Publications by authors named "C Christina Mehta"

370 Publications

Structurally nanoengineered antimicrobial peptide polymers: design, synthesis and biomedical applications.

World J Microbiol Biotechnol 2021 Jul 19;37(8):139. Epub 2021 Jul 19.

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India.

Antimicrobial resistance not only increases the contagiousness of infectious diseases but also a threat for the future as it is one of the health care concern around the globe. Conventional antibiotics are unsuccessful in combating chronic infections caused by multidrug-resistant (MDR) bacteria, therefore it is important to design and develop novel strategies to tackle this problems. Among various novel strategies, Structurally Nanoengineered Antimicrobial Peptide Polymers (SNAPPs) have been introduced in recent years to overcome this global health care issue and they are found to be more efficient in their performance. Many facile methods are adapted to synthesize complex SNAPPs with required dimensions and unique functionalities. Their unique characteristics and remarkable properties have been exploited for their immense applications in various fields including biomedicine, targeting therapies, gene delivery, bioimaging, and many more. This review article deals with its background, design, synthesis, mechanism of action, and wider applications in various fields of SNAPPs.
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http://dx.doi.org/10.1007/s11274-021-03109-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286942PMC
July 2021

Improving the endovascular management of blunt thoracic aortic injury.

Ann Thorac Surg 2021 Jul 13. Epub 2021 Jul 13.

Division of Cardiac Surgery, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Arkes Pavilion, Suite 730, Chicago, IL 60611. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2021.06.033DOI Listing
July 2021

Noninvasive Morphologic and Hemodynamic Evaluation of Type B Aortic Dissection: State of the Art and Future Perspectives.

Radiol Cardiothorac Imaging 2021 Jun 24;3(3):e200456. Epub 2021 Jun 24.

Department of Radiology (Z.A.Z., A.B., B.D.A.), Department of Surgery-Division of Cardiac Surgery (S.C.M., C.K.M.), Department of Surgery-Division of Vascular Surgery (A.W.H.), and Department of Medicine-Division of Cardiology (P.V.), Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 800, Chicago, IL 60611; Department of Radiology, University of Michigan, Ann Arbor, Mich (N.S.B.); Departments of Mechanical Engineering and Radiology, University of Wisconsin-Madison, Madison, Wis (A.R.A.); and Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.C., C.J.F.).

Stanford type B aortic dissection (TBAD) is associated with relatively high rates of morbidity and mortality, and appropriate treatment selection is important for optimizing patient outcomes. Depending on individualized risk factors, clinical presentation, and imaging findings, patients are generally stratified to optimal medical therapy anchored by antihypertensives or thoracic endovascular aortic repair (TEVAR). Using standard anatomic imaging with CT or MRI, several high-risk features including aortic diameter, false lumen (FL) features, size of entry tears, involvement of major aortic branch vessels, or evidence of visceral malperfusion have been used to select patients likely to benefit from TEVAR. However, even with these measures, the number needed to treat for TEVAR remains, and improved risk stratification is needed. Increasingly, the relationship between FL hemodynamics and adverse aortic remodeling in TBAD has been studied, and evolving noninvasive techniques can measure numerous FL hemodynamic parameters that may improve risk stratification. In addition to summarizing the current clinical state of the art for morphologic TBAD evaluation, this review provides a detailed overview of noninvasive methods for TBAD hemodynamics characterization, including computational fluid dynamics and four-dimensional flow MRI. CT, Image Postprocessing, MRI, Cardiac, Vascular, Aorta, Dissection © RSNA, 2021.
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http://dx.doi.org/10.1148/ryct.2021200456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250421PMC
June 2021

Opioid Use After Cardiac Surgery: Problem, or Problem of Perception?

Ann Thorac Surg 2021 Jul 3. Epub 2021 Jul 3.

Division of Cardiac Surgery Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital 676 N. St. Clair Street Arkes Pavilion, Suite 730 Chicago, IL 60611. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2021.05.094DOI Listing
July 2021

Psychosocial Mechanisms of Self-rated Successful Aging with HIV: A Structural Equation Model.

AIDS Behav 2021 Jun 11. Epub 2021 Jun 11.

Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA, USA.

This study tested a conceptual psychosocial model of self-rated successful aging (SRSA) with HIV. Our sample (n = 356) included older women living with HIV (OWLH): average age 56.5 years, 73% Black. SRSA was assessed using a research-based 10-point scale (higher scores = better outcomes). We conducted adjusted structural equation modeling. The global model included two latent variables-protective attributes (composite of positive psychosocial factors: resilience, personal mastery, optimism, spirituality) and psychological distress (composite of negative psychosocial factors: anxiety, depression, loneliness, internalized HIV-related stigma). The model showed good fit (χ(58) = 76, p = 0.06; RMSEA = 0.03; CFI = 0.99). Increased protective attributes were associated with improved SRSA both directly and mediated by improved coping with stress. While psychological distress did not have a direct effect on SRSA, it was indirectly associated with worsened SRSA via diminished protective attributes and via decreased coping with stress. Findings suggest the need for interventions enhancing positive and mitigating negative psychosocial factors in OWLH.
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http://dx.doi.org/10.1007/s10461-021-03340-7DOI Listing
June 2021