Publications by authors named "Can Gao"

60 Publications

Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer's disease models.

Cell Death Discov 2021 Sep 21;7(1):256. Epub 2021 Sep 21.

NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, 221004, Xuzhou, Jiangsu, China.

Alzheimer's disease (AD) is characterized by aberrant accumulation of extracellular β-amyloid (Aβ) peptides in the brain. Soluble Aβ oligomers are thought to be the most neurotoxic species and are correlated with cognitive dysfunction in early AD. However, there is still no effective treatment so far. We determined that Pep63, a small peptide, had a neuroprotective effect on synaptic plasticity and memory in our previous study. Here, we developed novel and multifunctional liposomes targeting both Aβ oligomers and fibrils based on a liposome delivery system. Transferrin-Pep63-liposomes (Tf-Pep63-Lip), possessing the ability for blood-brain barrier targeting, were also incorporated with phosphatidic acid (PA) and loaded with neuroprotective Pep63. We discovered that administration of Tf-Pep63-Lip could significantly reduce the Aβ burden in the hippocampus, and improve cognitive deficits in 6-month-old APP/PS1 mice in the Morris-Water maze task and fear-conditioning test with the combined effects of PA and Pep63. Tf-Pep63-Lip could capture Aβ oligomers or fibrils and then facilitated microglial chemotaxis nearby for clearance. Simultaneously, Tf-Pep63-Lip hindered Aβ1-42 aggregation and disaggregated Aβ1-42 assembly due to multivalent PA-Aβ. Pep63 effectively inhibited the binding between EphB2 and Aβ oligomers after release from liposomes and rescued NMDA receptors trafficking, the basis of synaptic plasticity. No side effects were observed in either APP/PS1 or wild-type mice, indicating that Tf-Pep63-Lip might be safe under the dosing regimen used in our experiment. Taken together, our results suggested that Tf-Pep63-Lip may serve as a safe and efficient agent for AD combination therapy.
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http://dx.doi.org/10.1038/s41420-021-00639-1DOI Listing
September 2021

The correlation between myocardial resilience after high-intensity exercise and markers of myocardial injury in swimmers.

Medicine (Baltimore) 2021 Sep;100(36):e27046

Medical Supervision Center, Internist of Sport Medicine Research Institute, General Administration of Sport of China, Beijing, China.

Abstract: To investigate how high-intensity exercise influences an athlete's myocardial resilience and the correlation between myocardial resilience and markers of myocardial ischemic injury.Fifteen swimmers participated in high-intensity exercises. Cardiac ultrasound was performed before and after exercise on each subject. Left ventricular general strain, systolic general strain rate, and the differences (▴general strain and ▴ general strain rate, respectively), before and after exercise were analyzed. Blood was collected at the morning of the exercise day and 6 hours after exercise to measure cardiac enzyme indicators.The correlation between myocardial resilience and markers of myocardial injury were evaluated. Most cardiac enzymes concentrations increased after exercise (P < .05). Cardiac troponin I, creatine kinase MB, and cardiac troponin T were all correlated with the degree of ▴ peak strain (differential value of posterior wall basal segment before and after exercise) and ▴ peak strain rate (differential value before and after exercise) (P < .05).After high-intensity exercise, the concentrations of creatine kinase MB and cardiac troponin T in the blood are positively correlated with two-dimensional ultrasound deformation indices, proving the fact that the seindices can be used as a diagnostic basis for myocardial injury, and are more sensitive than general strain. The two-dimensional strain echocardiogram is non-invasive and easily accepted by the patient. It can make up for the shortage of myocardial enzymes in the injury areas, including weak timeliness and the inability to locate injury.
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http://dx.doi.org/10.1097/MD.0000000000027046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428701PMC
September 2021

dCA1-NAc shell glutamatergic projection mediates context-induced memory recall of morphine.

Pharmacol Res 2021 Oct 28;172:105857. Epub 2021 Aug 28.

NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China. Electronic address:

Opioid relapse is generally caused by the recurrence of context-induced memory reinstatement of reward. However, the internal mechanisms that facilitate and modify these processes remain unknown. One of the key regions of the reward is the nucleus accumbens (NAc) which receives glutamatergic projections from the dorsal hippocampus CA1 (dCA1). It is not yet known whether the dCA1 projection to the NAc shell regulates the context-induced memory recall of morphine. Here, we used a common model of addiction-related behavior conditioned place preference paradigm, combined with immunofluorescence, chemogenetics, optogenetics, and electrophysiology techniques to characterize the projection of the dCA1 to the NAc shell, in context-induced relapse memory to morphine. We found that glutamatergic neurons of the dCA1 and gamma aminobutyric acidergic (GABA) neurons of the NAc shell are the key brain areas and neurons involved in the context-induced reinstatement of morphine memory. The dCA1-NAc shell glutamatergic input pathway and the excitatory synaptic transmission of the dCA1-NAc shell were enhanced via the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) when mice were re-exposed to environmental cues previously associated with drug intake. Furthermore, chemogenetic and optogenetic inactivation of the dCA1-NAc shell pathway decreased the recurrence of long- and short-term morphine-paired context memory in mice. These results provided evidence that the dCA1-NAc shell glutamatergic projections mediated the context-induced memory recall of morphine.
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http://dx.doi.org/10.1016/j.phrs.2021.105857DOI Listing
October 2021

High Mobility Organic Lasing Semiconductor with Crystallization-Enhanced Emission for Light-Emitting Transistors.

Angew Chem Int Ed Engl 2021 Sep 11;60(37):20274-20279. Epub 2021 Aug 11.

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Sciences, Tianjin University&Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300072, China.

