Publications by authors named "C. Dirk Keene"

100Publications

Clinician judged hearing impairment and associations with neuropathologic burden.

Neurology 2020 Aug 5. Epub 2020 Aug 5.

Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1212/WNL.0000000000010575DOI Listing
August 2020

Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure.

J Neurol Sci 2020 Jul 18;417:117049. Epub 2020 Jul 18.

Veterans Affairs (VA) Northwest Mental Illness, Research, Education, and Clinical Center (MIRECC), Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2020.117049DOI Listing
July 2020

Leveraging neuropathological data in pharmacoepidemiology: A promising approach for dementia prevention?

Pharmacoepidemiol Drug Saf 2020 Jun 29. Epub 2020 Jun 29.

Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

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http://dx.doi.org/10.1002/pds.5068DOI Listing
June 2020

Purification and Analysis of Caenorhabditis elegans Extracellular Vesicles.

J Vis Exp 2020 03 31(157). Epub 2020 Mar 31.

Department of Pathology, University of Washington;

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http://dx.doi.org/10.3791/60596DOI Listing
March 2020

Heterozygous missense variants cause ataxia, cognitive decline, and STUB1 mislocalization.

Neurol Genet 2020 Apr 10;6(2):1-13. Epub 2020 Feb 10.

Department of Neurology (D.-H.C., E.H., S.J., T.D.B.), University of Washington, Seattle; Department of Pathology (C.L., C.D.K.), Neuropathology Division, University of Washington, Seattle; Geriatric Research, Education, and Clinical Center (GRECC) (M.Y., D.G.C., W.H.R., T.D.B.), VA Puget Sound Health Care System, Seattle, WA; Department of Medicine (M.K.N.-K., W.H.R., T.D.B.), Division of Medical Genetics, University of Washington, Seattle; Mental Illness Research, Education, and Clinical Center (MIRECC) (J.S.M., W.H.R.), VA Puget Sound Health Care System, Seattle, WA; Department of Psychiatry and Behavioral Sciences (J.S.M., W.H.R.), University of Washington, Seattle; Department of Neurology (C.M.G.), University of Chicago, IL; Department of Medicine (D.G.C.), Division of Gerontology and Geriatric Medicine, University of Washington, Seattle; and Department of Pharmacology (D.G.C.), University of Washington, Seattle.

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http://dx.doi.org/10.1212/NXG.0000000000000397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073456PMC
April 2020

Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy.

J Neuropathol Exp Neurol 2020 May;79(5):465-473

Department of Epidemiology, National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1093/jnen/nlaa014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160616PMC
May 2020

Nasolacrimal Lymphangioma Presenting With Hemolacria.

Ophthalmic Plast Reconstr Surg 2020 Feb 24. Epub 2020 Feb 24.

Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington.

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http://dx.doi.org/10.1097/IOP.0000000000001622DOI Listing
February 2020

Hyperphosphorylated Tau, Increased Adenylate Cyclase 5 (ADCY5) Immunoreactivity, but No Neuronal Loss in ADCY5-Dyskinesia.

Mov Disord Clin Pract 2020 Jan 14;7(1):70-77. Epub 2019 Dec 14.

Department of Medicine, Division of Medical Genetics University of Washington Seattle Washington USA.

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http://dx.doi.org/10.1002/mdc3.12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962666PMC
January 2020

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade.

Sci Transl Med 2020 01;12(526)

Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1126/scitranslmed.aay6931DOI Listing
January 2020

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.

PLoS Genet 2019 12 13;15(12):e1008526. Epub 2019 Dec 13.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934317PMC
December 2019

Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology.

Prog Neurobiol 2020 02 25;185:101730. Epub 2019 Nov 25.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2019.101730DOI Listing
February 2020

Mitotic Index Thresholds Do Not Predict Clinical Outcome for IDH-Mutant Astrocytoma.

J Neuropathol Exp Neurol 2019 11;78(11):1002-1010

Department of Pathology, Division of Neuropathology.

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http://dx.doi.org/10.1093/jnen/nlz082DOI Listing
November 2019

Targeted Quantitative Proteomic Approach for High-Throughput Quantitative Profiling of Small GTPases in Brain Tissues of Alzheimer's Disease Patients.

Anal Chem 2019 10 10;91(19):12307-12314. Epub 2019 Sep 10.

Environmental Toxicology Graduate Program and Department of Chemistry , University of California , Riverside , California 92521 , United States.

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http://dx.doi.org/10.1021/acs.analchem.9b02485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939614PMC
October 2019

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gennady Roshchupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 Sep;51(9):1423-1424

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0495-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265117PMC
September 2019

A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease.

Acta Neuropathol Commun 2019 07 30;7(1):124. Epub 2019 Jul 30.

