Carl A Anderson

Carl A Anderson

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Carl A Anderson

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Refractive Index Measurement of Pharmaceutical Solids: A Review of Measurement Methods and Pharmaceutical Applications.

J Pharm Sci 2019 Jul 17. Epub 2019 Jul 17.

Division of Pharmaceutical, Social and Administrative Sciences, Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania 15282; Division of Pharmaceutical, Social and Administrative Sciences, Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, Pennsylvania 15282. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2019.06.029DOI Listing
July 2019

Prediction of Dissolution Profiles From Process Parameters, Formulation, and Spectroscopic Measurements.

J Pharm Sci 2019 Jun 8;108(6):2119-2127. Epub 2019 Feb 8.

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2019.01.023DOI Listing
June 2019

Development of an In-Line Near-Infrared Method for Blend Content Uniformity Assessment in a Tablet Feed Frame.

Appl Spectrosc 2019 Jun 5:3702819842189. Epub 2019 Jun 5.

2 GlaxoSmithKline, Analytical Sciences and Development, Collegeville, PA, USA.

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http://journals.sagepub.com/doi/10.1177/0003702819842189
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http://dx.doi.org/10.1177/0003702819842189DOI Listing
June 2019

Feedforward and Feedback Control of a Pharmaceutical Coating Process.

AAPS PharmSciTech 2019 Apr 1;20(4):157. Epub 2019 Apr 1.

Duquesne University Graduate School of Pharmaceutical Sciences, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1208/s12249-019-1348-5DOI Listing
April 2019

Influence of moisture variation on the performance of Raman spectroscopy in quantitative pharmaceutical analyses.

J Pharm Biomed Anal 2019 Feb 15;164:528-535. Epub 2018 Oct 15.

Duquesne University Graduate School of Pharmaceutical Sciences, Pittsburgh, PA 15282, United States; Duquesne University Center for Pharmaceutical Technology, Pittsburgh, PA 15282, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.10.022DOI Listing
February 2019

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Consequences of Identifying XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease.

Gastroenterology 2018 07 9;155(1):231-234. Epub 2018 Jun 9.

Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, UK; Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1053/j.gastro.2018.03.069DOI Listing
July 2018

Method Development and Validation of an Inline Process Analytical Technology Method for Blend Monitoring in the Tablet Feed Frame Using Raman Spectroscopy.

Anal Chem 2018 07 3;90(14):8436-8444. Epub 2018 Jul 3.

GlaxoSmithKline , Analytical Sciences and Development , King of Prussia , Pennsylvania 19406 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b01009DOI Listing
July 2018

A robust quantitative near infrared modeling approach for blend monitoring.

J Pharm Biomed Anal 2018 Jan 9;148:51-57. Epub 2017 Sep 9.

Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, PA 15282, United States; Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, PA 15282, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2017.09.011DOI Listing
January 2018

Investigation of the Sensitivity of Transmission Raman Spectroscopy for Polymorph Detection in Pharmaceutical Tablets.

Appl Spectrosc 2017 Aug 30;71(8):1856-1867. Epub 2017 Mar 30.

2 GlaxoSmithKline, Analytical Science and Development, King of Prussia, PA, USA.

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http://dx.doi.org/10.1177/0003702817690407DOI Listing
August 2017

Determination of Spatially Resolved Tablet Density and Hardness Using Near-Infrared Chemical Imaging (NIR-CI).

Appl Spectrosc 2017 Aug 21;71(8):1906-1914. Epub 2017 Mar 21.

1 Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1177/0003702817693856DOI Listing
August 2017

Understanding the Impact of Chemical Variability and Calibration Algorithms on Prediction of Solid Fraction of Roller Compacted Ribbons Using Near-Infrared (NIR) Spectroscopy.

Appl Spectrosc 2017 Jun 4;71(6):1209-1221. Epub 2016 Nov 4.

