Publications by authors named "Can Cui"

245 Publications

Surface Engineering of Laser-Induced Graphene Enables Long-Term Monitoring of On-Body Uric Acid and pH Simultaneously.

Nano Lett 2022 Jun 22. Epub 2022 Jun 22.

Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province, School of Engineering, Westlake University, 18 Shilongshan Road, Hangzhou 310024, China.

Laser-induced graphene (LIG) suffers from serious decay in long-term biosensing, which greatly restricts its practical applications. Herein, we report a new strategy to engineer the LIG surface with Au clusters and chitosan sequentially to form a C-Au-LIG electrode with a superhydrophilic and highly conductive 3D graphene surface, which demonstrates superior performance and negligible decay in both long-term storage and practical usage in vitro and in vivo environments. Moreover, the C-Au-LIG electrode can be used for detecting uric acid (UA) and pH simultaneously from a single differential pulse voltammetry curve with low-detection limitation, high accuracy, and negligible interference with other sweat biomarkers. The integrated C-Au-LIG wearable biosensor was employed to continuously monitor the UA content in human sweat, which can well reflect the daily intake of purines for at least 10 days. Therefore, the C-Au-LIG electrode demonstrates significant application potential and provides inspiration for surface engineering of other biosensor materials and electrodes.
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http://dx.doi.org/10.1021/acs.nanolett.2c01500DOI Listing
June 2022

Restaurant Interior Design under Digital Image Processing Based on Visual Sensing Technology.

Comput Intell Neurosci 2022 8;2022:3302700. Epub 2022 Jun 8.

Faculty of Humanities and Arts, Macau University of Science and Technology, Avenida Wai Long, Taipa 999078, Macau, China.

With the development of the social economy, people are paying more and more attention to decorative effects and the comfort and individual characteristics of decoration. To meet the increasingly high requirements of customers, many restaurants have begun to focus on the personalization of the dining environment, which is comfortable to build and focuses on the spiritual satisfaction and experience of customers during the dining process. In this study, a comprehensive analysis of digital image processing technology is performed to implement an automatic illumination system with improved performance for the restaurant interior design and embed the restaurant interior design with intelligence. The convolutional neural network (CNN) is employed in the automatic illumination system to develop the human body recognition model. After a test of its recognition accuracy, the parameters of CNN are optimized, and high recognition accuracy of 0.97 is achieved. Compared with other models, the process of training the designed model implemented in this study can finish in 40 minutes, and the performance has been well optimized. Moreover, the processing function of the model is also able to resist the interference of other external objects. The excellent automatic illuminating system can greatly improve the atmosphere as well as the service level of the restaurant at night, which can promote the modernization of the restaurant and give certain reference significance to the reform and advancement of the decoration industry.
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http://dx.doi.org/10.1155/2022/3302700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200518PMC
June 2022

Ancient Mitogenomes Reveal the Origins and Genetic Structure of the Neolithic Shimao Population in Northern China.

Front Genet 2022 27;13:909267. Epub 2022 May 27.

Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, Beijing, China.

Shimao City is considered an important political and religious center during the Late Neolithic Longshan period of the Middle Yellow River basin. The genetic history and population dynamics among the Shimao and other ancient populations, especially the Taosi-related populations, remain unknown. Here, we sequenced 172 complete mitochondrial genomes, ranging from the Yangshao to Longshan period, from individuals related to the Shimao culture in northern Shaanxi Province and Taosi culture in southern Shanxi Province, Middle Yellow River basin. Our results show that the populations inhabiting Shimao City had close genetic connections with an earlier population in the Middle Neolithic Yangshao period of northern Shaanxi Province, revealing a mostly local origin for the Shimao Society. In addition, among the populations in other regions of the Yellow River basin, the Shimao-related populations had the closest maternal affinity with the contemporaneous Taosi populations from the Longshan period. The Shimao-related populations also shared more affinity with present-day northern Han populations than with the minorities and southern Han in China. Our study provides a new perspective on the genetic origins and structure of the Shimao people and the population dynamics in the Middle Yellow River basin during the Neolithic period.
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http://dx.doi.org/10.3389/fgene.2022.909267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185412PMC
May 2022

Plasma CXCL3 Levels Are Associated with Tumor Progression and an Unfavorable Colorectal Cancer Prognosis.

J Immunol Res 2022 26;2022:1336509. Epub 2022 May 26.

Department of Clinical Laboratory, Xuzhou Central Hospital, China.

Background: The CXC chemokines belong to a unique family of chemotactic cytokines that influence the initiation, progression, and clinical outcome of many tumor types. Herein, we investigated the association of the CXC-chemokine ligand 3 (CXCL3) with tumor progression and an unfavorable prognosis for colorectal cancer (CRC).

Methods: The quantitative real-time polymerase chain reaction was used to explore the expression of CXCL3 in CRC tissue, adjacent tissue, and plasma. The usefulness of plasma levels of CXCL3 for the diagnosis of CRC was evaluated by receiver operating characteristic curve analysis. Pearson's correlation analysis assessed relationships among plasma CXCL3, cancer tissue CXCL3, and plasma carcinoembryonic antigen (CEA). Kaplan-Meier analysis was used to assess the survival of CRC patients with high and low expression levels of CXCL3. Survival differences were compared by log-rank test.

Results: Initial analysis of the GSE156720 dataset identified CXCL3 as the most enriched CXCL gene in CRC patients. Higher CXCL3 levels were detected in CRC tissue than in adjacent tissue ( < 0.001). Compared to healthy controls, CRC patient plasma CXCL3 levels were higher ( < 0.001). The area under the curve was 0.81 with a sensitivity of 0.71 and specificity of 0.82, distinguishing CRC from other tumor types. Plasma CXCL3 was positively related to CXCL3 in cancer tissue ( = 0.78, < 0.01), and also to plasma CEA ( = 0.50, < 0.01). Plasma CXCL3 was also related to tumor size ( = 0.034), staging ( < 0.001), tumor stage ( = 0.003), differentiation ( = 0.001), and lymph node metastasis ( = 0.007), but not to sex ( = 0.853), age ( = 0.691), tumor site ( = 1.347), or distant metastasis ( = 1.218).

