Publications by authors named "Carien M Niessen"

59Publications

Emerging mechanisms driving cell differentiation in vivo.

Curr Opin Cell Biol 2020 Dec 10;67:iii-v. Epub 2020 Nov 10.

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, USA. Electronic address:

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December 2020

Tracing the Evolutionary Origin of Desmosomes.

Curr Biol 2020 May;30(10):R535-R543

Department of Biological Sciences, 2101 E. Wesley Ave. SGM 203, University of Denver, CO 80210, USA. Electronic address:

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May 2020

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage.

Cell 2020 05 16;181(4):800-817.e22. Epub 2020 Apr 16.

Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland; Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany; Cologne Excellence Cluster for Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany. Electronic address:

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May 2020

Small-scale demixing in confluent biological tissues.

Soft Matter 2020 Apr;16(13):3325-3337

Department of Physics and BioInspired Syracuse, Institute for Material and Living Systems, Syracuse University, Syracuse, NY 13244, USA. and Indian Creek Farm, Ithaca, NY 14850, USA.

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April 2020

Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis.

J Invest Dermatol 2020 Oct 22;140(10):1927-1937.e5. Epub 2020 Feb 22.

Department of Dermatology, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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October 2020

Identification of Host Trafficking Genes Required for HIV-1 Virological Synapse Formation in Dendritic Cells.

J Virol 2020 04 16;94(9). Epub 2020 Apr 16.

Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom

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April 2020

Intrauterine growth restriction induces skin inflammation, increases TSLP and impairs epidermal barrier function.

J Mol Med (Berl) 2020 02 7;98(2):279-289. Epub 2020 Jan 7.

Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics, Experimental Pulmonology, University of Cologne, Kerpener Strasse 62, D-50937, Cologne, Germany.

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February 2020

Epithelial polarity limits EMT.

Nat Cell Biol 2019 03;21(3):299-300

Department of Dermatology, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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March 2019

E-cadherin binds to desmoglein to facilitate desmosome assembly.

Elife 2018 07 12;7. Epub 2018 Jul 12.

Department of Physics and Astronomy, Iowa State University, Ames, United States.

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July 2018

Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization.

Curr Opin Cell Biol 2018 10 1;54:89-97. Epub 2018 Jun 1.

Department of Dermatology, Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. Electronic address:

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October 2018

Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis.

Oncogene 2018 09 23;37(37):5136-5146. Epub 2018 May 23.

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Köln, Germany.

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September 2018

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective.

Cold Spring Harb Perspect Biol 2018 11 1;10(11). Epub 2018 Nov 1.

University of Cologne, Department of Dermatology, Cologne Excellence Cluster on Stress Responses in Aging Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) at the CECAD Research Center, 50931 Cologne, Germany.

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November 2018

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation.

J Invest Dermatol 2018 01 1;138(1):132-140. Epub 2017 Sep 1.

Center for Physiology and Pathophysiology, Institute of Vegetative Physiology, University of Köln, Köln, Germany.

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January 2018

The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma.

J Exp Med 2017 02 17;214(2):339-358. Epub 2017 Jan 17.

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50923 Köln, Germany

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February 2017

Epithelial Barriers in Murine Skin during Herpes Simplex Virus 1 Infection: The Role of Tight Junction Formation.

J Invest Dermatol 2017 04 6;137(4):884-893. Epub 2016 Dec 6.

Center for Biochemistry, University of Cologne, Cologne, Germany; Department of Dermatology, University of Cologne, Cologne, Germany. Electronic address:

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April 2017

The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying.

PLoS Genet 2016 Dec 2;12(12):e1006463. Epub 2016 Dec 2.

Institute for Genetics, University of Cologne, Cologne, Germany.

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December 2016

Degrees of Freedom: Your Future in Biomedical Research.

J Invest Dermatol 2016 06;136(6):1073-1076

University of Cologne, Department of Dermatology, Cologne Excellence Cluster on Stress Responses in Aging Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) at the CECAD Research Center, Joseph Stelzmannstrasse 26, 50931, Cologne, Germany.

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June 2016

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

Am J Physiol Renal Physiol 2016 07 27;311(1):F112-9. Epub 2016 Apr 27.

Department II of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Center for Molecular Medicine, University of Cologne, Cologne, Germany;

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July 2016

Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo.

J Invest Dermatol 2016 07 28;136(7):1471-1478. Epub 2016 Mar 28.

Institute of Molecular Medicine, Division of Pathobiochemistry, Martin Luther University Halle-Wittenberg, Halle, Germany. Electronic address:

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July 2016

Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling.

J Invest Dermatol 2015 Jun 23;135(6):1501-1509. Epub 2015 Feb 23.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany. Electronic address:

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June 2015

Epidermal polarity genes in health and disease.

