Publications by authors named "Can Wang"

519 Publications

[Influence of Different Soil Conditioner on the Transfer and Transformation of Cadmium and Phthalate Esters in Soil].

Huan Jing Ke Xue 2021 Aug;42(8):4024-4036

College of Resources and Environment, Southwest University, Chongqing 400715, China.

This study examines the existing common form of soil pollution, combined organic and inorganic pollution. Cadmium (Cd) is the most important inorganic element in soil pollution. Due to the widespread use of plastic film, phthalates have become the main organic pollutants in soil. Pot experiments were conducted with purple soil from southwest China, and Chinese cabbage was used as a biological indicator. Different concentration gradients of Cd and diethylhexyl phthalate (DEHP) was used as foreign pollutants. The soil was treated with one of the six common soil conditioners, namely potassium feldspar powder, oyster shell powder, biological carbon powder (biochar), calcium, potassium carbonate, and calcium phosphate, to examine the effect of conditioners on cadmium morphology, DEHP content in contaminated soil, and cadmium and DEHP absorption in Chinese cabbage. The results showed that biochar is the optimal soil conditioner for the remediation of cadmium-phthalate composite pollution in purple soil. Subsequently, the effects of soil biochar content on cadmium pollution and phthalate ester migration were studied. Uncontaminated control soil, Cd-contaminated soil, and DEHP-contaminated soil were examined by pot experiments, and biochar treatments with mass fraction of 0%, 0.5%, 1%, 3%, and 5% added to cadmium contaminated soil were used to determine its influence on Cd morphology and DEHP content of contaminated soil.
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http://dx.doi.org/10.13227/j.hjkx.202012067DOI Listing
August 2021

Desmin Correlated with Cx43 May Facilitate Intercellular Electrical Coupling during Chronic Heart Failure.

Evid Based Complement Alternat Med 2021 3;2021:6621132. Epub 2021 Jul 3.

Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.

Desmin is one of five major intermediate filament proteins in cardiomyocytes. Desmin contributes to the maintenance of healthy muscle. The desmin content in cardiomyocytes directly affects the long-term prognosis of patients with heart failure, and lack of desmin leads to myocyte contractile dysfunction. However, the mechanism is elusive. In this study, we measured desmin expression using western blotting and qPCR in the failed hearts of human patients and rats. Our results showed that desmin content was reduced at the protein level in failed hearts and isolated cardiomyocytes. The association of desmin and the gap junction proteins connexin 43 (Cx43) and zonula occludens-1 (ZO-1) was also investigated. Immunoprecipitation assay showed that desmin was associated with Cx43 in cardiomyocytes. To compare the electrical integration of skeletal myoblasts in cocultures with cardiac myocytes, familial amyloid polyneuropathy (FAP) activation rate was found in 33% desmin overexpressing skeletal myoblasts. Desmin not only affected Cx43 and ZO-1 expression but also facilitated the complex of Cx43 and ZO-1 in skeletal myoblasts, which enhanced cell-to-cell electrical coupling of skeletal myoblasts with cardiac myocytes. Desmin has potential as a novel therapeutic target for heart failure. Preservation of desmin may attenuate heart failure.
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http://dx.doi.org/10.1155/2021/6621132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275391PMC
July 2021

MRPL13 Act as a Novel Therapeutic Target and Could Promote Cell Proliferation in Non-Small Cell Lung Cancer.

Cancer Manag Res 2021 12;13:5535-5545. Epub 2021 Jul 12.

Department of Respiratory Medicine, Affiliated Hospital of Shandong University of Chinese Medicine, Jinan, People's Republic of China.

Background: The latent involvement of MRPL13 in non-small cell lung cancer (NSCLC) remains unclear. This study aimed to explore the role of MRPL13 in NSCLC.

Methods: All analyses were performed in R software 4.0, SPSS version 23, and GraphPad Prism 8. The "limma" package was used to identify differentially expressed genes. Univariate and multivariate cox analyses were used to identify prognosis-related genes. A549 and H1299 lung cancer cell lines were selected for phenotypic experiments.

Results: The high level of MRPL13 was correlated with poor T classification and overall survival. In vitro experiments showed that MRPL13 was highly expressed in NSCLC tissue and cell lines. MRPL13 knockdown inhibited the proliferation of lung cancer A549 and H1299 cell lines, which was further validated by in vivo experiment. Moreover, GSEA analysis suggested that the pathway of MYC target, PI3K/AKT/mTOR/ signaling, oxidative phosphorylation, and G2/M checkpoints may be the potential pathway where MRPL13 was involved. Meanwhile, MRPL13 demonstrated a negative correlation with M1 macrophage, CD8+ T cells, and CD4+ T cells, making it an underlying immunotherapy target of NSCLC.

Conclusion: MRPL13 may promote the proliferation of NSCLC cells and serve as an independent tumor marker and an emerging therapeutic target.
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http://dx.doi.org/10.2147/CMAR.S316428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285246PMC
July 2021

Emergent Magnetic Phenomenon with Unconventional Structure in Epitaxial Manganate Thin Films.

Adv Sci (Weinh) 2021 Jul 6;8(13):2100177. Epub 2021 May 6.

Institute of Physics Chinese Academy of Sciences Beijing 100190 China.

A variety of emergent phenomena are enabled by interface engineering in the complex oxides heterostructures. While extensive attention is attracted to LaMnO (LMO) thin films for observing the control of functionalities at its interface with substrate, the nature of the magnetic phases in the thin film is, however, controversial. Here, it is reported that the ferromagnetism in two and five unit cells thick LMO films epitaxially deposited on (001)-SrTiO substrates, a ferromagnetic/ferromagnetic coupling in eight and ten unit cells ones, and a striking ferromagnetic/antiferromagnetic pinning effect with apparent positive exchange bias in 15 and 20 unit cells ones are observed. This novel phenomenon in both 15 and 20 unit cells films indicates a coexistence of three magnetic orderings in a single LMO film. The high-resolution scanning transmission electron microscopy suggests a to symmetry transition from interface to surface, with the spatial stratification of MnO octahedral morphology, corresponding to different magnetic orderings. These results can shed some new lights on manipulating the functionality of oxides by interface engineering.
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http://dx.doi.org/10.1002/advs.202100177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261492PMC
July 2021

Electroacupuncture Attenuates Anxiety-Like Behaviors in a Rat Model of Post-traumatic Stress Disorder: The Role of the Ventromedial Prefrontal Cortex.