Conclusions: CXCL3 levels were increased in CRC patients, with plasma CXCL3 levels associated with tumor progression and an unfavorable CRC prognosis. The results of this study suggest that plasma CXCL3 may be a novel diagnostic and prognostic biomarker for CRC.
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http://dx.doi.org/10.1155/2022/1336509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162872PMC
June 2022

Post-Translational Modification of GPX4 is a Promising Target for Treating Ferroptosis-Related Diseases.

Front Mol Biosci 2022 12;9:901565. Epub 2022 May 12.

Advanced Innovation Center for Human Brain Protection, Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, China.

Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer, cardiovascular, and neuroscience research in the past 10 years. How to regulate GPX4 activity has become a hot topic nowadays. GPX4 protein level is regulated transcriptionally by transcription factor SP2 or Nrf2. GPX4 activity can be upregulated by supplementing intracellular selenium or glutathione, and also be inhibited by ferroptosis inducers such as ML162 and RSL3. These regulatory mechanisms of GPX4 level/activity have already shown a great potential for treating ferroptosis-related diseases in preclinical studies, especially in cancer cells. Until recently, research show that GPX4 can undergo post-translational modifications (PTMs), such as ubiquitination, succination, phosphorylation, and glycosylation. PTMs of GPX4 affect the protein level/activity of GPX4, indicating that modifying these processes can be a potential therapy for treating ferroptosis-related diseases. This article summarizes the protein characteristics, enzyme properties, and PTMs of GPX4. It also provides a hypothetical idea for treating ferroptosis-related diseases by targeting the PTMs of GPX4.
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http://dx.doi.org/10.3389/fmolb.2022.901565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133406PMC
May 2022

Family Functioning and Optimism as Protective Factors of Life Satisfaction Among Stroke Patients During the COVID-19 Epidemic in Shenyang, China.

Front Public Health 2022 26;10:738634. Epub 2022 Apr 26.

Department of Social Medicine, College of Health Management, China Medical University, Shenyang, China.

The coronavirus disease-19 (COVID-19) pandemic may result in detrimental consequences for stroke patient's wellbeing. Family functioning and optimism could help stroke patients cope with crises leading to possible improvements in life satisfaction. This study aims to explore the protective effects of family functioning and optimism on life satisfaction among stroke patients during the COVID-19 pandemic in China. This study was designed as a cross-sectional survey. A total of 207 stroke inpatients who were receiving pharmacotherapy and rehabilitation in general public hospital of Liaoning province during the COVID-19 pandemic in China were consecutive selected and interviewed by online questionnaires via the WeChat platform effectively from April 8 to 30, 2020. The scales included: Satisfaction with Life Scale (SWLS), Family Adaptation, Partnership, Growth, Affection, and Resolve (APGAR) Scale and Revised Life Orientation Test (LOT-R). Hierarchical multiple regression (HMR) analysis was conducted to test the associated factors of life satisfaction. Stroke patient's life satisfaction was at a high level (Mean = 26.46, SD = 6.23) during the pandemic. Stroke patient's residence, duration of stroke, stroke type, and community shut down measures were the strong predictors of life satisfaction. Family functioning and optimism increased life satisfaction among stroke patients. This study contributes to the research on the association between family functioning and optimism on life satisfaction among stroke patients during the COVID-19 pandemic. Interventions that improve family functioning and enhance optimism should be provided in order to elevate life satisfaction for stroke patients.
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http://dx.doi.org/10.3389/fpubh.2022.738634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087178PMC
May 2022

NLRP3-Mediated Inflammation in Atherosclerosis and Associated Therapeutics.

Front Cell Dev Biol 2022 13;10:823387. Epub 2022 Apr 13.

Henan Key Laboratory of Medical Tissue Regeneration, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China.

The NLRP3 inflammasome is a crucial constituent of the body's innate immune system, and a multiprotein platform which is initiated by pattern recognition receptors (PRRs). Its activation leads to caspase-1 maturation and release of inflammatory cytokines, interleukin-1β (IL-1β) and IL-18, and subsequently causes pyroptosis. Recently, the excess activation of NLRP3 inflammasome has been confirmed to mediate inflammatory responses and to participate in genesis and development of atherosclerosis. Therefore, the progress on the discovery of specific inhibitors against the NLRP3 inflammasome and the upstream and downstream inflammatory factors has become potential targets for clinical treatment. Here we review the recently described mechanisms about the NLRP3 inflammasome activation, and discuss emphatically the pharmacological interventions using statins and natural medication for atherosclerosis associated with NLRP3 inflammasome.
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http://dx.doi.org/10.3389/fcell.2022.823387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045366PMC
April 2022

Antioxidant Regulation and DNA Methylation Dynamics During Seed Germination Under Cold Stress.

Front Plant Sci 2022 8;13:856527. Epub 2022 Apr 8.

Research Institute of Sun Yat-sen University in Shenzhen, Shenzhen, China.

As a primary goal, adaptation to cold climate could expand an invasion range of exotic plants. Here, we aimed to explore the regulation strategy of seed development under cold stress through molecular physiology and multi-omics analysis. Significant increase of hydrogen peroxide, malondialdehyde, and electrolyte leakage observed under cold stress revealed that oxidative damage within seed cells was induced in the initial germination phase. Proteomic data underscored an activation of antioxidant activity to maintain redox homeostasis, with a cluster of antioxidant proteins identified. Genomic-wide transcriptome, in combination with time-series whole-genome bisulfite sequencing mining, elucidated that seven candidate genes, which were the target of DNA demethylation-dependent ROS scavenging, were possibly associated with an germ break. Progressive gain of CHH context DNA methylation identified in an early germination phrase suggested a role of a DNA methylation pathway, while an active DNA demethylation pathway was also initiated during late seed development, which was in line with the expression trend of methylation and demethylation-related genes verified through qRT-PCR. These data pointed out that cold-dependent DNA demethylation and an antioxidant regulatory were involved together in restoring seed germination. The expression level of total 441 genes presented an opposite trend to the methylation divergence, while the expression of total 395 genes was proved to be negatively associated with their methylation levels. These data provided new insights into molecular reprograming events during seed development.
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http://dx.doi.org/10.3389/fpls.2022.856527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024368PMC
April 2022

A High Serum Phosphate and Calcium-Phosphate Product Is Associated With Cerebral Small Vascular Disease in Patients With Stroke: A Real-World Study.