4 Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1177/0003702816671960DOI Listing
June 2017

In-line monitoring and optimization of powder flow in a simulated continuous process using transmission near infrared spectroscopy.

Int J Pharm 2017 Jun 23;526(1-2):199-208. Epub 2017 Apr 23.

Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA, 15282, USA; Duquesne University Center for Pharmaceutical Technology, 600 Forbes Avenue, Pittsburgh, PA, 15282, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2017.04.054DOI Listing
June 2017

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Nat Genet 2017 Feb 19;49(2):269-273. Epub 2016 Dec 19.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540332PMC
February 2017

Comprehensive Screening of Eight Known Causative Genes in Congenital Hypothyroidism With Gland-in-Situ.

J Clin Endocrinol Metab 2016 12 15;101(12):4521-4531. Epub 2016 Aug 15.

University of Cambridge Metabolic Research Laboratories (A.K.N., E.S., G.L., V.K.K.C., N.S.), Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Human Genetics (E.G.S., C.A.A.), The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; Research Centre for Regenerative and Restorative Medicine (H.C.), Department of Medical Genetics Istanbul Medipol University, Kavacık, Istanbul, Turkey; Pediatric Endocrine Unit (S.A., I.U.), Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman; Paediatric Endocrinology Department (A.D.), Mafraq Hospital, AbuDhabi, United Arab Emirates; Pediatric Department Prince Mohamed Bin Abdulaziz Hospital (A.M.H.), Madinah, Kingdom of Saudi Arabia; Department of Paediatrics (M.A.), Madina Maternity & Children's Hospital Madina Munawara, Saudi Arabia; 8. Department of Endocrinology (C.P.), Great Ormond St Hospital for Children, London, United Kingdom; Department of Paediatrics (N.N.), Luton and Dunstable University Hospital, Luton, United Kingdom; Division of Paediatric Endocrinology (Z.A.), Dr Sami Ulus Woman Health and Children Research Hospital Ankara, Turkey; Department of Paediatric Endocrinology (H.S.), Uludağ University, School of Medicine Bursa, Turkey; Department of Paediatric Endocrinology (E.B.), Dokuz Eylül University, Faculty of Medicine Izmir, Turkey; Developmental Endocrinology Research Group (M.D.), Section of Genetics and Epigenetics in Health and Disease, Genetics and Genomic Medicine Programme, University College London Institute of Child Health, London, United Kingdom; Department of Paediatrics (S.S.), Leicester Royal infirmary, Leicester United Kingdom; Centre for Paediatrics and Child Health (P.G.M.), Institute of Human Development University of Manchester, and Royal Manchester Children's Hospital, Manchester, United Kingdom; Paediatric Endocrinology Division (A.B.), College of Medicine, King Saud University and King Saud University Medical City, Riyadh, Saudi Arabia; Department of Paediatrics (R.W., A.T.), University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom; W Midlands Regional Genetics Laboratory (R.I.), Birmingham Women's Hospital NHS Foundation Trust, Birmingham, United Kingdom; Department of Paediatric Endocrinology (R.P.), Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom; Department of Paediatrics (K.T.), Diana Princess of Wales Hospital, Grimsby, United Kingdom; Department of Paediatric Endocrinology (J.H.D.), University Hospital Southampton, Southampton, United Kingdom; Department of Paediatrics (V.P.), Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough, United Kingdom; Department of Clinical Genetics (S.-M.P.), Cambridge University Hospitals NHS Foundation Trust, Cambridge United Kingdom; London N W Healthcare NHS Trust (A.F.M.), Harrow, Middlesex, United Kingdom; Division of Population Medicine (J.W.G.), School of Medicine, Cardiff University, Heath Park Cardiff, UK; Department of Paediatric Endocrinology (A.A.), St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Centre for Endocrinology (E.P.-G.), William Harvey Research Institute, Queen Mary University London and Children's Hospital, Barts Health NHS Trust, London, United Kingdom; Department of Medical Genetics (H.M., K.B., E.R.M.), University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom.

