Publications by authors named "Carl E Allen"

88Publications

Five decades of low intensity and low survival: adapting intensified regimens to cure pediatric Burkitt lymphoma in Africa.

Blood Adv 2020 Aug;4(16):4007-4019

Section of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.

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http://dx.doi.org/10.1182/bloodadvances.2020002178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448606PMC
August 2020

Early evidence of pulmonary dysfunction in survivors of childhood Hodgkin lymphoma.

Leuk Lymphoma 2020 Oct 10;61(10):2419-2427. Epub 2020 Jun 10.

Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.

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http://dx.doi.org/10.1080/10428194.2020.1772478DOI Listing
October 2020

Management of severe pulmonary Langerhans cell histiocytosis in children.

Pediatr Pulmonol 2020 08 8;55(8):2074-2081. Epub 2020 Jun 8.

Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, Texas.

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http://dx.doi.org/10.1002/ppul.24822DOI Listing
August 2020

Langerhans cell histiocytosis.

Blood 2020 04;135(16):1319-1331

Division of Pediatric Hematology-Oncology, Department of Pediatrics, Texas Children's Cancer Center and Baylor College of Medicine, Houston, TX.

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http://dx.doi.org/10.1182/blood.2019000934DOI Listing
April 2020

Priorities for Improving Outcomes for Nonmalignant Blood Diseases: A Report from the Blood and Marrow Transplant Clinical Trials Network.

Biol Blood Marrow Transplant 2020 May 5;26(5):e94-e100. Epub 2020 Feb 5.

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.bbmt.2020.01.024DOI Listing
May 2020

Building a better blast-trap.

Authors:
Carl E Allen

Pediatr Hematol Oncol 2020 02;37(1):1-4

Texas Children's Cancer Center, Texas Children's Hospital, Houston, Texas, USA.

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http://dx.doi.org/10.1080/08880018.2019.1687627DOI Listing
February 2020

The coming of age of Langerhans cell histiocytosis.

Nat Immunol 2020 01;21(1):1-7

Scientific Member of the Steering Committee, Nikolas Symposia, Piraeus, Greece.

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http://dx.doi.org/10.1038/s41590-019-0558-zDOI Listing
January 2020

Clinical responses and persistent V600E blood cells in children with LCH treated with MAPK pathway inhibition.

Blood 2019 04 4;133(15):1691-1694. Epub 2019 Feb 4.

Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX.

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http://dx.doi.org/10.1182/blood-2018-10-878363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460419PMC
April 2019

Thalidomide, A Rational Agent for Treatment of Multicentric Reticulohistiocytosis.

Dermatol Case Rep 2019 8;4(1). Epub 2019 Apr 8.

Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.35248/2684-124X.19.4.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289025PMC
April 2019

Langerhans-Cell Histiocytosis.

N Engl J Med 2018 08;379(9):856-868

From the Texas Children's Cancer Center and the Department of Pediatrics, Baylor College of Medicine, Houston (C.E.A., K.L.M.); and the Department of Oncological Sciences, the Precision Immunology Institute, and the Tisch Cancer Institute, Icahn School of Medicine, New York (M.M.).

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http://dx.doi.org/10.1056/NEJMra1607548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334777PMC
August 2018

Radiation pneumonitis in pediatric Hodgkin lymphoma patients receiving radiation therapy to the chest.

Pract Radiat Oncol 2018 Sep - Oct;8(5):e364-e368. Epub 2018 Feb 4.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2018.01.007DOI Listing
November 2018

The role of parental and perinatal characteristics on Langerhans cell histiocytosis: characterizing increased risk among Hispanics.

Ann Epidemiol 2018 08 17;28(8):521-528. Epub 2018 Apr 17.

Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.annepidem.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054892PMC
August 2018

Fire behind the fury: IL-18 and MAS.

Blood 2018 03;131(13):1393-1394

Baylor College of Medicine.

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http://dx.doi.org/10.1182/blood-2018-02-828186DOI Listing
March 2018

Evaluation and treatment of Langerhans cell histiocytosis patients with central nervous system abnormalities: Current views and new vistas.

Pediatr Blood Cancer 2018 Jan 25;65(1). Epub 2017 Sep 25.

Department of Pediatrics, Texas Children's Cancer and Hematology Centers and Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/pbc.26784DOI Listing
January 2018

Pediatric oncology enters an era of precision medicine.