Front Nutr 2022 4;9:801667. Epub 2022 Apr 4.

Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Cerebral small vessel disease (CSVD) is a slowly progressive disease, often accompanied by stroke, and results in dementia, depression, and cognitive impairment. It was already known that calcium and phosphorus metabolism (CPM) disorders were associated with vascular-related adverse events. The risk factors of CSVD and the relationship between serum calcium (Ca), phosphorus (P), calcium-phosphate product (Ca × P), and CSVD in patients with stroke without CPM disorders are still obscure. In our study, 528 patients with stroke without CPM disorders were enrolled in a cohort from a consecutive hospital-based stroke registry, with 488 patients with CSVD as cases and 140 without CSVD as controls. The patients with CSVD were further sub-grouped into lacunes, white matter hyperintensities (WMHs), and cerebral microbleeds (CMBs). By applying univariate and multivariate logistic regression analysis, the following novel findings were obtained: (i) up to 76.19% of patients with stroke had signs of CSVD, and lacunes are the most common subtype. Notably, 22.96% of patients with CSVD had multiple subtypes coexisted. (ii) Compared with patients without CSVD, patients with CSVD had higher levels of age, rate of hypertension or diabetes, serum Ca, P, Ca × P, and lower levels of white blood cell (WBC) and hemoglobin (HB). (iii) We developed 2 predictive models and nomograms for predicting CSVD, in addition to the known factors (age and hypertension). The levels of P and Ca × P were positively correlated with the risk of CSVD (P: OR = 3,720.401, 95% CI (646.665-21,404.249); Ca × P: OR = 1.294, 95% CI (1.222-1.370)). (iv) The models were further validated in subtypes of CSVD, including lacunes, WMHs, and CMBs, and the results were still valid among the subtypes. In summary, CSVD was highly prevalent in patients with stroke, and high serum P and Ca × P are potential risk factors of CSVD and all subtypes including lacunes, WMHs, and CMBs.
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http://dx.doi.org/10.3389/fnut.2022.801667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013770PMC
April 2022

Research on Innovation Ecosystem of Dairy Industry Cluster Based on Machine Learning and Improved Neural Network.

Comput Intell Neurosci 2022 4;2022:4509575. Epub 2022 Apr 4.

College of Economics and Management, Northeast Agricultural University, Heilongjiang, Harbin, China.

With the rapid development of global economy, the industrial cluster has become the new trend of world economic development. So far, the industrial cluster mode with space as the main division has been formed. The cooperation of industrial clusters is dynamic. The industries in the cluster cooperate with each other for mutual benefit and win-win, occupying a place in the fierce market competition. In addition, the industrial cluster is also conducive to strengthen the international economic division of labor and points out the direction of regional industrial transfer. China is now in a critical period of economic development; the industrial cluster plays an important role in China's industrial transformation and economic development. At present, the most common regional development mode in China is industrial cluster. The emergence of industrial cluster accelerates the development of industrial regional economy and the balance of industrial layout. Industrial clusters occupy a key position in China's economic industry chain, and the development and change in industrial clusters will directly affect the development of the entire industrial chain. This study first simulates the evolution path of industrial cluster and then establishes the relevant data model. Finally, through repast simulation, it puts forward conclusions and suggestions according to the verification results. The construction of dynamic model can realize the simulation of industrial cluster theory. According to the simulation results, we can find that the ecosystem in different stages will produce different characteristics; the formation and evolution of industrial clusters are actually the epitome of market development. In this process, the government guidance and market regulation are needed to accelerate the formation of industrial cluster ecosystem and increase the scale of industrial cluster.
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http://dx.doi.org/10.1155/2022/4509575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001137PMC
April 2022

miRNA sequencing analysis of healthy and atretic follicles of chickens revealed that miR-30a-5p inhibits granulosa cell death via targeting Beclin1.

J Anim Sci Biotechnol 2022 Apr 12;13(1):55. Epub 2022 Apr 12.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.

Background: The egg production performance of chickens is affected by many factors, including genetics, nutrition and environmental conditions. These factors all play a role in egg production by affecting the development of follicles. MicroRNAs (miRNAs) are important non-coding RNAs that regulate biological processes by targeting genes or other non-coding RNAs after transcription. In the animal reproduction process, miRNA is known to affect the development and atresia of follicles by regulating apoptosis and autophagy of granulosa cells (GCs).

Results: In this study, we identified potential miRNAs in the atretic follicles of broody chickens and unatretic follicles of healthy chickens. We identified gga-miR-30a-5p in 50 differentially expressed miRNAs and found that gga-miR-30a-5p played a regulatory role in the development of chicken follicles. The function of miR-30a-5p was explored through the transfection test of miR-30a-5p inhibitor and miR-30a-5p mimics. In the study, we used qPCR, western blot and flow cytometry to detect granulosa cell apoptosis, autophagy and steroid hormone synthesis. Confocal microscopy and transmission electron microscopy are used for the observation of autophagolysosomes. The levels of estradiol (E2), progesterone (P4), malondialdehyde (MDA) and superoxide dismutase (SOD) were detected by ELISA. The results showed that miR-30a-5p showed a negative effect on autophagy and apoptosis of granulosa cells, and also contributed in steroid hormones and reactive oxygen species (ROS) production. In addition, the results obtained from the biosynthesis and dual luciferase experiments showed that Beclin1 was the target gene of miR-30a-5p. The rescue experiment conducted further confirmed that Beclin1 belongs to the miR-30a-5p regulatory pathway.