N. Bud Grossman Center for Memory Research and Care, University of Minnesota, 2101 6th Street SE, Minneapolis, 55455, USA.

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http://dx.doi.org/10.1186/s40478-019-0765-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668119PMC
July 2019

Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia.

Am J Hum Genet 2019 05 11;104(5):936-947. Epub 2019 Apr 11.

Department of Pediatrics, Division of Genetic Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA; Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506793PMC
May 2019

Cognitive Resilience to Alzheimer's Disease Pathology in the Human Brain.

J Alzheimers Dis 2019 ;68(3):1071-1083

Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.

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http://dx.doi.org/10.3233/JAD-180942DOI Listing
January 2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gennady Roshchupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice.

J Clin Invest 2019 02 22;129(2):820-833. Epub 2019 Jan 22.

Department of Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

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http://dx.doi.org/10.1172/JCI122954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355242PMC
February 2019

A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis.

Alzheimers Dement 2019 01 19;15(1):93-105. Epub 2018 Nov 19.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.06.3057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383152PMC
January 2019

Mass synaptometry: High-dimensional multi parametric assay for single synapses.

J Neurosci Methods 2019 01 20;312:73-83. Epub 2018 Nov 20.

Department of Pathology, Stanford University Medical Center, Stanford, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363340PMC
January 2019

Modeling Alzheimer's disease in progeria mice. An age-related concept.

Pathobiol Aging Age Relat Dis 2018 4;8(1):1524815. Epub 2018 Oct 4.

Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1080/20010001.2018.1524815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179061PMC
October 2018

Glia-specific APOE epigenetic changes in the Alzheimer's disease brain.

Brain Res 2018 11 3;1698:179-186. Epub 2018 Aug 3.

Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98104, USA.

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http://dx.doi.org/10.1016/j.brainres.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388639PMC
November 2018

An anatomic transcriptional atlas of human glioblastoma.

Science 2018 05;360(6389):660-663

Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.

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http://dx.doi.org/10.1126/science.aaf2666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414061PMC
May 2018

APOE DNA methylation is altered in Lewy body dementia.

Alzheimers Dement 2018 07 12;14(7):889-894. Epub 2018 Mar 12.

Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.jalz.2018.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050144PMC
July 2018

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.

Mol Neurodegener 2018 02 6;13(1). Epub 2018 Feb 6.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, S182, 1660 South Columbian Way, Seattle, WA, 98108, USA.

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http://dx.doi.org/10.1186/s13024-018-0237-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802059PMC
February 2018

DNA methylation of TOMM40-APOE-APOC2 in Alzheimer's disease.

J Hum Genet 2018 Apr 25;63(4):459-471. Epub 2018 Jan 25.

Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1038/s10038-017-0393-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466631PMC
April 2018

First confirmed case of chronic traumatic encephalopathy in a professional bull rider.

Acta Neuropathol 2018 02 28;135(2):303-305. Epub 2017 Dec 28.

Department of Neurological Surgery, University of Washington, 352 9th Ave, Box 959924, Seattle, WA, 98104, USA.

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http://dx.doi.org/10.1007/s00401-017-1801-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773642PMC
February 2018

The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features.

J Alzheimers Dis 2018 ;61(1):17-28

Center for Neuropathology, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, USA.

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http://dx.doi.org/10.3233/JAD-170654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734127PMC
July 2018

Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism.

Oxid Med Cell Longev 2017 2;2017:7317251. Epub 2017 Oct 2.

Section on Gerontology and Geriatrics, Sticht Center for Healthy Aging and Alzheimer's Prevention & Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1155/2017/7317251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643153PMC
July 2018

Mixed neuropathologies and associations with domain-specific cognitive decline.

Neurology 2017 Oct 22;89(17):1773-1781. Epub 2017 Sep 22.

From the National Alzheimer's Coordinating Center (W.D.B., W.T.L., W.A.K.), Department of Pathology (C.D.K.), Department of Epidemiology (S.E.H., W.D.B., W.T.L., W.A.K.), and Department of Neurology (W.T.L.), University of Washington, Seattle; Department of Biostatistics, Epidemiology and Informatics (R.A.H.), University of Pennsylvania, Philadelphia; and Department of Pathology (R.L.W.), Oregon Health & Science University, Portland. W.D.B. is currently with the Department of Epidemiology and Biostatistics, University of California, San Francisco.

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http://dx.doi.org/10.1212/WNL.0000000000004567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664309PMC
October 2017

Psychosis in Spinocerebellar Ataxias: a Case Series and Study of Tyrosine Hydroxylase in Substantia Nigra.

Cerebellum 2018 04;17(2):143-151

Department of Neurology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA, 98195, USA.