Front Neurosci 2021 24;15:690159. Epub 2021 Jun 24.

Department of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Electroacupuncture (EA) is a promising clinical approach to treating posttraumatic stress disorder (PTSD), yet the mechanisms whereby EA can alleviate anxiety and other PTSD symptoms have yet to be clarified. In the present report, rats underwent EA for 14 consecutive days following modified single prolonged stress (MSPS) exposure. These animals were then evaluated in open field and elevated plus maze tests (OFT and EPM), while Fos immunohistochemical staining was performed to assess ventromedial prefrontal cortex (vmPFC) functional activation. In addition, an extracellular recording and stimulation system was used to analyze vmPFC inputs into the ventral tegmental area (VTA) in these rats. Temporary vmPFC inactivation was further performed to assess whether this was sufficient to reverse the anxiolytic effects of EA. Overall, rats that underwent EA treatment spent more time in the central region (OFT) and the open arm (EPM) relative to MSPS model animals ( < 0.05). These MSPS model animals also exhibited significantly fewer activated Fos-positive nuclei in the vmPFC following behavioral testing, while EA was associated with a significant relative increase in c-Fos expression in this region. The transient inactivation of the vmPFC was sufficient to reverse the effects of EA treatment on anxiety-like behaviors in MSPS model rats. MSPS and SEA rats exhibiting no differences in bursting activity between baseline and vmPFC stimulation, whereas bursting activity rose relative to baseline upon ventral mPFC stimulation in EA treated and control rats. Together, these findings indicate that the vmPFC and its inputs into the VTA are functionally linked to the anxiolytic activity of EA, implicating this pathway in the EA-mediated treatment of PTSD.
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http://dx.doi.org/10.3389/fnins.2021.690159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264195PMC
June 2021

Factors Affecting the Catalytic Efficiency and Synergism of Xylanase and Cellulase During Enzymatic Hydrolysis of Birch Wood.

Appl Biochem Biotechnol 2021 Jul 10. Epub 2021 Jul 10.

Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, No. 2 Energy Road, Tianhe District, Guangzhou, 510640, People's Republic of China.

Understanding factors that affect the catalytic efficiency and synergism of enzymes is helpful to enhance the process of bioconversion. In this study, birch wood (BW) was sequentially treated by delignification (DL), deacetylation (DA), and decrystallization (DC) treatments. The physiochemical structures of treated BW were characterized. Moreover, the influences of sequential treatments on the catalytic efficiency and synergism of xylanase and cellulase were studied. DL treatments efficiently improved the conversion of cellulose and xylan. A high degree of synergy (DS) between xylanase and cellulase was produced during hydrolysis of DL-treated BW. DA treatments enhanced xylan conversion but reduced the DS between xylanase and cellulase for xylan hydrolysis, whereas DC treatments enhanced cellulose conversion but reduced the DS between xylanase and cellulase for cellulose hydrolysis. The cellulose conversion of lithium chloride/N,N-dimethylacetamide (LiCl/DMAc)-treated BW (89.69%) was higher than the cellulose conversion of ball milling (BM)-treated BW (81.63%), whereas the xylan conversion of LiCl/DMAc-treated BW (83.77%) was lower than the xylan conversion of BM-treated BW (87.21%). This study showed that the catalytic efficiency and synergism of xylanase and cellulase are markedly affected by lignin hindrance, hemicellulose acetylation, and cellulose crystallization.
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http://dx.doi.org/10.1007/s12010-021-03590-0DOI Listing
July 2021

Abusive Supervision and Creativity: Investigating the Moderating Role of Performance Improvement Attribution and the Mediating Role of Psychological Availability.

Front Psychol 2021 21;12:658743. Epub 2021 Jun 21.

School of Business Administration, Zhongnan University of Economics and Law, Wuhan, China.

The existing studies have indicated that abusive supervision affects creativity; however, the specific impact mechanism is still unclear due to the uncertain relationship between leadership and employee creativity. Based on the resource perspective, this study examines the influence of abusive supervision on creativity through psychological availability (PA) and the moderating of this mediation by performance improvement attribution (PIA). Based on a survey of 234 employees', the hypotheses have been tested and the results reveal that abusive supervision had a detrimental effect on employee creativity partially mediated by employee PA, and employees' PIA moderated the mediation. This study offers new insights into the mechanisms associated with the relationship between abusive supervision and creativity.
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http://dx.doi.org/10.3389/fpsyg.2021.658743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255386PMC
June 2021

A Novel Classification of Glioma Subgroup, Which Is Highly Correlated With the Clinical Characteristics and Tumor Tissue Characteristics, Based on the Expression Levels of Gβ and Gγ Genes.

Front Oncol 2021 18;11:685823. Epub 2021 Jun 18.

Department of Neuro-oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical Unversity, Beijing, China.

Purpose: Glioma is a classical type of primary brain tumors that is most common seen in adults, and its high heterogeneity used to be a reference standard for subgroup classification. Glioma has been diagnosed based on histopathology, grade, and molecular markers including IDH mutation, chromosome 1p/19q loss, and H3K27M mutation. This subgroup classification cannot fully meet the current needs of clinicians and researchers. We, therefore, present a new subgroup classification for glioma based on the expression levels of Gβ and Gγ genes to complement studies on glioma and Gβγ subunits, and to support clinicians to assess a patient's tumor status.

Methods: Glioma samples retrieved from the CGGA database and the TCGA database. We clustered the gliomas into different groups by using expression values of Gβ and Gγ genes extracted from RNA sequencing data. The Kaplan-Meier method with a two-sided log-rank test was adopted to compare the OS of the patients between GNB2 group and non-GNB2 group. Univariate Cox regression analysis was referred to in order to investigate the prognostic role of each Gβ and Gγ genes. KEGG and ssGSEA analysis were applied to identify highly activated pathways. The "estimate" package, "GSVA" package, and the online analytical tools CIBERSORTx were employed to evaluate immune cell infiltration in glioma samples.

Results: Three subgroups were identified. Each subgroup had its own specific pathway activation pattern and other biological characteristics. High M2 cell infiltration was observed in the GNB2 subgroup. Different subgroups displayed different sensitivities to chemotherapeutics. GNB2 subgroup predicted poor survival in patients with gliomas, especially in patients with LGG with mutation IDH and non-codeleted 1p19q.

