Caleb Lareau

Caleb Lareau

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Caleb Lareau

Caleb Lareau

Publications by authors named "Caleb Lareau"

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31Publications

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CRISPR DNA base editors with reduced RNA off-target and self-editing activities.

Nat Biotechnol 2019 Sep 2;37(9):1041-1048. Epub 2019 Sep 2.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0236-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730565PMC
September 2019

Preprocessing and Computational Analysis of Single-Cell Epigenomic Datasets.

Methods Mol Biol 2019 ;1935:187-202

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-9057-3_13DOI Listing
June 2019

Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis.

Cell Rep 2019 Jun;27(11):3228-3240.e7

Division of Hematology/Oncology, Boston Children's Hospital, and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579117PMC
June 2019

Heritability of fetal hemoglobin, white cell count, and other clinical traits from a sickle cell disease family cohort.

Am J Hematol 2019 May 6;94(5):522-527. Epub 2019 Feb 6.

Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://doi.wiley.com/10.1002/ajh.25421
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http://dx.doi.org/10.1002/ajh.25421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449202PMC
May 2019

Impaired human hematopoiesis due to a cryptic intronic splicing mutation.

J Exp Med 2019 May 26;216(5):1050-1060. Epub 2019 Mar 26.

Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

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http://www.jem.org/lookup/doi/10.1084/jem.20181625
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http://dx.doi.org/10.1084/jem.20181625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504223PMC
May 2019

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors.

Nature 2019 May 17;569(7756):433-437. Epub 2019 Apr 17.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1161-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657343PMC
May 2019

Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM.

Nat Commun 2019 04 23;10(1):1903. Epub 2019 Apr 23.

Molecular Pathology Unit & Cancer Center, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41467-019-09670-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478907PMC
April 2019

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics.

Cell 2019 Mar 28;176(6):1325-1339.e22. Epub 2019 Feb 28.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193005
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http://dx.doi.org/10.1016/j.cell.2019.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408267PMC
March 2019

Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation.

Cell 2018 05 26;173(6):1535-1548.e16. Epub 2018 Apr 26.

Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94025, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989727PMC
May 2018

Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".

Nat Methods 2018 04 30;15(4):238-239. Epub 2018 Mar 30.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.4541DOI Listing
April 2018

diffloop: a computational framework for identifying and analyzing differential DNA loops from sequencing data.

Bioinformatics 2018 02;34(4):672-674

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/bioinformatics/btx623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860605PMC
February 2018

hichipper: a preprocessing pipeline for calling DNA loops from HiChIP data.

Nat Methods 2018 02;15(3):155-156

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nmeth.4583
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http://dx.doi.org/10.1038/nmeth.4583DOI Listing
February 2018

Confounding in ex vivo models of Diamond-Blackfan anemia.

Blood 2017 08 14;130(9):1165-1168. Epub 2017 Jun 14.

Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital, and.

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http://dx.doi.org/10.1182/blood-2017-05-783191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580274PMC
August 2017

dcVar: a method for identifying common variants that modulate differential correlation structures in gene expression data.

Front Genet 2015 19;6:312. Epub 2015 Oct 19.

Tandy School of Computer Science - Department of Mathematics, University of Tulsa Tulsa, OK, USA ; Laureate Institute for Brain Research Tulsa, OK, USA.

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http://dx.doi.org/10.3389/fgene.2015.00312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609883PMC
November 2015

Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients.

Ann Clin Transl Neurol 2015 Oct 31;2(10):972-7. Epub 2015 Jul 31.

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation Oklahoma City, Oklahoma.

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http://dx.doi.org/10.1002/acn3.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603380PMC
October 2015

Network theory for data-driven epistasis networks.

Methods Mol Biol 2015 ;1253:285-300

Department of Mathematics, University of Tulsa, 800 S. Tucker Drive, Rayzor Hall 2145, Tulsa, OK, 74104, USA.

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http://dx.doi.org/10.1007/978-1-4939-2155-3_15DOI Listing
July 2015

Differential co-expression network centrality and machine learning feature selection for identifying susceptibility hubs in networks with scale-free structure.

BioData Min 2015 3;8. Epub 2015 Feb 3.

Tandy School of Computer Science, Department of Mathematics, University of Tulsa, Tulsa, OK USA ; Laureate Institute for Brain Research, Tulsa, OK USA.

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http://dx.doi.org/10.1186/s13040-015-0040-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326454PMC
February 2015

Encore: Genetic Association Interaction Network centrality pipeline and application to SLE exome data.

Genet Epidemiol 2013 Sep 5;37(6):614-21. Epub 2013 Jun 5.

Tandy School of Computer Science, University of Tulsa, Tulsa, Oklahoma 74104, USA.

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http://dx.doi.org/10.1002/gepi.21739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955726PMC
September 2013