The development of high mobility organic laser semiconductors with strong emission is of great scientific and technical importance, but challenging. Herein, we present a high mobility organic laser semiconductor, 2,7-diphenyl-9H-fluorene (LD-1) showing unique crystallization-enhanced emission guided by elaborately modulating its crystal growth process. The obtained one-dimensional nanowires of LD-1 show outstanding integrated properties including: high absolute photoluminescence quantum yield (PLQY) approaching 80 %, high charge carrier mobility of 0.08 cm  V  s , Fabry-Perot lasing characters with a low threshold of 86 μJ cm and a high-quality factor of ≈2400. Furthermore, electrically induced emission was obtained from an individual LD-1 crystal nanowire-based light-emitting transistor due to the recombination of holes and electrons simultaneously injected into the nanowire, which provides a good platform for the study of electrically pumped organic lasers and other related ultrasmall integrated electrical-driven photonic devices.
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http://dx.doi.org/10.1002/anie.202108224DOI Listing
September 2021

Three-Dimensional Multilayer Vertical Filament Meshes for Enhancing Efficiency in Fog Water Harvesting.

ACS Omega 2021 Feb 28;6(5):3910-3920. Epub 2021 Jan 28.

Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, 2999 North Remin Road, Shanghai 201620, China.

Novel types of vertical filament mesh (VFM) fog harvesters, 3D VFM fog harvesters, and multilayer 3D VFM fog harvesters were developed by mimicking the water-harvesting nature of desert beetles and the spider silks from fog. Four different types of polymer filaments with different hydrophilic-hydrophobic properties were used. The polymer filaments were modified with the polyurethane-sodium alginate (PU-SA) mixture solution, and a simple spraying method was used to form alternating 3D PU-SA microbumps. Polymer VFMs exhibited a higher fog-harvesting efficiency than the vertical metal meshes. Moreover, the hydrophobic VFM was more efficient in fog harvesting than the hydrophilic VFM. Notably, the fog-harvesting efficiency of all VFMs increased by 30-80% after spraying with the mixed PU-SA solution to form a 3D geometric surface structure (3D PU-SA microbumps), which mimicked the desert beetle back surface. This modification caused the fog-harvesting efficiency of PTFE 3D VFM to be thrice higher than that of Fe VFM. This increase was attributed to the improved synergistic effects of fog capturing, droplet growing, and droplet shedding. The multilayer VFMs were more efficient in fog harvesting than the single-layer VFMs because of a larger droplet capture area. The fog-harvesting efficiency of two-layer and four-layer polymer VFMs was approximately 35% and about 45% higher than that of the single-layer polymer VFMs, respectively. The four-layer PTFE 3D VFM with the type B PU-SA bump surface (bump/PU-SA) had the highest efficiency of 287.6 mL/m/h. Besides the high fog-harvesting efficiency, the proposed polymer VFMs are highly stable, cost-effective, rust-free, and easy to install in practical applications. These advantages are ascribed to the elasticity of the polymer filaments. This work provides new ideas and methods for developing high-performance fog harvesters such as the 3D VFM.
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http://dx.doi.org/10.1021/acsomega.0c05776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876836PMC
February 2021

Novel Ramie Fabric-Based Draping Evaporator for Tunable Water Supply and Highly Efficient Solar Desalination.

ACS Appl Mater Interfaces 2021 Feb 2;13(6):7200-7207. Epub 2021 Feb 2.

Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China.

Interfacial solar-driven evaporation is a promising path to address the scarcity of freshwater. Lots of efforts have been made to develop highly efficient photothermal materials and optimize operational efficiency. However, the designed solar evaporator tends to directly contact with seawater, leading to inevitable parasitic heat loss and the total suppression of evaporation of the backside. Here, we show a novel draping fabric system by separating the evaporation interface from bulk water. The evaporation area was exposed to air with enhanced natural convection and double-side evaporation. The draping fabric was prepared by coating the mixture of carbon black (CB) and cross-linked sodium alginate (SA) on ramie fabric (CSRF). The draping CSRF realized an evaporation rate of 1.81 kg m h and efficiency of 96.6% under 1 sun illumination (1 kW m). In addition, by changing the yarn fineness of the fabric, a tunable water supply can be realized to optimize the energy distribution. This work provides a new strategy to design and optimize the solar evaporation system, exhibiting great potential in real-world applications.
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http://dx.doi.org/10.1021/acsami.0c20503DOI Listing
February 2021

Robust Facial Landmark Detection by Multiorder Multiconstraint Deep Networks.

IEEE Trans Neural Netw Learn Syst 2021 Jan 8;PP. Epub 2021 Jan 8.

Recently, heatmap regression has been widely explored in facial landmark detection and obtained remarkable performance. However, most of the existing heatmap regression-based facial landmark detection methods neglect to explore the high-order feature correlations, which is very important to learn more representative features and enhance shape constraints. Moreover, no explicit global shape constraints have been added to the final predicted landmarks, which leads to a reduction in accuracy. To address these issues, in this article, we propose a multiorder multiconstraint deep network (MMDN) for more powerful feature correlations and shape constraints' learning. Especially, an implicit multiorder correlating geometry-aware (IMCG) model is proposed to introduce the multiorder spatial correlations and multiorder channel correlations for more discriminative representations. Furthermore, an explicit probability-based boundary-adaptive regression (EPBR) method is developed to enhance the global shape constraints and further search the semantically consistent landmarks in the predicted boundary for robust facial landmark detection. It is interesting to show that the proposed MMDN can generate more accurate boundary-adaptive landmark heatmaps and effectively enhance shape constraints to the predicted landmarks for faces with large pose variations and heavy occlusions. Experimental results on challenging benchmark data sets demonstrate the superiority of our MMDN over state-of-the-art facial landmark detection methods.
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http://dx.doi.org/10.1109/TNNLS.2020.3044078DOI Listing
January 2021

Robust facial landmark detection by cross-order cross-semantic deep network.