Conclusion: The subgroup classification we proposed has great application value. It can be used to select chemotherapeutic drugs and the prognosis of patients with target gliomas. The unique relationships between subgroups and tumor-related pathways are worthy of further investigation to identify therapeutic Gβγ heterodimer targets.
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http://dx.doi.org/10.3389/fonc.2021.685823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250418PMC
June 2021

Low-threshold topological nanolasers based on the second-order corner state.

Light Sci Appl 2020 Jun 29;9(1):109. Epub 2020 Jun 29.

Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.

Topological lasers are immune to imperfections and disorder. They have been recently demonstrated based on many kinds of robust edge states, which are mostly at the microscale. The realization of 2D on-chip topological nanolasers with a small footprint, a low threshold and high energy efficiency has yet to be explored. Here, we report the first experimental demonstration of a topological nanolaser with high performance in a 2D photonic crystal slab. A topological nanocavity is formed utilizing the Wannier-type 0D corner state. Lasing behaviour with a low threshold of approximately 1 µW and a high spontaneous emission coupling factor of 0.25 is observed with quantum dots as the active material. Such performance is much better than that of topological edge lasers and comparable to that of conventional photonic crystal nanolasers. Our experimental demonstration of a low-threshold topological nanolaser will be of great significance to the development of topological nanophotonic circuitry for the manipulation of photons in classical and quantum regimes.
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http://dx.doi.org/10.1038/s41377-020-00352-1DOI Listing
June 2020

Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.

Dentomaxillofac Radiol 2021 Jun 23:20200485. Epub 2021 Jun 23.

Department of radiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Objectives: To describe the CT and MR imaging characteristics of primary carcinoma ex pleomorphic adenoma (Ca-ex-PA) in major salivary glands and present more information for recognizing this malignancy.

Methods: 212 patients with primary Ca-ex-PA in major salivary glands (169 in the parotid gland, 36 in the submandibular gland, 7 in the sublingual gland) underwent CT and MR imaging (plain and contrast-enhanced scans) prior to surgical management and histopathological examination. The CT and MR imaging findings of this condition were retrospectively reviewed and correlated with their pathological types: non-invasive carcinoma (Type I, 37 cases), minimally invasive carcinoma (Type II, 18 cases), and widely invasive carcinoma (TypeIII, 157 cases). The binary logistic regression analysis was used to analyze the independent influencing factors of morphology and boundary for differentiating between Type I/II and Type III of Ca-ex-PA, and the sensitivity, specificity and positive predictive value were calculated. Differences in apparent diffusion coefficient (ADC) values between Type I/II and Type III of Ca-ex-PA were calculated by independent sample -tests.

Results: On CT and MR imaging, there were 190/212 cases (89.6%) identified as lobular, 203/212 cases (95.8%) with enhancement, and 173/212 cases (81.6%) with inhomogeneous after contrast administration.Calcification within the mass was shown in 76 of 192 cases (39.6%) on plain CT examination. Of 55 neoplasms with Type I and II, 38 (69.1%) were presented as round or oval and 42 (76.4%) as well-defined margins. Of 157 neoplasms with Type III, 103 (65.6%) were presented as irregular form and 110 (70.1%) as uneven margins or with partial uneven margins.The sensitivity, specificity and positive predictive value for distinguishing Type I/II and Type III tumors according to the morphology and boundary were 78.34%, 63.64% and 86.01%, respectively. The mean ADC value of Ca-ex-PA (22 cases) in major salivary glands was about 0.93 × 10 mm s, and there was no significant difference in mean ADC value between Type I/II and Type III of this neoplasm. Cervical lymph node metastasis and distance metastasis were found in 67 patients (31.6%, Type III) and 32 patients (15.1%, Type I in 1; Type II in 1; and Type III in 30), respectively.

Conclusions: Most Ca-ex-PA is characterized by an irregular, lobular, and inhomogeneous enhanced neoplasm with uneven margin or partial uneven margin on CT and MR imaging, which is frequently corresponding with Type III. And a round or oval mass with well-defined margin usually correlates with Type I and II. Morphology and boundary are important basis for distinguishing Type I/II and Type III tumors. Calcification within the neoplasm shown on CT may be regarded as a specific sign for indicating this malignancy. Low ADC value is an important manifestation of this neoplasm.Ca-ex-PA with Type III is more likely to have cervical lymph node metastasis and distant metastasis.
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http://dx.doi.org/10.1259/dmfr.20200485DOI Listing
June 2021

Acaricidal activity of Cinnamomum cassia (Chinese cinnamon) against the tick Haemaphysalis longicornis is linked to its content of (E)-cinnamaldehyde.

Parasit Vectors 2021 Jun 22;14(1):330. Epub 2021 Jun 22.

Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, China.

Background: The tick Haemaphysalis longicornis (Neumann) is a well-known vector of numerous pathogens of veterinary and medical importance. Various control strategies, including the use of synthetic pesticides, have been developed to control this tick species. However, demand for effective and safe alternative pesticides is increasing due to the adverse effects associated with the intensive and injudicious use of synthetic pesticides, which include undesirable effects on non-target species and environmental pollution. Hence, the acaricidal activity of the extract and the essential oil of Cinnamomum cassia (Chinese cinnamon) and their major components, and the underlying mechanisms of this activity, were evaluated against unfed larvae and nymphs of H. longicornis.

Methods: The components of the extract and essential oil of C. cassia were determined by gas chromatography-mass spectrometry, and their larvicidal and nymphicidal activity were evaluated using the larval and nymphal packet test. The underlying detoxification mechanism was elucidated by targeting in vivo esterase and monooxygenase activity, and the toxicological effect was assessed on non-target Tenebrio molitor and Harmonia axyridis by topical application in open Petri dishes.

Results: (E)-cinnamaldehyde was the predominant component of the extract (50.79%) and essential oil (89.95%). The 50% lethal concentration (LC) for larvae and nymphs treated with the extract was 11.56 and 49.18 mg/mL, respectively. The essential oil, (E)-cinnamaldehyde and fenvalerate exhibited acaricidal activity, with LC values of 3.81, 3.15, and 0.14 mg/mL, respectively, against the larvae, and 21.31, 16.93, and 1.89 mg/mL, respectively, against the nymphs. (E)-cinnamaldehyde significantly increased esterase and monooxygenase activity in both larvae and nymphs. Unlike fenvalerate, C. cassia essential oil and (E)-cinnamaldehyde did not cause mortality of T. molitor or H. axyridis adults.

