Publications by authors named "Carlos Lopez-Larrea"

100Publications

The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.

Cytokine 2020 Oct 23;137:155354. Epub 2020 Oct 23.

Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain; Universidad de Oviedo, Oviedo, Spain; Red de Investigación Renal (REDINREN), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2020.155354DOI Listing
October 2020

Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome.

Gene 2020 Dec 31;762:145102. Epub 2020 Aug 31.

Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado deAsturias, ISPA, Oviedo, Spain; Universidad de Oviedo, Oviedo, Spain; Red de Investigación Renal (REDINREN), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2020.145102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456966PMC
December 2020

Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection.

J Mol Med (Berl) 2020 Sep 9;98(9):1245-1254. Epub 2020 Jul 9.

Translational Immunology Laboratory, Health Research Institute of the Principality of Asturias (ISPA), Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1007/s00109-020-01948-1DOI Listing
September 2020

Crosstalk Between Hypoxia and ER Stress Response: A Key Regulator of Macrophage Polarization.

Front Immunol 2019 8;10:2951. Epub 2020 Jan 8.

Translational Immunology Laboratory, Health Research Institute of the Principality of Asturias, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.3389/fimmu.2019.02951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961549PMC
November 2020

Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes.

Cell Rep 2019 10;29(4):860-872.e5

Translation Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias-ISPA, Oviedo, Spain; Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.035DOI Listing
October 2019

Acute myeloid leukemia and NK cells: two warriors confront each other.

Oncoimmunology 2019 31;8(2):e1539617. Epub 2018 Oct 31.

Translational Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Oviedo, Spain.

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1539617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343801PMC
October 2018

Gene variants in the NF-KB pathway (NFKB1, NFKBIA, NFKBIZ) and their association with type 2 diabetes and impaired renal function.

Hum Immunol 2018 Jun 27;79(6):494-498. Epub 2018 Mar 27.

Dermatología, HUCA, Oviedo, Spain; Universidad de Oviedo, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias-ISPA, Oviedo, Spain.

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http://dx.doi.org/10.1016/j.humimm.2018.03.008DOI Listing
June 2018

Immunosurveillance of Malignant Cells with Complex Karyotypes.

Trends Cell Biol 2017 12 19;27(12):880-884. Epub 2017 Sep 19.

Cell Biology and Metabolomics Platforms, Gustave Roussy Cancer Campus, 94805 Villejuif, France; Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; Institut National de la Santé et de la Recherche Médicale, UMR1138, Equipe labellisée Ligue Nationale Contre le Cancer, 75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; Université Pierre et Marie Curie, 75006 Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France; Department of Women's and Children's Health, Karolinska University Hospital, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.tcb.2017.09.001DOI Listing
December 2017

Epigenetic Networks Regulate the Transcriptional Program in Memory and Terminally Differentiated CD8+ T Cells.

J Immunol 2017 01 14;198(2):937-949. Epub 2016 Dec 14.

Department of Immunology, Central University Hospital of Asturias, 33011 Oviedo, Spain;

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http://dx.doi.org/10.4049/jimmunol.1601102DOI Listing
January 2017

HLA-B*40:01 Is Associated with Ankylosing Spondylitis in HLA-B27-positive Populations.

J Rheumatol 2016 06;43(6):1255-6

Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.3899/jrheum.151096DOI Listing
June 2016

Using NK Cell Lipid Raft Fractionation to Understand the Role of Lipid Rafts in NK Cell Receptor Signaling.

Methods Mol Biol 2016 ;1441:131-9

Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.

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http://dx.doi.org/10.1007/978-1-4939-3684-7_11DOI Listing
December 2017

Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort.

J Dermatol Sci 2015 Nov 27;80(2):111-5. Epub 2015 Jun 27.

Department of Dermatology II, Hospital Universitario Central Asturias, Calle Carretera de Rubín, s/n, 33011 Oviedo, Spain; Department of Medicine, Universidad de Oviedo, Calle San Francisco, 1, 33003 Oviedo, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2015.06.011DOI Listing
November 2015

CD4⁺CD28null T lymphocytes resemble CD8⁺CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients.

