Calum Sutherland

Calum Sutherland

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Calum Sutherland

Publications by authors named "Calum Sutherland"

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New developments for prevention of type 1 diabetes: a paradigm shift?

Br J Hosp Med (Lond) 2019 Jan;80(1):4-5

Professor of Molecular and Cellular Diabetes, Department of Cellular Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY.

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http://www.magonlinelibrary.com/doi/10.12968/hmed.2019.80.1.
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http://dx.doi.org/10.12968/hmed.2019.80.1.4DOI Listing
January 2019

A partnership with the proteasome; the destructive nature of GSK3.

Biochem Pharmacol 2018 01 1;147:77-92. Epub 2017 Nov 1.

Division of Molecular and Clinical Medicine, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954166PMC
January 2018

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.

Mol Cell Biol 2016 09 26;36(18):2403-17. Epub 2016 Aug 26.

Division of Cancer Research, School of Medicine, University of Dundee, Dundee, Scotland, United Kingdom Department of Pharmacology and Molecular Sciences and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00292-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007788PMC
September 2016

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug.

Biochim Biophys Acta 2016 08 27;1862(8):1412-22. Epub 2016 Apr 27.

Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland DD1 9SY, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894248PMC
August 2016

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons.

Cell Rep 2015 Oct 17;13(4):812-828. Epub 2015 Oct 17.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS 0408, Boston, MA 02215, USA; Institute for Translational Medicine, Fujian Medical University, Fuzhou 350108, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662601PMC
October 2015

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.

Biochem Soc Trans 2015 Aug 3;43(4):611-20. Epub 2015 Aug 3.

Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U.K.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST20150011
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http://dx.doi.org/10.1042/BST20150011DOI Listing
August 2015

Invited commentary on … Lithium treatment and risk for dementia in adults with bipolar disorder.

Br J Psychiatry 2015 Jul;207(1):52-4

Calum Sutherland, BSc, PhD, Division of Cardiovascular and Diabetes Medicine, Ninewells Medical School, Dundee, Scotland; Ashleigh C. Duthie, MRCPsych, MSc, Susan Carnegie Centre, Stracathro Hospital, near Brechin, Scotland.

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http://dx.doi.org/10.1192/bjp.bp.114.161729DOI Listing
July 2015

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.

J Cereb Blood Flow Metab 2015 Feb 19;35(2):188-92. Epub 2014 Nov 19.

1] Centre for Neuroregeneration, University of Edinburgh, Edinburgh, UK [2] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/jcbfm.2014.201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426747PMC
February 2015

High fat feeding is associated with stimulation of the hypothalamic-pituitary-adrenal axis and reduced anxiety in the rat.

Psychoneuroendocrinology 2015 Feb 9;52:272-80. Epub 2014 Dec 9.

Division of Neuroscience, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S03064530140045
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http://dx.doi.org/10.1016/j.psyneuen.2014.12.002DOI Listing
February 2015

CNP/cGMP signaling regulates axon branching and growth by modulating microtubule polymerization.

Dev Neurobiol 2013 Sep 24;73(9):673-87. Epub 2013 Jun 24.

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1002/dneu.22078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229251PMC
September 2013

Insulin resistance in the brain: an old-age or new-age problem?

Biochem Pharmacol 2012 Sep 16;84(6):737-45. Epub 2012 May 16.

Biomedical Research Institute, University of Dundee, UK.

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http://dx.doi.org/10.1016/j.bcp.2012.05.007DOI Listing
September 2012

Models of dementia: an introductory overview.

Biochem Soc Trans 2011 Aug;39(4):851-6

Biomedical Research Institute, University of Dundee, Ninewells Medical School, Dundee DD1 9SY, Scotland, UK.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST0390851
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http://dx.doi.org/10.1042/BST0390851DOI Listing
August 2011

Bioinformatic prediction and confirmation of beta-adducin as a novel substrate of glycogen synthase kinase 3.

J Biol Chem 2011 Jul 23;286(28):25274-83. Epub 2011 May 23.

Neurosignalling Group, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.251629
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http://dx.doi.org/10.1074/jbc.M111.251629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137098PMC
July 2011

What Are the bona fide GSK3 Substrates?

Authors:
Calum Sutherland

Int J Alzheimers Dis 2011 18;2011:505607. Epub 2011 May 18.

Biomedical Research Institute, University of Dundee, Dundee DD1 9SY, UK.

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http://www.hindawi.com/journals/ijad/2011/505607/
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http://dx.doi.org/10.4061/2011/505607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100594PMC
July 2011

High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task.

Behav Brain Res 2011 Feb 23;217(1):134-41. Epub 2010 Oct 23.

Centre for Neuroscience, Division of Medical Sciences, University of Dundee, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1016/j.bbr.2010.10.017DOI Listing
February 2011

Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology.

Biochem Pharmacol 2011 Feb 25;81(4):471-7. Epub 2010 Nov 25.

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G11 6TA, United Kingdom.

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http://dx.doi.org/10.1016/j.bcp.2010.11.010DOI Listing
February 2011

GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.

J Neurosci 2010 Apr;30(16):5635-43

Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.6154-09.2
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http://dx.doi.org/10.1523/JNEUROSCI.6154-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632347PMC
April 2010

Dissecting insulin signaling pathways: individualised therapeutic targets for diagnosis and treatment of insulin resistant states.