Conclusions: In summary, after deep miRNA sequencing on healthy and atretic follicles, the results indicated that miR-30a-5p inhibits granulosa cell death by inhibiting Beclin1.
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http://dx.doi.org/10.1186/s40104-022-00697-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003977PMC
April 2022

Effect of 0.02% and 0.01% atropine on astigmatism: a two-year clinical trial.

BMC Ophthalmol 2022 Apr 7;22(1):161. Epub 2022 Apr 7.

The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe road, Zhengzhou, 450000, China.

Background: To evaluate the effects of 0.02% and 0.01% atropine eye drops on ocular and corneal astigmatism over 2 years.

Methods: A prospective clinic-controlled trail. The cohort study assessed 400 myopic children and divided them into three groups: 138 and 142 children were randomized to use either 0.02% or 0.01% atropine eye drops, respectively. They wore single-vision (SV) spectacles, with one drop of atropine applied to both eyes once nightly. Control children (n = 120) only wore SV spectacles. Spherical equivalent refractive errors (SER) and corneal curvature were measured every 4 months. The SER and corneal curvature were assessed by cycloplegic autorefraction and IOLMaster. Ocular and corneal astigmatism were calculated by Thibos vector analysis and then split into its power vector components, J0 (with-the-rule astigmatism) and J45 (oblique).

Results: After 2 years, the ocular astigmatism increased by -0.38 ± 0.29 D, -0.47 ± 0.38 D, -0.41 ± 0.35 D in the 0.02%, 0.01% atropine groups and control group, respectively (p = 0.15). The corresponding corneal astigmatism increased by -0.20 ± 0.34 D, -0.28 ± 0.35 D and -0.26 ± 0.26 D (p = 0.18). The ocular astigmatism J0 increased by 0.19 ± 0.28 D, 0.22 ± 0.36 D, 0.18 ± 0.31 D in the 0.02% atropine, 0.01% atropine and control groups, respectively (p = 0.65). The corresponding corneal astigmatism J0 increased by -0.05 ± 0.34 D, -0.11 ± 0.37 D and -0.13 ± 0.30 D (p = 0.23). There was a small but significant increase in ocular astigmatism (including J0) (all P < 0.05), but there were no changes in the ocular astigmatism J45 and corneal astigmatism (including J0 and J45) in the three groups over time (all p > 0.05). However, there were no significant differences in the changes in ocular astigmatism (including J0) among the three groups.

Conclusions: Treatment with 0.02% and 0.01% atropine had no clinically significant effect on ocular and corneal astigmatism over 2 years.

Trial Registration: The First Affiliated Hospital of Zhengzhou University, ChiCTR-IPD-16008844 . Registered 14/07/2016.
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http://dx.doi.org/10.1186/s12886-022-02385-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991778PMC
April 2022

Single-Atom Tailored Hierarchical Transition Metal Oxide Nanocages for Efficient Lithium Storage.

Small 2022 Jun 5;18(22):e2200367. Epub 2022 Apr 5.

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.

Mitigating the mechanical degradation and enhancing the ionic/electronic conductivity are critical but challengeable issues toward improving electrochemical performance of conversion-type anodes in rechargeable batteries. Herein, these challenges are addressed by constructing interconnected 3D hierarchically porous structure synergistic with Nb single atom modulation within a Co O nanocage (3DH-Co O @Nb). Such a hierarchical-structure nanocage affords several fantastic merits such as rapid ion migration and enough inner space for alleviating volume variation induced by intragrain stress and optimized stability of the solid-electrolyte interface. Particularly, experimental studies in combination with theoretical analysis verify that the introduction of Nb into the Co O lattice not only improves the electron conductivity, but also accelerates the surface/near-surface reactions defined as pesudocapacitance behavior. Dynamic behavior reveals that the ensemble design shows huge potential for fast and large lithium storage. These features endow 3DH-Co O @Nb with remarkable battery performance, delivering ≈740 mA h g after ultra-long cycling of 1000 times under a high current density of 5 A g . Importantly, the assembled 3DH-Co O @Nb//LiCoO pouch cell also presents a long-lived cycle performance with only ≈0.059% capacity decay per cycle, inspiring the design of electrode materials from both the nanostructure and atomic level toward practical applications.
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http://dx.doi.org/10.1002/smll.202200367DOI Listing
June 2022

Dynamic investigation of battery materials via advanced visualization: from particle, electrode to cell level.

Adv Mater 2022 Apr 1:e2200777. Epub 2022 Apr 1.

State Key Laboratory of Materials Processing and Die and Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China.

Li-ion batteries, the most-popular secondary battery, are typically electrochemical systems controlled by ion insertion dynamics. The battery dynamics involves mass transport, charge transfer, ion-electron coupled reaction, electrolyte penetration, ion solvation, and interfacial evolution. However, the traditional electrochemical methods are hard to capture the accurate and individual details of different dynamic processes in the "black box" batteries, instead, only the net result of multi-factors on whole scale. Recently, different types of advanced visualization techniques are developed, which provide us powerful tools to track and monitor the internal on-site real-time dynamic processes inside the "black box" batteries, giving intuitionistic details and fine information at various scales from crystal lattice, single particle, electrode to cell level. Here, we review the recent progress on the investigation of electrochemical dynamics in battery materials via developed techniques across wide timescales and space-scales, including the dynamic process inside the active particle, kinetics issues at the electrode/electrolyte interface, dynamic inhomogeneity in electrode, and dynamic transportation in cell level. Finally, we summarize the fundamental principles to improve the battery dynamics and highlight new technologies for future more stringent conditions. In prospect, this review opens sight on battery interior for a clearer, deeper and more thorough understanding of dynamics. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/adma.202200777DOI Listing
April 2022

Facile, Atom-Economic, Chemical Thinning Strategy for Ultrathin Lithium Foils.

