Publications by authors named "C C Bîrsan"

11 Publications

  • Page 1 of 1

Soil mite communities (Acari: Mesostigmata) as indicators of urban ecosystems in Bucharest, Romania.

Sci Rep 2021 Feb 15;11(1):3794. Epub 2021 Feb 15.

Department of Ecology, Taxonomy and Nature Conservation, Romanian Academy, Institute of Biology Bucharest, street Splaiul Independenţei, no. 296, PO-BOX 56-53, 0603100, Bucharest, Romania.

The aim of the present study was to establish the effect of management type and of environmental variables on the structure, abundance and species richness of soil mites (Acari: Mesostigmata) in twelve urban green areas in Bucharest-Romania. Three categories of ecosystem based upon management type were investigated: protected area, managed (metropolitan, municipal and district parks) and unmanaged urban areas. The environmental variables which were analysed were: soil and air temperature, soil moisture and atmospheric humidity, soil pH and soil penetration resistance. In June 2017, 480 soil samples were taken, using MacFadyen soil core. The same number of measures was made for quantification of environmental variables. Considering these, we observed that soil temperature, air temperature, air humidity and soil penetration resistance differed significantly between all three types of managed urban green area. All investigated environmental variables, especially soil pH, were significantly related to community assemblage. Analysing the entire Mesostigmata community, 68 species were identified, with 790 individuals and 49 immatures. In order to highlight the response of the soil mite communities to the urban conditions, Shannon, dominance, equitability and soil maturity indices were quantified. With one exception (numerical abundance), these indices recorded higher values in unmanaged green areas compared to managed ecosystems. The same trend was observed between different types of managed green areas, with metropolitan parks having a richer acarological fauna than the municipal or district parks.
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http://dx.doi.org/10.1038/s41598-021-83417-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884781PMC
February 2021

Toenail Bracing Complicated With Group-A Beta-Haemolytic Streptococcus Infection.

Dermatol Surg 2017 09;43(9):1184-1185

Department of Dermatology, Nicolina Medical Center, Iasi, Romania Department of Dermato-Physiollogy, Apollonia University, Iasi, Romania "P. Poni" Institute of Macromolecular Chemistry, Iasi, Romania Department of Dermatology, Nicolina Medical Center, Iasi, Romania Department of Surgery, University of Medicine and Pharmacy, Tirgu-Mures, Romania Department of Pathology, University of Medicine and Pharmacy, Tirgu-Mures, Romania.

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http://dx.doi.org/10.1097/DSS.0000000000001108DOI Listing
September 2017

Pragmatic management of (suspected allergic) diaper dermatitis.

Contact Dermatitis 2017 Feb;76(2):129-130

Department of Pathology, University of Medicine Targu Mures, Tirgu Mures, 540099, Romania.

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http://dx.doi.org/10.1111/cod.12663DOI Listing
February 2017

Skin necrosis caused by prallethrin-A worldwide used insecticide.

Environ Toxicol Pharmacol 2016 Apr 9;43:103-4. Epub 2016 Mar 9.

Department of Dermatology, Nicolina Medical Center, Iasi, Romania; Department of Dermato-Physiology, Apollonia University, Iasi, Romania. Electronic address:

We report a case of necrosis caused by the use of prallethrin (mosquito repellent) on the skin in a 67-year-old diabetic female patient suffering from delusions of parasitosis. Cutaneous toxicity due to pyrethroids is less known or reported, despite well-documented pyrethroid poisoning involving the gastrointestinal, respiratory, cardiac, and nervous systems. Skin irritation has been described after acute accidental exposure but, as far as we know, no data have been published on the effects of pyrethroids when applied directly to the skin.
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http://dx.doi.org/10.1016/j.etap.2016.03.002DOI Listing
April 2016

Noninvasive Treatment of Pyogenic Granulomas in Young Children with Topical Timolol and Trichloroacetic Acid.

J Pediatr 2016 Feb 14;169:322-322.e1. Epub 2015 Nov 14.

Department of Pathology, University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania.

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http://dx.doi.org/10.1016/j.jpeds.2015.10.047DOI Listing
February 2016

Cutaneous factitia in elderly patients: alarm signal for psychiatric disorders.

Clin Interv Aging 2014 12;9:421-4. Epub 2014 Mar 12.

Department of Dermatology, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania.

Background: The factitious disorders, more commonly known in daily practice as pathomimia, are expressed in dermatology units by skin lesions induced voluntarily by the patient, in order to draw attention of the medical staff and/or the family members. The disorder is often challenging to diagnose and even more difficult to document in front of the patient or relatives. It represents a challenge for the physician, and any attempt at treatment may be followed by recurrence of the self-mutilation. This paper describes two cases of pathomimia diagnosed by dermatologists and treated in a psychiatry unit, highlighting the importance of collaboration in these situations.

Patients And Methods: Two case reports, describing old female patients with pathomimia, hospitalized in a department of dermatology for bizarre skin lesions.

Results: The first case was a 77-year-old female with unknown psychiatric problems and atrophic skin lesions on the face, self-induced for many months, with multiple hospitalizations in dermatology units, with no response to different therapeutic patterns, and full recovery after psychiatric treatment for a major depressive syndrome. The second case was a 61-year-old female patient with disseminated atrophic scars on the face, trunk, and limbs. She raised our interest because of possible psychiatric issues, as she had attempted to commit suicide. The prescription of antidepressants led to a significant clinical improvement.

