C. Roland Wolf

C. Roland Wolf

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C. Roland Wolf

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Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.

Toxicol Appl Pharmacol 2019 Mar 25;366:64-74. Epub 2019 Jan 25.

Department of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2019.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382462PMC
March 2019

Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes.

Mol Pharmacol 2019 01 25;95(1):97-105. Epub 2018 Oct 25.

School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (M.M., S.D., L.A.J., C.J.H., C.R.W.) and Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland (R.T., M.-A.G., A.V., J.M.)

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http://dx.doi.org/10.1124/mol.118.113555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277922PMC
January 2019

Discovery of common and rare genetic risk variants for colorectal cancer.

Authors:
Jeroen R Huyghe Stephanie A Bien Tabitha A Harrison Hyun Min Kang Sai Chen Stephanie L Schmit David V Conti Conghui Qu Jihyoun Jeon Christopher K Edlund Peyton Greenside Michael Wainberg Fredrick R Schumacher Joshua D Smith David M Levine Sarah C Nelson Nasa A Sinnott-Armstrong Demetrius Albanes M Henar Alonso Kristin Anderson Coral Arnau-Collell Volker Arndt Christina Bamia Barbara L Banbury John A Baron Sonja I Berndt Stéphane Bézieau D Timothy Bishop Juergen Boehm Heiner Boeing Hermann Brenner Stefanie Brezina Stephan Buch Daniel D Buchanan Andrea Burnett-Hartman Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Sergi Castellví-Bel Andrew T Chan Jenny Chang-Claude Stephen J Chanock Maria-Dolores Chirlaque Sang Hee Cho Charles M Connolly Amanda J Cross Katarina Cuk Keith R Curtis Albert de la Chapelle Kimberly F Doheny David Duggan Douglas F Easton Sjoerd G Elias Faye Elliott Dallas R English Edith J M Feskens Jane C Figueiredo Rocky Fischer Liesel M FitzGerald David Forman Manish Gala Steven Gallinger W James Gauderman Graham G Giles Elizabeth Gillanders Jian Gong Phyllis J Goodman William M Grady John S Grove Andrea Gsur Marc J Gunter Robert W Haile Jochen Hampe Heather Hampel Sophia Harlid Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Wan-Ling Hsu Wen-Yi Huang Thomas J Hudson David J Hunter Gemma Ibañez-Sanz Gregory E Idos Roxann Ingersoll Rebecca D Jackson Eric J Jacobs Mark A Jenkins Amit D Joshi Corinne E Joshu Temitope O Keku Timothy J Key Hyeong Rok Kim Emiko Kobayashi Laurence N Kolonel Charles Kooperberg Tilman Kühn Sébastien Küry Sun-Seog Kweon Susanna C Larsson Cecelia A Laurie Loic Le Marchand Suzanne M Leal Soo Chin Lee Flavio Lejbkowicz Mathieu Lemire Christopher I Li Li Li Wolfgang Lieb Yi Lin Annika Lindblom Noralane M Lindor Hua Ling Tin L Louie Satu Männistö Sanford D Markowitz Vicente Martín Giovanna Masala Caroline E McNeil Marilena Melas Roger L Milne Lorena Moreno Neil Murphy Robin Myte Alessio Naccarati Polly A Newcomb Kenneth Offit Shuji Ogino N Charlotte Onland-Moret Barbara Pardini Patrick S Parfrey Rachel Pearlman Vittorio Perduca Paul D P Pharoah Mila Pinchev Elizabeth A Platz Ross L Prentice Elizabeth Pugh Leon Raskin Gad Rennert Hedy S Rennert Elio Riboli Miguel Rodríguez-Barranco Jane Romm Lori C Sakoda Clemens Schafmayer Robert E Schoen Daniela Seminara Mitul Shah Tameka Shelford Min-Ho Shin Katerina Shulman Sabina Sieri Martha L Slattery Melissa C Southey Zsofia K Stadler Christa Stegmaier Yu-Ru Su Catherine M Tangen Stephen N Thibodeau Duncan C Thomas Sushma S Thomas Amanda E Toland Antonia Trichopoulou Cornelia M Ulrich David J Van Den Berg Franzel J B van Duijnhoven Bethany Van Guelpen Henk van Kranen Joseph Vijai Kala Visvanathan Pavel Vodicka Ludmila Vodickova Veronika Vymetalkova Korbinian Weigl Stephanie J Weinstein Emily White Aung Ko Win C Roland Wolf Alicja Wolk Michael O Woods Anna H Wu Syed H Zaidi Brent W Zanke Qing Zhang Wei Zheng Peter C Scacheri John D Potter Michael C Bassik Anshul Kundaje Graham Casey Victor Moreno Goncalo R Abecasis Deborah A Nickerson Stephen B Gruber Li Hsu Ulrike Peters