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http://dx.doi.org/10.1210/jc.2016-1879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155683PMC
December 2016

A reference panel of 64,976 haplotypes for genotype imputation.

Authors:
Shane McCarthy Sayantan Das Warren Kretzschmar Olivier Delaneau Andrew R Wood Alexander Teumer Hyun Min Kang Christian Fuchsberger Petr Danecek Kevin Sharp Yang Luo Carlo Sidore Alan Kwong Nicholas Timpson Seppo Koskinen Scott Vrieze Laura J Scott He Zhang Anubha Mahajan Jan Veldink Ulrike Peters Carlos Pato Cornelia M van Duijn Christopher E Gillies Ilaria Gandin Massimo Mezzavilla Arthur Gilly Massimiliano Cocca Michela Traglia Andrea Angius Jeffrey C Barrett Dorrett Boomsma Kari Branham Gerome Breen Chad M Brummett Fabio Busonero Harry Campbell Andrew Chan Sai Chen Emily Chew Francis S Collins Laura J Corbin George Davey Smith George Dedoussis Marcus Dorr Aliki-Eleni Farmaki Luigi Ferrucci Lukas Forer Ross M Fraser Stacey Gabriel Shawn Levy Leif Groop Tabitha Harrison Andrew Hattersley Oddgeir L Holmen Kristian Hveem Matthias Kretzler James C Lee Matt McGue Thomas Meitinger David Melzer Josine L Min Karen L Mohlke John B Vincent Matthias Nauck Deborah Nickerson Aarno Palotie Michele Pato Nicola Pirastu Melvin McInnis J Brent Richards Cinzia Sala Veikko Salomaa David Schlessinger Sebastian Schoenherr P Eline Slagboom Kerrin Small Timothy Spector Dwight Stambolian Marcus Tuke Jaakko Tuomilehto Leonard H Van den Berg Wouter Van Rheenen Uwe Volker Cisca Wijmenga Daniela Toniolo Eleftheria Zeggini Paolo Gasparini Matthew G Sampson James F Wilson Timothy Frayling Paul I W de Bakker Morris A Swertz Steven McCarroll Charles Kooperberg Annelot Dekker David Altshuler Cristen Willer William Iacono Samuli Ripatti Nicole Soranzo Klaudia Walter Anand Swaroop Francesco Cucca Carl A Anderson Richard M Myers Michael Boehnke Mark I McCarthy Richard Durbin

Nat Genet 2016 10 22;48(10):1279-83. Epub 2016 Aug 22.

Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388176PMC
October 2016

Effect of Sampling Frequency for Real-Time Tablet Coating Monitoring Using Near Infrared Spectroscopy.

Appl Spectrosc 2016 Sep 8;70(9):1476-88. Epub 2016 Aug 8.

Duquesne Center for Pharmaceutical Technology, Duquesne University, USA Graduate School of Pharmaceutical Sciences, Duquesne University, USA

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http://dx.doi.org/10.1177/0003702816662622DOI Listing
September 2016

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Nat Commun 2016 08 9;7:12342. Epub 2016 Aug 9.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1038/ncomms12342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980482PMC
August 2016

Method development and validation for pharmaceutical tablets analysis using transmission Raman spectroscopy.

Int J Pharm 2016 Feb 30;498(1-2):318-25. Epub 2015 Nov 30.

Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States; Duquesne Center for Pharmaceutical Technology, Duquesne University, 600 Forbes Avenue, Pittsburgh PA 15282, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2015.11.049DOI Listing
February 2016

Near-Infrared Spatially Resolved Spectroscopy for Tablet Quality Determination.

J Pharm Sci 2015 Dec 28;104(12):4074-4081. Epub 2015 Aug 28.

Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282. Electronic address:

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http://dx.doi.org/10.1002/jps.24618DOI Listing
December 2015

Improving near-infrared prediction model robustness with support vector machine regression: a pharmaceutical tablet assay example.

Appl Spectrosc 2014 1;68(12):1348-56. Epub 2014 Nov 1.

Duquesne University Center for Pharmaceutical Technology, School of Pharmacy, 600 Forbes Avenue, Pittsburgh, PA 15282 USA.

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http://dx.doi.org/10.1366/14-07486DOI Listing
July 2015

Genetics in PSC: what do the "risk genes" teach us?

Clin Rev Allergy Immunol 2015 Jun;48(2-3):154-64

Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, 4950 Nydalen, 0424, Oslo, Norway.

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http://dx.doi.org/10.1007/s12016-014-8417-zDOI Listing
June 2015

Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.

PLoS One 2014 7;9(10):e108384. Epub 2014 Oct 7.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom; Department of Infection, Division of Infection and Immunity, University College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108384PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188571PMC
June 2015

Modeling strategies for pharmaceutical blend monitoring and end-point determination by near-infrared spectroscopy.

Int J Pharm 2014 Oct 6;473(1-2):219-31. Epub 2014 Jul 6.

Duquesne Center for Pharmaceutical Technology, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2014.06.061DOI Listing
October 2014

Genetic studies of Crohn's disease: past, present and future.

Best Pract Res Clin Gastroenterol 2014 Jun 6;28(3):373-86. Epub 2014 May 6.

The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bpg.2014.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075408PMC
June 2014

Effects and detection of raw material variability on the performance of near-infrared calibration models for pharmaceutical products.

J Pharm Sci 2014 Feb 12;103(2):545-56. Epub 2013 Dec 12.

Duquesne University Center for Pharmaceutical Technology, School of Pharmacy, Pittsburgh, Pennsylvania, 15282.

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http://dx.doi.org/10.1002/jps.23816DOI Listing
February 2014

Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects.

Am J Hum Genet 2014 Feb 23;94(2):295-302. Epub 2014 Jan 23.

Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928658PMC
February 2014

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.

Cell 2013 Sep 12;155(1):57-69. Epub 2013 Sep 12.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1016/j.cell.2013.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790457PMC
September 2013

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nat Genet 2013 Jun 21;45(6):670-5. Epub 2013 Apr 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://petercroucher.com/wp-content/uploads/2013/10/51_Natur
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http://www.nature.com/doifinder/10.1038/ng.2616
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http://dx.doi.org/10.1038/ng.2616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667736PMC
June 2013

Effect of experimental design on the prediction performance of calibration models based on near-infrared spectroscopy for pharmaceutical applications.

Appl Spectrosc 2012 Dec;66(12):1442-53

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.

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http://dx.doi.org/10.1366/12-06689DOI Listing
December 2012

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors:
Luke Jostins Stephan Ripke Rinse K Weersma Richard H Duerr Dermot P McGovern Ken Y Hui James C Lee L Philip Schumm Yashoda Sharma Carl A Anderson Jonah Essers Mitja Mitrovic Kaida Ning Isabelle Cleynen Emilie Theatre Sarah L Spain Soumya Raychaudhuri Philippe Goyette Zhi Wei Clara Abraham Jean-Paul Achkar Tariq Ahmad Leila Amininejad Ashwin N Ananthakrishnan Vibeke Andersen Jane M Andrews Leonard Baidoo Tobias Balschun Peter A Bampton Alain Bitton Gabrielle Boucher Stephan Brand Carsten Büning Ariella Cohain Sven Cichon Mauro D'Amato Dirk De Jong Kathy L Devaney Marla Dubinsky Cathryn Edwards David Ellinghaus Lynnette R Ferguson Denis Franchimont Karin Fransen Richard Gearry Michel Georges Christian Gieger Jürgen Glas Talin Haritunians Ailsa Hart Chris Hawkey Matija Hedl Xinli Hu Tom H Karlsen Limas Kupcinskas Subra Kugathasan Anna Latiano Debby Laukens Ian C Lawrance Charlie W Lees Edouard Louis Gillian Mahy John Mansfield Angharad R Morgan Craig Mowat William Newman Orazio Palmieri Cyriel Y Ponsioen Uros Potocnik Natalie J Prescott Miguel Regueiro Jerome I Rotter Richard K Russell Jeremy D Sanderson Miquel Sans Jack Satsangi Stefan Schreiber Lisa A Simms Jurgita Sventoraityte Stephan R Targan Kent D Taylor Mark Tremelling Hein W Verspaget Martine De Vos Cisca Wijmenga David C Wilson Juliane Winkelmann Ramnik J Xavier Sebastian Zeissig Bin Zhang Clarence K Zhang Hongyu Zhao Mark S Silverberg Vito Annese Hakon Hakonarson Steven R Brant Graham Radford-Smith Christopher G Mathew John D Rioux Eric E Schadt Mark J Daly Andre Franke Miles Parkes Severine Vermeire Jeffrey C Barrett Judy H Cho

