Calum A MacRae

Calum A MacRae

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Calum A MacRae

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LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase.

Circ Genom Precis Med 2019 Sep 28;12(9):407-420. Epub 2019 Aug 28.

Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.).

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http://dx.doi.org/10.1161/CIRCGEN.119.002641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750970PMC
September 2019

Evolution of academic-industry partnerships in cardiovascular research and development.

Authors:
Calum A MacRae

Nat Rev Cardiol 2019 Aug;16(8):449-451

Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41569-019-0223-0DOI Listing
August 2019

Closing the 'phenotype gap' in precision medicine: improving what we measure to understand complex disease mechanisms.

Authors:
Calum A MacRae

Mamm Genome 2019 Aug 19;30(7-8):201-211. Epub 2019 Aug 19.

Cardiovascular Medicine, Genetics and Network Medicine Divisions, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Hale 7016, 75 Francis Street, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00335-019-09810-7DOI Listing
August 2019

Phenotypic Manifestations of Arrhythmogenic Cardiomyopathy in Children and Adolescents.

J Am Coll Cardiol 2019 Jul;74(3):346-358

Inherited Cardiac Arrhythmia Program, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.05.022DOI Listing
July 2019

Zebrafish model of amyloid light chain cardiotoxicity: regeneration versus degeneration.

Am J Physiol Heart Circ Physiol 2019 May 15;316(5):H1158-H1166. Epub 2019 Mar 15.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts.

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http://dx.doi.org/10.1152/ajpheart.00788.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580397PMC
May 2019

Screening drugs for myocardial disease in vivo with zebrafish: an expert update.

Expert Opin Drug Discov 2019 Apr 6;14(4):343-353. Epub 2019 Mar 6.

c Cardiovascular Medicine , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.

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https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1
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http://dx.doi.org/10.1080/17460441.2019.1577815DOI Listing
April 2019

Development of an entirely remote, non-physician led hypertension management program.

Clin Cardiol 2019 Feb 17;42(2):285-291. Epub 2019 Jan 17.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/clc.23141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712321PMC
February 2019

Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL).

J Biol Chem 2019 01 6;294(1):351-360. Epub 2018 Nov 6.

From the Department of Medicine, Division of Cardiology, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903,

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.003852
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http://dx.doi.org/10.1074/jbc.RA118.003852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322893PMC
January 2019

Rare Diseases Inform Myocardial Phenotypes for Precision Medicine.

Authors:
Calum A Macrae

J Card Fail 2018 10 13;24(10):680-681. Epub 2018 Sep 13.

Department of Cardiovascular Medicine, Genetics and Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10719164183098
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http://dx.doi.org/10.1016/j.cardfail.2018.09.005DOI Listing
October 2018

Genetics of Atrial Fibrillation.

J Am Heart Assoc 2018 10;7(20):e009884

5 Department of Cardiovascular Medicine American University of Beirut Medical Center Beirut Lebanon.

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009884
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http://dx.doi.org/10.1161/JAHA.118.009884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474960PMC
October 2018

Zebrafish assay development for cardiovascular disease mechanism and drug discovery.

Prog Biophys Mol Biol 2018 10 2;138:126-131. Epub 2018 Jul 2.

Brigham and Women's Hospital, Harvard Medical School, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00796107183009
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http://dx.doi.org/10.1016/j.pbiomolbio.2018.07.002DOI Listing
October 2018

Discovering New Diseases to Accelerate Precision Medicine.

Authors:
Calum A Macrae

Trans Am Clin Climatol Assoc 2017 ;128:83-89

BOSTON, MASSACHUSETTS.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525407PMC
May 2018

Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration.

Circulation 2018 05 18;137(20):2152-2165. Epub 2018 Jan 18.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA (N.N., Y.A., D.M.B., A.U., L.H.C.-D., N.N.H., J.L.W., R.T.L.)

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.030801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953786PMC
May 2018

A New Approach to an Old Problem: One Brave Idea.