Conclusions: This study demonstrates that C. cassia essential oil and (E)-cinnamaldehyde have the potential to be developed into botanical-based larvicidal and nymphicidal agents for tick control.
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http://dx.doi.org/10.1186/s13071-021-04830-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220678PMC
June 2021

Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila.

BMC Biol 2021 Jun 16;19(1):122. Epub 2021 Jun 16.

Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.

Background: The anticancer drug camptothecin (CPT), first isolated from Camptotheca acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila. Unlike known monoterpene indole alkaloids, CPT in C. acuminata is biosynthesized via the key intermediate strictosidinic acid, but how O. pumila synthesizes CPT has not been determined.

Results: In this study, we used nontargeted metabolite profiling to show that 3α-(S)-strictosidine and 3-(S), 21-(S)-strictosidinic acid coexist in O. pumila. After identifying the enzymes OpLAMT, OpSLS, and OpSTR as participants in CPT biosynthesis, we compared these enzymes to their homologues from two other representative CPT-producing plants, C. acuminata and Nothapodytes nimmoniana, to elucidate their phylogenetic relationship. Finally, using labelled intermediates to resolve the CPT biosynthesis pathway in O. pumila, we showed that 3α-(S)-strictosidine, not 3-(S), 21-(S)-strictosidinic acid, is the exclusive intermediate in CPT biosynthesis.

Conclusions: In our study, we found that O. pumila, another representative CPT-producing plant, exhibits metabolite diversity in its central intermediates consisting of both 3-(S), 21-(S)-strictosidinic acid and 3α-(S)-strictosidine and utilizes 3α-(S)-strictosidine as the exclusive intermediate in the CPT biosynthetic pathway, which differs from C. acuminata. Our results show that enzymes likely to be involved in CPT biosynthesis in O. pumila, C. acuminata, and N. nimmoniana have evolved divergently. Overall, our new data regarding CPT biosynthesis in O. pumila suggest evolutionary divergence in CPT-producing plants. These results shed new light on CPT biosynthesis and pave the way towards its industrial production through enzymatic or metabolic engineering approaches.
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http://dx.doi.org/10.1186/s12915-021-01051-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207662PMC
June 2021

Identification of an m6A-Related lncRNA Signature for Predicting the Prognosis in Patients With Kidney Renal Clear Cell Carcinoma.

Front Oncol 2021 26;11:663263. Epub 2021 May 26.

Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.

Purpose: This study aimed to construct an m6A-related long non-coding RNAs (lncRNAs) signature to accurately predict the prognosis of kidney clear cell carcinoma (KIRC) patients using data obtained from The Cancer Genome Atlas (TCGA) database.

Methods: The KIRC patient data were downloaded from TCGA database and m6A-related genes were obtained from published articles. Pearson correlation analysis was implemented to identify m6A-related lncRNAs. Univariate, Lasso, and multivariate Cox regression analyses were used to identifying prognostic risk-associated lncRNAs. Five lncRNAs were identified and used to construct a prognostic signature in training set. Kaplan-Meier curves and receiver operating characteristic (ROC) curves were applied to evaluate reliability and sensitivity of the signature in testing set and overall set, respectively. A prognostic nomogram was established to predict the probable 1-, 3-, and 5-year overall survival of KIRC patients quantitatively. GSEA was performed to explore the potential biological processes and cellular pathways. Besides, the lncRNA/miRNA/mRNA ceRNA network and PPI network were constructed based on weighted gene co-expression network analysis (WGCNA). Functional Enrichment Analysis was used to identify the biological functions of m6A-related lncRNAs.

Results: We constructed and verified an m6A-related lncRNAs prognostic signature of KIRC patients in TCGA database. We confirmed that the survival rates of KIRC patients with high-risk subgroup were significantly poorer than those with low-risk subgroup in the training set and testing set. ROC curves indicated that the prognostic signature had a reliable predictive capability in the training set (AUC = 0.802) and testing set (AUC = 0.725), respectively. Also, we established a prognostic nomogram with a high C-index and accomplished good prediction accuracy. The lncRNA/miRNA/mRNA ceRNA network and PPI network, as well as functional enrichment analysis provided us with new ways to search for potential biological functions.

Conclusions: We constructed an m6A-related lncRNAs prognostic signature which could accurately predict the prognosis of KIRC patients.
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http://dx.doi.org/10.3389/fonc.2021.663263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187870PMC
May 2021

Liposomal honokiol promotes hair growth via activating Wnt3a/β-catenin signaling pathway and down regulating TGF-β1 in C57BL/6N mice.

Biomed Pharmacother 2021 Jun 5;141:111793. Epub 2021 Jun 5.

Department of Neuro-oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100071, China. Electronic address:

Liposomal honokiol isolated from the genus Magnolia has been found to have antiangiogenic, anti-inflammatory and antitumor properties. However, there has no report on its role in hair growth. Hair follicles are life-long cycled organelles that go through from anagen, catagen and telogen stages and are regulated by diverse signaling pathways, including Wnt/β-catenin, Notch, Epidermal growth factor (EGF) and Sonic hegehog (SHH). Wnt signals are essential for the initiation of hair follicle placode development and a new potential target of hair loss treatment. This study was designed to investigate the effect of liposomal honokiol (Lip-honokiol) on inducing hair anagen. We identified the hair grew out in advance in the shaving area of C57BL/6N mice after the treatment of liposomal honokiol (Lip-honokiol) by daily abdominal injection. We first demonstrated that Lip-Honokiol activated the Wnt3a/β-catenin pathway and downregulated the transforming growth factor-β1 (TGF-β1) to promote hair growth in mice via immunohistochemistry and immunofluorescence staining. These findings suggest that Lip-honokiol activated the Wnt/β-catenin pathway and accelerated the transfer from the telogen to anagen stage and finally promoted the hair growth.
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http://dx.doi.org/10.1016/j.biopha.2021.111793DOI Listing
June 2021

Heterogeneous iron oxide nanoparticles anchored on carbon nanotubes for high-performance lithium-ion storage and fenton-like oxidation.

J Colloid Interface Sci 2021 May 26;601:283-293. Epub 2021 May 26.