Neural Netw 2021 Apr 16;136:233-243. Epub 2020 Nov 16.

College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, 518060, China.

Recently, convolutional neural networks (CNNs)-based facial landmark detection methods have achieved great success. However, most of existing CNN-based facial landmark detection methods have not attempted to activate multiple correlated facial parts and learn different semantic features from them that they can not accurately model the relationships among the local details and can not fully explore more discriminative and fine semantic features, thus they suffer from partial occlusions and large pose variations. To address these problems, we propose a cross-order cross-semantic deep network (CCDN) to boost the semantic features learning for robust facial landmark detection. Specifically, a cross-order two-squeeze multi-excitation (CTM) module is proposed to introduce the cross-order channel correlations for more discriminative representations learning and multiple attention-specific part activation. Moreover, a novel cross-order cross-semantic (COCS) regularizer is designed to drive the network to learn cross-order cross-semantic features from different activation for facial landmark detection. It is interesting to show that by integrating the CTM module and COCS regularizer, the proposed CCDN can effectively activate and learn more fine and complementary cross-order cross-semantic features to improve the accuracy of facial landmark detection under extremely challenging scenarios. Experimental results on challenging benchmark datasets demonstrate the superiority of our CCDN over state-of-the-art facial landmark detection methods.
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http://dx.doi.org/10.1016/j.neunet.2020.11.001DOI Listing
April 2021

Robust facial landmark detection by cross-order cross-semantic deep network.

Neural Netw 2021 Apr 16;136:233-243. Epub 2020 Nov 16.

College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, 518060, China.

Recently, convolutional neural networks (CNNs)-based facial landmark detection methods have achieved great success. However, most of existing CNN-based facial landmark detection methods have not attempted to activate multiple correlated facial parts and learn different semantic features from them that they can not accurately model the relationships among the local details and can not fully explore more discriminative and fine semantic features, thus they suffer from partial occlusions and large pose variations. To address these problems, we propose a cross-order cross-semantic deep network (CCDN) to boost the semantic features learning for robust facial landmark detection. Specifically, a cross-order two-squeeze multi-excitation (CTM) module is proposed to introduce the cross-order channel correlations for more discriminative representations learning and multiple attention-specific part activation. Moreover, a novel cross-order cross-semantic (COCS) regularizer is designed to drive the network to learn cross-order cross-semantic features from different activation for facial landmark detection. It is interesting to show that by integrating the CTM module and COCS regularizer, the proposed CCDN can effectively activate and learn more fine and complementary cross-order cross-semantic features to improve the accuracy of facial landmark detection under extremely challenging scenarios. Experimental results on challenging benchmark datasets demonstrate the superiority of our CCDN over state-of-the-art facial landmark detection methods.
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http://dx.doi.org/10.1016/j.neunet.2020.11.001DOI Listing
April 2021

Robust Face Alignment by Multi-Order High-Precision Hourglass Network.

IEEE Trans Image Process 2021 18;30:121-133. Epub 2020 Nov 18.

Heatmap regression (HR) has become one of the mainstream approaches for face alignment and has obtained promising results under constrained environments. However, when a face image suffers from large pose variations, heavy occlusions and complicated illuminations, the performances of HR methods degrade greatly due to the low resolutions of the generated landmark heatmaps and the exclusion of important high-order information that can be used to learn more discriminative features. To address the alignment problem for faces with extremely large poses and heavy occlusions, this paper proposes a heatmap subpixel regression (HSR) method and a multi-order cross geometry-aware (MCG) model, which are seamlessly integrated into a novel multi-order high-precision hourglass network (MHHN). The HSR method is proposed to achieve high-precision landmark detection by a well-designed subpixel detection loss (SDL) and subpixel detection technology (SDT). At the same time, the MCG model is able to use the proposed multi-order cross information to learn more discriminative representations for enhancing facial geometric constraints and context information. To the best of our knowledge, this is the first study to explore heatmap subpixel regression for robust and high-precision face alignment. The experimental results from challenging benchmark datasets demonstrate that our approach outperforms state-of-the-art methods in the literature.
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http://dx.doi.org/10.1109/TIP.2020.3032029DOI Listing
November 2020

RACO-1 modulates Hippo signalling in oesophageal squamous cell carcinoma.

J Cell Mol Med 2020 10 7;24(20):11912-11921. Epub 2020 Sep 7.

Department of Gastroenterology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.

Oesophageal cancer is one of the most lethal malignancies worldwide, whereas the 5-year survival is less than 20%. Although the detailed carcinogenic mechanisms are not totally clear, recent genomic sequencing data showed dysregulation of Hippo signalling could be a critical factor for oesophageal squamous cell carcinoma (ESCC) progression. Therefore, understanding of the molecular mechanisms that control Hippo signalling activity is of great importance to improve ESCC diagnostics and therapeutics. Our current study revealed RACO-1 as an inhibitory protein for YAP/TEAD axis. Depletion of RACO-1 increases the protein level of YAP and expression of YAP/TEAD target gene. Besides, RACO-1 silencing could promote ESCC cell invasion and migration, which effect could be rescued by YAP depletion in ESCC cells. Immunoprecipitation showed that RACO-1 associated with YAP and promote ubiquitination and degradation of YAP at k48 poly-ubiquitination site. Our research discovered a new regulator of Hippo signalling via modulating YAP stability. RACO-1 could be a promising factor, which serves cancer diagnostics and therapeutics in ESCC patients.
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http://dx.doi.org/10.1111/jcmm.15811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579699PMC
October 2020

High-performance amorphous organic semiconductor-based vertical field-effect transistors and light-emitting transistors.