Circ Res 2018 04;122(9):1172-1175

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (J.C., C.A.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.310941DOI Listing
April 2018

Network Analysis to Risk Stratify Patients With Exercise Intolerance.

Circ Res 2018 03 5;122(6):864-876. Epub 2018 Feb 5.

From the Department of Medicine (W.M.O., R.K.F.O., R.-S.W., D.M.R., B.M.W., C.A.M., J.L., A.B.W., D.M.S., J.A.L.), Division of Pulmonary and Critical Care Medicine (W.M.O., B.M.W., A.B.W., D.M.S.), Division of Cardiovascular Medicine (A.R.O., C.A.M., J.L., J.A.L., B.A.M.), and Department of Radiology (J.H.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Division of Respiratory Diseases, Department of Medicine, Federal University of São Paulo (UNIFESP), Brazil (R.K.F.O.); Department of Cardiology, Boston Children's Hospital and Harvard Medical School, MA (A.R.O.); Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston (G.A.A.); Division of Cardiology, Department of Medicine, Providence Veterans Affairs Medical Center and Alpert Medical School of Brown University, Providence, RI (G.C.); Department of Pulmonology, Medical University of Graz, Austria (A.T., H.O., G.K.); Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria (A.T., H.O., G.K.); and Department of Cardiology, Boston VA Healthcare System, MA (B.A.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924425PMC
March 2018

Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression.

Development 2018 02 5;145(3). Epub 2018 Feb 5.

Division of Cardiology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA

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http://dx.doi.org/10.1242/dev.161497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818010PMC
February 2018

A Comparison of Whole Genome Sequencing to Multigene Panel Testing in Hypertrophic Cardiomyopathy Patients.

Circ Cardiovasc Genet 2017 Oct;10(5)

From the Cardiovascular Division (A.L.C., N.K.L., B.M., D.A., M.W., P.O., C.A.M., C.E.S., C.Y.H.), Department of Pathology (H.L.R.), and Division of Genetics (C.B., R.C.G., C.A.M.), Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA (N.K.L., B.M., D.A., M.W., P.O., H.L.R., R.C.G., C.A.M., C.E.S., C.Y.H.); Albany Medical College, NY (L.C.); Broad Institute of Harvard and MIT, Cambridge, MA (H.L.R., R.C.G., C.A.M.); Laboratory for Molecular Medicine (H.L.R., K.M., M.L.), Leadership Team (R.C.G.), Partners HealthCare Personalized Medicine, Cambridge, MA; and Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683423PMC
October 2017

Closing the Genotype-Phenotype Loop for Precision Medicine.

Circulation 2017 10;136(16):1492-1494

From Cardiovascular Medicine Division, Brigham and Women's Hospital, Departments of Medicine (C.A.M., C.E.S.) and Genetics (C.E.S.), Harvard Medical School, Boston, MA; and Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.030831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540750PMC
October 2017

Skin and Vascular Disease-Inside-Out/Outside-In.

Authors:
Calum A MacRae

JAMA Cardiol 2017 09;2(9):944-945

Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamacardio.2017.1420DOI Listing
September 2017

The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial.

Ann Intern Med 2017 08 27;167(3):159-169. Epub 2017 Jun 27.

From VA Boston Healthcare System, Brigham and Women's Hospital, Harvard Medical School, and Partners HealthCare Personalized Medicine, Boston, Massachusetts; Baylor College of Medicine and UTHealth School of Public Health, Houston, Texas; Oregon Health & Science University, Portland, Oregon; Broad Institute of MIT and Harvard, Cambridge, Massachusetts; and Geisinger Health System, Danville, Pennsylvania.

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http://dx.doi.org/10.7326/M17-0188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856654PMC
August 2017

Genomic Medicine in Cardiovascular Fellowship Training.

Circulation 2017 07;136(4):345-346

From Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.027568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650094PMC
July 2017

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.