Institute of Materials for Energy and Environment, State Key Laboratory of Bio-Fibers and Eco-Textiles, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. Electronic address:

In this work, heterogeneous hematite (FeO) and magnetite (FeO) nanoparticles are jointly engineered on the external surface of multi-walled carbon nanotubes (CNTs) to construct a composite material ([email protected]/CNT). A simple one-step redox reaction is triggered in a hydrothermal reaction system containing functionalized CNT (FCNT) aqueous suspension and iron foils. Both FeO and FeO nanoparticles with controlled size are generated and well dispersed in the interconnected CNT framework. Controlled samples of [email protected] and FeO/CNT have also been prepared and used to investigate the synthetic mechanism and evaluate the lithium-ion storage performances. As an anodic active material for lithium-ion batteries, the [email protected]/CNT composite delivered a high reversible capacity of about 924 mAh·g for 200 continual charge/discharge cycles under a high current rate of 1000 mA·g. As a catalyst in a Fenton-like reaction for degrading methyl orange (MO) contaminant in waterbody, the [email protected]/CNT composite exhibited an attractive decomposition efficiency (99.5% decomposition within 60 min) and good stability. The beneficial factors contributing to the inspiring performances are discussed. The effective and scalable material design and synthesis method can be regarded to have good potential in other fields.
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http://dx.doi.org/10.1016/j.jcis.2021.05.137DOI Listing
May 2021

Cost-effectiveness analysis of the integrated control strategy for schistosomiasis japonica in a lake region of China: a case study.

Infect Dis Poverty 2021 May 28;10(1):79. Epub 2021 May 28.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research On Tropical Diseases, Shanghai, 200025, China.

Background: Schistosomiasis japonica remains an important public health concern due to its potential to cause severe outcomes and long-term sequelae. An integrated control strategy implemented in the Peoples' Republic of China has been shown to be effective to control or interrupt the transmission of schistosomiasis. The objective of this study is to estimate the disease burden of schistosomiasis and assess the cost-effectiveness of the integrated control strategy focused on different major interventions at three stages for schistosomiasis control in a lake setting, to provide reference for policy making or planning.

Methods: Annual cost data of schistosomiasis control during 2009-2019 were obtained from the control program implementers in Jiangling County, Hubei Province, China. Economic costs are provided in constant 2009 Chinese Yuan (CNY). Epidemiological data of schistosomiasis were collected from the Jiangling county station for schistosomiasis control. Disease burden of schistosomiasis was assessed by calculating years of life lost (YLLs) owing to premature death, years lived with disability (YLDs) and disability-adjusted life years (DALYs). DALYs were calculated as the sum of YLLs and YLDs. We then conducted a rudimentary cost-effectiveness analysis by determining the ratio by dividing the difference between the average cost of integrated control strategy at transmission control (2013-2016) or transmission interruption (2017-2019) and the average cost at stage of infection control (2009-2012) with the difference between the DALYs of schistosomiasis at different control stages. Descriptive statistics on the costs and DALYs were used in the analysis.

Results: The total economic costs for schistosomiasis control in Jiangling County from 2009 to 2019 were approximately CNY 606.88 million. The average annual economic costs for schistosomiasis prevention and control at stages of infection control (2009-2012), transmission control (2013-2016), and transmission interruption (2017-2019) were approximately CNY 41.98 million, CNY 90.19 million and CNY 26.06 million respectively. The overall disease burden caused by schistosomiasis presented a downward trend. Meanwhile, the disease burden of advanced cases showed an upward trend with the DALY increased from 943.72 to 1031.59 person-years. Most disease burden occurred in the age group over 45 years old (especially the elderly over 60 years old). Taking the infection control stage as the control, the incremental cost-effectiveness ratio of integrated control strategy was CNY 8505.5 per case averted, CNY 60 131.6 per DALY decreased at transmission control stage and CNY -2217.6 per case averted, CNY -18 116.0 per DALY decreased at transmission interruption stage.

Conclusions: The disease burden of schistosomiasis decreased significantly with the implementation of the integrated prevention and control strategy. Surveillance and management on elder population should be strengthened to decrease diseases burden. There remains a need for well-conducted studies that examine the long-term cost-effectiveness of the integrated control strategy for schistosomiasis. GRAPHIC ABSTARCT.
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http://dx.doi.org/10.1186/s40249-021-00863-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161988PMC
May 2021

Targeting Gα-integrin interaction ameliorates systemic inflammation.

Nat Commun 2021 05 27;12(1):3185. Epub 2021 May 27.

Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.

Systemic inflammation as manifested in sepsis is an excessive, life-threatening inflammatory response to severe bacterial or viral infection or extensive injury. It is also a thrombo-inflammatory condition associated with vascular leakage/hemorrhage and thrombosis that is not effectively treated by current anti-inflammatory or anti-thrombotic drugs. Here, we show that MB2mP6 peptide nanoparticles, targeting the Gα-mediated integrin "outside-in" signaling in leukocytes and platelets, inhibited both inflammation and thrombosis without causing hemorrhage/vascular leakage. MB2mP6 improved mouse survival when infused immediately or hours after onset of severe sepsis. Furthermore, platelet Gα knockout inhibited septic thrombosis whereas leukocyte Gα knockout diminished septic inflammation, each moderately improving survival. Dual platelet/leukocyte Gα knockout inhibited septic thrombosis and inflammation, further improving survival similar to MB2mP6. These results demonstrate that inflammation and thrombosis independently contribute to poor outcomes and exacerbate each other in systemic inflammation, and reveal a concept of dual anti-inflammatory/anti-thrombotic therapy without exacerbating vascular leakage.
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http://dx.doi.org/10.1038/s41467-021-23409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159967PMC
May 2021

Facile synthesis of a rod-like porous carbon framework confined magnetite nanoparticle composite for superior lithium-ion storage.

J Colloid Interface Sci 2021 Oct 18;600:602-612. Epub 2021 May 18.

Institute of Materials for Energy and Environment, State Key Laboratory of Bio-Fibers and Eco-Textiles, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. Electronic address:

This work demonstrates a streamlined method to engineer a rod-like porous carbon framework (RPC) confined magnetite nanoparticles composite (FeO/RPC) starting from metallic iron and gallic acid (GA) solution. First, a mild redox reaction was triggered between Fe and GA to prepare a rod-shaped metal-organic framework (MOF) ferric gallate sample (Fe-GA). Then, the Fe-GA sample was calcinated to obtain a prototypic RPC supported metal iron nanoparticle intermediate sample (Fe/RPC). Finally, the FeO/RPC composite was synthesized after a simple hydrothermal reaction. The FeO/RPC composite exhibited competitive electrochemical behaviors, which has a high gravimetric capacity of 1140 mAh·g at a high charge and discharge current of 1000 mA·g after 300 cycles. The engineered RPC supportive matrix not only offers adequate voids to buffer the volume expansion from inside well-dispersed FeO nanoparticles, but also facilitates both the ionic and electronic transport during the electrochemical reactions. The overall material synthesis involves of no hazardous or expensive chemicals, which can be regarded to be a scalable and green approach. The obtained samples have a good potential to be further developed for wider applications.
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http://dx.doi.org/10.1016/j.jcis.2021.05.065DOI Listing
October 2021

Screening and mitigating major threats of regional development to water ecosystems using ecosystem services as endpoints.