Nature 2012 Nov;491(7422):119-24

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1038/nature11582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803PMC
November 2012

Development of a fluid bed granulation design space using critical quality attribute weighted tolerance intervals.

J Pharm Sci 2012 Aug 8;101(8):2917-29. Epub 2012 May 8.

Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania 15282, USA.

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http://dx.doi.org/10.1002/jps.23185DOI Listing
August 2012

Radial tensile strength prediction of relaxing and relaxed compacts by near-infrared chemical imaging.

Int J Pharm 2011 Oct 20;418(2):297-303. Epub 2011 May 20.

Duquesne University Center for Pharmaceutical Technology, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03785173110046
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http://dx.doi.org/10.1016/j.ijpharm.2011.05.038DOI Listing
October 2011

Performance-based quality specifications: the relationship between process critical control parameters, critical quality attributes, and clinical performance.

J Pharm Sci 2011 Apr 30;100(4):1566-75. Epub 2010 Nov 30.

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549153220
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http://dx.doi.org/10.1002/jps.22373DOI Listing
April 2011

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:
Carl A Anderson Gabrielle Boucher Charlie W Lees Andre Franke Mauro D'Amato Kent D Taylor James C Lee Philippe Goyette Marcin Imielinski Anna Latiano Caroline Lagacé Regan Scott Leila Amininejad Suzannah Bumpstead Leonard Baidoo Robert N Baldassano Murray Barclay Theodore M Bayless Stephan Brand Carsten Büning Jean-Frédéric Colombel Lee A Denson Martine De Vos Marla Dubinsky Cathryn Edwards David Ellinghaus Rudolf S N Fehrmann James A B Floyd Timothy Florin Denis Franchimont Lude Franke Michel Georges Jürgen Glas Nicole L Glazer Stephen L Guthery Talin Haritunians Nicholas K Hayward Jean-Pierre Hugot Gilles Jobin Debby Laukens Ian Lawrance Marc Lémann Arie Levine Cecile Libioulle Edouard Louis Dermot P McGovern Monica Milla Grant W Montgomery Katherine I Morley Craig Mowat Aylwin Ng William Newman Roel A Ophoff Laura Papi Orazio Palmieri Laurent Peyrin-Biroulet Julián Panés Anne Phillips Natalie J Prescott Deborah D Proctor Rebecca Roberts Richard Russell Paul Rutgeerts Jeremy Sanderson Miquel Sans Philip Schumm Frank Seibold Yashoda Sharma Lisa A Simms Mark Seielstad A Hillary Steinhart Stephan R Targan Leonard H van den Berg Morten Vatn Hein Verspaget Thomas Walters Cisca Wijmenga David C Wilson Harm-Jan Westra Ramnik J Xavier Zhen Z Zhao Cyriel Y Ponsioen Vibeke Andersen Leif Torkvist Maria Gazouli Nicholas P Anagnou Tom H Karlsen Limas Kupcinskas Jurgita Sventoraityte John C Mansfield Subra Kugathasan Mark S Silverberg Jonas Halfvarson Jerome I Rotter Christopher G Mathew Anne M Griffiths Richard Gearry Tariq Ahmad Steven R Brant Mathias Chamaillard Jack Satsangi Judy H Cho Stefan Schreiber Mark J Daly Jeffrey C Barrett Miles Parkes Vito Annese Hakon Hakonarson Graham Radford-Smith Richard H Duerr Séverine Vermeire Rinse K Weersma John D Rioux