Nat Genet 2019 01 3;51(1):76-87. Epub 2018 Dec 3.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://www.nature.com/articles/s41588-018-0286-6
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http://dx.doi.org/10.1038/s41588-018-0286-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358437PMC
January 2019

Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy.

Clin Cancer Res 2018 05 6;24(9):2138-2147. Epub 2018 Feb 6.

Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3555DOI Listing
May 2018

Cytochrome b impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b /P450 reductase null (HBRN) mice.

Arch Toxicol 2018 Apr 24;92(4):1625-1638. Epub 2018 Jan 24.

Department of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.

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http://link.springer.com/10.1007/s00204-018-2162-7
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http://dx.doi.org/10.1007/s00204-018-2162-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882632PMC
April 2018

Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse.

J Physiol 2018 01 23;596(1):105-127. Epub 2017 Nov 23.

School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1113/JP274915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746521PMC
January 2018

Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites.

J Pharmacol Exp Ther 2017 10;363(1):12-19

Division of Cancer Research, Jacqui Wood Cancer Centre (D.L., C.J.H., C.R.W.), Molecular & Cellular Medicine (R.K.), and Biomarker & Drug Analysis Core (J.T.-J.H.), School of Medicine, Ninewells Hospital, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1124/jpet.117.243246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596814PMC
October 2017

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

Br J Cancer 2017 Aug 21;117(5):e1. Epub 2017 Mar 21.

Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1038/bjc.2017.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572186PMC
August 2017

Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants.

Drug Metab Dispos 2017 01 18;45(1):17-22. Epub 2016 Oct 18.

Division of Cancer Research, Level 9, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Dundee, DD1 9SY, United Kingdom

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http://dx.doi.org/10.1124/dmd.116.073437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193068PMC
January 2017

Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse.

Mol Cancer Res 2016 12 7;14(12):1195-1203. Epub 2016 Sep 7.

University of Dundee, School of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136472PMC
December 2016

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

J Lipid Res 2016 12 16;57(12):2130-2137. Epub 2016 Sep 16.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

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http://dx.doi.org/10.1194/jlr.M071183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321228PMC
December 2016

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

Br J Cancer 2016 Dec 8;115(12):1530-1539. Epub 2016 Nov 8.

Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1038/bjc.2016.363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155360PMC
December 2016

The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function.

Drug Metab Dispos 2016 Apr 5;44(4):576-90. Epub 2016 Feb 5.

Departments of Medicinal Chemistry and Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas (D.F.E, J.S.L., E.E.S.); Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, United Kingdom (C.R.W., C.J.H., L.A.M.); Regional Center of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science (M.O., M.P., V.N., K.B.) and Department of Pharmacology, Faculty of Medicine and Dentistry (P.A.), Palacký University, Olomouc, Czech Republic; Department of Chemistry, Washington State University, Pullman, Washington (S.C.H., U.P.D., C.B., J.A.B., J.P.J.); and Department of Pharmacology and Experimental Therapeutics, and the Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana (J.R.R., J.W.P., W.L.B.)

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http://dx.doi.org/10.1124/dmd.115.068569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810767PMC
April 2016

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model.

Drug Metab Dispos 2015 Nov 11;43(11):1679-90. Epub 2015 Aug 11.