J Leukoc Biol 2015 Sep 1;98(3):373-84. Epub 2015 Jun 1.

*Immunology Department and Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Spain; and Fundación Renal "Iñigo Alvarez de Toledo," Madrid, Spain

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http://dx.doi.org/10.1189/jlb.1A0514-276RRDOI Listing
September 2015

Epigenetic dynamics during CD4(+) T cells lineage commitment.

Int J Biochem Cell Biol 2015 Oct 11;67:75-85. Epub 2015 May 11.

Cellular Biology of Renal Diseases Laboratory, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Autónoma Madrid, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2015.04.020DOI Listing
October 2015

Increased natural killer cell chemotaxis to CXCL12 in patients with multiple sclerosis.

J Neuroimmunol 2015 May 7;282:39-44. Epub 2015 Mar 7.

Neurology Department, Hospital Universitario Central de Asturias, Oviedo 33011, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2015.03.007DOI Listing
May 2015

Disease complexity in acute coronary syndrome is related to the patient's immunological status.

Int J Cardiol 2015 10;189:115-23. Epub 2015 Apr 10.

Departamento de Inmunología, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.04.063DOI Listing
April 2016

The donor ABCB1 (MDR-1) C3435T polymorphism is a determinant of the graft glomerular filtration rate among tacrolimus treated kidney transplanted patients.

J Hum Genet 2015 May 12;60(5):273-6. Epub 2015 Feb 12.

1] Genética Molecular- Fundación Renal I. Alvarez de Toledo, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain [2] Departamento de Medicina, Universidad de Oviedo, Oviedo, Spain [3] Red de Investigación Renal-REDINREN, Madrid, Spain.

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http://dx.doi.org/10.1038/jhg.2015.12DOI Listing
May 2015

Association between the IL17RA rs4819554 polymorphism and reduced renal filtration rate in the Spanish RENASTUR cohort.

Hum Immunol 2015 Mar 27;76(2-3):75-8. Epub 2015 Jan 27.

Inmunología, HUCA, Oviedo, Spain; Red de Investigación Renal - Instituto Salud Carlo III, Madrid, Spain; Fundación Renal I. Alvarez de Toledo, Madrid, Spain.

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http://dx.doi.org/10.1016/j.humimm.2015.01.027DOI Listing
March 2015

Regulation of the transcriptional program by DNA methylation during human αβ T-cell development.

Nucleic Acids Res 2015 Jan 24;43(2):760-74. Epub 2014 Dec 24.

Department of Immunology, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain Fundación Renal 'Íñigo Álvarez de Toledo', 28003 Madrid, Spain

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http://dx.doi.org/10.1093/nar/gku1340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333391PMC
January 2015

Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention.

Oncoimmunology 2014 25;3:e28497. Epub 2014 Apr 25.

Department of Immunology; Hospital Universitario Central de Asturias; Oviedo, Spain ; Fundación Renal "Iñigo Álvarez de Toledo"; Madrid, Spain.

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http://dx.doi.org/10.4161/onci.28497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063154PMC
April 2014

L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration.

J Leukoc Biol 2014 Sep 6;96(3):437-45. Epub 2014 May 6.

Immunology and Fundación Renal "Íñigo Álvarez de Toledo", Madrid, Spain

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http://dx.doi.org/10.1189/jlb.2A1013-564RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395936PMC
September 2014

The Region Centromeric to HLA-C Is a Key Region for Understanding the Phenotypic Variability of Psoriatic Arthritis.

ISRN Dermatol 2014 30;2014:570178. Epub 2014 Jan 30.

Department of Functional Biology, IUOPA, University of Oviedo, C/Celestino Villamil S/N, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1155/2014/570178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926254PMC
March 2014

Role of BRD4 in hematopoietic differentiation of embryonic stem cells.

Epigenetics 2014 Apr 20;9(4):566-78. Epub 2014 Jan 20.