J Environ Manage 2021 Sep 21;293:112787. Epub 2021 May 21.

School of Environment, Tsinghua University, Beijing, 100084, China. Electronic address:

Coordinating the coercion of human activities to the ecosystem is a continuous strategic concern. A practical way to conceptualize socioeconomic development and link it to ecosystem response is urgently needed. This study proposed a two-staged method to reveal the threats concealed in socioeconomic development and show the return of water ecosystem services to regulation measures. Eight threat indexes referring to scale, structure and efficiencies of industrial, agriculture and domestic sectors were designed to assess the threats caused by unsustainable development features, while four indexes for evaluating water supply, habitat provision, regulation and quality purification service of ecosystem were set up. For each threat index, the evaluation result is a relative value derived from comparison with a reasonable level. The major threats could be screened out by ranking threat indexes, so that unreasonable development dimension could be identified and subsequent regulation scheme be prepared. On this basis, with the targeted adjustment of socioeconomic development, corresponding improvements in water ecosystem could be expected and quantified. In the case study of Beijing-Tianjin-Hebei District, the most remarkable threats include production inefficiency of the industrial sector and oversized population, of which degrees of deviation from reasonable levels exceed 70%. When all development dimensions were dragged to the suggested levels, the habitat provision and water supply service would witness the largest progress among four services, with the values rising from 0.49 to nearly 1. This method helps discover the critical defect of socioeconomic development in terms of ecosystem response and facilitate the decision maker to establish more sustainable initiatives.
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http://dx.doi.org/10.1016/j.jenvman.2021.112787DOI Listing
September 2021

Wafer-Scale and Full-Coverage Two-Dimensional Molecular Monolayers Strained by Solvent Surface Tension Balance.

ACS Appl Mater Interfaces 2021 Jun 21;13(22):26218-26226. Epub 2021 May 21.

Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210023, China.

Inspired by the outstanding properties discovered in two-dimensional materials, the bottom-up generation of molecular monolayers is becoming again extremely popular as a route to develop novel functional materials and devices with tailored characteristics and minimal materials consumption. However, achieving a full-coverage over a large-area still represents a grand challenge. Here we report a molecular self-assembly protocol at the water surface in which the monolayers are strained by a novel solvent surface tension balance (SSTB) instead of a physical film balance as in the conventional Langmuir-Blodgett (LB) method. The obtained molecular monolayers can be transferred onto any arbitrary substrate including rigid inorganic oxides and metals, as well as flexible polymeric dielectrics. As a proof-of-concept, their application as ideal modification layers of a dielectric support for high-performance organic field-effect transistors (OFETs) has been demonstrated. The field-effect mobilities of both p- and n-type semiconductors displayed dramatic improvements of 1-3 orders of magnitude on SSTB-derived molecular monolayer, reaching values as high as 6.16 cm V s and 0.68 cm V s for pentacene and PTCDI-C8, respectively. This methodology for the fabrication of wafer-scale and defect-free molecular monolayers holds potential toward the emergence of a new generation of high-performance electronics based on two-dimensional materials.
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http://dx.doi.org/10.1021/acsami.1c04198DOI Listing
June 2021

[Clinical observation on wheat grain moxibustion for chronic superficial gastritis of spleen-stomach deficiency and cold].

Zhongguo Zhen Jiu 2021 May;41(5):511-4

Department of TCM, Kongjiang Hospital, Yangpu District of Shanghai, Shanghai 200093, China.

Objective: To compare the clinical effect of wheat grain moxibustion and warming acupuncture on chronic superficial gastritis of spleen-stomach deficiency and cold.

Methods: A total of 200 patients with chronic superficial gastritis of spleen-stomach deficiency and cold were randomly divided into a wheat grain moxibustion group (100 cases, 13 cases dropped off ) and a warming acupuncture group (100 cases, 16 cases dropped off ). The acupoints of Zhongwan (CV 12), Tianshu (ST 25), Qihai (CV 6), Liangqiu (ST 34) and Zusanli (ST 36) were selected in both groups. The patients in the wheat grain moxibustion group were treated with wheat grain moxibustion, and 5 cone were given on every acupoint each time. Moxibustion was performed after acupuncture in the warming acupuncture group, and 3 cone each acupoint. Both groups were treated every other day for 15 times. The scores of clinical symptoms and signs, scores of physical component summary (PCS) and mental component summary (MCS) of quality of life in the two groups were recorded before and after treatment and during follow-up 1 month after treatment, and the clinical effects of the two groups were evaluated after treatment and during follow-up.

Results: After treatment and during follow-up, the scores of clinical symptoms and signs of the two groups were lower than before treatment (<0.05), and the scores of PCS and MCS of quality of life were higher than before treatment (<0.05). At follow-up, the score of clinical symptoms and signs in the wheat grain moxibustion group was lower than that in the warming acupuncture group (<0.01), and the scores of PCS and MCS of quality of life were higher than those in the warming acupuncture group (<0.001). The total effective rate of the wheat grain moxibustion group was 93.1% (81/87), which was higher than 82.1% (69/84) of the warming acupuncture group at follow-up (<0.001).

Conclusion: The wheat grain moxibustion can effectively improve the clinical symptoms, signs and quality of life in patients with chronic superficial gastritis of spleen-stomach deficiency and cold, and its long-term effect is better than warming acupuncture.
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http://dx.doi.org/10.13703/j.0255-2930.20200430-k0001DOI Listing
May 2021

Bioaerosol: A Key Vessel between Environment and Health.

Front Environ Sci Eng 2021 12;15(3):49. Epub 2021 May 12.

School of Environmental Science and Engineering, Tianjin University, Tianjin, 300350 China.

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http://dx.doi.org/10.1007/s11783-021-1422-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115387PMC
May 2021

A Real-Time Stability Control Method Through sEMG Interface for Lower Extremity Rehabilitation Exoskeletons.