Taconic Biosciences GmbH, Köln, Germany (N.S., A.R.); University Medicine of Greifswald, Center of Drug Absorption and Transport (C_DAT), Department of Clinical Pharmacology, Greifswald, Germany (S.O., D.B); and Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (Y.K., L.A.M., D.L., C.H., C.R.W)

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http://dx.doi.org/10.1124/dmd.115.065656DOI Listing
November 2015

Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity.

J Pharmacol Exp Ther 2015 Nov 26;355(2):137-44. Epub 2015 Aug 26.

Molecular Pharmacology Group, School of Medicine, Jacqui Wood Cancer Centre, University of Dundee, Dundee, United Kingdom (D.J.M., C.R.W., C.J.H.); and Bioinformatics and Biostatistics Group, Cancer Research UK London Research Institute, London, United Kingdom (P.C.)

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http://dx.doi.org/10.1124/jpet.115.227389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631951PMC
November 2015

Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.

Cancer Res 2015 Nov 11;75(21):4573-81. Epub 2015 Sep 11.

Division of Cancer, School of Medicine, Jacqui Wood Cancer Centre, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634205PMC
November 2015

Proteome-wide identification and quantification of S-glutathionylation targets in mouse liver.

Biochem J 2015 Jul 20;469(1):25-32. Epub 2015 Apr 20.

Molecular Pharmacology Group, Medical Research Institute, Level 9, Jacqui Wood Cancer Centre, Dundee DD1 9SY, U.K.

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http://dx.doi.org/10.1042/BJ20141256DOI Listing
July 2015

Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.

Mol Pharmacol 2015 Apr 5;87(4):733-9. Epub 2015 Feb 5.

Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (C.J.H., L.A.M., C.R.W.), TaconicArtemis, Cologne, Germany (N.S.); and Consultant in Investigative Toxicology, Linlithgow, United Kingdom (L.A.S.)

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http://dx.doi.org/10.1124/mol.114.097394DOI Listing
April 2015

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.

Mol Cell Proteomics 2015 Mar 5;14(3):750-60. Epub 2015 Jan 5.

From the ‡Jacqui Wood Cancer Centre, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland;

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M114.043661
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http://dx.doi.org/10.1074/mcp.M114.043661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349992PMC
March 2015

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.

Biochem J 2015 Feb;465(3):479-88

†Drug Discovery Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BJ20140582DOI Listing
February 2015

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.

Toxicol Sci 2014 Aug 25;140(2):259-70. Epub 2014 May 25.

University of Tuebingen, Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Toxicology, Wilhelmstr. 56, 72074 Tuebingen, Germany.

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http://academic.oup.com/toxsci/article/140/2/259/1694352/Phe
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http://dx.doi.org/10.1093/toxsci/kfu099DOI Listing
August 2014

In vivo regulation of human glutathione transferase GSTP by chemopreventive agents.

Cancer Res 2014 Aug 16;74(16):4378-87. Epub 2014 Jun 16.

Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Institute, College of Medicine, Dentistry & Nursing, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134684PMC
August 2014

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity.

PLoS One 2013 23;8(9):e75494. Epub 2013 Sep 23.

Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, United Kingdom ; School of Contemporary Science, University of Abertay Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075494PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781062PMC
July 2014

Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism.

Drug Metab Dispos 2014 Jun 26;42(6):1022-30. Epub 2014 Mar 26.

TaconicArtemis, Köln, Germany (N.S., A.R.); and Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (L.A.M., A.K.M., C.J.H., C.R.W.).

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http://dx.doi.org/10.1124/dmd.114.057885DOI Listing
June 2014

Epigenetic profiles as defined signatures of xenobiotic exposure.

Mutat Res Genet Toxicol Environ Mutagen 2014 Apr 31;764-765:3-9. Epub 2013 Aug 31.

MRC Human Genetics Unit at the Institute of Genetics and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mrgentox.2013.08.007DOI Listing
April 2014

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

Toxicology 2014 Apr 14;318:1-12. Epub 2014 Feb 14.

Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.

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http://dx.doi.org/10.1016/j.tox.2014.02.002DOI Listing
April 2014

A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor.

J Proteome Res 2014 Feb 12;13(2):866-74. Epub 2013 Dec 12.