Curr Probl Cancer 2017 May - Jun;41(3):194-200. Epub 2017 Feb 1.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1016/j.currproblcancer.2017.01.002DOI Listing
March 2018

Evaluation of maternal and perinatal characteristics on childhood lymphoma risk: A population-based case-control study.

Pediatr Blood Cancer 2017 05 28;64(5). Epub 2016 Nov 28.

Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1002/pbc.26321DOI Listing
May 2017

Hydroxyurea: a new old therapy for Langerhans cell histiocytosis.

Blood 2016 11 29;128(20):2462-2465. Epub 2016 Sep 29.

Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX.

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http://dx.doi.org/10.1182/blood-2016-06-721993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114488PMC
November 2016

Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders.

Authors:
Asbjørg Stray-Pedersen Hanne Sørmo Sorte Pubudu Samarakoon Tomasz Gambin Ivan K Chinn Zeynep H Coban Akdemir Hans Christian Erichsen Lisa R Forbes Shen Gu Bo Yuan Shalini N Jhangiani Donna M Muzny Olaug Kristin Rødningen Ying Sheng Sarah K Nicholas Lenora M Noroski Filiz O Seeborg Carla M Davis Debra L Canter Emily M Mace Timothy J Vece Carl E Allen Harshal A Abhyankar Philip M Boone Christine R Beck Wojciech Wiszniewski Børre Fevang Pål Aukrust Geir E Tjønnfjord Tobias Gedde-Dahl Henrik Hjorth-Hansen Ingunn Dybedal Ingvild Nordøy Silje F Jørgensen Tore G Abrahamsen Torstein Øverland Anne Grete Bechensteen Vegard Skogen Liv T N Osnes Mari Ann Kulseth Trine E Prescott Cecilie F Rustad Ketil R Heimdal John W Belmont Nicholas L Rider Javier Chinen Tram N Cao Eric A Smith Maria Soledad Caldirola Liliana Bezrodnik Saul Oswaldo Lugo Reyes Francisco J Espinosa Rosales Nina Denisse Guerrero-Cursaru Luis Alberto Pedroza Cecilia M Poli Jose L Franco Claudia M Trujillo Vargas Juan Carlos Aldave Becerra Nicola Wright Thomas B Issekutz Andrew C Issekutz Jordan Abbott Jason W Caldwell Diana K Bayer Alice Y Chan Alessandro Aiuti Caterina Cancrini Eva Holmberg Christina West Magnus Burstedt Ender Karaca Gözde Yesil Hasibe Artac Yavuz Bayram Mehmed Musa Atik Mohammad K Eldomery Mohammad S Ehlayel Stephen Jolles Berit Flatø Alison A Bertuch I Celine Hanson Victor W Zhang Lee-Jun Wong Jianhong Hu Magdalena Walkiewicz Yaping Yang Christine M Eng Eric Boerwinkle Richard A Gibbs William T Shearer Robert Lyle Jordan S Orange James R Lupski

J Allergy Clin Immunol 2017 01 16;139(1):232-245. Epub 2016 Jul 16.

Baylor-Hopkins Center for Mendelian Genomics of the Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex; Department of Pediatrics, Baylor College of Medicine, and Texas Children's Hospital, Houston, Tex; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Tex. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222743PMC
January 2017

ALPS DNT cells: active senior living with mTOR.

Authors:
Carl E Allen

Blood 2016 07;128(2):152

BAYLOR COLLEGE OF MEDICINE.

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http://dx.doi.org/10.1182/blood-2016-05-713032DOI Listing
July 2016

Langerhans Cell Histiocytosis: Emerging Insights and Clinical Implications.

Oncology (Williston Park) 2016 Feb;30(2):122-32, 139

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February 2016

Biological and clinical significance of somatic mutations in Langerhans cell histiocytosis and related histiocytic neoplastic disorders.

Hematology Am Soc Hematol Educ Program 2015 ;2015:559-64

Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX; Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX; and Division of Pediatric Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.

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http://dx.doi.org/10.1182/asheducation-2015.1.559DOI Listing
October 2016

Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis.

Hematology Am Soc Hematol Educ Program 2015 ;2015:177-82

Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX; and Department of Pediatrics, Graduate Program in Translational Biology and Molecular Medicine, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX.

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http://www.asheducationbook.org/cgi/doi/10.1182/asheducation
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http://dx.doi.org/10.1182/asheducation-2015.1.177DOI Listing
October 2016

Cell(s) of Origin of Langerhans Cell Histiocytosis.