Nano Lett 2022 Apr 22;22(7):3047-3053. Epub 2022 Mar 22.

State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, Hubei P. R. China.

Metallic lithium is considered as the ultimate anode material for lithium-based batteries due to its highest energy density. However, as an anode, commercial Li metal foils are too thick, with a large amount of trouble to balance its exorbitant areal capacity with common cathodes in full cells. Here, a new chemical thinning strategy is proposed via a simple surface dissolving reaction between lithium and naphthalene, which enables scalable, continuous, and roll-to-roll preparation of ultrathin Li foil. A Li foil less than 15 μm with a clean surface can be successfully obtained within 20 min. The thinning rate and thickness of the lithium foil can be easily adjusted by changing the concentration, temperature, and operation mode. The produced Li-Naph solution after thinning can also be used as a multifunctional reagent of great value, and the Li ions in the final waste solution can be further extracted in the form of LiCO, showing superior lithium atom economy of our strategy.
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http://dx.doi.org/10.1021/acs.nanolett.2c00338DOI Listing
April 2022

Correlation between leukocyte phenotypes and prognosis of amyotrophic lateral sclerosis.

Elife 2022 03 15;11. Epub 2022 Mar 15.

Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

The prognostic role of immune cells in amyotrophic lateral sclerosis (ALS) remains undetermined. Therefore, we conducted a longitudinal cohort study including 288 ALS patients with up to 5-year follow-up during 2015-2020 recruited at the only tertiary referral center for ALS in Stockholm, Sweden, and measured the levels of differential leukocytes and lymphocyte subpopulations. The primary outcome was risk of death after diagnosis of ALS and the secondary outcomes included functional status and disease progression rate. Cox model was used to evaluate the associations between leukocytes and risk of death. Generalized estimating equation model was used to assess the correlation between leukocytes and functional status and disease progression rate. We found that leukocytes, neutrophils, and monocytes increased gradually over time since diagnosis and were negatively correlated with functional status, but not associated with risk of death or disease progression rate. For lymphocyte subpopulations, NK cells (HR= 0.61, 95% CI = [0.42-0.88] per SD increase) and Th2-diffrentiated CD4 central memory T cells (HR= 0.64, 95% CI = [0.48-0.85] per SD increase) were negatively associated with risk of death, while CD4 effector memory cells re-expressing CD45RA (EMRA) T cells (HR= 1.39, 95% CI = [1.01-1.92] per SD increase) and CD8 T cells (HR= 1.38, 95% CI = [1.03-1.86] per SD increase) were positively associated with risk of death. None of the lymphocyte subpopulations was correlated with functional status or disease progression rate. Our findings suggest a dual role of immune cells in ALS prognosis, where neutrophils and monocytes primarily reflect functional status whereas NK cells and different T lymphocyte populations act as prognostic markers for survival.
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http://dx.doi.org/10.7554/eLife.74065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923665PMC
March 2022

Precise Measurement of the Thickness of Vaginal Intraepithelial Neoplasia.

J Low Genit Tract Dis 2022 Mar 10. Epub 2022 Mar 10.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China Translational Oncology & Urology Research (TOUR) Team, School of Cancer and Pharmaceutical Studies, King's College London, London, United Kingdom Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.

Objectives: Although carbon dioxide laser vaporization is frequently used for treating vaginal intraepithelial neoplasia (VaIN), the optimal depth of epithelial destruction with laser vaporization requires elucidation. We aimed to evaluate VaIN depth and better illustrate epithelial destruction during laser vaporization.

Materials And Methods: We included 246 women diagnosed with VaIN (low-grade VaIN [VaIN 1], 123 women; high-grade VaIN [VaIN 2/3], 123 women) using colposcopy-directed biopsy at our hospital from January 1, 2019, to April 30, 2020. The thickness of the noninvolved epithelium, if available, was determined. All available data, including cytology and histological information, were recorded. The t test and Pearson χ2 test were used for statistical analysis. Statistical significance was set at p < .05.

Results: The involved epithelial thicknesses in VaIN 2/3 and VaIN 1 were 0.41 ± 0.21 and 0.40 ± 0.19 mm, respectively, which were both greater than their noninvolved epithelial thickness values (0.17 ± 0.10 and 0.17 ± 0.08 mm, p < .01 and p < .01, respectively). In subgroup comparisons between the VaIN 2/3 and VaIN 1 groups, the involved epithelial thickness did not differ between premenopausal patients, postmenopausal women receiving estrogen, and postmenopausal women who did not receive estrogen (p > .05). In the VaIN 2/3 group, the lesion thickness in premenopausal was greater than that in postmenopausal women receiving estrogen (p = .016) and those who were not receiving estrogen (p = .017).

Conclusions: The thickness of VaIN is generally less than 1 mm for women of all ages, except in rare cases of visible lesions with papillary hyperplasia.
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http://dx.doi.org/10.1097/LGT.0000000000000672DOI Listing
March 2022

Panic, Psycho-Behavioral Responses, and Risk Perception in the Earliest Stage of the COVID-19 Pandemic in China.

Front Med (Lausanne) 2022 25;9:766842. Epub 2022 Feb 25.

Department of Social Medicine, College of Health Management, China Medical University, Shenyang, China.

Background: Coronavirus Disease-19 (COVID-19), a rising global pandemic, has triggered psychological crises among the public. Panic, a severe symptom of mental disorders, is increasing in the public in China and it is urgent to provide research for intervention development.

Objectives: This study aimed to assess the prevalence of public panic in China during the earliest stage of the COVID-19 pandemic and to explore the associated psychological behavioral responses and public's risk perception of the pandemic.

Methods: A cross-sectional study using a web-based survey with convenience sampling was conducted with 2,484 participants nationally from February 11 to February 24, 2020 in China. A self-developed questionnaire was applied to assess the prevalence of public panic and its associated factors. Multivariable logistic regression analysis was applied to assess the risk and protective factors of public panic.