Endocr Metab Immune Disord Drug Targets 2009 Jun;9(2):187-98

Biomedical Research Institute, University of Dundee, Ninewells Medical School, Dundee, Scotland, DD1 9SY, UK.

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http://dx.doi.org/10.2174/187153009788452408DOI Listing
June 2009

Filaggrin in the frontline: role in skin barrier function and disease.

J Cell Sci 2009 May;122(Pt 9):1285-94

Epithelial Genetics Group, Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry and Nursing, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1242/jcs.033969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721001PMC
May 2009

Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels.

J Biol Chem 2009 Apr 10;284(14):9331-40. Epub 2009 Feb 10.

Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M806774200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666585PMC
April 2009

Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo.

Biochem J 2009 Mar;418(3):665-71

Biomedical Research Institute, Department of Obstetrics and Gynaecology, Ninewells Hospital, Dundee, Scotland, U.K.

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http://dx.doi.org/10.1042/BJ20082176DOI Listing
March 2009

Measuring GSK3 expression and activity in cells.

Methods Mol Biol 2008 ;468:45-65

Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee, Scotland.

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http://dx.doi.org/10.1007/978-1-59745-249-6_4DOI Listing
January 2009

Anaesthesia generates neuronal insulin resistance by inducing hypothermia.

BMC Neurosci 2008 Oct 9;9:100. Epub 2008 Oct 9.

Biomedical Research Institute, University of Dundee, Ninewells Hospital, Dundee, Scotland, DD1 9SY, UK.

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http://dx.doi.org/10.1186/1471-2202-9-100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586025PMC
October 2008

Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.

J Biol Chem 2008 Jun 6;283(26):18227-37. Epub 2008 May 6.

Neurosciences Institute, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK.

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http://dx.doi.org/10.1074/jbc.M801645200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440596PMC
June 2008

Novel procedure to investigate the effect of phosphorylation on protein complex formation in vitro and in cells.

Biochemistry 2008 Feb 26;47(7):2153-61. Epub 2008 Jan 26.

Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom.

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http://dx.doi.org/10.1021/bi702030wDOI Listing
February 2008

Molecular connexions between dementia and diabetes.

Neurosci Biobehav Rev 2007 24;31(7):1046-63. Epub 2007 Apr 24.

Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK.

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http://dx.doi.org/10.1016/j.neubiorev.2007.04.004DOI Listing
December 2007

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells.

Diabetes 2007 Sep 11;56(9):2218-27. Epub 2007 Jun 11.

Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK.

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http://dx.doi.org/10.2337/db07-0343DOI Listing
September 2007

A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression.

J Mol Endocrinol 2006 Oct;37(2):227-37

Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK.

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https://jme.bioscientifica.com/view/journals/jme/37/2/037022
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http://dx.doi.org/10.1677/jme.1.02084DOI Listing
October 2006

Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells.

J Biol Chem 2005 Mar 4;280(10):9509-18. Epub 2005 Jan 4.

Division of Molecular Physiology, Medical Sciences Institute/Wellcome Trust Building Complex, Faculty of Life Sciences, University of Dundee, DD1 5EH, United Kingdom.

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http://www.jbc.org/cgi/doi/10.1074/jbc.M411648200
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http://dx.doi.org/10.1074/jbc.M411648200DOI Listing
March 2005

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.

Biochem J 2005 Feb;385(Pt 3):639-48

MRC Protein Phosphorylation Unit, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.

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http://biochemj.org/lookup/doi/10.1042/BJ20041782
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http://dx.doi.org/10.1042/BJ20041782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134738PMC
February 2005

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.

J Biol Chem 2005 Feb 29;280(6):4367-73. Epub 2004 Nov 29.

Biomedical Research Centre and Cancer Research UK Molecular Pharmacology Unit, Level 5, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M412711200DOI Listing
February 2005

GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.

J Biol Chem 2004 Nov 5;279(48):50176-80. Epub 2004 Oct 5.

Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland.

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http://dx.doi.org/10.1074/jbc.C400412200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1832086PMC
November 2004

Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.

BMC Mol Biol 2004 Sep 6;5:15. Epub 2004 Sep 6.

Department of Pathology and Neurosciences, University of Dundee, Ninewells Medical School and Hospital, Dundee, DD1 9SY United Kingdom.

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http://dx.doi.org/10.1186/1471-2199-5-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517930PMC
September 2004

The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1.

BMC Pharmacol 2004 Aug 24;4:17. Epub 2004 Aug 24.

Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

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http://bmcpharma.biomedcentral.com/articles/10.1186/1471-221
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http://dx.doi.org/10.1186/1471-2210-4-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516774PMC
August 2004

Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element.

FEBS Lett 2003 Aug;549(1-3):72-6

Department of Pharmacology and Neurosciences, University of Dundee, Ninewells Medical School and Hospital, Dundee 108-8639, UK.

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http://dx.doi.org/10.1016/s0014-5793(03)00774-9DOI Listing
August 2003

Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity.

J Biol Chem 2002 Mar 9;277(12):9889-95. Epub 2002 Jan 9.

Division of Cellular Signalling, School of Life Sciences, Wellcome Trust Biocentre/Medical Sciences Institute Complex, Dow Street, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109870200
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http://dx.doi.org/10.1074/jbc.M109870200DOI Listing
March 2002