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http://dx.doi.org/10.1007/s12311-017-0882-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843512PMC
April 2018

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017

Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies.

J Neuropathol Exp Neurol 2017 Jun;76(6):458-466

From the Department of Pathology, University of Washington, Seattle, Washington (CSL, CDK); Department of Pathology, Stanford University, Stanford, California (MEF, KSM, TJM); Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota (LSH, KOL); Geriatric Research, Education, and Clinical Center, Minneapolis VA Health Care System, Minneapolis, Minnesota (LSH); Pacific Health Research and Education Institute (PHREI), Honolulu, Hawaii (LRW); and Department of Geriatric Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii (LRW).

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http://dx.doi.org/10.1093/jnen/nlx030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334750PMC
June 2017

Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions.

Exp Mol Pathol 2017 04 1;102(2):198-202. Epub 2017 Feb 1.

Department of Pathology, Division of Neuropathology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yexmp.2017.01.016DOI Listing
April 2017

Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample.

Alzheimers Dement 2017 Jun 19;13(6):654-662. Epub 2016 Nov 19.

National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.jalz.2016.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438283PMC
June 2017

Primary Gliosarcoma of the Optic Nerve: A Unique Adult Optic Pathway Glioma.

Ophthalmic Plast Reconstr Surg 2017 Jul/Aug;33(4):e88-e92

*Department of Pathology, Division of Neuropathology, and †Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington, U.S.A.

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http://dx.doi.org/10.1097/IOP.0000000000000798DOI Listing
September 2017

Orbital peripheral nerve sheath tumors.

Surv Ophthalmol 2017 Jan - Feb;62(1):43-57. Epub 2016 Aug 26.

Department of Ophthalmology, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1016/j.survophthal.2016.08.002DOI Listing
May 2017

Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.

J Alzheimers Dis 2016 09;54(2):669-78

Sticht Center on Aging, Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.3233/JAD-160036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439429PMC
September 2016

The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.

Acta Neuropathol 2016 10 29;132(4):545-61. Epub 2016 Jul 29.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.

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http://dx.doi.org/10.1007/s00401-016-1600-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026939PMC
October 2016

Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines.

Pathobiol Aging Age Relat Dis 2016 16;6:32397. Epub 2016 Jun 16.

Department of Pathology, University of Washington, Seattle, WA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912600PMC
http://dx.doi.org/10.3402/pba.v6.32397DOI Listing
June 2016

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.

Neuron 2016 05;90(4):724-39

Department of Neurology, Yale University, New Haven, CT 06511, USA; Department of Neuroscience, Yale University, New Haven, CT 06511, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898967PMC
May 2016

Mutational status of IDH1 in uveal melanoma.

Exp Mol Pathol 2016 06 4;100(3):476-81. Epub 2016 May 4.

Department of Pathology, Division of Neuropathology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA, United States.

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http://dx.doi.org/10.1016/j.yexmp.2016.05.002DOI Listing
June 2016

Unbiased Stereological Analysis of Reactive Astrogliosis to Estimate Age-Associated Cerebral White Matter Injury.

J Neuropathol Exp Neurol 2016 06 3;75(6):539-54. Epub 2016 May 3.

From the Department of Pediatrics, Oregon Health & Science University, Portland, Oregon (DWM, DDB, XG, SAB); Department of Neurology, Oregon Health & Science University, Portland, Oregon (SAB); and Department of Pathology, University of Washington, Seattle, Washington, District of Columbia (NOP, TJM, CDK).

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http://dx.doi.org/10.1093/jnen/nlw032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250206PMC
June 2016

Unusually long duration and delayed penetrance in a family with FTD and mutation in MAPT (V337M).

Am J Med Genet B Neuropsychiatr Genet 2017 01 16;174(1):70-74. Epub 2016 Mar 16.

Department of Neurology, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1002/ajmg.b.32443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297469PMC
January 2017

Precision Medicine: Clarity for the Complexity of Dementia.

Am J Pathol 2016 Mar 24;186(3):500-6. Epub 2015 Dec 24.

Department of Pathology, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816691PMC
March 2016

Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease.

Neurodegener Dis 2016 10;16(1-2):39-43. Epub 2015 Nov 10.

Departments of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, N.C., USA.

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http://dx.doi.org/10.1159/000438925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674306PMC
September 2016

The APOE Gene is Differentially Methylated in Alzheimer's Disease.

J Alzheimers Dis 2015 ;48(3):745-55

Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA.

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http://dx.doi.org/10.3233/JAD-143060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469491PMC
July 2016

Multiplexed In-cell Immunoassay for Same-sample Protein Expression Profiling.

Sci Rep 2015 Sep 2;5:13651. Epub 2015 Sep 2.

Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1038/srep13651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556981PMC
September 2015