Conclusion: These cases indicate that a real psychiatric disease may be recorded in patients suffering from pathomimia. Therefore, complete psychiatric evaluation in order to choose the proper therapy is mandatory for all these cases. Dermatologists and all physicians who take care of old patients must recognize the disorder in order to provide optimum care for this chronic condition. We emphasize therefore the importance of psychiatric evaluation and treatment to avoid the major risk of suicide. Skin lesions must be regarded as an alarm signal in critical cases, especially in senior people.
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http://dx.doi.org/10.2147/CIA.S56185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958542PMC
September 2014

Parotid dermoid cyst: a case report.

Int J Surg Pathol 2013 Apr 16;21(2):197-201. Epub 2012 Aug 16.

Loma Linda University Medical Center, Loma Linda, CA, USA.

A dermoid cyst arising in the parotid is rare and usually represents the rare first branchial cleft type II anomaly, which can have morphology similar to a dermoid cyst. This study reports the case of a 20-year-old woman who presented with a parotid mass, which on histologic review was consistent with a dermoid cyst. This appears to be the first case report of a parotid dermoid cyst with focus on the gross and histopathologic findings and to be presented in a histopathology focused journal. The discussion includes the clinical presentation, imaging findings, gross pathology, histologic features, and differential diagnosis of parotid dermoid cysts. Although there was no prior fine needle aspiration (FNA) of the lesion in this case, parotid masses are commonly subject to FNA prior to excision. Therefore, a brief review of the FNA findings in dermoid cysts is also included.
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http://dx.doi.org/10.1177/1066896912456082DOI Listing
April 2013

[Incidence of tuberculous infection in Caracal in 2000].

Pneumologia 2001 Jan-Mar;50(1):14-6

Spitalul Municipal Caracal, judeţul Olt.

Taking into consideration the informational value of the yearly risk of tuberculous infection as an isolated epidemic indicator which is able to define by itself the present phase and the trends of the tuberculous endemic in a population, we tried to establish its value at the first grade pupils in the city of Caracal by using two methods: 1. the indirect one starting from the prevalence of infection using the A. Lotte formula: YRI = 1.24% +/- 0.45, p = 0.05, s = 0.32, Es = 0.16 (the average level in 1992, 1993, 1994, 1999 and 2000); 2. the direct one, by testing with tuberculin a group of 184 pupils twice at one year's interval. YRI = 2.65% in 1999/2000. By using the student test we demonstrated that the two values are statistically different, without being able to state which one is closer to reality, but irrespective of the chosen value, to reach the present level of yearly tuberculous infection of the western countries we need about ten to twenty years, if we admit that beginning from this moment the annual decrease will be maximal (14%).
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July 2001

Insights into transition state stabilization of the beta-1,4-glycosidase Cex by covalent intermediate accumulation in active site mutants.

Nat Struct Biol 1998 Sep;5(9):812-8

Protein Engineering Network of Centres of Excellence, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Canada.

The catalytic mechanism of 'retaining' beta-glycosidases has been the subject of considerable interest and debate for many years. The visualization of a covalent glycosyl enzyme intermediate by X-ray crystallography was first accomplished with a saccharide substrate substituted with fluorine at its 2-position. The structure implicated major roles for residue His 205 and for the 2-hydroxyl position of the proximal saccharide in binding and catalysis. Here we have studied the kinetic behavior of various His 205 mutants. One of these mutants, a double mutant H205N/E127A, has been used to stabilize a covalent glycosyl-enzyme intermediate involving an unsubstituted sugar, permitting crystallographic analysis of the interactions between its 2-hydroxyl group and the enzyme.
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http://dx.doi.org/10.1038/1852DOI Listing
September 1998

Mechanisms of cellulases and xylanases.

Biochem Soc Trans 1998 May;26(2):156-60

Protein Engineering Network of Centres of Excellence of Canada, Vancouver, B.C., Canada.

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http://dx.doi.org/10.1042/bst0260156DOI Listing
May 1998

Exploring the cellulose/xylan specificity of the beta-1,4-glycanase cex from Cellulomonas fimi through crystallography and mutation.

Biochemistry 1998 Apr;37(14):4751-8

Protein Engineering Network of Centres of Excellence, Ontario Cancer Institute, University of Toronto, Toronto, Canada.

The retaining beta-1,4-glycanase Cex from Cellulomonas fimi, a family 10 glycosyl hydrolase, hydrolyzes xylan 40-fold more efficiently than cellulose. To gain insight into the nature of its preference for xylan, we determined the crystal structure of the Cex catalytic domain (Cex-cd) trapped as its covalent 2-deoxy-2-fluoroxylobiosyl-enzyme intermediate to 1.9 A resolution. Together with the crystal structure of unliganded Cex-cd [White, A., et al. (1994) Biochemistry 33, 12546-12552] and the previously determined crystal structure of the covalent 2-deoxy-2-fluorocellobiosyl-Cex-cd intermediate [White, A., et al. (1996) Nat. Struct. Biol. 3, 149-154], this structure provides a convincing rationale for the observed substrate specificity in Cex. Two active site residues, Gln87 and Trp281, are found to sterically hinder the binding of glucosides and must rearrange to accommodate these substrates. Such rearrangements are not necessary for the binding of xylobiosides. The importance of this observation was tested by examining the catalytic behavior of the enzyme with Gln87 mutated to Met. This mutation had no measurable effect on substrate affinity or turnover number relative to the wild type enzyme, indicating that the Met side chain could accommodate the glucoside moiety as effectively as the wild type Gln residue. Subsequent mutagenesis studies will address the role of entropic versus enthalpic contributions to binding by introducing side chains that might be more rigid in the unliganded enzyme.
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http://dx.doi.org/10.1021/bi9729211DOI Listing
April 1998