Caoimhin G Concannon

Caoimhin G Concannon

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Caoimhin G Concannon

Caoimhin G Concannon

Publications by authors named "Caoimhin G Concannon"

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ER stress signaling has an activating transcription factor 6α (ATF6)-dependent "off-switch".

J Biol Chem 2018 11 4;293(47):18270-18284. Epub 2018 Oct 4.

From the Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 6, Ireland

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http://dx.doi.org/10.1074/jbc.RA118.002121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254332PMC
November 2018

Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.

J Transl Med 2016 07 1;14(1):196. Epub 2016 Jul 1.

Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1186/s12967-016-0948-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930591PMC
July 2016

Erratum to: Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.

J Transl Med 2016 07 26;14(1):222. Epub 2016 Jul 26.

Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1186/s12967-016-0984-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962400PMC
July 2016

Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.

Eur J Pharmacol 2016 Jun 17;780:53-64. Epub 2016 Mar 17.

Centre for Systems Medicine and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2016.03.031DOI Listing
June 2016

Endoplasmic reticulum stress-mediated upregulation of miR-29a enhances sensitivity to neuronal apoptosis.

Eur J Neurosci 2016 Mar 9;43(5):640-52. Epub 2016 Feb 9.

Centre for the Study of Neurological Disorders and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin, 2, Ireland.

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http://dx.doi.org/10.1111/ejn.13160DOI Listing
March 2016

Increased expression of microRNA-29a in ALS mice: functional analysis of its inhibition.

J Mol Neurosci 2014 Jun 4;53(2):231-41. Epub 2014 Apr 4.

Centre for the Study of Neurological Disorders, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1007/s12031-014-0290-yDOI Listing
June 2014

Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis.

J Cell Sci 2014 Feb 27;127(Pt 3):609-19. Epub 2013 Nov 27.

Centre for Systems Medicine and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://jcs.biologists.org/content/joces/127/3/609.full.pdf
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http://jcs.biologists.org/cgi/doi/10.1242/jcs.137158
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http://dx.doi.org/10.1242/jcs.137158DOI Listing
February 2014

AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1.

J Neurochem 2013 Mar 26;124(5):721-34. Epub 2012 Dec 26.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1111/jnc.12108DOI Listing
March 2013

CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.

Brain 2013 Feb 29;136(Pt 2):577-92. Epub 2013 Jan 29.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1093/brain/aws337DOI Listing
February 2013

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis.

Neurobiol Aging 2012 Sep 30;33(9):2200-9. Epub 2011 Jul 30.

Experimental Neurosurgery, Center for Neurology and Neurosurgery, Goethe University Hospital, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.06.012DOI Listing
September 2012

Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer.

Int J Cancer 2012 Aug 8;131(4):E494-500. Epub 2011 Nov 8.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1002/ijc.26468DOI Listing
August 2012

Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy.

Gut 2012 May 14;61(5):725-33. Epub 2011 Nov 14.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 Saint Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1136/gutjnl-2011-300433DOI Listing
May 2012

'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.

Biochim Biophys Acta 2012 May 7;1817(5):744-53. Epub 2012 Feb 7.

Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/j.bbabio.2012.01.016DOI Listing
May 2012

Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.

J Neurosci 2012 Apr;32(15):5024-38

Department of Physiology and Medical Physics, Centre for Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.1523/JNEUROSCI.6366-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622103PMC
April 2012

Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.

Antioxid Redox Signal 2011 May 18;14(10):1863-76. Epub 2011 Feb 18.

Department of Physiology and Medical Physics, RCSI Neuroscience Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1089/ars.2010.3544DOI Listing
May 2011

Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.

Eur J Neurosci 2011 Feb 31;33(3):401-8. Epub 2010 Dec 31.

Department of Physiology and Medical Physics and RCSI Neuroscience Research Centre, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1111/j.1460-9568.2010.07538.xDOI Listing
February 2011

Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition.

Mol Cell Biol 2010 Dec 4;30(23):5484-501. Epub 2010 Oct 4.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1128/MCB.00575-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976426PMC
December 2010

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.

J Cell Sci 2010 May 31;123(Pt 9):1401-6. Epub 2010 Mar 31.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, RCSI York House, York Street, Dublin 2, Ireland.

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http://jcs.biologists.org/content/joces/123/9/1401.full.pdf
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http://jcs.biologists.org/cgi/doi/10.1242/jcs.061143
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http://dx.doi.org/10.1242/jcs.061143DOI Listing
May 2010

AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis.

J Cell Biol 2010 Apr 29;189(1):83-94. Epub 2010 Mar 29.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland Research Institute, Dublin 2, Ireland.

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http://dx.doi.org/10.1083/jcb.200909166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854380PMC
April 2010

The amyloid precursor protein intracellular domain(AICD) disrupts actin dynamics and mitochondrial bioenergetics.

J Neurochem 2010 Apr;113(1):275-84

Department of Physiology and Medical Physics and RCSI Neuroscience Research Centre, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06615.xDOI Listing
April 2010

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma.

FASEB J 2010 Mar 4;24(3):853-61. Epub 2009 Nov 4.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1096/fj.09-145870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231945PMC
March 2010

Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells.

Mol Pharmacol 2009 Nov 27;76(5):998-1010. Epub 2009 Aug 27.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1124/mol.109.058156DOI Listing
November 2009

Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.

J Neurosci 2009 Mar;29(9):2997-3008

Department of Physiology and Medical Physics and Royal College of Surgeons in Ireland Neuroscience Research Centre, Dublin 2, Ireland.

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http://dx.doi.org/10.1523/JNEUROSCI.0354-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666202PMC
March 2009

Effects of transient focal cerebral ischemia in mice deficient in puma.

Neurosci Lett 2009 Feb 13;451(3):237-40. Epub 2009 Jan 13.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

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http://linkinghub.elsevier.com/retrieve/pii/S030439400900039
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http://dx.doi.org/10.1016/j.neulet.2009.01.019DOI Listing
February 2009

Control of motoneuron survival by angiogenin.

J Neurosci 2008 Dec;28(52):14056-61

Department of Physiology and Medical Physics and Royal College of Surgeons in Ireland Neuroscience Research Centre, RCSI, Dublin 2, Ireland.

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http://www.jneurosci.org/content/28/52/14056.full.pdf
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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.3399-08.2
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http://dx.doi.org/10.1523/JNEUROSCI.3399-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671464PMC
December 2008

NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner.

J Neurochem 2008 May 13;105(3):891-903. Epub 2007 Dec 13.

Department of Physiology and Medical Physics and RCSI Neuroscience Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.

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http://dx.doi.org/10.1111/j.1471-4159.2007.05187.xDOI Listing
May 2008

6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA.

J Neurochem 2008 Mar 6;104(6):1599-612. Epub 2007 Nov 6.

Grupo de Neurofarmacología, Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla-La Mancha, Albacete, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2007.05115.xDOI Listing
March 2008

Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL.

Apoptosis 2006 Jul;11(7):1247-55

Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland.

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http://dx.doi.org/10.1007/s10495-006-7233-1DOI Listing
July 2006

Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis.

J Biol Chem 2006 Mar 28;281(9):5837-44. Epub 2005 Dec 28.

Department of Physiology and Medical Physics and RCSI Neuroscience Research Centre, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

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http://dx.doi.org/10.1074/jbc.M511562200DOI Listing
March 2006

CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization.

Cell Stress Chaperones 2005 ;10(1):59-65

Cell Stress and Apoptosis Research Group, Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074572PMC
http://dx.doi.org/10.1379/csc-69r.1DOI Listing
July 2005