Results: There were 23.39% (581/2,484) of the participants who reported experiencing panic during the earliest stage of the COVID-19 pandemic. Taking temperature repeatedly, being nervous in a crowd, being suspicious of infection in the family, being worried about the future, and worries about high infectivity of the COVID-19, lack of effective therapies, and wide impact of the COVID-19 pandemic increased the odds of public panic. Whereas, avoiding gatherings during holidays was negatively associated with the odds of public panic.

Conclusions: Psycho-behavioral responses were closely associated with public panic during the earliest stage of the COVID-19 pandemic in China. Defusing excessive health-related worries, the guidance of appropriate self-protective behaviors, strengthening of health education in communities, and available treatment for mental disorders should be adopted to monitor the psychological responses and to guide the behaviors of the public.
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http://dx.doi.org/10.3389/fmed.2022.766842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914041PMC
February 2022

Tfh-cell-derived interleukin 21 sustains effector CD8 T cell responses during chronic viral infection.

Immunity 2022 03 24;55(3):475-493.e5. Epub 2022 Feb 24.

Blood Research Institute, Versiti Wisconsin, Milwaukee, WI 53226, USA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address:

CD4 T cell-derived interleukin 21 (IL-21) sustains CD8 T cell responses during chronic viral infection, but the helper subset that confers this protection remains unclear. Here, we applied scRNA and ATAC-seq approaches to determine the heterogeneity of IL-21CD4 T cells during LCMV clone 13 infection. CD4 T cells were comprised of three transcriptionally and epigenetically distinct populations: Cxcr6 Th1 cells, Cxcr5 Tfh cells, and a previously unrecognized Slamf6 memory-like (Tml) subset. T cell differentiation was specifically redirected toward the Tml subset during chronic, but not acute, LCMV infection. Although this subset displayed an enhanced capacity to accumulate and some developmental plasticity, it remained largely quiescent, which may hinder its helper potential. Conversely, mixed bone marrow chimera experiments revealed that Tfh cell-derived IL-21 was critical to sustain CD8 T cell responses and viral control. Thus, strategies that bolster IL-21Tfh cell responses may prove effective in enhancing CD8 T cell-mediated immunity.
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http://dx.doi.org/10.1016/j.immuni.2022.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916994PMC
March 2022

Spatial compressive imaging deep learning framework using joint input of multi-frame measurements and degraded maps.

Authors:
Can Cui Jun Ke

Opt Express 2022 Jan;30(2):1235-1248

Traditional compressive imaging reconstruction is often based on an iterative approach, which costs much time. To deal with the issue, a couple of groups have used deep learning for reconstruction to ensure low running time with good performance. However, the excessive dependence on data and network structure also creates a network with a lack of flexibility and interpretation. Such networks are often inapplicable when compression ratios are high. In order to solve these issues, we study an end-to-end network Joinput-CiNet (joint input compressive imaging net). We use a tailored encoding module to make the imaging degradation model part of the network input. Then the network can obtain prior knowledge of the imaging system, thereby improving training efficiency and reconstruction performance. With five broadly used image datasets and experimentally collected infrared (IR) measurements, Joinput-CiNet demonstrates superior reconstruction performance at low compression rates such as 1:16 and 1:64 with fast speed compared with other networks.
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http://dx.doi.org/10.1364/OE.445127DOI Listing
January 2022

Deep Learning-Based Imbalanced Classification With Fuzzy Support Vector Machine.

Front Bioeng Biotechnol 2021 21;9:802712. Epub 2022 Jan 21.

College of Electronic and Information Engineering, Tongji University, Shanghai, China.

Imbalanced classification is widespread in the fields of medical diagnosis, biomedicine, smart city and Internet of Things. The imbalance of data distribution makes traditional classification methods more biased towards majority classes and ignores the importance of minority class. It makes the traditional classification methods ineffective in imbalanced classification. In this paper, a novel imbalance classification method based on deep learning and fuzzy support vector machine is proposed and named as DFSVM. DFSVM first uses a deep neural network to obtain an embedding representation of the data. This deep neural network is trained by using triplet loss to enhance similarities within classes and differences between classes. To alleviate the effects of imbalanced data distribution, oversampling is performed in the embedding space of the data. In this paper, we use an oversampling method based on feature and center distance, which can obtain more diverse new samples and prevent overfitting. To enhance the impact of minority class, we use a fuzzy support vector machine (FSVM) based on cost-sensitive learning as the final classifier. FSVM assigns a higher misclassification cost to minority class samples to improve the classification quality. Experiments were performed on multiple biological datasets and real-world datasets. The experimental results show that DFSVM has achieved promising classification performance.
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http://dx.doi.org/10.3389/fbioe.2021.802712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815771PMC
January 2022

Treatment of Severe Japanese Encephalitis Complicated With Hashimoto's Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case Report.

Front Immunol 2021 7;12:807937. Epub 2022 Jan 7.

Neuro-intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

A severely comatose female patient was diagnosed with Japanese encephalitis (JE). Her condition was complicated by Hashimoto's thyroiditis (HT) and Guillain-Barré syndrome (GBS). After antiviral, glucocorticoid, and immunoglobulin treatment, the patient's consciousness was restored, and she could breathe spontaneously. Following this, new-onset, primarily demyelinating GBS developed, which progressed to demyelination combined with axonal injury. The patient was switched to protein A immunoadsorption (PAIA) therapy, and her Hughes score decreased rapidly, from 4 to 1 after 6 months. This patient is the first to receive PAIA combined with an antiviral-glucocorticoid-immunoglobulin regimen to treat encephalitis, meningitis, HT, and GBS caused by JE infection, thereby reflecting the importance of clinical application of PAIA in the treatment of immunological complications of JE.
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http://dx.doi.org/10.3389/fimmu.2021.807937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777188PMC
February 2022

Filamin C regulates skeletal muscle atrophy by stabilizing dishevelled-2 to inhibit autophagy and mitophagy.

Mol Ther Nucleic Acids 2022 Mar 29;27:147-164. Epub 2021 Nov 29.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.