Nat Genet 2011 Mar 6;43(3):246-52. Epub 2011 Feb 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597PMC
March 2011

Basic statistical analysis in genetic case-control studies.

Nat Protoc 2011 Feb 3;6(2):121-33. Epub 2011 Feb 3.

Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/nprot.2010.182
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http://dx.doi.org/10.1038/nprot.2010.182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154648PMC
February 2011

Synthetic associations are unlikely to account for many common disease genome-wide association signals.

PLoS Biol 2011 Jan 18;9(1):e1000580. Epub 2011 Jan 18.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB101HH, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1000580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022527PMC
January 2011

A new definition of pharmaceutical quality: assembly of a risk simulation platform to investigate the impact of manufacturing/product variability on clinical performance.

J Pharm Sci 2010 Dec;99(12):5046-59

Duquesne University Graduate School of Pharmaceutical Sciences, 410A Mellon Hall, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, USA.

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http://dx.doi.org/10.1002/jps.22219DOI Listing
December 2010

Pharmaceutical applications of separation of absorption and scattering in near-infrared spectroscopy (NIRS).

J Pharm Sci 2010 Dec;99(12):4766-83

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA.

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http://dx.doi.org/10.1002/jps.22228DOI Listing
December 2010

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Nat Genet 2010 Dec;42(12):1118-25

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551PMC
December 2010

Application of Monte Carlo simulation-based photon migration for enhanced understanding of near-infrared (NIR) diffuse reflectance. Part II: Photon radial diffusion in NIR chemical images.

J Pharm Sci 2010 Oct;99(10):4174-82

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA.

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http://dx.doi.org/10.1002/jps.22125DOI Listing
October 2010

Data quality control in genetic case-control association studies.

Nat Protoc 2010 Sep 26;5(9):1564-73. Epub 2010 Aug 26.

Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nprot.2010.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025522PMC
September 2010

Application of Monte Carlo simulation-based photon migration for enhanced understanding of near-infrared (NIR) diffuse reflectance. Part I: Depth of penetration in pharmaceutical materials.

J Pharm Sci 2010 May;99(5):2399-412

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549153265
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http://dx.doi.org/10.1002/jps.22013DOI Listing
May 2010

Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

Authors:
Jason Z Liu Federica Tozzi Dawn M Waterworth Sreekumar G Pillai Pierandrea Muglia Lefkos Middleton Wade Berrettini Christopher W Knouff Xin Yuan Gérard Waeber Peter Vollenweider Martin Preisig Nicholas J Wareham Jing Hua Zhao Ruth J F Loos Inês Barroso Kay-Tee Khaw Scott Grundy Philip Barter Robert Mahley Antero Kesaniemi Ruth McPherson John B Vincent John Strauss James L Kennedy Anne Farmer Peter McGuffin Richard Day Keith Matthews Per Bakke Amund Gulsvik Susanne Lucae Marcus Ising Tanja Brueckl Sonja Horstmann H-Erich Wichmann Rajesh Rawal Norbert Dahmen Claudia Lamina Ozren Polasek Lina Zgaga Jennifer Huffman Susan Campbell Jaspal Kooner John C Chambers Mary Susan Burnett Joseph M Devaney Augusto D Pichard Kenneth M Kent Lowell Satler Joseph M Lindsay Ron Waksman Stephen Epstein James F Wilson Sarah H Wild Harry Campbell Veronique Vitart Muredach P Reilly Mingyao Li Liming Qu Robert Wilensky William Matthai Hakon H Hakonarson Daniel J Rader Andre Franke Michael Wittig Arne Schäfer Manuela Uda Antonio Terracciano Xiangjun Xiao Fabio Busonero Paul Scheet David Schlessinger David St Clair Dan Rujescu Gonçalo R Abecasis Hans Jörgen Grabe Alexander Teumer Henry Völzke Astrid Petersmann Ulrich John Igor Rudan Caroline Hayward Alan F Wright Ivana Kolcic Benjamin J Wright John R Thompson Anthony J Balmforth Alistair S Hall Nilesh J Samani Carl A Anderson Tariq Ahmad Christopher G Mathew Miles Parkes Jack Satsangi Mark Caulfield Patricia B Munroe Martin Farrall Anna Dominiczak Jane Worthington Wendy Thomson Steve Eyre Anne Barton Vincent Mooser Clyde Francks Jonathan Marchini

Nat Genet 2010 May 25;42(5):436-40. Epub 2010 Apr 25.

Department of Statistics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612983PMC
May 2010

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

Nat Genet 2009 Dec 15;41(12):1330-4. Epub 2009 Nov 15.

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http://dx.doi.org/10.1038/ng.483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812019PMC
December 2009

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Authors:
Marcin Imielinski Robert N Baldassano Anne Griffiths Richard K Russell Vito Annese Marla Dubinsky Subra Kugathasan Jonathan P Bradfield Thomas D Walters Patrick Sleiman Cecilia E Kim Aleixo Muise Kai Wang Joseph T Glessner Shehzad Saeed Haitao Zhang Edward C Frackelton Cuiping Hou James H Flory George Otieno Rosetta M Chiavacci Robert Grundmeier Massimo Castro Anna Latiano Bruno Dallapiccola Joanne Stempak Debra J Abrams Kent Taylor Dermot McGovern Gary Silber Iwona Wrobel Antonio Quiros Jeffrey C Barrett Sarah Hansoul Dan L Nicolae Judy H Cho Richard H Duerr John D Rioux Steven R Brant Mark S Silverberg Kent D Taylor M Michael Barmuda Alain Bitton Themistocles Dassopoulos Lisa Wu Datta Todd Green Anne M Griffiths Emily O Kistner Michael T Murtha Miguel D Regueiro Jerome I Rotter L Philip Schumm A Hillary Steinhart Stephen R Targan Ramnik J Xavier Cécile Libioulle Cynthia Sandor Mark Lathrop Jacques Belaiche Olivier Dewit Ivo Gut Simon Heath Debby Laukens Myriam Mni Paul Rutgeerts André Van Gossum Diana Zelenika Denis Franchimont J P Hugot Martine de Vos Severine Vermeire Edouard Louis Lon R Cardon Carl A Anderson Hazel Drummond Elaine Nimmo Tariq Ahmad Natalie J Prescott Clive M Onnie Sheila A Fisher Jonathan Marchini Jilur Ghori Suzannah Bumpstead Rhian Gwillam Mark Tremelling Panos Delukas John Mansfield Derek Jewell Jack Satsangi Christopher G Mathew Miles Parkes Michel Georges Mark J Daly Melvin B Heyman George D Ferry Barbara Kirschner Jessica Lee Jonah Essers Richard Grand Michael Stephens Arie Levine David Piccoli John Van Limbergen Salvatore Cucchiara Dimitri S Monos Stephen L Guthery Lee Denson David C Wilson Straun F A Grant Mark Daly Mark S Silverberg Jack Satsangi Hakon Hakonarson

Nat Genet 2009 Dec 15;41(12):1335-40. Epub 2009 Nov 15.