Hematol Oncol Clin North Am 2015 Oct 20;29(5):825-38. Epub 2015 Aug 20.

Texas Children's Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2015.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699587PMC
October 2015

How I treat Langerhans cell histiocytosis.

Blood 2015 Jul 31;126(1):26-35. Epub 2015 Mar 31.

Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX; and.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-12-56
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http://dx.doi.org/10.1182/blood-2014-12-569301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492195PMC
July 2015

Treatment of Langerhans cell histiocytosis: it is time to learn from the past: response to Minkov and Rodriguez-Galindo.

Br J Haematol 2015 Oct 30;171(1):150-1. Epub 2015 Mar 30.

Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1111/bjh.13371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573766PMC
October 2015

Pediatric lymphomas and histiocytic disorders of childhood.

Pediatr Clin North Am 2015 Feb;62(1):139-65

Program for Cell Enhancement and Technologies for Immunotherapy, BMT Division, Department of Pediatrics, Children's National Health System, The George Washington University, 111 Michigan Avenue, Northwest, Washington, DC 20010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pcl.2014.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250829PMC
February 2015

Progress in understanding the pathogenesis of Langerhans cell histiocytosis: back to Histiocytosis X?

Br J Haematol 2015 Apr 28;169(1):3-13. Epub 2014 Nov 28.

Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY, USA; Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA; Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA; Department of Internal Medicine III, University Hospital, RWTH Aachen, Aachen, Germany.

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http://dx.doi.org/10.1111/bjh.13247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193221PMC
April 2015

Up-front therapy for LCH: is it time to test an alternative to vinblastine/prednisone?

Br J Haematol 2015 Apr 16;169(2):299-301. Epub 2014 Nov 16.

Baylor College of Medicine and Texas Children's Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/bjh.13208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791956PMC
April 2015

Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis.

Blood 2014 Nov 8;124(19):3007-15. Epub 2014 Sep 8.

Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX; Department of Molecular and Human Genetics, Human Genome Sequencing Center, Division of Pediatric Hematology-Oncology, Department of Pediatrics, Program in Translational Biology and Molecular Medicine, and.

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http://dx.doi.org/10.1182/blood-2014-05-577825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224195PMC
November 2014

fHLH: becoming a blended family.

Blood 2014 Aug;124(8):1210-1

BAYLOR COLLEGE OF MEDICINE.

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http://dx.doi.org/10.1182/blood-2014-06-582791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141507PMC
August 2014

Determination of an appropriate cut-off value for ferritin in the diagnosis of hemophagocytic lymphohistiocytosis.

Pediatr Blood Cancer 2014 Nov 21;61(11):2101-3. Epub 2014 Apr 21.

Pediatric Hematology and Oncology, University Hospital Medical Center, Hamburg, Germany.

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http://dx.doi.org/10.1002/pbc.25058DOI Listing
November 2014

Systemic inflammatory response syndrome after administration of unmodified T lymphocytes.

Mol Ther 2014 Jun 21;22(6):1134-1138. Epub 2014 Mar 21.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital, Texas Children's Hospital, Houston, Texas, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2014.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048900PMC
June 2014

Updates on histiocytic disorders.

Pediatr Blood Cancer 2014 Jul 9;61(7):1329-35. Epub 2014 Mar 9.

Children's Cancer Center, Staten Island University Hospital, Staten Island, New York.

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http://dx.doi.org/10.1002/pbc.25017DOI Listing
July 2014

Pathological consequence of misguided dendritic cell differentiation in histiocytic diseases.

Adv Immunol 2013 ;120:127-61

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, USA; Tisch Cancer Institute; Immunology Institute.

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http://dx.doi.org/10.1016/B978-0-12-417028-5.00005-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985340PMC
December 2013

Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab.

Pediatr Blood Cancer 2013 Jan 22;60(1):101-9. Epub 2012 Apr 22.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1002/pbc.24188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410971PMC
January 2013

How I treat hemophagocytic lymphohistiocytosis.

Blood 2011 Oct 9;118(15):4041-52. Epub 2011 Aug 9.

Divisions of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-03-27
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http://dx.doi.org/10.1182/blood-2011-03-278127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204727PMC
October 2011

Neither IL-17A mRNA nor IL-17A protein are detectable in Langerhans cell histiocytosis lesions.

Mol Ther 2011 Aug 7;19(8):1433-9. Epub 2011 Jun 7.

Texas Children's Hospital Cancer Center and Hematology Service, Houston, Texas, USA.

