Publications by authors named "C Pradeep"

55 Publications

Prevalence of metabolic syndrome and its correlation with sexual dysfunction in adult psychiatric patients treated with psychotropics in a tertiary care hospital.

Int J Clin Pract 2021 Jun 22:e14559. Epub 2021 Jun 22.

Department of Pharmacy Practice, Vinayaka Mission's College of Pharmacy, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, India.

Background: In the past two decades, there has been a profound increase in the incidence of metabolic disorders among the general population, and psychotropics are also said to play a major role in the development of metabolic syndrome.

Aim: Determining the prevalence of metabolic syndrome (MetS) and sexual dysfunction (SD) and their correlation in psychiatric patients treated with psychotropics in a tertiary care hospital in Salem region, Tamil Nadu, India.

Materials And Methods: A cross-sectional study was conducted in the psychiatric department of Vinayaka Mission's Medical College and Hospitals, Salem on patients (n = 108) treated with psychotropics. The sociodemographic information, anthropometric measurements, and laboratory tests for metabolic functions were collected and assessed to determine the presence of metabolic syndrome (as per NCEP ATP III criteria). All the results were statistically analysed and P-value < .05 was considered to be statistically significant.

Results: The overall prevalence of MetS in the study population was 25.93%. The study found significant relationships between using olanzapine, risperidone, buspirone, and the presence of MetS. Depression was also found to be associated with the development of MetS.

Conclusion: From this current study, it may be concluded that the psychiatric population is at risk for developing MetS, and the use of atypical antipsychotics (olanzapine, risperidone), anti-anxiety agent (buspirone) and clinical depression is significantly associated with metabolic syndrome. Hence, the metabolic function of psychiatric patients must be regularly assessed for early detection and management of any metabolic abnormalities. The study did not find a significant correlation between SD and MetS in psychiatric patients.
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http://dx.doi.org/10.1111/ijcp.14559DOI Listing
June 2021

Ameliorated Antibacterial and Antioxidant Properties by Mediated Green Synthesis of Silver Nanoparticles.

Biomolecules 2021 04 4;11(4). Epub 2021 Apr 4.

Laboratory of Plant Healthcare and Diagnostics, PG Department of Biotechnology and Microbiology, Karnatak University, Dharwad 580 003, Karnataka, India.

Biosynthesis of silver nanoparticles using beneficial is a simple, eco-friendly and cost-effective route. Secondary metabolites secreted by act as capping and reducing agents that can offer constancy and can contribute to biological activity. The present study aimed to synthesize silver nanoparticles using cell filtrate and investigate different bioactive metabolites based on LC-MS/MS analysis. The synthesized silver nanoparticles (AgNPs) from were characterized by ultraviolet-visible spectrophotometry, Fourier transform infrared spectrometry (FT-IR), energy-dispersive spectroscopy (EDS), dynamic light scattering (DLS), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The surface plasmon resonance of synthesized particles formed a peak centered near 438 nm. The DLS study determined the average size of AgNPs to be 21.49 nm. The average size of AgNPs was measured to be 72 nm by SEM. The cubic crystal structure from XRD analysis confirmed the synthesized particles as silver nanoparticles. The AgNPs exhibited remarkable antioxidant properties, as determined by DPPH and ferric reducing antioxidant power (FRAP) assay. The AgNPs also exhibited broad-spectrum antibacterial activity against two Gram-positive bacteria ( and ) and two Gram-negative bacteria ( and ). The minimum inhibitory concentration (MIC) of AgNPs towards bacterial growth was evaluated. The antibacterial activity of AgNPs was further confirmed by fluorescence microscopy and SEM analysis.
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http://dx.doi.org/10.3390/biom11040535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066458PMC
April 2021

GC-MS analysis of phytoconstituents from Amomum nilgiricum and molecular docking interactions of bioactive serverogenin acetate with target proteins.

Sci Rep 2020 10 2;10(1):16438. Epub 2020 Oct 2.