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267927PMC
December 2009

Marker selection for genetic case-control association studies.

Nat Protoc 2009 23;4(5):743-52. Epub 2009 Apr 23.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nprot.2009.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025519PMC
June 2009

A near-infrared spectroscopic investigation of relative density and crushing strength in four-component compacts.

J Pharm Sci 2009 Mar;98(3):1095-109

Duquesne University Graduate School of Pharmaceutical Sciences, 410A Mellon Hall, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, USA.

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http://dx.doi.org/10.1002/jps.21473DOI Listing
March 2009

Scattering orthogonalization of near-infrared spectra for analysis of pharmaceutical tablets.

Anal Chem 2009 Feb;81(4):1389-96

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA.

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http://dx.doi.org/10.1021/ac802105vDOI Listing
February 2009

A genome-wide linkage scan for age at menarche in three populations of European descent.

J Clin Endocrinol Metab 2008 Oct 22;93(10):3965-70. Epub 2008 Jul 22.

Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland 4029, Australia.

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http://dx.doi.org/10.1210/jc.2007-2568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579643PMC
October 2008

Characterization of pharmaceutical powder blends by NIR chemical imaging.

J Pharm Sci 2008 Aug;97(8):3305-20

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA.

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http://dx.doi.org/10.1002/jps.21230DOI Listing
August 2008

Process characterization of powder blending by near-infrared spectroscopy: blend end-points and beyond.

J Pharm Biomed Anal 2008 Aug 22;47(4-5):738-45. Epub 2008 Mar 22.

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.

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http://dx.doi.org/10.1016/j.jpba.2008.03.013DOI Listing
August 2008

Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

Am J Hum Genet 2008 Jul 26;83(1):112-9. Epub 2008 Jun 26.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN Oxford, UK.

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http://dx.doi.org/10.1016/j.ajhg.2008.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443836PMC
July 2008

Determination of figures of merit for near-infrared and Raman spectrometry by net analyte signal analysis for a 4-component solid dosage system.

AAPS PharmSciTech 2007 Nov 9;8(4):E96. Epub 2007 Nov 9.

Duquesne University Center for Pharmaceutical Technology, 410A Mellon Hall, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.

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http://link.springer.com/10.1208/pt0804096
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http://dx.doi.org/10.1208/pt0804096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750682PMC
November 2007

Estimation of variance components for age at menarche in twin families.

Behav Genet 2007 Sep 7;37(5):668-77. Epub 2007 Aug 7.

Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane 4029, Australia.

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http://dx.doi.org/10.1007/s10519-007-9163-2DOI Listing
September 2007

Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene.

Inflamm Bowel Dis 2007 Aug;13(8):941-6

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1002/ibd.20162DOI Listing
August 2007

Demonstration of a shear-based solid-state phase transformation in a small molecular organic system: chlorpropamide.

J Pharm Sci 2007 May;96(5):1100-13

Duquesne University Mylan School of Pharmacy, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, USA.

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http://dx.doi.org/10.1002/jps.20920DOI Listing
May 2007

Process analytical technology case study, part III: calibration monitoring and transfer.

AAPS PharmSciTech 2005 Oct 6;6(2):E284-97. Epub 2005 Oct 6.

Duquesne University Center for Pharmaceutical Technology, Pittsburgh, PA 15282.

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http://dx.doi.org/10.1208/pt060239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750542PMC
October 2005

Waiting for Hippocrates: the "right to die" and the U.S. Constitution.

Authors:
Carl A Anderson

Linacre Q 1996 Aug;63(3):60-72

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http://dx.doi.org/10.1080/20508549.1999.11878358DOI Listing
August 1996

The role of government in protecting children with disabilities.

Authors:
Carl A Anderson

Linacre Q 1991 Aug;58(3):69-78

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http://dx.doi.org/10.1080/00243639.1991.11878121DOI Listing
August 1991