Nanoscale 2020 Sep;12(35):18371-18378

Department of Chemistry, School of Science, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072, China.

Herein, two kinds of vertical organic optoelectronic devices, vertical organic field-effect transistors (VOFETs) and light-emitting transistors (VOLETs), were constructed based on amorphous organic semiconductors of N,N'-di(1-naphthyl)-N,N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine (NPB) as hole injecting and transport layers and tris(8-hydroxy-quinolinato) aluminum (Alq3) as the emitting layer. High device performances with a large on/off ratio of ∼6 × 103, current density of ∼40 mA cm-2, and fast response of ∼5 ms at a frequency of 20 Hz and a brightness of 126 cd m-2 were demonstrated for these two vertical devices with good device stability and repeatability. These results suggest the potential applications of amorphous organic semiconductors with good film-forming characteristics and easy device fabrication ability in vertical optoelectronic circuits.
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http://dx.doi.org/10.1039/d0nr03569fDOI Listing
September 2020

Regulation of Hippo/YAP signaling and Esophageal Squamous Carcinoma progression by an E3 ubiquitin ligase PARK2.

Theranostics 2020 25;10(21):9443-9457. Epub 2020 Jul 25.

Xinxiang Key Laboratory for Molecular Therapy of Cancer, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China.

Esophageal squamous cell carcinoma (ESCC) is one of the most commonly diagnosed cancer types in China. Recent genomic sequencing analysis indicated the over-activation of Hippo/YAP signaling might play important roles for the carcinogenic process and progression for ESCC patients. However, little is known about the molecular mechanisms that controls Hippo signaling activity in ESCC. Our previous studies indicated that PLCE1-an important risk factor for ESCC-linked to ESCC progression through snail signaling, during this period, we found PARK2 was an important downstream target of PLCE1-snail axis. PARK2 was decreased in ESCC human samples, and correlated with good prognosis in ESCC patients. Further research showed that PARK2 could inhibit YAP, which functions as key downstream effectors of the Hippo pathway. Here, we aim to reveal the molecular mechanisms of PARK2 modulated Hippo pathway in ESCC. To evaluate the function of PARK2 in ESCC, we used a tissue microarray (TMA) of 223 human ESCC patients and immunohistochemistry to analyze the correlation between PARK2 expression and clinicopathologic variables. Depletion of endogenous PARK2 and YAP from ESCC cells using CRISPR/Cas9 technologies. Flow cytometry and EdU cell proliferation assay were used to detect proliferation of ESCC cells. Nude mice subcutaneous injection and Ki-67 staining were used to evaluate tumor growth . Migration and invasion assays were performed. In addition, lung metastasis models in mice were used to validate the function of PARK2 . Identification of PARK2 involved in hippo pathway was achieved by expression microarray screening, double immunofluorescence staining and co-immunoprecipitation assays. The RNA-seq analysis results were validated through quantitative real-time PCR (qRT-PCR) analysis. The protein half-life of YAP was analyzed by Cycloheximide assay, and the TEAD activity was detected by Luciferase reporter assays. Clinical sample of ESCC revealed that low PARK2 expression correlated with late tumor stage (P < 0.001), poor differentiation (P < 0.04), lymph node (P < 0.001) and distant metastasis (P = 0.0087). Multivariate Cox proportional regression analysis further revealed that PARK2 expression (P = 0.032) is an independent prognostic factor for the overall survival of ESCC patients. Besides, the immunohistochemistry results showed that PARK2 negatively correlated with YAP protein level (P 0.001). PARK2 depletion promotes ESCC progression both through Hippo/YAP axis, while PARK2 overexpression suppresses ESCC tumor progression by Hippo signaling. Co-IP and ubiquitination assays revealed that PARK2 could interact with YAP in the cytosol and promotes YAP K48-linked ubiquitination at K90 sites. Clinical sample analysis and mechanistic study have validated PARK2 as a tumor suppressor for ESCC. Multivariate Cox proportional regression analysis further revealed that PARK2 is an independent prognostic factor for the overall survival of ESCC patients. Cellular and molecular mechanisms in this study showed that PARK2 associated with YAP protein in the cytosol, promoted YAP ubiquitination and proteasome-dependent degradation in ESCC cells. Therefore, as a novel modulator for Hippo signaling, modulation of PARK2 activity or gene expression level could be an appealing strategy to treat esophageal.
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http://dx.doi.org/10.7150/thno.46078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449928PMC
June 2021

An Eco-friendly Porous Nanocomposite Fabric-Based Triboelectric Nanogenerator for Efficient Energy Harvesting and Motion Sensing.

ACS Appl Mater Interfaces 2020 Sep 14;12(38):42880-42890. Epub 2020 Sep 14.

Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China.

A wearable and effective tribopositive material, especially an economical and eco-friendly triboelectric fabric developed from biomaterials, is highly crucial for the development of green wearable triboelectric nanogenerators. In this work, we design a porous nanocomposite fabric (PNF) with strong charge accumulation capacity through a facile dry-casting method and use it as a tribopositive material to construct attractive wearable triboelectric nanogenerators (abbreviated as TENGs). Specifically, the porous nanocomposite is developed by the incorporation of nano-AlO fillers into cellulose acetate networks. By adjusting the concentration of casting solution and the content of nano-AlO fillers, we systematically engineer the physical properties of the PNF for obtaining a large triboelectric charge yield. When a 10 wt % solution concentration and 10 wt % nanofiller content are adopted for the PNF, the corresponding PNF-TENG can deliver an electrical performance of ∼2.5 mW/cm on a 0.8 MΩ external resistor. This remarkable output can be ascribed to the synergistic effect between the appropriate porous network and improved dielectric properties of the nanocomposite. Moreover, the PNF-TENG also exhibits good reliable electrical outputs under multiple stain-washing measurements or after experiencing cyclical contact-separation 13,500 times. Also, the device is capable of charging various capacitors, lighting LED arrays, and driving commercial wrist watches and is proven to be an efficient and reliable green wearable power source. Furthermore, a PNF-TENG-based elbow supporter and a grip ball, as self-powered sensors, are proposed to realize real-time detection for human actions during sports exercise. This work proposes an eco-friendly nanocomposite fabric as an effective tribopositive material, verifies the feasibility of developing environmentally friendly wearable power sources and sensors, and provides new insights into the design of green wearable triboelectric nanogenerators.
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http://dx.doi.org/10.1021/acsami.0c12709DOI Listing
September 2020