Jacqui Wood Cancer Centre, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee , James Arrott Drive, Dundee DD1 9SY, Scotland.

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http://dx.doi.org/10.1021/pr400897tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923450PMC
February 2014

Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications.

Xenobiotica 2014 Jan 11;44(2):96-108. Epub 2013 Jul 11.

TaconicArtemis, Neurather Ring 1, Koeln 51063, Germany , and.

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http://dx.doi.org/10.3109/00498254.2013.815831DOI Listing
January 2014

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice.

Drug Metab Dispos 2014 Jan 10;42(1):70-7. Epub 2013 Oct 10.

Division of Cancer Research, Medical Research Institute, University of Dundee, and Ninewells Hospital and Medical School, Dundee, United Kingdom.

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http://dx.doi.org/10.1124/dmd.113.055277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935460PMC
January 2014

Generation and utility of genetically humanized mouse models.

Drug Discov Today 2013 Dec 18;18(23-24):1200-11. Epub 2013 Jul 18.

TaconicArtemis, Neurather Ring 1, Koeln 51063, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13596446130024
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http://dx.doi.org/10.1016/j.drudis.2013.07.007DOI Listing
December 2013

The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells.

J Biol Chem 2013 Jul 23;288(28):20228-37. Epub 2013 May 23.

Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany.

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http://dx.doi.org/10.1074/jbc.M113.474916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711290PMC
July 2013

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system.

Mol Pharmacol 2013 Jun 25;83(6):1209-17. Epub 2013 Mar 25.

Division of Cancer Research, Medical Research Institute, University of Dundee, Jacqui Wood Cancer Centre, Ninewells Hospitaland Medical School, Dundee, United Kingdom.

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http://dx.doi.org/10.1124/mol.112.084616DOI Listing
June 2013

Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice.

Mol Neurobiol 2013 Apr 6;47(2):662-72. Epub 2012 Nov 6.

Research Institute for Medicines and Pharmaceutical Sciences (iMED.UL), Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal.

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http://dx.doi.org/10.1007/s12035-012-8368-4DOI Listing
April 2013

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

Drug Metab Dispos 2013 Jan 19;41(1):12-23. Epub 2012 Oct 19.

Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1124/dmd.112.048991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533425PMC
January 2013

Water quality assessment using the AREc32 reporter gene assay indicative of the oxidative stress response pathway.

J Environ Monit 2012 Nov;14(11):2877-85

National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Brisbane, QLD 4108, Australia.

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http://xlink.rsc.org/?DOI=c2em30506b
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http://dx.doi.org/10.1039/c2em30506bDOI Listing
November 2012

Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo.

PPAR Res 2012 21;2012:216817. Epub 2012 Mar 21.

CRUK Molecular Pharmacology Unit, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1155/2012/216817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324915PMC
August 2012

Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway.

Mol Neurobiol 2012 Jun 27;45(3):466-77. Epub 2012 Apr 27.

Research Institute for Medicines and Pharmaceutical Sciences-iMED.UL, Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal.

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http://dx.doi.org/10.1007/s12035-012-8266-9DOI Listing
June 2012

Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1.

Drug Metab Dispos 2012 Feb 28;40(2):283-9. Epub 2011 Oct 28.

Centre for Neuroscience, Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1124/dmd.111.042085DOI Listing
February 2012

The role of bioreductive activation of antitumour anthracycline drugs in cytotoxic activity against sensitive and multidrug resistant leukaemia HL60 cells.

Eur J Pharmacol 2012 Jan 15;674(2-3):112-25. Epub 2011 Nov 15.

Department of Biochemistry, University of Szczecin, 3c Felczaka St, 71-412 Szczecin, Poland.

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http://dx.doi.org/10.1016/j.ejphar.2011.10.047DOI Listing
January 2012

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.

Drug Metab Dispos 2011 Dec 22;39(12):2169-73. Epub 2011 Sep 22.

Section of Molecular Carcinogenesis, Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.1124/dmd.111.041343DOI Listing
December 2011

Increased skin papilloma formation in mice lacking glutathione transferase GSTP.

