psychiatry, McGill University Montreal, QC, Canada.

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http://dx.doi.org/10.3389/fncel.2013.00168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788346PMC
October 2013

The epigenetic effects of antidepressant treatment on human prefrontal cortex BDNF expression.

Int J Neuropsychopharmacol 2011 Apr 7;14(3):427-9. Epub 2010 Dec 7.

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http://dx.doi.org/10.1017/S1461145710001422DOI Listing
April 2011

A deletion in tropomyosin-related kinase B and the development of human anxiety.

Biol Psychiatry 2011 Mar 3;69(6):604-7. Epub 2010 Dec 3.

McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2010.10.008DOI Listing
March 2011

A deletion in tropomyosin-related kinase B and the development of human anxiety.

Biol Psychiatry 2011 Mar 3;69(6):604-7. Epub 2010 Dec 3.

McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2010.10.008DOI Listing
March 2011

A deletion in tropomyosin-related kinase B and the development of human anxiety.

Biol Psychiatry 2011 Mar 3;69(6):604-7. Epub 2010 Dec 3.

McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2010.10.008DOI Listing
March 2011

A deletion in tropomyosin-related kinase B and the development of human anxiety.

Biol Psychiatry 2011 Mar 3;69(6):604-7. Epub 2010 Dec 3.

McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2010.10.008DOI Listing
March 2011

A deletion in tropomyosin-related kinase B and the development of human anxiety.

Biol Psychiatry 2011 Mar 3;69(6):604-7. Epub 2010 Dec 3.

McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2010.10.008DOI Listing
March 2011

A deletion in tropomyosin-related kinase B and the development of human anxiety.

Biol Psychiatry 2011 Mar 3;69(6):604-7. Epub 2010 Dec 3.

McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2010.10.008DOI Listing
March 2011

The effects of pH on DNA methylation state: In vitro and post-mortem brain studies.

J Neurosci Methods 2008 Sep 6;174(1):123-5. Epub 2008 Jul 6.

McGill Group for Suicide Studies, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1016/j.jneumeth.2008.06.027DOI Listing
September 2008

The effects of pH on DNA methylation state: In vitro and post-mortem brain studies.

J Neurosci Methods 2008 Sep 6;174(1):123-5. Epub 2008 Jul 6.

McGill Group for Suicide Studies, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1016/j.jneumeth.2008.06.027DOI Listing
September 2008

Application of microarray outlier detection methodology to psychiatric research.

BMC Psychiatry 2008 Apr 23;8:29. Epub 2008 Apr 23.

McGill Group for Suicide Studies, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1186/1471-244X-8-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364617PMC
April 2008

Confirmation of region-specific patterns of gene expression in the human brain.

Neurogenetics 2007 Aug 21;8(3):219-24. Epub 2007 Mar 21.

McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1007/s10048-007-0084-2DOI Listing
August 2007

Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways.

Hippocampus 2006 ;16(3):250-60

Department of Psychology, Division of Neuroscience and The Brain Research Centre at UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4.

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http://doi.wiley.com/10.1002/hipo.20157
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http://dx.doi.org/10.1002/hipo.20157DOI Listing
May 2006

Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis?

J Psychiatry Neurosci 2006 Mar;31(2):84-92

Neuroscience Program, UBC Hospital, University of British Columbia, Vancouver, BC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413959PMC
March 2006

Temporally specific proliferation events are induced in the hippocampus following acute focal injury.

J Neurosci Res 2006 Feb;83(3):349-61

The Neuroscience Program, University of British Columbia, Vancouver, British Columbia, Canada.

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http://doi.wiley.com/10.1002/jnr.20724
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http://dx.doi.org/10.1002/jnr.20724DOI Listing
February 2006

Isolectin-IB 4 as a vascular stain for the study of adult neurogenesis.

J Neurosci Methods 2006 Jan 10;150(1):138-42. Epub 2005 Aug 10.

The Neuroscience Program, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4.

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http://dx.doi.org/10.1016/j.jneumeth.2005.06.018DOI Listing
January 2006

Nestin-expressing cells and their relationship to mitotically active cells in the subventricular zones of the adult rat.

Eur J Neurosci 2005 Dec;22(12):3059-66

The Neuroscience Program, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4.

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http://doi.wiley.com/10.1111/j.1460-9568.2005.04499.x
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http://dx.doi.org/10.1111/j.1460-9568.2005.04499.xDOI Listing
December 2005

Isolectin-IB 4 as a vascular stain for the study of adult neurogenesis.

J Neurosci Methods 2006 Jan 10;150(1):138-42. Epub 2005 Aug 10.

The Neuroscience Program, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4.

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http://dx.doi.org/10.1016/j.jneumeth.2005.06.018DOI Listing
January 2006