Laboratory of Plant Healthcare and Diagnostics, PG Department of Biotechnology and Microbiology, Karnataka University, Dharwad, Karnataka, India.

Amomum nilgiricum is one of the plant species reported from Western Ghats of India, belonging to the family Zingiberaceae, with ethno-botanical values, and is well-known for their ethno medicinal applications. In the present investigation, ethyl acetate and methanol extracts of A. nilgiricum were analyzed by Fourier transform infrared spectrometer (FTIR) and gas chromatography-mass spectrometry (GC-MS) to identify the important functional groups and phytochemical constituents. The FTIR spectra revealed the occurrence of functional characteristic peaks of aromatic amines, carboxylic acids, ketones, phenols and alkyl halides group from leaf and rhizome extracts. The GC-MS analysis of ethyl acetate and methanol extracts from leaves, and methanol extract from rhizomes of A. nilgiricum detected the presence of 25 phytochemical compounds. Further, the leaf and rhizome extracts of A. nilgiricum showed remarkable antibacterial and antifungal activities at 100 mg/mL. The results of DPPH and ferric reducing antioxidant power assay recorded maximum antioxidant activity in A. nilgiricum methanolic leaf extract. While, ethyl acetate leaf extract exhibited maximum α-amylase inhibition activity, followed by methanolic leaf extract exhibiting aldose reductase inhibition. Subsequently, these 25 identified compounds were analyzed for their bioactivity through in silico molecular docking studies. Results revealed that among the phytochemical compounds identified, serverogenin acetate might have maximum antibacterial, antifungal, antiviral, antioxidant and antidiabetic properties followed by 2,4-dimethyl-1,3-dioxane and (1,3-C)propanedioic acid. To our best knowledge, this is the first description on the phytochemical constituents of the leaves and rhizomes of A. nilgiricum, which show pharmacological significance, as there has been no literature available yet on GC-MS and phytochemical studies of this plant species. The in silico molecular docking of serverogenin acetate was also performed to confirm its broad spectrum activities based on the binding interactions with the antibacterial, antifungal, antiviral, antioxidant and antidiabetic target proteins. The results of the present study will create a way for the invention of herbal medicines for several ailments by using A. nilgiricum plants, which may lead to the development of novel drugs.
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http://dx.doi.org/10.1038/s41598-020-73442-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532471PMC
October 2020

Post-functionalization through covalent modification of organic counter ions: a stepwise and controlled approach for novel hybrid polyoxometalate materials.

Dalton Trans 2020 Sep;49(35):12174-12179

School of Basic Sciences, Indian Institute of Technology Mandi, Mandi 175005, Himachal Pradesh, India.

Post-functionalization of Class I type polyoxometalate-organic hybrids through covalent modification of the organic counter ions in a step-wise and controlled manner is reported for the first time. The properties of the post-functionalized hybrids have been studied and compared with those of their parent hybrids revealing marked differences in properties.
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http://dx.doi.org/10.1039/d0dt01410aDOI Listing
September 2020

Discovery of a Novel Mycobacterial F-ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines.

Angew Chem Int Ed Engl 2020 08 26;59(32):13295-13304. Epub 2020 May 26.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Republic of Singapore.

The F F -ATP synthase is required for growth and viability of Mycobacterium tuberculosis and is a validated clinical target. A mycobacterium-specific loop of the enzyme's rotary γ subunit plays a role in the coupling of ATP synthesis within the enzyme complex. We report the discovery of a novel antimycobacterial, termed GaMF1, that targets this γ subunit loop. Biochemical and NMR studies show that GaMF1 inhibits ATP synthase activity by binding to the loop. GaMF1 is bactericidal and is active against multidrug- as well as bedaquiline-resistant strains. Chemistry efforts on the scaffold revealed a dynamic structure activity relationship and delivered analogues with nanomolar potencies. Combining GaMF1 with bedaquiline or novel diarylquinoline analogues showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay. These results suggest that GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-ATP synthase inhibitors.
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http://dx.doi.org/10.1002/anie.202002546DOI Listing
August 2020
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