Cold Spring Harb Perspect Med 2014 Dec 1;4(12):a015255. Epub 2014 Dec 1.

Department of Dermatology, Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.

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December 2014

Mammalian aPKC/Par polarity complex mediated regulation of epithelial division orientation and cell fate.

Exp Cell Res 2014 Nov 13;328(2):296-302. Epub 2014 Aug 13.

Department of Dermatology, Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmannstrasse 26, 50931 Cologne, Germany. Electronic address:

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November 2014

Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy.

Mol Ther 2014 May 28;22(5):929-39. Epub 2014 Jan 28.

1] Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany [2] Department I for Internal Medicine, University Hospital Cologne, Cologne, Germany.

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May 2014

Clinician scientists and PhDs: the need to connect basic research to translational medicine-a personal experience.

J Invest Dermatol 2014 Feb;134(2):295-298

Department of Dermatology, Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases, SFB 829 "Molecular Mechanisms Regulating Skin Homeostasis," University of Cologne, Cologne, Germany.

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February 2014

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation.

J Cell Biol 2013 Sep 9;202(6):887-900. Epub 2013 Sep 9.

Department of Dermatology, Center for Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.

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September 2013

Montagna Symposium 2012: Keeping it all together--adhesion, the cytoskeleton, and signaling in morphogenesis and tissue function.

J Invest Dermatol 2013 May;133(5):1124-8

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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May 2013

Analysis of bulge stem cells from the epidermis using flow cytometry.

Methods Mol Biol 2013 ;989:33-43

Department of Dermatology, Cologne Excellence Cluster on Cellular Stress Responses in Aging associated Diseases (CECAD), University of Cologne, Cologne, Germany.

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September 2013

The in vivo function of mammalian cell and tissue polarity regulators--how to shape and maintain the epidermal barrier.

J Cell Sci 2012 Aug 30;125(Pt 15):3501-10. Epub 2012 Aug 30.

Department of Dermatology, Center for Molecular Medicine, Robert Kochstrasse 21, 50931 Cologne, Germany.

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August 2012

Classical and desmosomal cadherins at a glance.

J Cell Sci 2012 Jun;125(Pt 11):2547-52

Department of Cell Biology, Emory University, Atlanta, GA 30322, USA.

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June 2012

Adherens junctions in mammalian development, homeostasis and disease: lessons from mice.

Subcell Biochem 2012 ;60:321-55

Department of Dermatology, Center for Molecular Medicine, University of Cologne, Room 4A.05, Robert Kochstrasse 21, 50931, Cologne, Germany.

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February 2014

Cadherin-dependent differential cell adhesion in Xenopus causes cell sorting in vitro but not in the embryo.

J Cell Sci 2012 Apr 10;125(Pt 8):1877-83. Epub 2012 Feb 10.

University of Toronto, Department of Cell and Systems Biology, Toronto, M5S 3G5 Canada.

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April 2012

Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation.

Physiol Rev 2011 Apr;91(2):691-731

Department of Dermatology, Center for Molecular Medicine, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.

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April 2011

CD44 regulates tight-junction assembly and barrier function.

J Invest Dermatol 2011 Apr 30;131(4):932-43. Epub 2010 Dec 30.

Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

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April 2011

An adhesion-independent, aPKC-dependent function for cadherins in morphogenetic movements.

J Cell Sci 2009 Jul 23;122(Pt 14):2514-23. Epub 2009 Jun 23.

Center for Molecular Medicine Cologne, University of Cologne, 50923 Cologne, Germany.

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July 2009

Cadherin-mediated regulation of tight junctions in stratifying epithelia.

Ann N Y Acad Sci 2009 May;1165:163-8

Department of Dermatology, Center for Molecular Medicine Cologne, University of Cologne, Colgne, Germany.

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May 2009

Molecular components of the adherens junction.

Biochim Biophys Acta 2008 Mar 14;1778(3):562-71. Epub 2008 Jan 14.

Center for Molecular Medicine, University of Cologne, LFI, 05, Room 59, Joseph Stelzmannstrasse 9, D-50931 Cologne, Germany.

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March 2008

Tight junctions/adherens junctions: basic structure and function.

Authors:
Carien M Niessen

J Invest Dermatol 2007 Nov;127(11):2525-32

Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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November 2007

Another job for the talented p120-catenin.

Cell 2006 Dec;127(5):875-7

Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph Stelzmannstrasse 9, 50931 Cologne.

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December 2006

Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation.

J Invest Dermatol 2007 Apr 16;127(4):782-91. Epub 2006 Nov 16.

Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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April 2007

Cadherin-mediated cell sorting not determined by binding or adhesion specificity.

J Cell Biol 2002 Jan 14;156(2):389-399. Epub 2002 Jan 14.

Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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January 2002