Cancer Epigenetics Laboratory; Instituto Universitario de Oncología del Principado de Asturias (IUOPA); HUCA; Universidad de Oviedo; Oviedo, Spain; Department of Immunology and Oncology; Centro Nacional de Biotecnología/CNB-CSIC; Cantoblanco; Madrid, Spain.

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http://dx.doi.org/10.4161/epi.27711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121367PMC
April 2014

NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp.

J Leukoc Biol 2014 Mar 29;95(3):487-95. Epub 2013 Oct 29.

1.Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006 Oviedo, Spain.

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http://doi.wiley.com/10.1189/jlb.0613316
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http://dx.doi.org/10.1189/jlb.0613316DOI Listing
March 2014

Epigenetic modulation of the immune function: a potential target for tolerance.

Epigenetics 2013 Jul 17;8(7):694-702. Epub 2013 Jun 17.

Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.4161/epi.25201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781188PMC
July 2013

A search for new CYP3A4 variants as determinants of tacrolimus dose requirements in renal-transplanted patients.

Pharmacogenet Genomics 2013 Aug;23(8):445-8

Molecular Genetics-Laboratory of Medicine, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.

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http://dx.doi.org/10.1097/FPC.0b013e3283636856DOI Listing
August 2013

Molecular mechanisms involved in the aging of the T-cell immune response.

Curr Genomics 2012 Dec;13(8):589-602

Immunology Department, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain.

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http://dx.doi.org/10.2174/138920212803759749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492799PMC
December 2012

When Aging Reaches CD4+ T-Cells: Phenotypic and Functional Changes.

Front Immunol 2013 10;4:107. Epub 2013 May 10.

Immunology Department, Hospital Universitario Central de Asturias Oviedo, Spain.

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http://dx.doi.org/10.3389/fimmu.2013.00107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650461PMC
May 2013

The C-terminal module IV of connective tissue growth factor is a novel immune modulator of the Th17 response.

Lab Invest 2013 Jul 6;93(7):812-24. Epub 2013 May 6.

Cellular Biology in Renal Diseases Laboratory, Instituto de Investigacion Sanitaria Fundación Jiménez Díaz, Universidad Autónoma Madrid, Madrid, Spain.

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http://dx.doi.org/10.1038/labinvest.2013.67DOI Listing
July 2013

Genetic study confirms association of HLA-DPA1(∗)01:03 subtype with ankylosing spondylitis in HLA-B27-positive populations.

Hum Immunol 2013 Jun 28;74(6):764-7. Epub 2013 Feb 28.

Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1016/j.humimm.2013.02.001DOI Listing
June 2013

DNA methylation: a promising landscape for immune system-related diseases.

Trends Genet 2012 Oct 21;28(10):506-14. Epub 2012 Jul 21.

Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1016/j.tig.2012.06.005DOI Listing
October 2012

Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.

Eur J Immunol 2012 Aug;42(8):2142-51

Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.

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http://dx.doi.org/10.1002/eji.201142070DOI Listing
August 2012

Mobilization and homing of hematopoietic stem cells.

Adv Exp Med Biol 2012 ;741:152-70

Department of Immunology, Asturias Central University Hospital, Oviedo, Spain.

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http://link.springer.com/10.1007/978-1-4614-2098-9_11
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http://dx.doi.org/10.1007/978-1-4614-2098-9_11DOI Listing
June 2012

Immunology and the challenge of transplantation.

Adv Exp Med Biol 2012 ;741:27-43

Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1007/978-1-4614-2098-9_3DOI Listing
June 2012

Sensing in nature. Preface.

Adv Exp Med Biol 2012 ;739:v-vii

Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.

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April 2012

Immune systems evolution.

Adv Exp Med Biol 2012 ;739:237-51

Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1007/978-1-4614-1704-0_15DOI Listing
April 2012

The emergence of the major histocompatilibility complex.

Adv Exp Med Biol 2012 ;738:277-89

Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1007/978-1-4614-1680-7_16DOI Listing
April 2012

Autophagy and self-defense.

Adv Exp Med Biol 2012 ;738:169-84

Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://link.springer.com/10.1007/978-1-4614-1680-7_11
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http://dx.doi.org/10.1007/978-1-4614-1680-7_11DOI Listing
April 2012

The origin of the bacterial immune response.