Authors:
Philipp S Wild Janine F Felix Arne Schillert Alexander Teumer Ming-Huei Chen Maarten J G Leening Uwe Völker Vera Großmann Jennifer A Brody Marguerite R Irvin Sanjiv J Shah Setia Pramana Wolfgang Lieb Reinhold Schmidt Alice V Stanton Dörthe Malzahn Albert Vernon Smith Johan Sundström Cosetta Minelli Daniela Ruggiero Leo-Pekka Lyytikäinen Daniel Tiller J Gustav Smith Claire Monnereau Marco R Di Tullio Solomon K Musani Alanna C Morrison Tune H Pers Michael Morley Marcus E Kleber Jayashri Aragam Emelia J Benjamin Joshua C Bis Egbert Bisping Ulrich Broeckel Susan Cheng Jaap W Deckers Fabiola Del Greco M Frank Edelmann Myriam Fornage Lude Franke Nele Friedrich Tamara B Harris Edith Hofer Albert Hofman Jie Huang Alun D Hughes Mika Kähönen Knhi Investigators Jochen Kruppa Karl J Lackner Lars Lannfelt Rafael Laskowski Lenore J Launer Margrét Leosdottir Honghuang Lin Cecilia M Lindgren Christina Loley Calum A MacRae Deborah Mascalzoni Jamil Mayet Daniel Medenwald Andrew P Morris Christian Müller Martina Müller-Nurasyid Stefania Nappo Peter M Nilsson Sebastian Nuding Teresa Nutile Annette Peters Arne Pfeufer Diana Pietzner Peter P Pramstaller Olli T Raitakari Kenneth M Rice Fernando Rivadeneira Jerome I Rotter Saku T Ruohonen Ralph L Sacco Tandaw E Samdarshi Helena Schmidt Andrew S P Sharp Denis C Shields Rossella Sorice Nona Sotoodehnia Bruno H Stricker Praveen Surendran Simon Thom Anna M Töglhofer André G Uitterlinden Rolf Wachter Henry Völzke Andreas Ziegler Thomas Münzel Winfried März Thomas P Cappola Joel N Hirschhorn Gary F Mitchell Nicholas L Smith Ervin R Fox Nicole D Dueker Vincent W V Jaddoe Olle Melander Martin Russ Terho Lehtimäki Marina Ciullo Andrew A Hicks Lars Lind Vilmundur Gudnason Burkert Pieske Anthony J Barron Robert Zweiker Heribert Schunkert Erik Ingelsson Kiang Liu Donna K Arnett Bruce M Psaty Stefan Blankenberg Martin G Larson Stephan B Felix Oscar H Franco Tanja Zeller Ramachandran S Vasan Marcus Dörr

J Clin Invest 2017 May 10;127(5):1798-1812. Epub 2017 Apr 10.

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https://www.jci.org/articles/view/84840
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http://dx.doi.org/10.1172/JCI84840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409098PMC
May 2017

Cisplatin Analogs Confer Protection against Cyanide Poisoning.

Cell Chem Biol 2017 May 13;24(5):565-575.e4. Epub 2017 Apr 13.

Division of Cardiology, Department of Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472353PMC
May 2017

Zebrafish mesonephric renin cells are functionally conserved and comprise two distinct morphological populations.

Am J Physiol Renal Physiol 2017 04 8;312(4):F778-F790. Epub 2017 Feb 8.

University/British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, Little France, The University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1152/ajprenal.00608.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407072PMC
April 2017

Elucidation of -mediated Noonan syndrome with cardiac hypertrophy.

JCI Insight 2017 03 9;2(5):e91225. Epub 2017 Mar 9.

Department of Molecular Pharmacology and Experimental Therapeutics and Windland Smith Rice Sudden Death Genomics Laboratory.

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http://dx.doi.org/10.1172/jci.insight.91225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333962PMC
March 2017

Using Zebrafish for High-Throughput Screening of Novel Cardiovascular Drugs.

JACC Basic Transl Sci 2017 Feb 27;2(1):1-12. Epub 2017 Feb 27.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacbts.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113531PMC
February 2017

THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage.

Stroke 2016 12 15;47(12):3005-3013. Epub 2016 Nov 15.