Front Neurosci 2021 13;15:645374. Epub 2021 Apr 13.

Guangdong Provincial Key Lab of Robotics and Intelligent System, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Herein, we propose a real-time stable control gait switching method for the exoskeleton rehabilitation robot. Exoskeleton rehabilitation robots have been extensively developed during the past decade and are able to offer valuable motor ability to paraplegics. However, achieving stable states of the human-exoskeleton system while conserving wearer strength remains challenging. The constant switching of gaits during walking may affect the center of gravity, resulting in imbalance of human-exoskeleton system. In this study, it was determined that forming an equilateral triangle with two crutch-supporting points and a supporting leg has a positive impact on walking stability and ergonomic interaction. First, the gaits planning and stability analysis based on human kinematics model and zero moment point method for the lower limb exoskeleton are demonstrated. Second, a neural interface based on surface electromyography (sEMG), which realizes the intention recognition and muscle fatigue estimation, is constructed. Third, the stability of human-exoskeleton system and ergonomic effects are tested through different gaits with planned and unplanned gait switching strategy on the SIAT lower limb rehabilitation exoskeleton. The intention recognition based on long short-term memory (LSTM) model can achieve an accuracy of nearly 99%. The experimental results verified the feasibility and efficiency of the proposed gait switching method for enhancing stability and ergonomic effects of lower limb rehabilitation exoskeleton.
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http://dx.doi.org/10.3389/fnins.2021.645374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076547PMC
April 2021

Comparative transcriptome analysis reveals the differential response to cadmium stress of two Pleurotus fungi: Pleurotus cornucopiae and Pleurotus ostreatus.

J Hazard Mater 2021 08 6;416:125814. Epub 2021 Apr 6.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, Sichuan, PR China; Key Laboratory of Environment Protection, Soil ecological protection and pollution control, Sichuan University & Department of Ecology and Environment of Sichuan, Chengdu 610065, Sichuan, PR China. Electronic address:

Pleurotus has great potential for heavy metal mycoremediation. Using comparative transcriptome analysis, the response of Pleurotus ostreatus and Pleurotus cornucopiae under Cd contamination was evaluated. P. ostreatus and P. cornucopia accumulated 0.34 and 0.46 mg/g Cd in mycelium, respectively. Cd removal elevated with its concentration elevation, which reached 56.47% and 54.60% for P. ostreatus and P. cornucopia with Cd at 20 mg/L. Low-level Cd (≤ 1 mg/L) had no significant influence on either fungus, while varied response was observed under high-level Cd. 705 differentially expressed genes (DEGs) were identified in P. cornucopia at Cd1 and Cd20, whereas 12,551 DEGs in P. ostreatus. Differentially regulated functional categories and pathways were also identified. ATP-binding cassette transporters were involved in Cd transport in P. cornucopia, whereas the endocytosis and phagosome pathways were more enhanced in P. ostreatus. 26 enzymes including peroxisomal enzymes catalase and superoxide dismutase were upregulated in P. ostreatus, whereas only cytosolic catalase was overexpressed in P. cornucopia, suggesting their different Cd detoxification pathways. Also, the mitogen-activated protein kinase signaling pathway involved in Cd resistance in both species instead of glutathione metabolism, although more active in P. ostreatus. These findings provided new insight into the molecular mechanism of mycoremediation and accumulator screening.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125814DOI Listing
August 2021

Bioaerosol is an important transmission route of antibiotic resistance genes in pig farms.

Environ Int 2021 09 14;154:106559. Epub 2021 Apr 14.

Advanced Water Management Centre, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia. Electronic address:

Although pig farms are hotspots of antibiotic resistance due to intensive use of antibiotics, little is known about the abundance, diversity and transmission of airborne antibiotic resistance genes (ARGs). This study reports that bioaerosol is an important spread route of ARGs in pig farms. ARGs, mobile genetic elements (MGEs), and bacterial communities were investigated in both air and feces samples during winter and summer. The average concentration of airborne ARGs and MGEs during winter is higher than that during summer when using the ventilation system. The tetM is identified as the predominant airborne ARG with abundance of 6.3 ± 1.2 log copies/m. Clostridium and Streptococcus are two dominant bacteria and several opportunistic pathogens are detected in air samples. High temperature is favorable for more diverse bacterial communities, but relative humidity has negative effects. The wind speed promotes the spread of airborne ARGs. The network analysis results show the average fecal contribution to airborne bacteria is 19.9% and 59.4% during summer and winter, respectively. Horizontal gene transfer plays an important role in the dissemination of airborne ARGs during winter (77.8% possibility), while a lower possibility of 12.0% in summer.
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http://dx.doi.org/10.1016/j.envint.2021.106559DOI Listing
September 2021

Biosimilar or Not: Physicochemical and Biological Characterization of MabThera and Its Two Biosimilar Candidates.

ACS Pharmacol Transl Sci 2021 Apr 12;4(2):790-801. Epub 2021 Mar 12.

Shanghai Institute for Food and Drug Control, NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai 201203, China.

The development of therapeutic biosimilar antibodies has become an important driving force of the modern biopharmaceutical industry. In this study, physiochemical characteristics (amino acid sequence, intact/subunit molecular weight, isoelectric point, post-translation modification, and disulfide linkage pattern), purity (charge variants, high and low molecular weight variants), antigen binding activity, Fc receptor binding affinity and Fc-effector function (CDC and ADCC) were analyzed by using an extensive set of state-of-the-art and orthogonal analytical technologies to provide a comprehensive characterization of the innovative product rituximab and two biosimilar candidates. The similarity study showed that biosimilar candidate 1 (BC1) and the reference product (RP) MabThera had an identical protein amino acid sequences and highly similar primary structures along with similar purity, heterogeneity profiles, antigen binding activity, Fc receptor binding affinity, and Fc-effector functions. Biosimilar candidate 2 (BC2), which had an amino acid replacement at a constant region, a different -glycosylation profiling, and purity, was not analytically similar to RP. Although BC2 showed improvement such as an increased level of afucose, another IgG1 allotype, and similar biological activities, it was not recommended to be applied as a biosimilar compound in drug registration because the biosimilar manufacturer must first show that its primary structure was identical to that of RP. Our physicochemical characterizations and bioassay comparability study provided a deepened understanding of the structure-function relationship of quality attributes.
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http://dx.doi.org/10.1021/acsptsci.0c00225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033751PMC
April 2021

Advances in airborne microorganisms detection using biosensors: A critical review.