Cancer Res 2011 Nov 5;71(22):7048-60. Epub 2011 Oct 5.

Cancer Research UK Molecular Pharmacology Unit, Medical Research Institute, Ninewells Hospital & Medical School, Dundee, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218105PMC
November 2011

The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s.

Drug Metab Dispos 2011 Aug 9;39(8):1423-32. Epub 2011 May 9.

Department of Pharmaceutical Technology and Biochemistry, Chemical Faculty, Gdańsk University of Technology, Gdansk, Poland.

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http://dx.doi.org/10.1124/dmd.111.038984DOI Listing
August 2011

Knockout and transgenic mice in glutathione transferase research.

Drug Metab Rev 2011 May 22;43(2):152-64. Epub 2011 Mar 22.

Cancer Research UK, Molecular Pharmacology Group, Biomedical Research Institute, University of Dundee College of Medicine Dentistry and Nursing, Ninewells Hospital, Dundee, United Kingdom.

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http://dx.doi.org/10.3109/03602532.2011.562900DOI Listing
May 2011

Spatial p21 expression profile in the mid-term mouse embryo.

Transgenic Res 2011 Feb 28;20(1):23-8. Epub 2010 Mar 28.

Division of Developmental Biology, The Roslin Institute and Royal (Dick), School of Veterinary Studies, University of Edinburgh, Roslin, EH25 9PS, UK.

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http://dx.doi.org/10.1007/s11248-010-9385-6DOI Listing
February 2011

Spatial monitoring of toxicity in HMOX-LacZ transgenic mice.

Transgenic Res 2010 Oct 14;19(5):897-902. Epub 2010 Jan 14.

Division of Developmental Biology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, Roslin, Midlothian, EH25 9PS, UK.

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http://dx.doi.org/10.1007/s11248-010-9363-zDOI Listing
October 2010

Peroxiredoxin gene expression signatures in liver reflect toxic insult.

Assay Drug Dev Technol 2010 Aug;8(4):512-7

Division of Gene Function and Development, Roslin Institute, Roslin, United Kingdom.

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http://www.liebertpub.com/doi/10.1089/adt.2009.0246
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http://dx.doi.org/10.1089/adt.2009.0246DOI Listing
August 2010

In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice.

Drug Metab Dispos 2010 Jul 30;38(7):1046-53. Epub 2010 Mar 30.

TaconicArtemis, Cologne, Germany.

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http://dx.doi.org/10.1124/dmd.109.031872DOI Listing
July 2010

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.

Chem Biol 2010 Jan;17(1):75-85

Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S107455210900446
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http://dx.doi.org/10.1016/j.chembiol.2009.12.013DOI Listing
January 2010

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.

Proc Natl Acad Sci U S A 2009 Dec 13;106(49):20859-64. Epub 2009 Nov 13.

Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Institute, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0911351106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777186PMC
December 2009

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man.

Expert Rev Clin Pharmacol 2009 Mar;2(2):105-9

Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1586/17512433.2.2.105DOI Listing
March 2009

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.

Biochem J 2009 Jan;417(1):43-54

Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD19SY, UK.

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http://dx.doi.org/10.1042/BJ20080740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605957PMC
January 2009

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

Am J Respir Crit Care Med 2008 Dec 11;178(12):1202-10. Epub 2008 Sep 11.

Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.

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http://dx.doi.org/10.1164/rccm.200801-178OCDOI Listing
December 2008

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

J Biol Chem 2008 Nov 19;283(46):31385-93. Epub 2008 Sep 19.

Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Institute, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M803496200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581580PMC
November 2008

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

Drug Metab Dispos 2008 Oct 21;36(10):2136-44. Epub 2008 Jul 21.

Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical, School, Dundee, United Kingdom.

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http://dx.doi.org/10.1124/dmd.108.021733DOI Listing
October 2008

Illuminating role of CYP1A1 in skin function.

J Invest Dermatol 2008 Jul 10;128(7):1866-8. Epub 2008 Jan 10.

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http://dx.doi.org/10.1038/sj.jid.5701236DOI Listing
July 2008

Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.