From the Department of Neurosurgery (T.S.-S., X.F., G.W.H., K.J.P., S.M.C., K.J.Q., J.P.H., D.H.K.) and Division of Medical Genetics, Department of Internal Medicine (D.M.M.), The University of Texas Medical School at Houston; Department of Genetics, Harvard Medical School, Boston, MA (M.L.H., S.V.N., S.R.D., S.C.G., B.M., S.M.D., C.E.S., J.G.S.); Department of Neurosurgery (S.V.N.), Department of Medicine (M.S.L., C.A.M.), and Cardiovascular Division (C.E.S.), Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.).

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http://dx.doi.org/10.1161/STROKEAHA.116.014161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134902PMC
December 2016

Animal-based studies will be essential for precision medicine.

Sci Transl Med 2016 08;8(352):352ed12

K. C. Kent Lloyd is a professor at the Department of Surgery, School of Medicine, and the Director of the Mouse Biology Program, University of California, Davis, 2795 Second Street, Suite 400, Davis, CA 95618, USA. Email: N. Robinson is a professor at Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany, and The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032, USA. Email: A. MacRae is the Chief of cardiovascular medicine at Brigham and Women's Hospital and an associate professor of medicine at Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Email:

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http://dx.doi.org/10.1126/scitranslmed.aaf5474DOI Listing
August 2016

A countermeasure development pipeline.

Ann N Y Acad Sci 2016 08;1378(1):58-67

Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/nyas.13224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420827PMC
August 2016

The Future of Cardiovascular Biomedicine.

Circulation 2016 Jun;133(25):2601-2

From Harvard Medical School/Brigham and Women's Hospital, Cardiovascular Medicine, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.020553DOI Listing
June 2016

The Future of Cardiovascular Therapeutics.

Circulation 2016 Jun;133(25):2610-7

From Cardiovascular Medicine Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (C.A.M., J.L.); Harvard Medical School, Boston, MA (C.A.M., J.L.); and Cardiology Division, Department of Medicine, Vanderbilt University Medical School, Nashville, TN (D.M.R.).

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http://circ.ahajournals.org/content/circulationaha/133/25/26
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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023555DOI Listing
June 2016

The Future of Genetics and Genomics: Closing the Phenotype Gap in Precision Medicine.

Circulation 2016 Jun;133(25):2634-9

From Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (C.A.M.); Department of Medicine, Harvard Medical School, Boston, MA (C.A.M.); Broad Institute of Harvard and MIT, Boston, MA (C.A.M.); National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.S.V.); Evans Departments of Medicine and Epidemiology, Boston University Schools of Medicine and Public Health, MA (R.S.V.); and Preventive Medicine and Cardiology Sections, Boston University School of Medicine, MA (R.S.V.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188655PMC
June 2016

The Future of Cardiovascular Education and Training.

Circulation 2016 Jun;133(25):2734-42

From Children's Hospital Boston, MA (D.W.B.); Harvard Medical School, Boston, MA (D.W.B., C.A.M.); Brigham and Women's Hospital, Boston, MA (C.A.M.); and Christiana Care Health System, Newark, DE (T.J.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023554DOI Listing
June 2016

In vitro and in vivo reprogramming for the conduction system.

Authors:
Calum A MacRae

Trends Cardiovasc Med 2016 Jan 28;26(1):21-2. Epub 2015 Aug 28.

Division of Cardiovascular Medicine, Brigham and Women׳s Hospital, Boston, MA; Harvard Stem Cell Institute, Cambridge, MA; The Broad Institute of MIT and Harvard, Cambridge, MA; Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2015.08.005DOI Listing
January 2016

Fusiform Aneurysms Are Associated with Aortic Root Dilatation in Patients with Subarachnoid Hemorrhage.

World Neurosurg 2015 Dec 13;84(6):1681-5. Epub 2015 Jul 13.

Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2015.07.011DOI Listing
December 2015

Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.

Proc Natl Acad Sci U S A 2015 Dec 23;112(49):E6780-9. Epub 2015 Nov 23.

Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106; Gladstone Institutes, San Francisco, CA 94158; Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH 44106; Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, CA 94158

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http://dx.doi.org/10.1073/pnas.1512968112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679037PMC
December 2015

Effect Size Does Matter: The Long Road to Mechanistic Insight From Genome-Wide Association.

Circulation 2015 Nov 20;132(21):1943-5. Epub 2015 Oct 20.

From the Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (C.A.M.); Department of Medicine, Harvard Medical School, Boston, MA (C.A.M., M.R.P.); and Renal Division, Beth Israel Deaconess Medical Center, Boston, MA (M.R.P.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.019306DOI Listing
November 2015

The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3.

Proc Natl Acad Sci U S A 2015 Nov 4;112(46):14284-9. Epub 2015 Nov 4.

Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1510495112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655542PMC
November 2015

Zebrafish as tools for drug discovery.

Nat Rev Drug Discov 2015 Oct 11;14(10):721-31. Epub 2015 Sep 11.

Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrd4627DOI Listing
October 2015

Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium.

Am J Physiol Renal Physiol 2015 Sep 22;309(6):F531-9. Epub 2015 Jul 22.

University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, Little France, The University of Edinburgh, Edinburgh, United Kingdom; and.

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http://dx.doi.org/10.1152/ajprenal.00247.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572395PMC
September 2015

A Critical Need for Clinical Context in the Genomic Era.

Authors:
Calum A MacRae

Circulation 2015 Sep 14;132(11):992-3. Epub 2015 Aug 14.

From Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and the Broad Institute of Harvard and MIT, Cambridge, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.018371DOI Listing
September 2015

Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration.

Dev Cell 2015 Aug 6;34(4):387-99. Epub 2015 Aug 6.

Department of Stem Cell and Regenerative Biology, Harvard University, and the Brigham Regenerative Medicine Center, Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA 02139, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/developmental-cell/pdf/S1534-5807(15)004
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http://linkinghub.elsevier.com/retrieve/pii/S153458071500424
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http://dx.doi.org/10.1016/j.devcel.2015.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550513PMC
August 2015

Summarizing polygenic risks for complex diseases in a clinical whole-genome report.

Genet Med 2015 Jul 23;17(7):536-44. Epub 2014 Oct 23.

1] Harvard Medical School, Boston, Massachusetts, USA [2] Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA [3] Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/gim.2014.143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547452PMC
July 2015

Selecting causal genes from genome-wide association studies via functionally coherent subnetworks.

Nat Methods 2015 Feb 22;12(2):154-9. Epub 2014 Dec 22.

1] Donnelly Centre, University of Toronto, Toronto, Ontario, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. [3] Department of Computer Science, University of Toronto, Toronto, Ontario, Canada. [4] Center for Cancer Systems Biology (CCSB), Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [5] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. [6] Canadian Institute for Advanced Research, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nmeth.3215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480866PMC
February 2015

A new phenotypic lexicon for accelerated translation: rise of the machines.

Authors:
Calum A MacRae

Circulation 2015 Jan;131(3):234-6

From the Cardiovascular Medicine Division, Brigham and Women's Hospital, Boston, MA; and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.014067DOI Listing
January 2015

RING finger protein RNF207, a novel regulator of cardiac excitation.

J Biol Chem 2014 Dec 3;289(49):33730-40. Epub 2014 Oct 3.

From the Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, Rhode Island 02903,

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http://dx.doi.org/10.1074/jbc.M114.592295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256309PMC
December 2014

Arrhythmogenic Cardiomyopathy - New Insights into Disease Mechanisms and Drug Discovery.

Prog Pediatr Cardiol 2014 Dec;37(1-2):3-7

Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.ppedcard.2014.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260412PMC
December 2014

Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus.

EBioMedicine 2014 Dec 13;1(2-3):107-15. Epub 2014 Nov 13.

Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States ; Harvard Medical School, Boston, MA 02215, United States ; Broad Institute of Harvard and MIT, Cambridge, MA, United States.