Front Environ Sci Eng 2021 5;15(3):47. Epub 2021 Apr 5.

School of Mechanical Engineering and Safety Engineering, Institute of Particle Technology, University of Wuppertal, Wuppertal, D-42119 Germany.

Humanity has been facing the threat of a variety of infectious diseases. Airborne microorganisms can cause airborne infectious diseases, which spread rapidly and extensively, causing huge losses to human society on a global scale. In recent years, the detection technology for airborne microorganisms has developed rapidly; it can be roughly divided into biochemical, immune, and molecular technologies. However, these technologies still have some shortcomings; they are time-consuming and have low sensitivity and poor stability. Most of them need to be used in the ideal environment of a laboratory, which limits their applications. A biosensor is a device that converts biological signals into detectable signals. As an interdisciplinary field, biosensors have successfully introduced a variety of technologies for bio-detection. Given their fast analysis speed, high sensitivity, good portability, strong specificity, and low cost, biosensors have been widely used in environmental monitoring, medical research, food and agricultural safety, military medicine and other fields. In recent years, the performance of biosensors has greatly improved, becoming a promising technology for airborne microorganism detection. This review introduces the detection principle of biosensors from the three aspects of component identification, energy conversion principle, and signal amplification. It also summarizes its research and application in airborne microorganism detection. The new progress and future development trend of the biosensor detection of airborne microorganisms are analyzed.
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http://dx.doi.org/10.1007/s11783-021-1420-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023783PMC
April 2021

Carbon footprint and predicting the impact of climate change on carbon sequestration ecosystem services of organic rice farming and conventional rice farming: A case study in Phichit province, Thailand.

J Environ Manage 2021 Jul 3;289:112458. Epub 2021 Apr 3.

State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC), School of Environment, Tsinghua University, Beijing, 100084, China; Tsinghua-Rio Tinto Joint Research Centre for Resources, Energy and Sustainable Development, Beijing, 100084, China.

Organic rice farming is a sustainable rice cultivation system that eliminates chemical inputs and has the potential to reduce environmental impacts. This study aims to: 1) evaluate and compare the carbon footprint intensity and the value of carbon sequestration ecosystem services (VCSES) between organic rice farming (OF) and conventional rice farming (CF) and 2) estimate the impact of climate change on soil organic carbon (SOC), rice yield, and VCSES of two farming types in Phichit province, Thailand. The results showed that the carbon footprint intensity in OF and CF were significantly different with -0.13 and 0.82 kg COeq kg rice yield, respectively. The differences in SOC stocks (ΔSOCS) were more significant in OF with the increase of 1107.6 kg C ha year (4061.2 kg COeq ha year), while the ΔSOCS value in CF was 625 kg C ha year (2291.7 kg COeq ha year). The VCSES in OF (541,196 US$ ha year) was nearly two times higher than in CF (305,388 US$ ha year). Under future climate change, rice yields of both farming types are expected to increase under Representative Concentration Pathway (RCP) 2.6, RCP4.5, and RCP6.0, and it will decline under RCP8.5. The SOC and VCSES values are predicted to increase, except under RCP8.5. The dramatic declines can be found from the near future (2020-2039) to the very far future (2080-2099) period. Our finding indicates that even though climate change will have negative effects on SOC and VCSES, the OF will have less impact compared with CF.
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http://dx.doi.org/10.1016/j.jenvman.2021.112458DOI Listing
July 2021

Reporting quality of clinical practice guidelines regarding gout and hyperuricemia according to the RIGHT checklist: systematic review.

Syst Rev 2021 04 5;10(1):99. Epub 2021 Apr 5.

Gout Laboratory, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao, China.

Background: The Reporting Items for Practice Guidelines in Healthcare (RIGHT) checklist was used to assess the reporting quality of 2009-2019 clinical practice guidelines (CPGs) regarding gout and hyperuricemia, aimed to improve the reporting quality of future guidelines.

Methods: We searched PubMed, the Chinese Biomedical Literature database, the Wanfang Database, and the China National Knowledge Infrastructure from January 2009 to June 2019 for guidelines regarding gout and hyperuricemia. We also searched the websites of guideline development organizations (the Guidelines International Network, the National Institute for Health and Clinical Excellence, the American College of Rheumatology, and the European League Against Rheumatism (EULAR)). Furthermore, supplementary guidelines reported in included articles were systematically searched, as well as Google Scholar.

Results: Seventeen guidelines were included, of which one was in Chinese and 16 were in English. The mean reporting rate of the 35 items specified was 14.9 (42.5%); only five CPGs (29.4%) had a reporting rate >50%. Of the 35 items, three were very frequently reported. The reporting proportion of the seven domains (basic information, background, evidence, recommendations, review and quality assurance, funding and declaration and management of interests, and other information) were 64.7%, 36.8%, 50.6%, 42.9%, 8.82%, 33.8%, and 31.4%, respectively.

Conclusion: The reporting quality of the present guidelines for gout and hyperuricemia is relatively poor. We suggest that the RIGHT reporting checklist should be used by CPG developers to ensure higher reporting quality of future guidelines.
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http://dx.doi.org/10.1186/s13643-021-01645-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8022392PMC
April 2021

Near-room temperature ferromagnetic insulating state in highly distorted LaCoO with CoO square pyramids.

Nat Commun 2021 Mar 25;12(1):1853. Epub 2021 Mar 25.

Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.

Dedicated control of oxygen vacancies is an important route to functionalizing complex oxide films. It is well-known that tensile strain significantly lowers the oxygen vacancy formation energy, whereas compressive strain plays a minor role. Thus, atomic reconstruction by extracting oxygen from a compressive-strained film is challenging. Here we report an unexpected LaCoO phase with a zigzag-like oxygen vacancy ordering through annealing a compressive-strained LaCoO in vacuum. The synergetic tilt and distortion of CoO square pyramids with large La and Co shifts are quantified using scanning transmission electron microscopy. The large in-plane expansion of CoO square pyramids weaken the crystal field splitting and facilitated the ordered high-spin state of Co, which produces an insulating ferromagnetic state with a Curie temperature of ~284 K and a saturation magnetization of ~0.25 μ/Co. These results demonstrate that extracting targeted oxygen from a compressive-strained oxide provides an opportunity for creating unexpected crystal structures and novel functionalities.
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http://dx.doi.org/10.1038/s41467-021-22099-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994406PMC
March 2021
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