Publications by authors named "C S Hyun"

305 Publications

The Intestinal Stem Cell Marker SMOC2 Is an Independent Prognostic Marker Associated With Better Survival in Gastric Cancer.

Anticancer Res 2021 Jul;41(7):3689-3698

Department of Pathology, Jeju National University School of Medicine and Jeju National University Hospital, Jeju, Republic of Korea;

Background/aim: SPARC-related modular calcium-binding protein 2 (SMOC2), a secreted matricellular protein, is reported to be involved in cancer progression such as cell cycle, angiogenesis, and invasion. In this study, we aimed to investigate the expression of SMOC2 in various gastric lesions and assessed its prognostic value in a large cohort of gastric cancer (GC) patients.

Patients And Methods: SMOC2 mRNA levels were measured by quantitative real-time PCR using 26 matched fresh-frozen GC samples. SMOC2 protein expression was determined by immunohistochemistry on tissue microarrays including 734 GC specimens and its correlations with clinicopathological features and survival were evaluated.

Results: The transcription level of SMOC2 was higher in GC samples compared to normal mucosa (p=0.006). Its expression levels were associated with the intestinal stem cell (ISC) marker, LGR5, but there were no correlations with EPHB2 and OLFM4 or the candidate cancer stem cell markers CD133 and CD44. SMOC2 expression was significantly increased in the intestinal metaplasia and was further increased in gastric adenomas and early gastric cancers (EGC). In total, 34% of GCs were positive for SMOC2, and SMOC2 positivity was higher in old (p=0.001) and male (p<0.001) patients, and in well-differentiated GC (p<0.001). SMOC2 expression had a negative association with perineural invasion (p<0.001) and tumor stage (p<0.001). In survival analysis, SMOC2-positive GC patients had much better clinical outcomes in overall survival rates (p<0.001) compared to SMOC2-negative GC patients. The prognostic impact of SMOC2 remained significant both in intestinal (p<0.001) and diffuse-type GC (p<0.001). Remarkably, a multivariate analysis demonstrated SMOC2 as an independent prognostic marker [hazard ratio (HR)=0.732, p=0.045] along with venous invasion (p=0.012), tumor stage (p<0.001) and CDX2 (p=0.028).

Conclusion: Our results suggest that SMOC2 can be a prognostic marker for better clinical outcomes in GC.
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http://dx.doi.org/10.21873/anticanres.15160DOI Listing
July 2021

Sleep disorders and depression due to menopausal symptoms in middle-aged Korean females.

J Phys Ther Sci 2021 Jul 1;33(7):526-530. Epub 2021 Jul 1.

Department of Nursing, Andong National University: 1375 Gyeongdong-ro Andong-si Gyeongsangbuk-do, Andong, Gyeongsangbuk-do 36722, Republic of Korea.

[Purpose] The purpose of this study was to identify the differences in the incidence of sleep disorders and depression in postmenopausal middle-aged females in South Korea. [Participants and Methods] This study was a cross-sectional study. A total of 87 middle-aged females between the ages of 40 and 60 years were selected through convenience sampling. The data were collected with a self-reported questionnaire from May 1 to May 29, 2017. [Results] The mean menopause score of the study was 5.37. The menopause symptoms indicated significant differences in sexual life. The association between the incidence of menopausal symptoms and sleep disorders and depression scores based on a scale of 1 to 10 was analyzed. Menopausal symptoms strongly affected sleep and depression in middle-aged females. [Conclusion] The findings of this study may be useful in understanding depression and sleep disorders in middle-aged females and for developing more specific programs for depression and sleep disorders. Management strategies are also needed.
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http://dx.doi.org/10.1589/jpts.33.526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245266PMC
July 2021

Contrasting early successional dynamics of bacterial and fungal communities in recently deglaciated soils of the maritime Antarctic.

Mol Ecol 2021 Jul 2. Epub 2021 Jul 2.

Korea Polar Research Institute (KOPRI), Incheon, Korea.