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http://dx.doi.org/10.1016/j.ebiom.2014.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457406PMC
December 2014

Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion.

Cardiovasc Res 2014 Nov 24;104(2):280-9. Epub 2014 Sep 24.

Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 500 W 120th Street, MC 8904, New York, NY 10027, USA

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http://dx.doi.org/10.1093/cvr/cvu212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296114PMC
November 2014

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity.

EMBO Mol Med 2014 Nov;6(11):1493-507

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Cardiac Amyloidosis Program, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.15252/emmm.201404190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237473PMC
November 2014

A clinical approach to inherited premature coronary artery disease.

Circ Cardiovasc Genet 2014 Aug;7(4):558-64

From the Center for Cardiovascular Genetics, Cardiovascular Division, Department of Medicine (N.O.S.) and Division of Statistical Genomics (N.O.S.), Washington University School of Medicine, Saint Louis, MO; and Cardiovascular Division, Brigham and Women's Hospital (C.A.M.) and Department of Medicine (C.A.M.), Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403638PMC
August 2014

Genetic testing in cardiovascular diseases.

Curr Opin Cardiol 2014 May;29(3):235-40

aDepartment of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany bCardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/HCO.0000000000000055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129647PMC
May 2014

Long QT syndrome.

Circulation 2014 Apr;129(14):1524-9

Inherited Cardiac Arrhythmia Program, Boston Children's Hospital (D.J.A.) and Cardiovascular Genetics Program, Brigham and Women's Hospital (C.A.M.), Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.003985DOI Listing
April 2014

Clinically relevant functional annotation of genotype.

Circ Cardiovasc Genet 2014 Feb;7(1):2-3

Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School Boston, MA.

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188549PMC
February 2014

Reponse to De Leeuw and Houge.

Am J Hum Genet 2014 Jan;94(1):154-5

Experimental and Clinical Research Center, Charité Medical Faculty and Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2013.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882908PMC
January 2014

Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration.

Proc Natl Acad Sci U S A 2014 Jan 13;111(4):1403-8. Epub 2014 Jan 13.

Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.

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http://dx.doi.org/10.1073/pnas.1311705111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910613PMC
January 2014

Sequential effects of spadetail, one-eyed pinhead and no tail on midline convergence of nephric primordia during zebrafish embryogenesis.

Dev Biol 2013 Dec 13;384(2):290-300. Epub 2013 Jul 13.

British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, QMRI, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom; Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ydbio.2013.07.002DOI Listing
December 2013

Mendelian forms of structural cardiovascular disease.

Authors:
Calum A MacRae

Curr Cardiol Rep 2013 Oct;15(10):399

Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s11886-013-0399-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884814PMC
October 2013

Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity.

Basic Res Cardiol 2013 Sep 28;108(5):378. Epub 2013 Aug 28.

Divisions of Cardiovascular Medicine and Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB 431, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s00395-013-0378-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914405PMC
September 2013

The developmental basis of adult arrhythmia: atrial fibrillation as a paradigm.

Front Physiol 2013 Sep 12;4:221. Epub 2013 Sep 12.

Medicine, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School Boston, MA, USA.

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http://dx.doi.org/10.3389/fphys.2013.00221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771314PMC
September 2013

miR-21 represses Pdcd4 during cardiac valvulogenesis.

Development 2013 May 11;140(10):2172-80. Epub 2013 Apr 11.

Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1242/dev.084475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640220PMC
May 2013

Recent advances in in vivo screening for antiarrhythmic drugs.

Authors:
Calum A MacRae

Expert Opin Drug Discov 2013 Feb 12;8(2):131-41. Epub 2013 Jan 12.

Harvard Medical School, Brigham and Women's Hospital, Cardiovascular Division, 75 Francis Street, Boston, MA 02115, USA.

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February 2013

Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish.

Drug Discov Today Dis Models 2013 ;10(1)

Harvard Medical School, Massachusetts General Hospital, Brigham and Women's Hospital.

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http://dx.doi.org/10.1016/j.ddmod.2013.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834265PMC
January 2013