Aged sol-gel solution-processed texture tin oxide for high-efficient perovskite solar cells.

Nanotechnology 2020 Jul 8;31(31):315205. Epub 2020 Apr 8.

Department of Microelectronic Science and Engineering, Laboratory of Clean Energy Storage and Conversion, School of Physical Science and Technology, Ningbo University, Ningbo 315211, People's Republic of China.

Mesoporous n-i-p perovskite solar cells (PeSCs) demonstrate attractive potential for obtaining high power conversion efficiencies (PCEs), by employing inorganic electron transport layers (ETLs). However, these ETLs composed of dual layers (a condense layer and a mesoporous layer) suffer the composite process and high sintering temperature. Here, we demonstrate a simple and efficient process to improve the device performance of PeSCs by using a textured SnO film. Self-aged sol-gel SnO solution after spin coating results in a textured structure without sacrificing the surface coverage. Excellent light trapping ability is achieved by optimizing the aged time of sol-gel SnO solution, which mimics the evolution of the conventional mesoporous layer. Such a SnO textured structure provides a large contact area for rapid charge extraction, and alleviates interfacial recombination loss. Therefore, this PeSC yields an optimal PCE of 19%, which is prominent in state-of-the-art SnO-based devices. These results indicate that one-step solution processed SnO with a textured structure offers a simple and efficient way to improve the device performance of PeSCs without a complex process.
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http://dx.doi.org/10.1088/1361-6528/ab87cbDOI Listing
July 2020

Excitatory VTA to DH projections provide a valence signal to memory circuits.

Nat Commun 2020 03 19;11(1):1466. Epub 2020 Mar 19.

Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, 60611, USA.

The positive or negative value (valence) of past experiences is normally integrated into neuronal circuits that encode episodic memories and plays an important role in guiding behavior. Here, we show, using mouse behavioral models, that glutamatergic afferents from the ventral tegmental area to the dorsal hippocampus (VTA→DH) signal negative valence to memory circuits, leading to the formation of fear-inducing context memories and to context-specific reinstatement of fear. To a lesser extent, these projections also contributed to opioid-induced place preference, suggesting a role in signaling positive valence as well, and thus a lack of dedicated polarity. Manipulations of VTA terminal activity were more effective in females and paralleled by sex differences in glutamatergic signaling. By prioritizing retrieval of negative and positive over neutral memories, the VTA→DH circuit can facilitate the selection of adaptive behaviors when current and past experiences are valence congruent.
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http://dx.doi.org/10.1038/s41467-020-15035-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081331PMC
March 2020

IQGAP1/ERK regulates fear memory formation via histone posttranslational modifications induced by HDAC2.

Neurobiol Learn Mem 2020 05 5;171:107210. Epub 2020 Mar 5.

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China. Electronic address:

Epigenetic mechanisms of learning and memory are particularly interesting topics in neuroscience that have recently been investigated. As shown in our previous study, IQGAP1, a scaffolding protein of MAPK, is involved in fear memory through interactions with GluN2A-containing NMDA receptors and the ERK1/2 cascade. However, researchers have not determined whether histone posttranslational modifications are regulated by the IQGAP1/ERK signaling pathway. We performed in vivo studies using IQGAP1 and IQGAP1 mice to provide insights into the specific functions of IQGAP1 in memory processes and the precise mechanisms underlying its regulatory effects. IQGAP1 mice exhibited impaired fear memory, decreased levels of phosphorylated ERK1/2 and histone H3S10, decreased acetylation of H3K14, and decreased c-Fos expression in the hippocampus compared to IQGAP1 mice after fear conditioning. HDAC2 was significantly enriched at the c-fos gene promoter in IQGAP1 mice. Correspondingly, the disruption of the epigenetic regulation induced by ERK1/2 signaling through an intra-hippocampal injection of the MEK antagonist U0126 or GluN2A-selective pharmacological antagonist NVP-AAM077 blocked context-dependent memory formation, while no changes were observed after treatment with the GluN2B-selective antagonist Ro25-6981. The administration of SAHA, a non-specific HDAC inhibitor, or knock-down of HDAC2 with shHDAC2-AAV in the dorsal hippocampus significantly rescued the impaired fear memory formation, H3S10 phosphorylation, H3K14 acetylation, and c-Fos expression in IQGAP1 mice. Thus, we postulated that the IQGAP1/ERK-dependent mechanism regulating histone posttranslational modifications via HDAC2 potentially underlies memory formation.
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http://dx.doi.org/10.1016/j.nlm.2020.107210DOI Listing
May 2020

Triplet fusion upconversion using sterically protected 9,10-diphenylanthracene as the emitter.

Phys Chem Chem Phys 2020 Mar;22(11):6300-6307

ARC Centre of Excellence in Exciton Science, School of Chemistry, Bio21 Institute, The University of Melbourne, Melbourne, Australia.