Although microorganisms are the very first colonizers of recently deglaciated soils even prior to plant colonization, the drivers and patterns of microbial community succession at early-successional stages remain poorly understood. The successional dynamics and assembly processes of bacterial and fungal communities were compared on a glacier foreland in the maritime Antarctic across the ~10-year soil-age gradient from bare soil to sparsely vegetated area. Bacterial communities shifted more rapidly than fungal communities in response to glacial retreat; species turnover (primarily the transition from glacier- to soil-favouring taxa) contributed greatly to bacterial beta diversity, but this pattern was less clear in fungi. Bacterial communities underwent more predictable (more deterministic) changes along the soil-age gradient, with compositional changes paralleling the direction of changes in soil physicochemical properties following deglaciation. In contrast, the compositional shift in fungal communities was less associated with changes in deglaciation-induced changes in soil geochemistry and most fungal taxa displayed mosaic abundance distribution across the landscape, suggesting that the successional dynamics of fungal communities are largely governed by stochastic processes. A co-occurrence network analysis revealed that biotic interactions between bacteria and fungi are very weak in early succession. Taken together, these results collectively suggest that bacterial and fungal communities in recently deglaciated soils are largely decoupled from each other during succession and exert very divergent trajectories of succession and assembly under different selective forces.
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http://dx.doi.org/10.1111/mec.16054DOI Listing
July 2021

COVID-19 Vaccination-Associated Lymphadenopathy on FDG PET/CT: Distinctive Features in Adenovirus-Vectored Vaccine.

Clin Nucl Med 2021 Jun 10. Epub 2021 Jun 10.

From the Department of Nuclear Medicine Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Purpose: This study investigated 18F-FDG PET/CT features of adenovirus-vectored vaccination against COVID-19 in healthy subjects.

Patients And Methods: Thirty-one health care workers had been vaccinated Vaxzevria and underwent FDG PET/CT as an optional test for a cancer screening program. Size and FDG uptake of the hypermetabolic lymph nodes were measured. Uptake value of spleen was also measured with liver for comparison.

Results: All examinees who underwent FDG PET/CT within 14 days' interval showed hypermetabolic lymphadenopathies ipsilateral to vaccine injection. All examinees with hypermetabolic lymphadenopathy had simultaneous muscular uptakes until 23 days' interval. Among 12 examinees who underwent FDG PET/CT more than 15 days after vaccination, only 3 male examinees did not show hypermetabolism in the axillary lymph nodes. There was no female examinee with negative hypermetabolic lymphadenopathy until 29 days after vaccination.

Conclusions: Hypermetabolic reactive lymphadenopathy in the ipsilateral axillary area with or without supraclavicular area is most likely to occur in a healthy person with recent adenovirus-vectored COVID-19 vaccination on FDG PET/CT.
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http://dx.doi.org/10.1097/RLU.0000000000003800DOI Listing
June 2021

Mask induced dermatoses during COVID-19 pandemic: A questionnaire-based study in 12 hospitals of Korea.

Clin Exp Dermatol 2021 Jun 3. Epub 2021 Jun 3.

Department of Dermatology, Korea University College of Medicine, Seoul, Korea.

Background: During coronavirus disease 2019 (COVID-19) pandemic, various adverse skin reactions to long-term mask wearing have been reported.

Objective: We aimed to assess the clinical features of mask-induced dermatoses and recommend prevention and treatment options.

Methods: From April to August 2020, questionnaires including preexisting skin disorders, patients' reported mask-related symptoms, their daily mask wearing duration and frequency, types of masks used, whether they are health care workers, and demographic information were distributed to patients of 12 hospitals. Dermatologists assessed skin lesions, confirmed diagnosis, and recorded treatment modalities.

Results: Itchiness was the most frequent symptom, mostly affecting the cheeks. Most common skin disease was new-onset contact dermatitis (33.94%), followed by new-onset acne (16.97%) and aggravation of preexisting acne (16.97%). Daily wearing (p=0.018) was significantly associated with new-onset contact dermatitis. More than half of the patients with preexisting skin problems experienced aggravation while wearing masks. Longer duration (more than 6 hours/day, p=0.043) and cotton masks (p<0.001) significantly increased acne flare-up. Healthcare workers had a higher incidence of skin disease. Skin lesions were generally mild and well tolerated with topical agents.

Limitations: Effect of seasonal characteristics and other risk factors were not assessed. The patients were visiting dermatologic clinics and had interest in their skin status. Thus, a selection bias may exist.

Conclusion: Mask-induced/triggered dermatoses contribute to increase the dermatological burden during pandemic.
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http://dx.doi.org/10.1111/ced.14776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239570PMC
June 2021