Adv Exp Med Biol 2012 ;738:1-13

Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://link.springer.com/10.1007/978-1-4614-1680-7_1
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http://dx.doi.org/10.1007/978-1-4614-1680-7_1DOI Listing
April 2012

NKG2D and its ligands: active factors in the outcome of solid organ transplantation?

Kidney Int Suppl (2011) 2011 Aug;1(2):52-57

Department of Immunology, Hospital Universitario Central de Asturias , Oviedo, Spain ; Fundación Renal 'Iñigo Alvarez de Toledo' , Madrid, Spain.

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http://dx.doi.org/10.1038/kisup.2011.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089716PMC
August 2011

Conceptual aspects of self and nonself discrimination.

Self Nonself 2011 Jan 1;2(1):19-25. Epub 2011 Jan 1.

Functional Biology Department; Instituto Universitario Oncologico del Principado de Asturias (IUOPA); Universidad de Oviedo; Oviedo, Spain.

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http://dx.doi.org/10.4161/self.2.1.15094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136900PMC
January 2011

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

Nat Genet 2011 Jul 10;43(8):761-7. Epub 2011 Jul 10.

Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/ng.873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640413PMC
July 2011

IL-15 preferentially enhances functional properties and antigen-specific responses of CD4+CD28(null) compared to CD4+CD28+ T cells.

Aging Cell 2011 Oct 27;10(5):844-52. Epub 2011 Jun 27.

Department of Immunology, Hospital Universitario Central de Asturias, C ⁄ Julián Clavería s ⁄ n,Oviedo, Spain.

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http://dx.doi.org/10.1111/j.1474-9726.2011.00725.xDOI Listing
October 2011

NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system.

Age (Dordr) 2011 Dec 6;33(4):591-605. Epub 2011 Jan 6.

Histocompatibility Unit, Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1007/s11357-010-9200-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220398PMC
December 2011

Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy.

Biochem Biophys Res Commun 2010 Jul;397(3):576-9

Genética Molecular-Red de Investigación Renal (REDINREN)-Fundación Renal, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain.

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http://dx.doi.org/10.1016/j.bbrc.2010.06.003DOI Listing
July 2010

Endoplasmic reticulum stress signals in defined human embryonic stem cell lines and culture conditions.

Stem Cell Rev Rep 2010 Sep;6(3):462-72

Histocompatibility and Transplantation Unit, Hospital Universitario Central de Asturias, 33006, Oviedo, Spain.

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http://dx.doi.org/10.1007/s12015-010-9135-4DOI Listing
September 2010

CD127(low) expression in CD4+CD25(high) T cells as immune biomarker of renal function in transplant patients.

Transplantation 2009 Aug;88(3 Suppl):S85-93

Histocompatibility Unit, Immunology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1097/TP.0b013e3181afebdbDOI Listing
August 2009

Advances in translational transplant immunology.

Transplantation 2009 Aug;88(3 Suppl):S1-7

Immunology, Histocompatibility Unit, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1097/TP.0b013e3181af6473DOI Listing
August 2009

KIR genes and their role in spondyloarthropathies.

Adv Exp Med Biol 2009 ;649:286-99

Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1007/978-1-4419-0298-6_22DOI Listing
September 2009

Molecular mechanism of spondyloarthropathies. Preface.

Adv Exp Med Biol 2009 ;649:v-ix

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September 2009

CD8dim and NKG2D expression defines related subsets of CD4+ T cells in HIV-infected patients with worse prognostic factors.

J Acquir Immune Defic Syndr 2009 Aug;51(4):390-8

Histocompatibility Unit, Immunology Department; Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1097/FTD.0b013e3181679015DOI Listing
August 2009

Influence of HLA-B*5703 and HLA-B*1403 on susceptibility to spondyloarthropathies in the Zambian population.

J Rheumatol 2008 Nov 15;35(11):2236-40. Epub 2008 Oct 15.

Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.3899/jrheum.080395DOI Listing
November 2008