FilaminC (Flnc) is a member of the actin binding protein family, which is preferentially expressed in the cardiac and skeletal muscle tissues. Although it is known to interact with proteins associated with myofibrillar myopathy, its unique role in skeletal muscle remains largely unknown. In this study, we identify the biological functions of Flnc and using chicken primary myoblast cells and animal models, respectively. From the results, we observe that the growth rate and mass of the skeletal muscle of fast-growing chickens (broilers) were significantly higher than those in slow-growing chickens (layers). Furthermore, we find that the expression of Flnc in the skeletal muscle of broilers was higher than that in the layers. Our results indicated that Flnc was highly expressed in the skeletal muscle, especially in the skeletal muscle of broilers than in layers. This suggests that Flnc plays a positive regulatory role in myoblast development. Flnc knockdown resulted in muscle atrophy, whereas the overexpression of Flnc promotes muscle hypertrophy in an animal model. We also found that Flnc interacted with dishevelled-2 (Dvl2), activated the wnt/β-catenin signaling pathway, and controlled skeletal muscle development. Flnc also antagonized the LC3-mediated autophagy system by decreasing Dvl2 ubiquitination. Moreover, Flnc knockdown activated and significantly increased mitophagy. In summary, these results indicate that the absence of Flnc induces autophagy or mitophagy and regulates muscle atrophy.
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http://dx.doi.org/10.1016/j.omtn.2021.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683659PMC
March 2022

Bridging Effects of Sulfur Anions at Titanium Oxide and Perovskite Interfaces on Interfacial Defect Passivation and Performance Enhancement of Perovskite Solar Cells.

ACS Omega 2021 Dec 7;6(50):34485-34493. Epub 2021 Dec 7.

Institute of Materials, China Academy of Engineering Physics, Jiangyou, Sichuan 621908, China.

Interfacial defects at the electron transport layer (ETL) and perovskite (PVK) interface are critical to the power conversion efficiency (PCE) and stabilities of the perovskite solar cells (PSCs) via significantly affecting the quality of both interface contacts and PVK layers. Here, we demonstrate a simple ionic bond passivation method, employing NaS solution treatment of the surface of titanium dioxide (TiO) layers, to effectively passivate the traps at the TiO/Cs(MAFA)Pb(BrI) PVK interface and enhance the performance of PSCs. X-ray photoelectron spectroscopy and other characterizations show that the NaS treatment introduced S ions at the TiO/PVK interface, where S ions effectively bridged the TiO ETL and the PVK layer via forming chemical bonds with Ti atoms and with uncoordinated Pb atoms and resulted in the reduced defect density and improved the crystallinity of PVK layers. In addition, the S ions can effectively enlarge the grain size of the PVK layers. The average PCE of solar cells is improved from 15.77 to 19.06% via employing the NaS-treated TiO layers. This work demonstrates a simple and facile interface passivation method using ionic bond passivation to afford high-performance PSCs. The bridging effect of S ions may inspire the further exploration of the ionic bond passivation and sulfur-based passivation materials.
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http://dx.doi.org/10.1021/acsomega.1c04685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697378PMC
December 2021

LIFE: A Generalizable Autodidactic Pipeline for 3D OCT-A Vessel Segmentation.

Med Image Comput Comput Assist Interv 2021 Sep-Oct;12901:514-524. Epub 2021 Sep 21.

Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, USA.

Optical coherence tomography (OCT) is a non-invasive imaging technique widely used for ophthalmology. It can be extended to OCT angiography (OCT-A), which reveals the retinal vasculature with improved contrast. Recent deep learning algorithms produced promising vascular segmentation results; however, 3D retinal vessel segmentation remains difficult due to the lack of manually annotated training data. We propose a learning-based method that is only supervised by a self-synthesized modality named local intensity fusion (LIF). LIF is a capillary-enhanced volume computed directly from the input OCT-A. We then construct the local intensity fusion encoder (LIFE) to map a given OCT-A volume and its LIF counterpart to a shared latent space. The latent space of LIFE has the same dimensions as the input data and it contains features common to both modalities. By binarizing this latent space, we obtain a volumetric vessel segmentation. Our method is evaluated in a human fovea OCT-A and three zebrafish OCT-A volumes with manual labels. It yields a Dice score of 0.7736 on human data and 0.8594 ± 0.0275 on zebrafish data, a dramatic improvement over existing unsupervised algorithms.
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http://dx.doi.org/10.1007/978-3-030-87193-2_49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692169PMC
September 2021

Orthokeratology Lenses Versus Administration of 0.01% Atropine Eye Drops for Axial Length Elongation in Children With Myopic Anisometropia.

Eye Contact Lens 2022 Jan;48(1):45-50

From the The Affiliated Eye Hospital of Suzhou Vocational Health College; Suzhou, China.

Objective: To investigate the effect of orthokeratology (OK) lenses and that of 0.01% atropine eye drops on axial length (AL) elongation in children with myopic anisometropia.

Methods: Ninety-five children with myopic anisometropia who used OK lenses (N=49) or 0.01% atropine eye drops (N=46) were enrolled in this retrospective 1-year study. For all children, the eyes with higher spherical equivalent refractive error (SER) were assigned to the H-eye subgroup, whereas the fellow eyes with lower SER were assigned to the L-eye subgroup.

Results: After 1-year treatment, the mean change in the AL of H eyes and L eyes in the OK lenses group was 0.18±0.16 mm and 0.24±0.15 mm, respectively (P=0.15), and 0.28±0.20 mm and 0.25±0.18 mm, respectively (P=0.48), in the 0.01% atropine group. Multivariate regression analyses showed significant differences in AL change between H and L eyes after treatment with OK lens (P=0.03), whereas no significant difference in the 0.01% atropine (P=0.22). The change in the AL in the H-eye group was less with OK lenses than with 0.01% atropine (P=0.04), whereas there was no significant difference between the change in AL in the L-eye group between treatment with OK lens and 0.01% atropine (P=0.89).