Improving the efficiency of triplet fusion upconversion (TF-UC) in the solid-state is still challenging due to the aggregation and phase separation of chromophores. In this work, two 9,10-diphenylanthracene (DPA) derivatives based on the modification of the 9,10-phenyl rings with bulky isopropyl groups (bDPA-1 and bDPA-2) were used as emitters. By using platinum octaethylporphyrin (PtOEP) as the sensitizer, TF-UC performance was comprehensively investigated in 3 media: toluene solution, polyurethane thin film and nano/micro-crystals in a polyvinyl alcohol matrix. Only a small difference in upconversion efficiency between the bulky DPAs and the DPA reference was observed in toluene solution and polyurethane thin film. However, a large improvement of TF-UC quantum yield was achieved in bDPA-2/PtOEP crystals (ΦUC = (0.92 ± 0.05)%) with a low excitation intensity threshold (52 mW cm-2) compared to that of DPA/PtOEP crystals (ΦUC = (0.09 ± 0.03)%). This difference was largely attributed to improved dispersibility of the PtOEP sensitizer in the bDPA-2 emitter crystals. The bulky DPAs also show excellent stability under UV irradiation with exposure to oxygen compared to DPA. These results provide a strategy for developing efficient solid-state TF-UC systems based on nano/micro-particles of emitter-sensitizer mixtures.
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http://dx.doi.org/10.1039/c9cp06311kDOI Listing
March 2020

Tetraphenylethene 9,10-Diphenylanthracene Derivatives - Synthesis and Photophysical Properties.

Chempluschem 2019 Jun 11;84(6):746-753. Epub 2019 Apr 11.

School of Chemistry ARC Centre of Excellence in Exciton Science, The University of Melbourne, Parkville, Victoria, 3010, Australia.

A series of tetraphenylethene 9,10-diphenylanthracene (TPE-DPA) derivatives have been synthesized, and their photophysical properties studied. Photoluminescence measurements in PMMA, neat films and nanoparticle dispersions reveal that different aggregation states are formed, which leads to different photophysical behavior. The triplet excited state properties were studied using Pt(II) octaethylporphyrin (PtOEP) as triplet sensitizer. Upconverted emission from the DPA moiety is observed in nanoparticle dispersions of each derivative. A higher upconverted emission intensity is observed in aerated (compared to deaerated) solutions of the derivatives following irradiation, which is attributed to oxidation of the TPE moiety. These results provide valuable insight for the design of AIE luminogens for triplet-triplet annihilation upconversion (TTA-UC).
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http://dx.doi.org/10.1002/cplu.201900100DOI Listing
June 2019

Apex structures enhance water drainage on leaves.

Proc Natl Acad Sci U S A 2020 01 14;117(4):1890-1894. Epub 2020 Jan 14.

Chinese Academy of Sciences Key Laboratory of Bio-inspired Materials and Interfacial Sciences, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190 Beijing, China;

The rapid removal of rain droplets at the leaf apex is critical for leaves to avoid damage under rainfall conditions, but the general water drainage principle remains unclear. We demonstrate that the apex structure enhances water drainage on the leaf by employing a curvature-controlled mechanism that is based on shaping a balance between reduced capillarity and enhanced gravity components. The leaf apex shape changes from round to triangle to acuminate, and the leaf surface changes from flat to bent, resulting in the increase of the water drainage rate, high-dripping frequencies, and the reduction of retention volumes. For wet tropical plants, such as , Gaussian curvature reconfiguration at the drip tip leads to the capillarity transition from resistance to actuation, further enhancing water drainage to the largest degree possible. The phenomenon is distinct from the widely researched liquid motion control mechanisms, and it offers a specific parametric approach that can be applied to achieve the desired fluidic behavior in a well-controlled way.
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http://dx.doi.org/10.1073/pnas.1909924117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995007PMC
January 2020

SHARPIN Inhibits Esophageal Squamous Cell Carcinoma Progression by Modulating Hippo Signaling.

Neoplasia 2020 02 26;22(2):76-85. Epub 2019 Dec 26.

Department of Gastroenterology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, Henan Province, PR China; Center for Cancer Research, Xinxiang Medical University, Xinxiang 453003, Henan Province, PR China; Xinxiang Key Laboratory for Molecular Therapy of Cancer, Xinxiang Medical University, Xinxiang 453003, Henan Province, PR China. Electronic address:

Esophageal cancer is one of the leading malignancies worldwide, while around sixty percent of newly diagnosed cases are in China. In recent years, genome-wide sequencing studies and cancer biology studies show that Hippo signaling functions a critical role in esophageal squamous cell carcinoma (ESCC) progression, which could be a promising therapeutic targets in ESCC treatment. However, the detailed mechanisms of Hippo signaling dys-regulation in ESCC remain not clear. Here we identify SHARPIN protein as an endogenous inhibitor for YAP protein. SHARPIN depletion significantly decreases cell migration and invasion capacity in ESCC, which effects could be rescued by further YAP depletion. Depletion SHARPIN increases YAP protein level and YAP/TEAD target genes, such as CTGF and CYR61 in ESCC. Immuno-precipitation assay shows that SHARPIN associates with YAP, promoting YAP degradation possibly via inducing YAP K48-dependent poly-ubiquitination. Our study reveals a novel post-translational mechanism in modulating Hippo signaling in ESCC. Overexpression or activation of SHARPIN could be a promising strategy to target Hippo signaling for ESCC patients.
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http://dx.doi.org/10.1016/j.neo.2019.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939053PMC
February 2020

HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction.

J Neuroinflammation 2019 Dec 3;16(1):249. Epub 2019 Dec 3.

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China.