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http://dx.doi.org/10.1038/mt.2011.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149162PMC
August 2011

Erdheim-Chester: beyond the lesion.

Blood 2011 Mar;117(10):2745-6

Texas Children's Cancer Center, USA.

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http://dx.doi.org/10.1182/blood-2011-01-330233DOI Listing
March 2011

Diagnosing hemophagocytic lymphohistiocytosis: sheep vs. wolf.

Authors:
Carl E Allen

Pediatr Hematol Oncol 2011 Apr;28(3):173-5

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http://dx.doi.org/10.3109/08880018.2011.563997DOI Listing
April 2011

Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality.

Pediatr Blood Cancer 2011 Jan;56(1):154-5

Baylor College of Medicine, Department of Pediatrics, Texas Children's Cancer Center/Hematology Service, and Epidemiology Center, Houston, TX, USA.

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http://dx.doi.org/10.1002/pbc.22774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444147PMC
January 2011

ZAS3 accentuates transforming growth factor β signaling in epithelial cells.

Cell Signal 2011 Jan 21;23(1):105-13. Epub 2010 Aug 21.

Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1016/j.cellsig.2010.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967717PMC
January 2011

Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis.

Pediatr Blood Cancer 2009 May;52(5):621-5

Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas 77030-2399, USA.

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http://dx.doi.org/10.1002/pbc.21838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660724PMC
May 2009

Transformation by oncogenic Ras expands the early genomic response to transforming growth factor beta in intestinal epithelial cells.

Neoplasia 2008 Oct;10(10):1073-82

Center for Cell and Developmental Biology, The Research Institute at Nationwide Children's Hospital and the Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546594PMC
http://dx.doi.org/10.1593/neo.07739DOI Listing
October 2008

Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.

Gene Expr 2007 ;14(2):83-100

Department of Pediatrics and Center for Cell and Developmental Biology, Columbus Children's Research Institute, Columbus, OH 43205, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042042PMC
http://dx.doi.org/10.3727/105221607783417574DOI Listing
March 2008

Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis.

Pediatr Blood Cancer 2008 Jun;50(6):1227-35

Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

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http://doi.wiley.com/10.1002/pbc.21423
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http://dx.doi.org/10.1002/pbc.21423DOI Listing
June 2008

Langerhans cell histiocytosis: a review of past, current and future therapies.

Drugs Today (Barc) 2007 Sep;43(9):627-43

Texas Children's Cancer Center/Hematology Service, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1358/dot.2007.43.9.1088823DOI Listing
September 2007

Pediatric residency duty hours before and after limitations.

Pediatrics 2006 Dec;118(6):e1805-11

Division of Health Services Research, American Academy of Pediatrics, 141 Northwest Point Blvd, Elk Grove Village, IL 60007, USA.

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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2006-0210DOI Listing
December 2006

Inhibition of NF-kappaB by ZAS3, a zinc-finger protein that also binds to the kappaB motif.

Proc Natl Acad Sci U S A 2003 Oct 6;100(21):12301-6. Epub 2003 Oct 6.

Ohio State Biochemistry Program, Ohio State University, Columbus, OH 43210, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.2133048100
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http://dx.doi.org/10.1073/pnas.2133048100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC218753PMC
October 2003

Genetic mapping of an insertional hydrocephalus-inducing mutation allelic to hy3.

Mamm Genome 2002 Nov;13(11):625-32

Division of Molecular and Human Genetics, Dept. of Pediatrics, Children's Research Institute, The Ohio State University, 700 Children's Drive, Rm. W492, Columbus, OH 43205, USA.

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http://link.springer.com/content/pdf/10.1007/s00335-002-2201
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http://link.springer.com/10.1007/s00335-002-2201-8
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http://dx.doi.org/10.1007/s00335-002-2201-8DOI Listing
November 2002

Developmental anomalies and neoplasia in animals and cells deficient in the large zinc finger protein KRC.

Genes Chromosomes Cancer 2002 Dec;35(4):287-98

Program of Molecular, Cellular, and Developmental Biology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA.

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http://doi.wiley.com/10.1002/gcc.10128
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http://dx.doi.org/10.1002/gcc.10128DOI Listing
December 2002

The kappa B transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study.

BMC Immunol 2002 Aug 22;3:10. Epub 2002 Aug 22.

Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122077PMC
http://dx.doi.org/10.1186/1471-2172-3-10DOI Listing
August 2002