Drug Metab Dispos 2008 Jul 17;36(7):1322-31. Epub 2008 Apr 17.

Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1124/dmd.108.021261DOI Listing
July 2008

p21-LacZ reporter mice reflect p53-dependent toxic insult.

Toxicol Appl Pharmacol 2008 Mar 14;227(3):440-50. Epub 2007 Dec 14.

Division of Gene Function and Development, Roslin Institute, Roslin, Midlothian, EH25 9PS, UK.

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http://dx.doi.org/10.1016/j.taap.2007.11.029DOI Listing
March 2008

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

Toxicol Appl Pharmacol 2008 Feb 26;226(3):318-27. Epub 2007 Sep 26.

Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic.

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http://dx.doi.org/10.1016/j.taap.2007.09.017DOI Listing
February 2008

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

Proc Natl Acad Sci U S A 2007 Dec 28;104(49):19589-94. Epub 2007 Nov 28.

Cancer Research U.K. Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0709483104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148333PMC
December 2007

Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.

Cancer Res 2007 Oct;67(19):9248-57

Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1764DOI Listing
October 2007

Development of a liquid chromatography-electrospray ionization tandem mass spectrometry method for detecting oxaliplatin-DNA intrastrand cross-links in biological samples.

Chem Res Toxicol 2007 Aug 18;20(8):1177-82. Epub 2007 Jul 18.

Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, Leicester, U.K.

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http://dx.doi.org/10.1021/tx700088jDOI Listing
August 2007

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system.

J Pharmacol Exp Ther 2007 Jul 13;322(1):40-7. Epub 2007 Apr 13.

Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1124/jpet.107.121780DOI Listing
July 2007

Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis.

Dev Biol 2007 Mar 26;303(1):66-81. Epub 2006 Oct 26.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 du CNRS, U. 596 de l'INSERM, Université Louis Pasteur, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France.

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http://dx.doi.org/10.1016/j.ydbio.2006.10.032DOI Listing
March 2007

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

Cancer Res 2006 Nov;66(22):10983-94

Cancer Research UK Molecular Pharmacology Unit and Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2298DOI Listing
November 2006

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.

Drug Metab Rev 2006 ;38(3):515-97

Consultant in Investigative Toxicology, St. Andrews, Fife, United Kingdom.

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http://dx.doi.org/10.1080/03602530600786232 DOI Listing
September 2006

In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.

Drug Metab Dispos 2006 Aug 12;34(8):1386-92. Epub 2006 May 12.

Division of Cancer Medicine, Biomedical Research Centre, University of Dundee, Ninewells Hospital & Medical School, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1124/dmd.106.009852DOI Listing
August 2006

In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

Drug Metab Dispos 2006 Apr 13;34(4):534-8. Epub 2006 Jan 13.

School of Chemical Engineering and Analytical Science, University of Manchester, The Mill, PO Box 88, Manchester, M60 1QD, UK.

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http://dx.doi.org/10.1124/dmd.105.007625DOI Listing
April 2006

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity.

Toxicol Lett 2006 Mar 15;162(1):111-7. Epub 2005 Dec 15.

Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, University of Dundee, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1016/j.toxlet.2005.10.016DOI Listing
March 2006

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility.

Genes Chromosomes Cancer 2006 Feb;45(2):126-35

Department of Surgery & Molecular Oncology, University of Dundee, Ninewells Hospital, United Kingdom.

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http://dx.doi.org/10.1002/gcc.20271DOI Listing
February 2006

Disruption of the glutathione transferase pi class genes.

Methods Enzymol 2005 ;401:116-35

Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom.

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http://dx.doi.org/10.1016/S0076-6879(05)01007-4DOI Listing
February 2006

Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005 Dec;149(2):191-7

Department of Biochemistry, Charles University, Albertov 2030, 12840 Prague 2, Czech Republic.

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December 2005

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

J Biol Chem 2005 Nov 14;280(46):38617-24. Epub 2005 Sep 14.

Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M505974200DOI Listing
November 2005

Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse.

Cancer Res 2005 May;65(10):4211-7

Cancer Research UK, Molecular Pharmacology Unit and Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4103DOI Listing
May 2005