Background: Inflammation can induce cognitive dysfunction in patients who undergo surgery. Previous studies have demonstrated that both acute peripheral inflammation and anaesthetic insults, especially isoflurane (ISO), are risk factors for memory impairment. Few studies are currently investigating the role of ISO under acute peri-inflammatory conditions, and it is difficult to predict whether ISO can aggravate inflammation-induced cognitive deficits. HDACs, which are essential for learning, participate in the deacetylation of lysine residues and the regulation of gene transcription. However, the cell-specific mechanism of HDACs in inflammation-induced cognitive impairment remains unknown.

Methods: Three-month-old C57BL/6 mice were treated with single versus combined exposure to LPS injected intraperitoneally (i.p.) to simulate acute abdominal inflammation and isoflurane to investigate the role of anaesthesia and acute peripheral inflammation in cognitive impairment. Behavioural tests, Western blotting, ELISA, immunofluorescence, qRT-PCR, and ChIP assays were performed to detect memory, the expressions of inflammatory cytokines, HDAC2, BDNF, c-Fos, acetyl-H3, microglial activity, Bdnf mRNA, c-fos mRNA, and Bdnf and c-fos transcription in the hippocampus.

Results: LPS, but not isoflurane, induced neuroinflammation-induced memory impairment and reduced histone acetylation by upregulating histone deacetylase 2 (HDAC2) in dorsal hippocampal CaMKII neurons. The hyperexpression of HDAC2 in neurons was mediated by the activation of microglia. The decreased level of histone acetylation suppressed the transcription of Bdnf and c-fos and the expressions of BDNF and c-Fos, which subsequently impaired memory. The adeno-associated virus ShHdac2, which suppresses Hdac2 after injection into the dorsal hippocampus, reversed microglial activation, hippocampal glutamatergic BDNF and c-Fos expressions, and memory deficits.

Conclusions: Reversing HDAC2 in hippocampal CaMKII neurons exert a neuroprotective effect against neuroinflammation-induced memory deficits.
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http://dx.doi.org/10.1186/s12974-019-1640-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889553PMC
December 2019

Histone H3K9 Trimethylation Downregulates the Expression of Brain-Derived Neurotrophic Factor in the Dorsal Hippocampus and Impairs Memory Formation During Anaesthesia and Surgery.

Front Mol Neurosci 2019 25;12:246. Epub 2019 Oct 25.

Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, Xuzhou, China.

Brain-derived neurotrophic factor (BDNF) is essential for cognitive and memory functions. Abnormal BDNF expression in the central nervous system may impair these functions. Anaesthesia and surgery can induce perioperative neurocognitive disorders (PND). Clinical studies show that BDNF expression is decreased in patients presenting with cognitive impairment after anaesthesia and surgery. However, the molecular mechanism is still unclear. Epigenetic regulation plays an important role in cognition. The hypermethylation of H3K9 is crucial for transcriptional silencing and the onset of cognitive disorders. Here, we hypothesised that H3K9 trimethylation repressed BDNF expression and impaired memory formation or recall during anaesthesia and surgery. Laparotomy under isoflurane inhalation anaesthesia, behavioural tests, Western blotting, quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR), chromatin immunoprecipitation (ChIP), and immunohistochemistry were used in this study. BDNF expression was decreased in the hippocampus after anaesthesia and surgery. Cognitive impairment affected memory formation but not recall. The trimethylation of H3K9 downregulated BDNF expression. The overexpression of BDNF or use of exogenous BDNF improved the impairment of memory formation caused by anaesthesia and surgery. Therefore, inhibiting H3K9 trimethylation and increasing the expression of BDNF may help prevent PND in the clinical setting.
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http://dx.doi.org/10.3389/fnmol.2019.00246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823536PMC
October 2019

Controllable High-Speed Electrostatic Manipulation of Water Droplets on a Superhydrophobic Surface.

Adv Mater 2019 Oct 13;31(43):e1905449. Epub 2019 Sep 13.

School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.

Biological processes and technological applications cannot work without liquid control, where versatile water droplet manipulation is a significant issue. Droplet motion is conventionally manipulated by functionalizing the target surface or by utilizing additives in the droplet, still, with uncontrolled limitation on superhydrophobic surfaces since droplets are either unable to move fast or are difficult to stop while moving. A controllable high-speed "all-in-one" no-loss droplet manipulation, that is, in-plane moving and stopping/pinning in any direction on a superhydrophobic surface, with electrostatic charging is demonstrated. The experimental results reveal that the transport speed can vary from zero to several hundreds of millimeters per second. Controlled dynamic switching between the onset moving state and the offset pinning state of a water droplet can be achieved by out-of-plane electrostatic charging. This work opens the possibility of droplet control techniques in various applications, such as combinatory chemistry, biochemical, and medical detection.
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http://dx.doi.org/10.1002/adma.201905449DOI Listing
October 2019

Bioinspired inner microstructured tube controlled capillary rise.

Proc Natl Acad Sci U S A 2019 06 10;116(26):12704-12709. Epub 2019 Jun 10.

Chinese Academy of Sciences Key Laboratory of Bio-inspired Materials and Interfacial Sciences, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 100190 Beijing, China.

Effective, long-range, and self-propelled water elevation and transport are important in industrial, medical, and agricultural applications. Although research has grown rapidly, existing methods for water film elevation are still limited. Scaling up for practical applications in an energy-efficient way remains a challenge. Inspired by the continuous water cross-boundary transport on the peristome surface of , here we demonstrate the use of peristome-mimetic structures for controlled water elevation by bending biomimetic plates into tubes. The fabricated structures have unique advantages beyond those of natural pitcher plants: bulk water diode transport behavior is achieved with a high-speed passing state (several centimeters per second on a milliliter scale) and a gating state as a result of the synergistic effect between peristome-mimetic structures and tube curvature without external energy input. Significantly, on further bending the peristome-mimetic tube into a "candy cane"-shaped pipe, a self-siphon with liquid diode behavior is achieved. Such a transport mechanism should inspire the design of next generation water transport devices.
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http://dx.doi.org/10.1073/pnas.1821493116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600971PMC
June 2019

Traditional Chinese medicine training for cardiac rehabilitation: a randomized comparison with aerobic and resistance training.