Conclusions: In myopic anisometropic children, AL differences between 2 eyes decrease by wearing OK lenses but do not change after administration of 0.01% atropine eye drops. The increased effect of OK lenses, but not 0.01% atropine, in reducing axial elongation at 1 year in the eye with higher SER in anisometropic children warrants further investigation.
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http://dx.doi.org/10.1097/ICL.0000000000000848DOI Listing
January 2022

Effects of Optimism on Work Satisfaction Among Nurses: A Mediation Model Through Work-Family Conflict.

Front Psychiatry 2021 25;12:779396. Epub 2021 Nov 25.

Department of Social Medicine, College of Health Management, China Medical University, Shenyang, China.

Nurses are suffering from various stressors which adversely impact their work satisfaction and mental health. Research is scarce on optimism, one of the positive psychological resource which may reduce work-family conflict and improve work satisfaction. This study aims to assess work satisfaction among Chinese nurses and to observe and illustrate the relationships among optimism, work-family conflict, and work satisfaction. This study was designed as a cross-sectional study with stratified sampling. From September 2019 to December 2020, a self-administered WeChat questionnaire was collected from 768 nurses online in China to evaluate the nurses' work satisfaction, optimism, and work-family conflict. Spearman correlation and hierarchical multiple regression analysis were applied to examine associated factors of work satisfaction. A structural equation model was employed to test the mediating effect of work-family conflict in the relationship between optimism and work satisfaction. Optimism were observed to have a positive correlation with work satisfaction while the correlation between work-family conflict and work satisfaction was observed to be negative. Optimism and work-family conflict explained 4.8 and 9.2% of the incremental variances of work satisfaction, respectively. Work-family conflict served as a mediator in the relationship between optimism and work satisfaction. Nurses in China experienced high levels of work satisfaction. Optimism could increase the chance of higher work satisfaction while work-family conflict increased the risk of lower work satisfaction. Psychological interventions and improvement of working conditions are essential to relieve work-family conflicts and enhance work satisfaction.
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http://dx.doi.org/10.3389/fpsyt.2021.779396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656394PMC
November 2021

Prenatal anxiety and the associated factors among Chinese pregnant women during the COVID-19 pandemic--a smartphone questionnaire survey study.

BMC Psychiatry 2021 12 10;21(1):619. Epub 2021 Dec 10.

Department of Social Medicine, College of Health Management, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, 110122, P.R. China.

Backgrounds: The uncertainty of the pandemic of Coronavirus Disease 2019 (COVID-19) brought about tremendous psychological harm for pregnant women, causing their high rates of prenatal anxiety. The impacts of COVID-19 pandemic and symptoms of pregnant status are highly linked with prenatal anxiety. Whereas, self-efficacy and support from family and friends could attenuate the development of prenatal anxiety. Thus, the purpose of the study is to evaluate the prevalence of prenatal anxiety and its influence factors among pregnant women during the pandemic of COVID-19 in Shenyang, China.

Methods: A cross-sectional study with face-to-face interview between April 24, 2020 and May 3, 2020 during the COVID-19 pandemic was applied among pregnant women in Shenyang Women's and Children's Hospital. Chi-square tests were calculated to determine the differences in prenatal anxiety among categorical variables. Multivariable logistic regression was employed to investigate the risk factors of prenatal anxiety.

Results: The percentage of prenatal anxiety (GAD-7 score ≥ 7) among pregnant women during the pandemic of COVID-19 was 34/304 (11.18%). Logistic regression indicated that vomiting (OR 4.454, 95% CI 1.113-17.821) and feeling susceptible to SARS-CoV-2 infection (OR 2.966, 95% CI 1.151-7.642) increased the odds of prenatal anxiety. Satisfaction with medical care (OR 0.303, 95% CI 0.113-0.813) and self-efficacy (OR 0.253, 95% CI 0.100-0.639) decreased the odds of prenatal anxiety. High monthly income (OR 0.246, 95% CI 0.078 ~ 0.780) reduced the chances of suffering from prenatal anxiety.

Conclusion: The pregnant women in China exerted a higher prevalence of prenatal anxiety during the COVID-19 pandemic than that without COVID-19 pandemic. Effective management on symptoms of pregnant status should be delivered to relieve prenatal anxiety for the pregnant women. Furthermore, interventions on self-efficacy enhancement and high-quality medical prenatal care should be provided to prevent from the susceptibility of SARS-CoV-2 infection and reduce prenatal anxiety.
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http://dx.doi.org/10.1186/s12888-021-03624-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661313PMC
December 2021

Experimental and Simulation Research on the Preparation of Carbon Nano-Materials by Chemical Vapor Deposition.

Materials (Basel) 2021 Nov 30;14(23). Epub 2021 Nov 30.

Key Laboratory of Low-Dimensional Materials and Big Data, School of Chemical Engineering, Guizhou Minzu University, Guiyang 550025, China.

Carbon nano-materials have been widely used in many fields due to their electron transport, mechanics, and gas adsorption properties. This paper introduces the structure and properties of carbon nano-materials the preparation of carbon nano-materials by chemical vapor deposition method (CVD)-which is one of the most common preparation methods-and reaction simulation. A major factor affecting the material structure is its preparation link. Different preparation methods or different conditions will have a great impact on the structure and properties of the material (mechanical properties, electrical properties, magnetism, etc.). The main influencing factors (precursor, substrate, and catalyst) of carbon nano-materials prepared by CVD are summarized. Through simulation, the reaction can be optimized and the growth mode of substances can be controlled. Currently, numerical simulations of the CVD process can be utilized in two ways: changing the CVD reactor structure and observing CVD chemical reactions. Therefore, the development and research status of computational fluid dynamics (CFD) for CVD are summarized, as is the potential of combining experimental studies and numerical simulations to achieve and optimize controllable carbon nano-materials growth.
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http://dx.doi.org/10.3390/ma14237356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658281PMC
November 2021
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