Coron Artery Dis 2019 08;30(5):360-366

National Institute of Sports Medicine, Beijing, China.

Background: The aim of this study was to investigate the efficacy and safety of different exercise regimens in the rehabilitation of patients with stable coronary heart disease.

Patients And Methods: This study was a randomized controlled trial to screen 141 patients with stable coronary heart disease who were admitted to the General Administration of Sport of China Sports Medical Science Institute from January 2018 to September 2018. They were randomly divided into the aerobic and resistance training (ART) group for 12 weeks (36 cases), the traditional Chinese medicine training (TCMT) group 12 weeks (37 cases), and the control (CON) group (39 cases). We analyzed the baseline parameters of all participants and the 12-week exercise plate test parameters and related physical and body parameters.

Result: After 12 weeks of intervention, volume of oxygen (VO2), VO2/kg, metabolic equivalents, VO2/heart rate, stroke volume, and peaked grip strength and flexibility parameters of the ART group and the TCMT group were significantly higher than those of the control group (P<0.05). Resting heart rate of the TCMT group was significantly lower than the CON group, but there was no significant difference between the ART and CON groups (P>0.05). Ventilation/VO2 of the TCMT group was significantly higher than that of the CON group. BMI of the ART group was significantly lower than that of the TCMT group and the CON group, and body fat mass of the TCMT group was significantly smaller than that of the ART group, but there was no difference between the TCMT group and the CON group for BMI and body fat mass.

Conclusion: Both ART and TCMT can improve the cardiopulmonary aerobic exercise capacity and physical fitness of patients with stable coronary heart disease. Although the degree of improvement is different, they all have certain effects on the rehabilitation of patients with stable coronary heart disease and the application is safe.
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http://dx.doi.org/10.1097/MCA.0000000000000734DOI Listing
August 2019

Ketamine improved depressive-like behaviors via hippocampal glucocorticoid receptor in chronic stress induced- susceptible mice.

Behav Brain Res 2019 05 10;364:75-84. Epub 2019 Feb 10.

Nanjing Medical University, Nanjing, Jiangsu, 211166, China; Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China. Electronic address:

Chronic stress is an important factor for depression. Most individuals recover from stress, while some develop into depression. The pathogenesis of resilience or susceptibility remains unclear. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis and releases stress hormones to regulate individual response to stress. Hence, we assessed the effects of chronic social defeat stress (CSDS) on susceptible behaviors, plasma corticosterone (CORT) concentration, glucocorticoid receptor (GR) expressions in hippocampus and medial prefrontal cortex (mPFC). Mice that plasma CORT concentration is increased 2 h after single social defeat stress developed into susceptible mice after 10 d social defeat stress. The plasma CORT concentration was still higher than that of resilient mice 48 h after the last defeat stress. Mice administered CORT via drinking water showed susceptibility. Mifepristone, a GR antagonist improved susceptibility to chronic stress. Single dose ketamine treatment improved depressive-like behaviors, decreased plasma CORT concentration, rescued GR expression and nuclear translocation in the hippocampus of susceptible mice. These results suggested that abnormal CORT concentration after stress may predict susceptibility to depression in clinic. Ketamine may exert the antidepressant effect via normalizing HPA axis response and have significance in the clinic.
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http://dx.doi.org/10.1016/j.bbr.2019.01.057DOI Listing
May 2019

PM: A barrier to fitness and health promotion in China.

J Sport Health Sci 2017 Sep 13;6(3):292-294. Epub 2017 Apr 13.

Sport Biological Center, China Institute of Sport Science, Beijing 100061, China.

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http://dx.doi.org/10.1016/j.jshs.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189240PMC
September 2017

Physical activity guidelines for Chinese children and adolescents: The next essential step.

Authors:
Jincheng Xu Can Gao

J Sport Health Sci 2018 Jan 4;7(1):120-122. Epub 2017 Jul 4.

Sports Hospital, National Institute of Sports Medicine, Beijing 100061, China.

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http://dx.doi.org/10.1016/j.jshs.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180532PMC
January 2018

Drop Cargo Transfer via Unidirectional Lubricant Spreading on Peristome-Mimetic Surface.

ACS Nano 2018 Nov 18;12(11):11307-11315. Epub 2018 Oct 18.

Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beijing Advanced Innovation Center for Biomedical Engineering , Beihang University , Beijing 100191 , P. R. China.

To promote drop mobility, lubricating the gap between liquid drop and solid surface is a facile method which has been widely exploited by nature. Examples include lotus and rice leaves using entrapped air to "lubricate" water and Nepenthes pitcher plant using a slippery water layer to trap insects. Inspired by these, here, we report a strategy for transporting drop cargoes via the unidirectional spreading of immiscible lubricants on the peristome-mimetic surface. Oleophilic/hydrophobic peristome-mimetic surfaces were fabricated through replicating three-dimensional printed samples. The peristome-mimetic surface, via unidirectional immiscible hexadecane spreading, can transport a wide diversity of drop cargoes over a long distance with no loss with controllable drop volumes and velocities, hence mixing multiphase liquids and even reacting liquids. We anticipate this unidirectional drop cargo transport technique will find use in microfluidics, microreactors, water harvesting systems, etc.
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http://dx.doi.org/10.1021/acsnano.8b06023DOI Listing
November 2018
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